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P53315 (SOL4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconolactonase 4

Short name=6PGL
EC=3.1.1.31
Gene names
Name:SOL4
Ordered Locus Names:YGR248W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Ref.6

Catalytic activity

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.

Subcellular location

Cytoplasm. Nucleus Ref.4 Ref.6.

Miscellaneous

Present with 4320 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt, oxidative branch

Inferred by curator Ref.6. Source: SGD

   Cellular_componentcytosol

Inferred from direct assay Ref.6. Source: SGD

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function6-phosphogluconolactonase activity

Inferred from direct assay Ref.6. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2552556-phosphogluconolactonase 4
PRO_0000090085

Sequences

Sequence LengthMass (Da)Tools
P53315 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 691C9DDA04E5BEF6

FASTA25528,448
        10         20         30         40         50         60 
MVKLQRFSEK KSLIHEFGKF ILEKQESALT GDADAVFNIA ISGGSMNQAL YESLVNDKNI 

        70         80         90        100        110        120 
FPHIKWPQWR IFFCDERLVP FEDPQSNYGQ FKKTVLDPLV HQGNQLNLGP TVYTINESLI 

       130        140        150        160        170        180 
GGGETANRKI AEEYASMLPA SFDLILLGCG EDGHTCSLFP GVEFNYLVEE MDRKVLWCNN 

       190        200        210        220        230        240 
SPKAPKDRIT FTLAVVAEAK SVCFLVRGAA KKAIMHDVLI VKNSELPSVL VNEMVGTKVT 

       250 
WFLDDEAGAL IPENC 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of a 17.9 kb region from Saccharomyces cerevisiae chromosome VII reveals the presence of eight open reading frames, including BRF1 (TFIIIB70) and GCN5 genes."
Feroli F., Carignani G., Pavanello A., Guerreiro P., Azevedo D., Rodrigues-Pousada C., Melchioretto P., Panzeri L., Agostoni Carbone M.L.
Yeast 13:373-377(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism."
Stanford D.R., Whitney M.L., Hurto R.L., Eisaman D.M., Shen W.-C., Hopper A.K.
Genetics 168:117-127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z73033 Genomic DNA. Translation: CAA97277.1.
BK006941 Genomic DNA. Translation: DAA08339.1.
PIRS64574.
RefSeqNP_011764.3. NM_001181377.3.

3D structure databases

ProteinModelPortalP53315.
SMRP53315. Positions 39-252.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33499. 41 interactions.
IntActP53315. 4 interactions.
MINTMINT-2780364.
STRING4932.YGR248W.

Proteomic databases

PaxDbP53315.
PeptideAtlasP53315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGR248W; YGR248W; YGR248W.
GeneID853163.
KEGGsce:YGR248W.

Organism-specific databases

CYGDYGR248w.
SGDS000003480. SOL4.

Phylogenomic databases

eggNOGCOG0363.
GeneTreeENSGT00550000075110.
HOGENOMHOG000256285.
KOK01057.
OMAFYWVDER.
OrthoDBEOG7MD51D.

Enzyme and pathway databases

BioCycYEAST:MONOMER3O-4047.
UniPathwayUPA00115; UER00409.

Gene expression databases

GenevestigatorP53315.

Family and domain databases

InterProIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsTIGR01198. pgl. 1 hit.
ProtoNetSearch...

Other

NextBio973270.

Entry information

Entry nameSOL4_YEAST
AccessionPrimary (citable) accession number: P53315
Secondary accession number(s): D6VV28
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways