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Protein

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

Gene

COQ6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6. Can also use 3-hexaprenyl-4-aminobenzoic acid (HAB) as substrate.UniRule annotation1 Publication

Miscellaneous

Present with 2940 molecules/cell in log phase SD medium.1 Publication

Cofactori

FADUniRule annotation1 Publication

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation2 Publications
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • ubiquinone biosynthetic process Source: SGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processUbiquinone biosynthesis
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:YGR255C-MONOMER
YEAST:YGR255C-MONOMER
UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrialUniRule annotation1 Publication (EC:1.14.13.-UniRule annotation1 Publication)
Gene namesi
Name:COQ61 PublicationUniRule annotation
Ordered Locus Names:YGR255CImported
ORF Names:G9165
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR255C
SGDiS000003487 COQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi202G → A: Accumulates ubiquinone biosynthesis intermediates lacking the C5-ring hydroxyl. 1 Publication1
Mutagenesisi386G → A: Accumulates ubiquinone biosynthesis intermediates lacking the C5-ring hydroxyl; when associated with D-388. 1 Publication1
Mutagenesisi388N → D: Accumulates ubiquinone biosynthesis intermediates lacking the C5-ring hydroxyl; when associated with A-386. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionUniRule annotationAdd BLAST17
ChainiPRO_000020758118 – 479Ubiquinone biosynthesis monooxygenase COQ6, mitochondrialAdd BLAST462

Proteomic databases

MaxQBiP53318
PaxDbiP53318
PRIDEiP53318
TopDownProteomicsiP53318

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation2 Publications

Protein-protein interaction databases

BioGridi33506, 131 interactors
IntActiP53318, 8 interactors
MINTiP53318
STRINGi4932.YGR255C

Structurei

3D structure databases

ProteinModelPortaliP53318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiH/COQ6 family.UniRule annotationCurated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000015152
HOGENOMiHOG000255772
InParanoidiP53318
KOiK06126
OMAiCHPVGGQ
OrthoDBiEOG092C4BLJ

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_03193 COQ6_monooxygenase, 1 hit
InterProiView protein in InterPro
IPR002938 FAD-bd
IPR036188 FAD/NAD-bd_sf
IPR018168 Ubi_Hdrlase_CS
IPR010971 UbiH/COQ6
IPR000689 UbQ_mOase_COQ6
PfamiView protein in Pfam
PF01494 FAD_binding_3, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01989 COQ6, 1 hit
TIGR01988 Ubi-OHases, 1 hit
PROSITEiView protein in PROSITE
PS01304 UBIH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFSKVMLTR RILVRGLATA KSSAPKLTDV LIVGGGPAGL TLAASIKNSP
60 70 80 90 100
QLKDLKTTLV DMVDLKDKLS DFYNSPPDYF TNRIVSVTPR SIHFLENNAG
110 120 130 140 150
ATLMHDRIQS YDGLYVTDGC SKATLDLARD SMLCMIEIIN IQASLYNRIS
160 170 180 190 200
QYDSKKDSID IIDNTKVVNI KHSDPNDPLS WPLVTLSNGE VYKTRLLVGA
210 220 230 240 250
DGFNSPTRRF SQIPSRGWMY NAYGVVASMK LEYPPFKLRG WQRFLPTGPI
260 270 280 290 300
AHLPMPENNA TLVWSSSERL SRLLLSLPPE SFTALINAAF VLEDADMNYY
310 320 330 340 350
YRTLEDGSMD TDKLIEDIKF RTEEIYATLK DESDIDEIYP PRVVSIIDKT
360 370 380 390 400
RARFPLKLTH ADRYCTDRVA LVGDAAHTTH PLAGQGLNMG QTDVHGLVYA
410 420 430 440 450
LEKAMERGLD IGSSLSLEPF WAERYPSNNV LLGMADKLFK LYHTNFPPVV
460 470
ALRTFGLNLT NKIGPVKNMI IDTLGGNEK
Length:479
Mass (Da):53,527
Last modified:October 1, 1996 - v1
Checksum:iB6D4286545CCE695
GO

Sequence cautioni

The sequence CAA56704 differs from that shown. Reason: Frameshift at positions 212 and 434.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60V → I in CAA56704 (Ref. 5) Curated1
Sequence conflicti68K → R in CAA56704 (Ref. 5) Curated1
Sequence conflicti313K → E in CAA56705 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003698 Genomic DNA Translation: AAB61341.1
X99228 Genomic DNA Translation: CAA67617.1
Z73040 Genomic DNA Translation: CAA97284.1
X80690 Genomic DNA Translation: CAA56704.1 Frameshift.
X80690 Genomic DNA Translation: CAA56705.1
BK006941 Genomic DNA Translation: DAA08346.1
PIRiS64587
RefSeqiNP_011771.1, NM_001181384.1

Genome annotation databases

EnsemblFungiiYGR255C; YGR255C; YGR255C
GeneIDi853170
KEGGisce:YGR255C

Similar proteinsi

Entry informationi

Entry nameiCOQ6_YEAST
AccessioniPrimary (citable) accession number: P53318
Secondary accession number(s): D6VV35, Q05674, Q05675
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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