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P53322

- TNA1_YEAST

UniProt

P53322 - TNA1_YEAST

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Protein
High-affinity nicotinic acid transporter
Gene
TNA1, YGR260W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the uptake of nicotinic acid.

GO - Molecular functioni

  1. nicotinamide mononucleotide transmembrane transporter activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. nicotinamide mononucleotide transmembrane transport Source: GOC
  2. nicotinamide mononucleotide transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30929-MONOMER.

Protein family/group databases

TCDBi2.A.1.14.11. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity nicotinic acid transporter
Alternative name(s):
Nicotinic acid permease
Gene namesi
Name:TNA1
Ordered Locus Names:YGR260W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR260w.
SGDiS000003492. TNA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 130130Extracellular Reviewed prediction
Add
BLAST
Transmembranei131 – 15121Helical; Reviewed prediction
Add
BLAST
Topological domaini152 – 1521Cytoplasmic Reviewed prediction
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Topological domaini174 – 18714Extracellular Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Topological domaini209 – 2179Cytoplasmic Reviewed prediction
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Topological domaini239 – 25012Extracellular Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST
Topological domaini272 – 32352Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei324 – 34421Helical; Reviewed prediction
Add
BLAST
Topological domaini345 – 35511Extracellular Reviewed prediction
Add
BLAST
Transmembranei356 – 37621Helical; Reviewed prediction
Add
BLAST
Topological domaini377 – 3848Cytoplasmic Reviewed prediction
Transmembranei385 – 40521Helical; Reviewed prediction
Add
BLAST
Topological domaini406 – 4105Extracellular Reviewed prediction
Transmembranei411 – 43121Helical; Reviewed prediction
Add
BLAST
Topological domaini432 – 44413Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei445 – 46521Helical; Reviewed prediction
Add
BLAST
Topological domaini466 – 4749Extracellular Reviewed prediction
Transmembranei475 – 49521Helical; Reviewed prediction
Add
BLAST
Topological domaini496 – 53439Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534High-affinity nicotinic acid transporter
PRO_0000121369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Phosphoserine1 Publication
Cross-linki283 – 283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP53322.
PaxDbiP53322.
PeptideAtlasiP53322.

Expressioni

Gene expression databases

GenevestigatoriP53322.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CSG2P352061EBI-2051164,EBI-2051140
ERG11P106141EBI-2051164,EBI-5127
ERP1Q053591EBI-2051164,EBI-6581
ERV25P548371EBI-2051164,EBI-6642
PHO88P382641EBI-2051164,EBI-13350
SHR3Q027741EBI-2051164,EBI-17099
SPF1P399861EBI-2051164,EBI-3128
SWP1Q027951EBI-2051164,EBI-12666

Protein-protein interaction databases

BioGridi33511. 87 interactions.
DIPiDIP-8004N.
MINTiMINT-4488034.
STRINGi4932.YGR260W.

Structurei

3D structure databases

ProteinModelPortaliP53322.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088258.
HOGENOMiHOG000167306.
OMAiAINMYLS.
OrthoDBiEOG7S4XG9.

Family and domain databases

InterProiIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

P53322-1 [UniParc]FASTAAdd to Basket

« Hide

MSNKFTMESP KHLVDDVLFI SPTNDGSEEK PTEVTFQEDE GHDASLHNRS    50
HDKKSELATE REIMATTTDD DGIPSPSHPM EKRVLRKMDI YLIPLMGMLY 100
FLSNLDKSNI GNAEVAGLSK DIHLVGTQYN TCVTVFFATY VLFDPIGTNL 150
LKIMGPPLMM SICLTCFGAI SLGTAWVKNY AQLIVVRLLL GAFEGMIYPA 200
INMYLSVCYR REQYALRFAF VFSAACLSSS FGGLIAYGCS KISGSLKDWQ 250
YIYIVEGCIS LGFVPFYAFG LSKNLEDSWF FNKEEKEYIS ERYKTMNTFD 300
PDEKFEWFQV WQAVKDVKTW ASAVALFGID LTTFGLTVFL PIIITSMGFT 350
NVRAQLMTVP IYFLTAIVFF ICAVWSDRIK LRSPFILGAC LTTSIGIAIV 400
LGSQVHGVRY FGVYILCMGI YVNAACNCLW LSGNTGNYFK RATALGINLF 450
FGSGSGLVSG QIFVAKDKPR YIKGLSISLA FQVFSIFMTV VQIFLYKREN 500
DKKKAIIDRC NELGEPIPYD ERLSDKNPEF KYMY 534
Length:534
Mass (Da):60,135
Last modified:October 1, 1996 - v1
Checksum:iADE7C1DE793FDAA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07777 Genomic DNA. Translation: CAA69082.1.
Z73044 Genomic DNA. Translation: CAA97289.1.
BK006941 Genomic DNA. Translation: DAA08350.1.
PIRiS64593.
RefSeqiNP_011776.1. NM_001181389.1.

Genome annotation databases

EnsemblFungiiYGR260W; YGR260W; YGR260W.
GeneIDi853175.
KEGGisce:YGR260W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07777 Genomic DNA. Translation: CAA69082.1 .
Z73044 Genomic DNA. Translation: CAA97289.1 .
BK006941 Genomic DNA. Translation: DAA08350.1 .
PIRi S64593.
RefSeqi NP_011776.1. NM_001181389.1.

3D structure databases

ProteinModelPortali P53322.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33511. 87 interactions.
DIPi DIP-8004N.
MINTi MINT-4488034.
STRINGi 4932.YGR260W.

Protein family/group databases

TCDBi 2.A.1.14.11. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBi P53322.
PaxDbi P53322.
PeptideAtlasi P53322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR260W ; YGR260W ; YGR260W .
GeneIDi 853175.
KEGGi sce:YGR260W.

Organism-specific databases

CYGDi YGR260w.
SGDi S000003492. TNA1.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00620000088258.
HOGENOMi HOG000167306.
OMAi AINMYLS.
OrthoDBi EOG7S4XG9.

Enzyme and pathway databases

BioCyci YEAST:G3O-30929-MONOMER.

Miscellaneous databases

NextBioi 973305.

Gene expression databases

Genevestigatori P53322.

Family and domain databases

InterProi IPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes."
    Clemente M.L., Sartori G., Cardazzo B., Carignani G.
    Yeast 13:287-290(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w)."
    Llorente B., Dujon B.
    FEBS Lett. 475:237-241(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-283.
    Strain: SUB592.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTNA1_YEAST
AccessioniPrimary (citable) accession number: P53322
Secondary accession number(s): D6VV39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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