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P53319

- 6PGD2_YEAST

UniProt

P53319 - 6PGD2_YEAST

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Protein

6-phosphogluconate dehydrogenase, decarboxylating 2

Gene

GND2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051NADPBy similarity
Binding sitei105 – 1051SubstrateBy similarity
Active sitei185 – 1851Proton acceptorBy similarity
Active sitei192 – 1921Proton donorBy similarity
Binding sitei193 – 1931SubstrateBy similarity
Binding sitei262 – 2621Substrate; via amide nitrogenBy similarity
Binding sitei289 – 2891SubstrateBy similarity
Binding sitei449 – 4491Substrate; shared with dimeric partnerBy similarity
Binding sitei455 – 4551Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NADPBy similarity
Nucleotide bindingi35 – 373NADPBy similarity
Nucleotide bindingi77 – 793NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: SGD

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt, oxidative branch Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYEAST:YGR256W-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating 2 (EC:1.1.1.44)
Gene namesi
Name:GND2
Ordered Locus Names:YGR256W
ORF Names:G9170
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR256w.
SGDiS000003488. GND2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4924926-phosphogluconate dehydrogenase, decarboxylating 2PRO_0000090076Add
BLAST

Proteomic databases

MaxQBiP53319.
PaxDbiP53319.
PeptideAtlasiP53319.
PRIDEiP53319.

Expressioni

Gene expression databases

GenevestigatoriP53319.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi33508. 30 interactions.
DIPiDIP-6605N.
IntActiP53319. 1 interaction.
MINTiMINT-702969.
STRINGi4932.YGR256W.

Structurei

3D structure databases

ProteinModelPortaliP53319.
SMRiP53319. Positions 6-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 1333Substrate bindingBy similarity
Regioni188 – 1892Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
GeneTreeiENSGT00390000009023.
HOGENOMiHOG000255147.
InParanoidiP53319.
KOiK00033.
OMAiPECANET.
OrthoDBiEOG7F252Z.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53319 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKAVGDLGL VGLAVMGQNL ILNAADHGFT VVAYNRTQSK VDRFLANEAK
60 70 80 90 100
GKSIIGATSI EDLVAKLKKP RKIMLLIKAG APVDTLIKEL VPHLDKGDII
110 120 130 140 150
IDGGNSHFPD TNRRYEELTK QGILFVGSGV SGGEDGARFG PSLMPGGSAE
160 170 180 190 200
AWPHIKNIFQ SIAAKSNGEP CCEWVGPAGS GHYVKMVHNG IEYGDMQLIC
210 220 230 240 250
EAYDIMKRIG RFTDKEISEV FDKWNTGVLD SFLIEITRDI LKFDDVDGKP
260 270 280 290 300
LVEKIMDTAG QKGTGKWTAI NALDLGMPVT LIGEAVFARC LSAIKDERKR
310 320 330 340 350
ASKLLAGPTV PKDAIHDREQ FVYDLEQALY ASKIISYAQG FMLIREAARS
360 370 380 390 400
YGWKLNNPAI ALMWRGGCII RSVFLAEITK AYRDDPDLEN LLFNEFFASA
410 420 430 440 450
VTKAQSGWRR TIALAATYGI PTPAFSTALA FYDGYRSERL PANLLQAQRD
460 470 480 490
YFGAHTFRIL PECASAHLPV DKDIHINWTG HGGNISSSTY QA
Length:492
Mass (Da):53,923
Last modified:October 1, 1996 - v1
Checksum:i3D75D53563987735
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99228 Genomic DNA. Translation: CAA67612.1.
Z73041 Genomic DNA. Translation: CAA97285.1.
AY692811 Genomic DNA. Translation: AAT92830.1.
BK006941 Genomic DNA. Translation: DAA08347.1.
PIRiS64588.
RefSeqiNP_011772.3. NM_001181385.3.

Genome annotation databases

EnsemblFungiiYGR256W; YGR256W; YGR256W.
GeneIDi853172.
KEGGisce:YGR256W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99228 Genomic DNA. Translation: CAA67612.1 .
Z73041 Genomic DNA. Translation: CAA97285.1 .
AY692811 Genomic DNA. Translation: AAT92830.1 .
BK006941 Genomic DNA. Translation: DAA08347.1 .
PIRi S64588.
RefSeqi NP_011772.3. NM_001181385.3.

3D structure databases

ProteinModelPortali P53319.
SMRi P53319. Positions 6-479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33508. 30 interactions.
DIPi DIP-6605N.
IntActi P53319. 1 interaction.
MINTi MINT-702969.
STRINGi 4932.YGR256W.

Proteomic databases

MaxQBi P53319.
PaxDbi P53319.
PeptideAtlasi P53319.
PRIDEi P53319.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR256W ; YGR256W ; YGR256W .
GeneIDi 853172.
KEGGi sce:YGR256W.

Organism-specific databases

CYGDi YGR256w.
SGDi S000003488. GND2.

Phylogenomic databases

eggNOGi COG0362.
GeneTreei ENSGT00390000009023.
HOGENOMi HOG000255147.
InParanoidi P53319.
KOi K00033.
OMAi PECANET.
OrthoDBi EOG7F252Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci YEAST:YGR256W-MONOMER.

Miscellaneous databases

NextBioi 973296.
PROi P53319.

Gene expression databases

Genevestigatori P53319.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 10.5 kb DNA fragment from the yeast chromosome VII reveals the presence of three new open reading frames and of a tRNAThr gene."
    Mazzoni C., Ruzzi M., Rinaldi T., Solinas F., Montebove F., Frontali L.
    Yeast 13:369-372(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei6PGD2_YEAST
AccessioniPrimary (citable) accession number: P53319
Secondary accession number(s): D6VV36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3