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P53318 (COQ6_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquinone biosynthesis monooxygenase COQ6

EC=1.14.13.-
Gene names
Name:COQ6
Ordered Locus Names:YGR255C
ORF Names:G9165
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

FAD Potential.

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side Ref.1.

Miscellaneous

Present with 2940 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the UbiH/COQ6 family.

Sequence caution

The sequence CAA56705.1 differs from that shown. Reason: Frameshift at positions 212 and 434.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Ubiquinone biosynthesis monooxygenase COQ6
PRO_0000207581

Experimental info

Sequence conflict601V → I in CAA56704. Ref.5
Sequence conflict681K → R in CAA56704. Ref.5
Sequence conflict3131K → E in CAA56705. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P53318 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: B6D4286545CCE695

FASTA47953,527
        10         20         30         40         50         60 
MFFSKVMLTR RILVRGLATA KSSAPKLTDV LIVGGGPAGL TLAASIKNSP QLKDLKTTLV 

        70         80         90        100        110        120 
DMVDLKDKLS DFYNSPPDYF TNRIVSVTPR SIHFLENNAG ATLMHDRIQS YDGLYVTDGC 

       130        140        150        160        170        180 
SKATLDLARD SMLCMIEIIN IQASLYNRIS QYDSKKDSID IIDNTKVVNI KHSDPNDPLS 

       190        200        210        220        230        240 
WPLVTLSNGE VYKTRLLVGA DGFNSPTRRF SQIPSRGWMY NAYGVVASMK LEYPPFKLRG 

       250        260        270        280        290        300 
WQRFLPTGPI AHLPMPENNA TLVWSSSERL SRLLLSLPPE SFTALINAAF VLEDADMNYY 

       310        320        330        340        350        360 
YRTLEDGSMD TDKLIEDIKF RTEEIYATLK DESDIDEIYP PRVVSIIDKT RARFPLKLTH 

       370        380        390        400        410        420 
ADRYCTDRVA LVGDAAHTTH PLAGQGLNMG QTDVHGLVYA LEKAMERGLD IGSSLSLEPF 

       430        440        450        460        470 
WAERYPSNNV LLGMADKLFK LYHTNFPPVV ALRTFGLNLT NKIGPVKNMI IDTLGGNEK 

« Hide

References

« Hide 'large scale' references
[1]"The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis."
Gin P., Hsu A.Y., Rothman S.C., Jonassen T., Lee P.T., Tzagoloff A., Clarke C.F.
J. Biol. Chem. 278:25308-25316(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
[2]"Sequence analysis of a 10.5 kb DNA fragment from the yeast chromosome VII reveals the presence of three new open reading frames and of a tRNAThr gene."
Mazzoni C., Ruzzi M., Rinaldi T., Solinas F., Montebove F., Frontali L.
Yeast 13:369-372(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]Miosga T.
Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF003698 Genomic DNA. Translation: AAB61341.1.
X99228 Genomic DNA. Translation: CAA67617.1.
Z73040 Genomic DNA. Translation: CAA97284.1.
X80690 Genomic DNA. Translation: CAA56704.1. Frameshift.
X80690 Genomic DNA. Translation: CAA56705.1. Frameshift.
BK006941 Genomic DNA. Translation: DAA08346.1.
PIRS64587.
RefSeqNP_011771.1. NM_001181384.1.

3D structure databases

ProteinModelPortalP53318.
SMRP53318. Positions 29-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33506. 17 interactions.
IntActP53318. 7 interactions.
MINTMINT-619446.

Proteomic databases

PaxDbP53318.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR255C; YGR255C; YGR255C.
GeneID853170.
KEGGsce:YGR255C.

Organism-specific databases

CYGDYGR255c.
SGDS000003487. COQ6.

Phylogenomic databases

eggNOGCOG0654.
GeneTreeENSGT00390000015152.
HOGENOMHOG000255772.
KOK06126.
OMAYGPHPHS.
OrthoDBEOG747PT4.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-16019.
YEAST:YGR255C-MONOMER.
ReactomeREACT_191296. Metabolism.
UniPathwayUPA00232.

Gene expression databases

GenevestigatorP53318.

Family and domain databases

InterProIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
IPR018168. Ubi_Hdrlase_CS.
IPR010971. Ubi_Hdrxlases.
IPR000689. UbQ_biosynth_mOase.
[Graphical view]
PfamPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSPR00420. RNGMNOXGNASE.
TIGRFAMsTIGR01989. COQ6. 1 hit.
TIGR01988. Ubi-OHases. 1 hit.
PROSITEPS01304. UBIH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio973291.
PROP53318.

Entry information

Entry nameCOQ6_YEAST
AccessionPrimary (citable) accession number: P53318
Secondary accession number(s): D6VV35, Q05674, Q05675
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways