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Protein

Mitochondrial carrier protein MTM1

Gene

MTM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the mitochondrial activation of SOD2 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner. Responds to calorie restriction (CR) strength.3 Publications

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • pyridoxal phosphate binding Source: SGD
  • transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • cellular iron ion homeostasis Source: SGD
  • mitochondrial transport Source: GO_Central
  • pyridoxal phosphate transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-30927-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier protein MTM1
Alternative name(s):
Manganese trafficking factor for mitochondrial SOD2
Gene namesi
Name:MTM1
Ordered Locus Names:YGR257C
ORF Names:G9175
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR257C
SGDiS000003489 MTM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 36Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei126 – 146Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei162 – 182Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei229 – 249Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei268 – 286Helical; Name=5Sequence analysisAdd BLAST19
Transmembranei331 – 352Helical; Name=6Sequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Loss of mitochondrial manganese superoxide dismutase SOD2 activity due to misincorporation of iron into SOD2 rather than manganese. Normal SOD2 activity when in association with YFH1 deletion. Doesn't impair activity of a cytosolic version of manganese SOD. The iron regulatory transcription factor AFT1 is constitutively active. Accumulates mtDNA mutations. Elevated mitochondrial iron and manganese levels.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906971 – 366Mitochondrial carrier protein MTM1Add BLAST366

Proteomic databases

MaxQBiP53320
PaxDbiP53320
PRIDEiP53320

Interactioni

Protein-protein interaction databases

BioGridi33509, 55 interactors
DIPiDIP-5452N
IntActiP53320, 1 interactor
MINTiP53320
STRINGi4932.YGR257C

Structurei

3D structure databases

ProteinModelPortaliP53320
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 149Solcar 1Add BLAST136
Repeati156 – 250Solcar 2Add BLAST95
Repeati266 – 359Solcar 3Add BLAST94

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00790000123051
HOGENOMiHOG000214473
InParanoidiP53320
KOiK15119
OMAiKWLCEKS
OrthoDBiEOG092C2KWL

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 2 hits
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P53320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRNTSNSL TLKERMLSAG AGSVLTSLIL TPMDVVRIRL QQQQMIPDCS
60 70 80 90 100
CDGAAEVPNA VSSGSKMKTF TNVGGQNLNN AKIFWESACF QELHCKNSSL
110 120 130 140 150
KFNGTLEAFT KIASVEGITS LWRGISLTLL MAIPANMVYF SGYEYIRDVS
160 170 180 190 200
PIASTYPTLN PLFCGAIARV FAATSIAPLE LVKTKLQSIP RSSKSTKTWM
210 220 230 240 250
MVKDLLNETR QEMKMVGPSR ALFKGLEITL WRDVPFSAIY WSSYELCKER
260 270 280 290 300
LWLDSTRFAS KDANWVHFIN SFASGCISGM IAAICTHPFD VGKTRWQISM
310 320 330 340 350
MNNSDPKGGN RSRNMFKFLE TIWRTEGLAA LYTGLAARVI KIRPSCAIMI
360
SSYEISKKVF GNKLHQ
Length:366
Mass (Da):40,763
Last modified:October 1, 1996 - v1
Checksum:iB0358B6EE818CB1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99228 Genomic DNA Translation: CAA67613.1
Z73042 Genomic DNA Translation: CAA97286.1
BK006941 Genomic DNA Translation: DAA08348.1
PIRiS64589
RefSeqiNP_011773.3, NM_001181386.3

Genome annotation databases

EnsemblFungiiYGR257C; YGR257C; YGR257C
GeneIDi853173
KEGGisce:YGR257C

Similar proteinsi

Entry informationi

Entry nameiMTM1_YEAST
AccessioniPrimary (citable) accession number: P53320
Secondary accession number(s): D6VV37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Journals
    Controlled vocabulary of journals
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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