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Protein

6-phosphogluconolactonase 4

Gene

SOL4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication

Miscellaneous

Present with 4320 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (ZWF1)
  2. 6-phosphogluconolactonase 3 (SOL3), 6-phosphogluconolactonase 4 (SOL4)
  3. 6-phosphogluconate dehydrogenase, decarboxylating 2 (GND2), 6-phosphogluconate dehydrogenase, decarboxylating 1 (GND1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

  • 6-phosphogluconolactonase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-4047
ReactomeiR-SCE-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase 4 (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:SOL4
Ordered Locus Names:YGR248W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR248W
SGDiS000003480 SOL4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900851 – 2556-phosphogluconolactonase 4Add BLAST255

Proteomic databases

MaxQBiP53315
PaxDbiP53315
PRIDEiP53315
TopDownProteomicsiP53315

Interactioni

Protein-protein interaction databases

BioGridi33499, 65 interactors
IntActiP53315, 5 interactors
MINTiP53315
STRINGi4932.YGR248W

Structurei

3D structure databases

ProteinModelPortaliP53315
SMRiP53315
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000075110
HOGENOMiHOG000256285
InParanoidiP53315
KOiK01057
OrthoDBiEOG092C54SY

Family and domain databases

CDDicd01400 6PGL, 1 hit
InterProiView protein in InterPro
IPR005900 6-phosphogluconolactonase_DevB
IPR006148 Glc/Gal-6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR01198 pgl, 1 hit

Sequencei

Sequence statusi: Complete.

P53315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLQRFSEK KSLIHEFGKF ILEKQESALT GDADAVFNIA ISGGSMNQAL
60 70 80 90 100
YESLVNDKNI FPHIKWPQWR IFFCDERLVP FEDPQSNYGQ FKKTVLDPLV
110 120 130 140 150
HQGNQLNLGP TVYTINESLI GGGETANRKI AEEYASMLPA SFDLILLGCG
160 170 180 190 200
EDGHTCSLFP GVEFNYLVEE MDRKVLWCNN SPKAPKDRIT FTLAVVAEAK
210 220 230 240 250
SVCFLVRGAA KKAIMHDVLI VKNSELPSVL VNEMVGTKVT WFLDDEAGAL

IPENC
Length:255
Mass (Da):28,448
Last modified:October 1, 1996 - v1
Checksum:i691C9DDA04E5BEF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73033 Genomic DNA Translation: CAA97277.1
BK006941 Genomic DNA Translation: DAA08339.1
PIRiS64574
RefSeqiNP_011764.3, NM_001181377.3

Genome annotation databases

EnsemblFungiiYGR248W; YGR248W; YGR248W
GeneIDi853163
KEGGisce:YGR248W

Similar proteinsi

Entry informationi

Entry nameiSOL4_YEAST
AccessioniPrimary (citable) accession number: P53315
Secondary accession number(s): D6VV28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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