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Protein

Mitochondrial carrier protein MTM1

Gene

MTM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the mitochondrial activation of SOD2 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner. Responds to calorie restriction (CR) strength.3 Publications

GO - Molecular functioni

  • metallochaperone activity Source: SGD
  • pyridoxal phosphate binding Source: SGD
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • manganese ion transport Source: SGD
  • pyridoxal phosphate transport Source: SGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30927-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier protein MTM1
Alternative name(s):
Manganese trafficking factor for mitochondrial SOD2
Gene namesi
Name:MTM1
Ordered Locus Names:YGR257C
ORF Names:G9175
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR257C.
SGDiS000003489. MTM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3620Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei162 – 18221Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei229 – 24921Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei268 – 28619Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei331 – 35222Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Loss of mitochondrial manganese superoxide dismutase SOD2 activity due to misincorporation of iron into SOD2 rather than manganese. Normal SOD2 activity when in association with YFH1 deletion. Doesn't impair activity of a cytosolic version of manganese SOD. The iron regulatory transcription factor AFT1 is constitutively active. Accumulates mtDNA mutations. Elevated mitochondrial iron and manganese levels.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Mitochondrial carrier protein MTM1PRO_0000090697Add
BLAST

Proteomic databases

MaxQBiP53320.
PRIDEiP53320.

Interactioni

Protein-protein interaction databases

BioGridi33509. 11 interactions.
DIPiDIP-5452N.
IntActiP53320. 1 interaction.
MINTiMINT-559667.

Structurei

3D structure databases

ProteinModelPortaliP53320.
SMRiP53320. Positions 15-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati14 – 149136Solcar 1Add
BLAST
Repeati156 – 25095Solcar 2Add
BLAST
Repeati266 – 35994Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
InParanoidiP53320.
KOiK15119.
OMAiIFWESAC.
OrthoDBiEOG092C2KWL.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRNTSNSL TLKERMLSAG AGSVLTSLIL TPMDVVRIRL QQQQMIPDCS
60 70 80 90 100
CDGAAEVPNA VSSGSKMKTF TNVGGQNLNN AKIFWESACF QELHCKNSSL
110 120 130 140 150
KFNGTLEAFT KIASVEGITS LWRGISLTLL MAIPANMVYF SGYEYIRDVS
160 170 180 190 200
PIASTYPTLN PLFCGAIARV FAATSIAPLE LVKTKLQSIP RSSKSTKTWM
210 220 230 240 250
MVKDLLNETR QEMKMVGPSR ALFKGLEITL WRDVPFSAIY WSSYELCKER
260 270 280 290 300
LWLDSTRFAS KDANWVHFIN SFASGCISGM IAAICTHPFD VGKTRWQISM
310 320 330 340 350
MNNSDPKGGN RSRNMFKFLE TIWRTEGLAA LYTGLAARVI KIRPSCAIMI
360
SSYEISKKVF GNKLHQ
Length:366
Mass (Da):40,763
Last modified:October 1, 1996 - v1
Checksum:iB0358B6EE818CB1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99228 Genomic DNA. Translation: CAA67613.1.
Z73042 Genomic DNA. Translation: CAA97286.1.
BK006941 Genomic DNA. Translation: DAA08348.1.
PIRiS64589.
RefSeqiNP_011773.3. NM_001181386.3.

Genome annotation databases

EnsemblFungiiYGR257C; YGR257C; YGR257C.
GeneIDi853173.
KEGGisce:YGR257C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99228 Genomic DNA. Translation: CAA67613.1.
Z73042 Genomic DNA. Translation: CAA97286.1.
BK006941 Genomic DNA. Translation: DAA08348.1.
PIRiS64589.
RefSeqiNP_011773.3. NM_001181386.3.

3D structure databases

ProteinModelPortaliP53320.
SMRiP53320. Positions 15-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33509. 11 interactions.
DIPiDIP-5452N.
IntActiP53320. 1 interaction.
MINTiMINT-559667.

Proteomic databases

MaxQBiP53320.
PRIDEiP53320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR257C; YGR257C; YGR257C.
GeneIDi853173.
KEGGisce:YGR257C.

Organism-specific databases

EuPathDBiFungiDB:YGR257C.
SGDiS000003489. MTM1.

Phylogenomic databases

GeneTreeiENSGT00790000123051.
HOGENOMiHOG000214473.
InParanoidiP53320.
KOiK15119.
OMAiIFWESAC.
OrthoDBiEOG092C2KWL.

Enzyme and pathway databases

BioCyciYEAST:G3O-30927-MONOMER.

Miscellaneous databases

PROiP53320.

Family and domain databases

Gene3Di1.50.40.10. 2 hits.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 2 hits.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTM1_YEAST
AccessioniPrimary (citable) accession number: P53320
Secondary accession number(s): D6VV37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.