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Protein

Regulator of Ty1 transposition protein 102

Gene

RTT102

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable component of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. Probable component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

Miscellaneous

Present with 1550 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • chromatin remodeling Source: SGD
  • chromosome segregation Source: SGD
  • nucleosome disassembly Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription elongation from RNA polymerase II promoter Source: SGD

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30940-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of Ty1 transposition protein 102
Gene namesi
Name:RTT102
Ordered Locus Names:YGR275W
ORF Names:G9378
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR275W.
SGDiS000003507. RTT102.

Subcellular locationi

GO - Cellular componenti

  • RSC complex Source: SGD
  • SWI/SNF complex Source: SGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975011 – 157Regulator of Ty1 transposition protein 102Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53330.
PRIDEiP53330.

PTM databases

iPTMnetiP53330.

Interactioni

Subunit structurei

Interacts with STH1 and SWI3. Component of the two forms of the RSC complex composed of at least either RSC1 or RSC2, and ARP7, ARP9, LDB7, NPL6, RSC3, RSC30, RSC4, RSC58, RSC6, RSC8, RSC9, SFH1, STH1, HTL1 and probably RTT102. The complexes interact with histone and histone variant components of centromeric chromatin. Probable additional component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33525. 106 interactors.
DIPiDIP-3864N.
IntActiP53330. 55 interactors.
MINTiMINT-522104.

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 9Combined sources7
Beta strandi25 – 30Combined sources6
Beta strandi60 – 65Combined sources6
Beta strandi86 – 88Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I6MX-ray2.80D1-157[»]
ProteinModelPortaliP53330.
SMRiP53330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP53330.
OMAiKANNGGH.
OrthoDBiEOG092C5YXD.

Family and domain databases

InterProiView protein in InterPro
IPR018304. Rtt102.
PfamiView protein in Pfam
PF09510. Rtt102p. 1 hit.

Sequencei

Sequence statusi: Complete.

P53330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQTLITKA NKVSYYGNPT SKESWRYDWY QPSKVSSNVQ QPQQQLGDME
60 70 80 90 100
NNLEKYPFRY KTWLRNQEDE KNLQRESCED ILDLKEFDRR ILKKSLMTSH
110 120 130 140 150
TKGDTSKATG APSANQGDEA LSVDDIRGAV GNSEAIPGLS AGVNNDNTKE

SKDVKMN
Length:157
Mass (Da):17,795
Last modified:September 13, 2005 - v2
Checksum:iD71CA1234D0D0176
GO

Sequence cautioni

The sequence AAS56708 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA58897 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA97305 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84098 Genomic DNA. Translation: CAA58897.1. Different initiation.
Z73060 Genomic DNA. Translation: CAA97305.1. Different initiation.
AY558382 Genomic DNA. Translation: AAS56708.1. Different initiation.
BK006941 Genomic DNA. Translation: DAA08363.1.
PIRiS64608.
RefSeqiNP_011791.4. NM_001181404.3.

Genome annotation databases

EnsemblFungiiYGR275W; YGR275W; YGR275W.
GeneIDi853192.
KEGGisce:YGR275W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84098 Genomic DNA. Translation: CAA58897.1. Different initiation.
Z73060 Genomic DNA. Translation: CAA97305.1. Different initiation.
AY558382 Genomic DNA. Translation: AAS56708.1. Different initiation.
BK006941 Genomic DNA. Translation: DAA08363.1.
PIRiS64608.
RefSeqiNP_011791.4. NM_001181404.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I6MX-ray2.80D1-157[»]
ProteinModelPortaliP53330.
SMRiP53330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33525. 106 interactors.
DIPiDIP-3864N.
IntActiP53330. 55 interactors.
MINTiMINT-522104.

PTM databases

iPTMnetiP53330.

Proteomic databases

MaxQBiP53330.
PRIDEiP53330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR275W; YGR275W; YGR275W.
GeneIDi853192.
KEGGisce:YGR275W.

Organism-specific databases

EuPathDBiFungiDB:YGR275W.
SGDiS000003507. RTT102.

Phylogenomic databases

InParanoidiP53330.
OMAiKANNGGH.
OrthoDBiEOG092C5YXD.

Enzyme and pathway databases

BioCyciYEAST:G3O-30940-MONOMER.

Miscellaneous databases

PROiPR:P53330.

Family and domain databases

InterProiView protein in InterPro
IPR018304. Rtt102.
PfamiView protein in Pfam
PF09510. Rtt102p. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT102_YEAST
AccessioniPrimary (citable) accession number: P53330
Secondary accession number(s): D6VV52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 13, 2005
Last modified: June 7, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.