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P53322

- TNA1_YEAST

UniProt

P53322 - TNA1_YEAST

Protein

High-affinity nicotinic acid transporter

Gene

TNA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Involved in the uptake of nicotinic acid.

    GO - Molecular functioni

    1. nicotinamide mononucleotide transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. nicotinamide mononucleotide transmembrane transport Source: GOC
    2. nicotinamide mononucleotide transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30929-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.14.11. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High-affinity nicotinic acid transporter
    Alternative name(s):
    Nicotinic acid permease
    Gene namesi
    Name:TNA1
    Ordered Locus Names:YGR260W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR260w.
    SGDiS000003492. TNA1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534High-affinity nicotinic acid transporterPRO_0000121369Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271Phosphoserine1 Publication
    Cross-linki283 – 283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP53322.
    PaxDbiP53322.
    PeptideAtlasiP53322.

    Expressioni

    Gene expression databases

    GenevestigatoriP53322.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CSG2P352061EBI-2051164,EBI-2051140
    ERG11P106141EBI-2051164,EBI-5127
    ERP1Q053591EBI-2051164,EBI-6581
    ERV25P548371EBI-2051164,EBI-6642
    PHO88P382641EBI-2051164,EBI-13350
    SHR3Q027741EBI-2051164,EBI-17099
    SPF1P399861EBI-2051164,EBI-3128
    SWP1Q027951EBI-2051164,EBI-12666

    Protein-protein interaction databases

    BioGridi33511. 87 interactions.
    DIPiDIP-8004N.
    MINTiMINT-4488034.
    STRINGi4932.YGR260W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53322.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 130130ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini152 – 1521CytoplasmicSequence Analysis
    Topological domaini174 – 18714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 2179CytoplasmicSequence Analysis
    Topological domaini239 – 25012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini272 – 32352CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini345 – 35511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini377 – 3848CytoplasmicSequence Analysis
    Topological domaini406 – 4105ExtracellularSequence Analysis
    Topological domaini432 – 44413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini466 – 4749ExtracellularSequence Analysis
    Topological domaini496 – 53439CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei411 – 43121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei445 – 46521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00620000088258.
    HOGENOMiHOG000167306.
    OMAiAINMYLS.
    OrthoDBiEOG7S4XG9.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53322-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNKFTMESP KHLVDDVLFI SPTNDGSEEK PTEVTFQEDE GHDASLHNRS    50
    HDKKSELATE REIMATTTDD DGIPSPSHPM EKRVLRKMDI YLIPLMGMLY 100
    FLSNLDKSNI GNAEVAGLSK DIHLVGTQYN TCVTVFFATY VLFDPIGTNL 150
    LKIMGPPLMM SICLTCFGAI SLGTAWVKNY AQLIVVRLLL GAFEGMIYPA 200
    INMYLSVCYR REQYALRFAF VFSAACLSSS FGGLIAYGCS KISGSLKDWQ 250
    YIYIVEGCIS LGFVPFYAFG LSKNLEDSWF FNKEEKEYIS ERYKTMNTFD 300
    PDEKFEWFQV WQAVKDVKTW ASAVALFGID LTTFGLTVFL PIIITSMGFT 350
    NVRAQLMTVP IYFLTAIVFF ICAVWSDRIK LRSPFILGAC LTTSIGIAIV 400
    LGSQVHGVRY FGVYILCMGI YVNAACNCLW LSGNTGNYFK RATALGINLF 450
    FGSGSGLVSG QIFVAKDKPR YIKGLSISLA FQVFSIFMTV VQIFLYKREN 500
    DKKKAIIDRC NELGEPIPYD ERLSDKNPEF KYMY 534
    Length:534
    Mass (Da):60,135
    Last modified:October 1, 1996 - v1
    Checksum:iADE7C1DE793FDAA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07777 Genomic DNA. Translation: CAA69082.1.
    Z73044 Genomic DNA. Translation: CAA97289.1.
    BK006941 Genomic DNA. Translation: DAA08350.1.
    PIRiS64593.
    RefSeqiNP_011776.1. NM_001181389.1.

    Genome annotation databases

    EnsemblFungiiYGR260W; YGR260W; YGR260W.
    GeneIDi853175.
    KEGGisce:YGR260W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07777 Genomic DNA. Translation: CAA69082.1 .
    Z73044 Genomic DNA. Translation: CAA97289.1 .
    BK006941 Genomic DNA. Translation: DAA08350.1 .
    PIRi S64593.
    RefSeqi NP_011776.1. NM_001181389.1.

    3D structure databases

    ProteinModelPortali P53322.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33511. 87 interactions.
    DIPi DIP-8004N.
    MINTi MINT-4488034.
    STRINGi 4932.YGR260W.

    Protein family/group databases

    TCDBi 2.A.1.14.11. the major facilitator superfamily (mfs).

    Proteomic databases

    MaxQBi P53322.
    PaxDbi P53322.
    PeptideAtlasi P53322.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR260W ; YGR260W ; YGR260W .
    GeneIDi 853175.
    KEGGi sce:YGR260W.

    Organism-specific databases

    CYGDi YGR260w.
    SGDi S000003492. TNA1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00620000088258.
    HOGENOMi HOG000167306.
    OMAi AINMYLS.
    OrthoDBi EOG7S4XG9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30929-MONOMER.

    Miscellaneous databases

    NextBioi 973305.

    Gene expression databases

    Genevestigatori P53322.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes."
      Clemente M.L., Sartori G., Cardazzo B., Carignani G.
      Yeast 13:287-290(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w)."
      Llorente B., Dujon B.
      FEBS Lett. 475:237-241(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-283.
      Strain: SUB592.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTNA1_YEAST
    AccessioniPrimary (citable) accession number: P53322
    Secondary accession number(s): D6VV39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3