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P53318

- COQ6_YEAST

UniProt

P53318 - COQ6_YEAST

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Protein

Ubiquinone biosynthesis monooxygenase COQ6

Gene
COQ6, YGR255C, G9165
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cofactori

FAD Reviewed prediction.

Pathwayi

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. N,N-dimethylaniline monooxygenase activity Source: SGD
  3. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Source: Reactome

GO - Biological processi

  1. ubiquinone biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16019.
YEAST:YGR255C-MONOMER.
ReactomeiREACT_188932. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis monooxygenase COQ6 (EC:1.14.13.-)
Gene namesi
Name:COQ6
Ordered Locus Names:YGR255C
ORF Names:G9165
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR255c.
SGDiS000003487. COQ6.

Subcellular locationi

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Ubiquinone biosynthesis monooxygenase COQ6PRO_0000207581Add
BLAST

Proteomic databases

MaxQBiP53318.
PaxDbiP53318.

Expressioni

Gene expression databases

GenevestigatoriP53318.

Interactioni

Protein-protein interaction databases

BioGridi33506. 17 interactions.
IntActiP53318. 7 interactions.
MINTiMINT-619446.

Structurei

3D structure databases

ProteinModelPortaliP53318.
SMRiP53318. Positions 24-471.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiH/COQ6 family.

Phylogenomic databases

eggNOGiCOG0654.
GeneTreeiENSGT00390000015152.
HOGENOMiHOG000255772.
KOiK06126.
OMAiNSPVRKF.
OrthoDBiEOG747PT4.

Family and domain databases

InterProiIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
IPR018168. Ubi_Hdrlase_CS.
IPR010971. Ubi_Hdrxlases.
IPR000689. UbQ_biosynth_mOase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSiPR00420. RNGMNOXGNASE.
TIGRFAMsiTIGR01989. COQ6. 1 hit.
TIGR01988. Ubi-OHases. 1 hit.
PROSITEiPS01304. UBIH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53318-1 [UniParc]FASTAAdd to Basket

« Hide

MFFSKVMLTR RILVRGLATA KSSAPKLTDV LIVGGGPAGL TLAASIKNSP    50
QLKDLKTTLV DMVDLKDKLS DFYNSPPDYF TNRIVSVTPR SIHFLENNAG 100
ATLMHDRIQS YDGLYVTDGC SKATLDLARD SMLCMIEIIN IQASLYNRIS 150
QYDSKKDSID IIDNTKVVNI KHSDPNDPLS WPLVTLSNGE VYKTRLLVGA 200
DGFNSPTRRF SQIPSRGWMY NAYGVVASMK LEYPPFKLRG WQRFLPTGPI 250
AHLPMPENNA TLVWSSSERL SRLLLSLPPE SFTALINAAF VLEDADMNYY 300
YRTLEDGSMD TDKLIEDIKF RTEEIYATLK DESDIDEIYP PRVVSIIDKT 350
RARFPLKLTH ADRYCTDRVA LVGDAAHTTH PLAGQGLNMG QTDVHGLVYA 400
LEKAMERGLD IGSSLSLEPF WAERYPSNNV LLGMADKLFK LYHTNFPPVV 450
ALRTFGLNLT NKIGPVKNMI IDTLGGNEK 479
Length:479
Mass (Da):53,527
Last modified:October 1, 1996 - v1
Checksum:iB6D4286545CCE695
GO

Sequence cautioni

The sequence CAA56705.1 differs from that shown. Reason: Frameshift at positions 212 and 434.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601V → I in CAA56704. 1 Publication
Sequence conflicti68 – 681K → R in CAA56704. 1 Publication
Sequence conflicti313 – 3131K → E in CAA56705. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003698 Genomic DNA. Translation: AAB61341.1.
X99228 Genomic DNA. Translation: CAA67617.1.
Z73040 Genomic DNA. Translation: CAA97284.1.
X80690 Genomic DNA. Translation: CAA56704.1. Frameshift.
X80690 Genomic DNA. Translation: CAA56705.1. Frameshift.
BK006941 Genomic DNA. Translation: DAA08346.1.
PIRiS64587.
RefSeqiNP_011771.1. NM_001181384.1.

Genome annotation databases

EnsemblFungiiYGR255C; YGR255C; YGR255C.
GeneIDi853170.
KEGGisce:YGR255C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003698 Genomic DNA. Translation: AAB61341.1 .
X99228 Genomic DNA. Translation: CAA67617.1 .
Z73040 Genomic DNA. Translation: CAA97284.1 .
X80690 Genomic DNA. Translation: CAA56704.1 . Frameshift.
X80690 Genomic DNA. Translation: CAA56705.1 . Frameshift.
BK006941 Genomic DNA. Translation: DAA08346.1 .
PIRi S64587.
RefSeqi NP_011771.1. NM_001181384.1.

3D structure databases

ProteinModelPortali P53318.
SMRi P53318. Positions 24-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33506. 17 interactions.
IntActi P53318. 7 interactions.
MINTi MINT-619446.

Proteomic databases

MaxQBi P53318.
PaxDbi P53318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR255C ; YGR255C ; YGR255C .
GeneIDi 853170.
KEGGi sce:YGR255C.

Organism-specific databases

CYGDi YGR255c.
SGDi S000003487. COQ6.

Phylogenomic databases

eggNOGi COG0654.
GeneTreei ENSGT00390000015152.
HOGENOMi HOG000255772.
KOi K06126.
OMAi NSPVRKF.
OrthoDBi EOG747PT4.

Enzyme and pathway databases

UniPathwayi UPA00232 .
BioCyci MetaCyc:MONOMER-16019.
YEAST:YGR255C-MONOMER.
Reactomei REACT_188932. Ubiquinol biosynthesis.

Miscellaneous databases

NextBioi 973291.
PROi P53318.

Gene expression databases

Genevestigatori P53318.

Family and domain databases

InterProi IPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
IPR018168. Ubi_Hdrlase_CS.
IPR010971. Ubi_Hdrxlases.
IPR000689. UbQ_biosynth_mOase.
[Graphical view ]
Pfami PF01494. FAD_binding_3. 1 hit.
[Graphical view ]
PRINTSi PR00420. RNGMNOXGNASE.
TIGRFAMsi TIGR01989. COQ6. 1 hit.
TIGR01988. Ubi-OHases. 1 hit.
PROSITEi PS01304. UBIH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis."
    Gin P., Hsu A.Y., Rothman S.C., Jonassen T., Lee P.T., Tzagoloff A., Clarke C.F.
    J. Biol. Chem. 278:25308-25316(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
  2. "Sequence analysis of a 10.5 kb DNA fragment from the yeast chromosome VII reveals the presence of three new open reading frames and of a tRNAThr gene."
    Mazzoni C., Ruzzi M., Rinaldi T., Solinas F., Montebove F., Frontali L.
    Yeast 13:369-372(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Miosga T.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOQ6_YEAST
AccessioniPrimary (citable) accession number: P53318
Secondary accession number(s): D6VV35, Q05674, Q05675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2940 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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