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P53318

- COQ6_YEAST

UniProt

P53318 - COQ6_YEAST

Protein

Ubiquinone biosynthesis monooxygenase COQ6

Gene

COQ6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cofactori

    FAD.Curated

    Pathwayi

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. N,N-dimethylaniline monooxygenase activity Source: SGD
    3. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: Reactome

    GO - Biological processi

    1. ubiquinone biosynthetic process Source: SGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Ubiquinone biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-16019.
    YEAST:YGR255C-MONOMER.
    ReactomeiREACT_188932. Ubiquinol biosynthesis.
    UniPathwayiUPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinone biosynthesis monooxygenase COQ6 (EC:1.14.13.-)
    Gene namesi
    Name:COQ6
    Ordered Locus Names:YGR255C
    ORF Names:G9165
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR255c.
    SGDiS000003487. COQ6.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Ubiquinone biosynthesis monooxygenase COQ6PRO_0000207581Add
    BLAST

    Proteomic databases

    MaxQBiP53318.
    PaxDbiP53318.

    Expressioni

    Gene expression databases

    GenevestigatoriP53318.

    Interactioni

    Protein-protein interaction databases

    BioGridi33506. 17 interactions.
    IntActiP53318. 7 interactions.
    MINTiMINT-619446.

    Structurei

    3D structure databases

    ProteinModelPortaliP53318.
    SMRiP53318. Positions 24-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UbiH/COQ6 family.Curated

    Phylogenomic databases

    eggNOGiCOG0654.
    GeneTreeiENSGT00390000015152.
    HOGENOMiHOG000255772.
    KOiK06126.
    OMAiNSPVRKF.
    OrthoDBiEOG747PT4.

    Family and domain databases

    InterProiIPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    IPR018168. Ubi_Hdrlase_CS.
    IPR010971. Ubi_Hdrxlases.
    IPR000689. UbQ_biosynth_mOase.
    [Graphical view]
    PfamiPF01494. FAD_binding_3. 1 hit.
    [Graphical view]
    PRINTSiPR00420. RNGMNOXGNASE.
    TIGRFAMsiTIGR01989. COQ6. 1 hit.
    TIGR01988. Ubi-OHases. 1 hit.
    PROSITEiPS01304. UBIH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53318-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFSKVMLTR RILVRGLATA KSSAPKLTDV LIVGGGPAGL TLAASIKNSP    50
    QLKDLKTTLV DMVDLKDKLS DFYNSPPDYF TNRIVSVTPR SIHFLENNAG 100
    ATLMHDRIQS YDGLYVTDGC SKATLDLARD SMLCMIEIIN IQASLYNRIS 150
    QYDSKKDSID IIDNTKVVNI KHSDPNDPLS WPLVTLSNGE VYKTRLLVGA 200
    DGFNSPTRRF SQIPSRGWMY NAYGVVASMK LEYPPFKLRG WQRFLPTGPI 250
    AHLPMPENNA TLVWSSSERL SRLLLSLPPE SFTALINAAF VLEDADMNYY 300
    YRTLEDGSMD TDKLIEDIKF RTEEIYATLK DESDIDEIYP PRVVSIIDKT 350
    RARFPLKLTH ADRYCTDRVA LVGDAAHTTH PLAGQGLNMG QTDVHGLVYA 400
    LEKAMERGLD IGSSLSLEPF WAERYPSNNV LLGMADKLFK LYHTNFPPVV 450
    ALRTFGLNLT NKIGPVKNMI IDTLGGNEK 479
    Length:479
    Mass (Da):53,527
    Last modified:October 1, 1996 - v1
    Checksum:iB6D4286545CCE695
    GO

    Sequence cautioni

    The sequence CAA56705.1 differs from that shown. Reason: Frameshift at positions 212 and 434.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601V → I in CAA56704. 1 PublicationCurated
    Sequence conflicti68 – 681K → R in CAA56704. 1 PublicationCurated
    Sequence conflicti313 – 3131K → E in CAA56705. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003698 Genomic DNA. Translation: AAB61341.1.
    X99228 Genomic DNA. Translation: CAA67617.1.
    Z73040 Genomic DNA. Translation: CAA97284.1.
    X80690 Genomic DNA. Translation: CAA56704.1. Frameshift.
    X80690 Genomic DNA. Translation: CAA56705.1. Frameshift.
    BK006941 Genomic DNA. Translation: DAA08346.1.
    PIRiS64587.
    RefSeqiNP_011771.1. NM_001181384.1.

    Genome annotation databases

    EnsemblFungiiYGR255C; YGR255C; YGR255C.
    GeneIDi853170.
    KEGGisce:YGR255C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003698 Genomic DNA. Translation: AAB61341.1 .
    X99228 Genomic DNA. Translation: CAA67617.1 .
    Z73040 Genomic DNA. Translation: CAA97284.1 .
    X80690 Genomic DNA. Translation: CAA56704.1 . Frameshift.
    X80690 Genomic DNA. Translation: CAA56705.1 . Frameshift.
    BK006941 Genomic DNA. Translation: DAA08346.1 .
    PIRi S64587.
    RefSeqi NP_011771.1. NM_001181384.1.

    3D structure databases

    ProteinModelPortali P53318.
    SMRi P53318. Positions 24-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33506. 17 interactions.
    IntActi P53318. 7 interactions.
    MINTi MINT-619446.

    Proteomic databases

    MaxQBi P53318.
    PaxDbi P53318.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR255C ; YGR255C ; YGR255C .
    GeneIDi 853170.
    KEGGi sce:YGR255C.

    Organism-specific databases

    CYGDi YGR255c.
    SGDi S000003487. COQ6.

    Phylogenomic databases

    eggNOGi COG0654.
    GeneTreei ENSGT00390000015152.
    HOGENOMi HOG000255772.
    KOi K06126.
    OMAi NSPVRKF.
    OrthoDBi EOG747PT4.

    Enzyme and pathway databases

    UniPathwayi UPA00232 .
    BioCyci MetaCyc:MONOMER-16019.
    YEAST:YGR255C-MONOMER.
    Reactomei REACT_188932. Ubiquinol biosynthesis.

    Miscellaneous databases

    NextBioi 973291.
    PROi P53318.

    Gene expression databases

    Genevestigatori P53318.

    Family and domain databases

    InterProi IPR002938. mOase_FAD-bd.
    IPR003042. Rng_hydrolase-like.
    IPR018168. Ubi_Hdrlase_CS.
    IPR010971. Ubi_Hdrxlases.
    IPR000689. UbQ_biosynth_mOase.
    [Graphical view ]
    Pfami PF01494. FAD_binding_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00420. RNGMNOXGNASE.
    TIGRFAMsi TIGR01989. COQ6. 1 hit.
    TIGR01988. Ubi-OHases. 1 hit.
    PROSITEi PS01304. UBIH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis."
      Gin P., Hsu A.Y., Rothman S.C., Jonassen T., Lee P.T., Tzagoloff A., Clarke C.F.
      J. Biol. Chem. 278:25308-25316(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
    2. "Sequence analysis of a 10.5 kb DNA fragment from the yeast chromosome VII reveals the presence of three new open reading frames and of a tRNAThr gene."
      Mazzoni C., Ruzzi M., Rinaldi T., Solinas F., Montebove F., Frontali L.
      Yeast 13:369-372(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Miosga T.
      Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOQ6_YEAST
    AccessioniPrimary (citable) accession number: P53318
    Secondary accession number(s): D6VV35, Q05674, Q05675
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2940 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3