Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

High-affinity nicotinic acid transporter

Gene

TNA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the uptake of nicotinic acid.

GO - Molecular functioni

  • carboxylic acid transmembrane transporter activity Source: SGD

GO - Biological processi

  • carboxylic acid transport Source: SGD
  • quinolinic acid transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30929-MONOMER.

Protein family/group databases

TCDBi2.A.1.14.11. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity nicotinic acid transporter
Alternative name(s):
Nicotinic acid permease
Gene namesi
Name:TNA1
Ordered Locus Names:YGR260W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR260W.
SGDiS000003492. TNA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 130ExtracellularSequence analysisAdd BLAST130
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152CytoplasmicSequence analysis1
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 187ExtracellularSequence analysisAdd BLAST14
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 217CytoplasmicSequence analysis9
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 250ExtracellularSequence analysisAdd BLAST12
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 323CytoplasmicSequence analysisAdd BLAST52
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 355ExtracellularSequence analysisAdd BLAST11
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 384CytoplasmicSequence analysis8
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 410ExtracellularSequence analysis5
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 444CytoplasmicSequence analysisAdd BLAST13
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 474ExtracellularSequence analysis9
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Topological domaini496 – 534CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213691 – 534High-affinity nicotinic acid transporterAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP53322.
PRIDEiP53322.

PTM databases

iPTMnetiP53322.

Interactioni

Protein-protein interaction databases

BioGridi33511. 87 interactors.
DIPiDIP-8004N.
MINTiMINT-4488034.

Structurei

3D structure databases

ProteinModelPortaliP53322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088258.
HOGENOMiHOG000167306.
InParanoidiP53322.
OMAiDEKFEWF.
OrthoDBiEOG092C2CRD.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

P53322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKFTMESP KHLVDDVLFI SPTNDGSEEK PTEVTFQEDE GHDASLHNRS
60 70 80 90 100
HDKKSELATE REIMATTTDD DGIPSPSHPM EKRVLRKMDI YLIPLMGMLY
110 120 130 140 150
FLSNLDKSNI GNAEVAGLSK DIHLVGTQYN TCVTVFFATY VLFDPIGTNL
160 170 180 190 200
LKIMGPPLMM SICLTCFGAI SLGTAWVKNY AQLIVVRLLL GAFEGMIYPA
210 220 230 240 250
INMYLSVCYR REQYALRFAF VFSAACLSSS FGGLIAYGCS KISGSLKDWQ
260 270 280 290 300
YIYIVEGCIS LGFVPFYAFG LSKNLEDSWF FNKEEKEYIS ERYKTMNTFD
310 320 330 340 350
PDEKFEWFQV WQAVKDVKTW ASAVALFGID LTTFGLTVFL PIIITSMGFT
360 370 380 390 400
NVRAQLMTVP IYFLTAIVFF ICAVWSDRIK LRSPFILGAC LTTSIGIAIV
410 420 430 440 450
LGSQVHGVRY FGVYILCMGI YVNAACNCLW LSGNTGNYFK RATALGINLF
460 470 480 490 500
FGSGSGLVSG QIFVAKDKPR YIKGLSISLA FQVFSIFMTV VQIFLYKREN
510 520 530
DKKKAIIDRC NELGEPIPYD ERLSDKNPEF KYMY
Length:534
Mass (Da):60,135
Last modified:October 1, 1996 - v1
Checksum:iADE7C1DE793FDAA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07777 Genomic DNA. Translation: CAA69082.1.
Z73044 Genomic DNA. Translation: CAA97289.1.
BK006941 Genomic DNA. Translation: DAA08350.1.
PIRiS64593.
RefSeqiNP_011776.1. NM_001181389.1.

Genome annotation databases

EnsemblFungiiYGR260W; YGR260W; YGR260W.
GeneIDi853175.
KEGGisce:YGR260W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07777 Genomic DNA. Translation: CAA69082.1.
Z73044 Genomic DNA. Translation: CAA97289.1.
BK006941 Genomic DNA. Translation: DAA08350.1.
PIRiS64593.
RefSeqiNP_011776.1. NM_001181389.1.

3D structure databases

ProteinModelPortaliP53322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33511. 87 interactors.
DIPiDIP-8004N.
MINTiMINT-4488034.

Protein family/group databases

TCDBi2.A.1.14.11. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP53322.

Proteomic databases

MaxQBiP53322.
PRIDEiP53322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR260W; YGR260W; YGR260W.
GeneIDi853175.
KEGGisce:YGR260W.

Organism-specific databases

EuPathDBiFungiDB:YGR260W.
SGDiS000003492. TNA1.

Phylogenomic databases

GeneTreeiENSGT00620000088258.
HOGENOMiHOG000167306.
InParanoidiP53322.
OMAiDEKFEWF.
OrthoDBiEOG092C2CRD.

Enzyme and pathway databases

BioCyciYEAST:G3O-30929-MONOMER.

Miscellaneous databases

PROiP53322.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTNA1_YEAST
AccessioniPrimary (citable) accession number: P53322
Secondary accession number(s): D6VV39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.