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Protein

6-phosphogluconolactonase 4

Gene

SOL4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

Pathwayi

GO - Molecular functioni

  1. 6-phosphogluconolactonase activity Source: SGD

GO - Biological processi

  1. pentose-phosphate shunt, oxidative branch Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-4047.
ReactomeiREACT_233695. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonase 4 (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
Name:SOL4
Ordered Locus Names:YGR248W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR248w.
SGDiS000003480. SOL4.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2552556-phosphogluconolactonase 4PRO_0000090085Add
BLAST

Proteomic databases

MaxQBiP53315.
PaxDbiP53315.
PeptideAtlasiP53315.

Expressioni

Gene expression databases

GenevestigatoriP53315.

Interactioni

Protein-protein interaction databases

BioGridi33499. 41 interactions.
IntActiP53315. 4 interactions.
MINTiMINT-2780364.
STRINGi4932.YGR248W.

Structurei

3D structure databases

ProteinModelPortaliP53315.
SMRiP53315. Positions 39-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiP53315.
KOiK01057.
OMAiYRNSESA.
OrthoDBiEOG7MD51D.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

P53315-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKLQRFSEK KSLIHEFGKF ILEKQESALT GDADAVFNIA ISGGSMNQAL
60 70 80 90 100
YESLVNDKNI FPHIKWPQWR IFFCDERLVP FEDPQSNYGQ FKKTVLDPLV
110 120 130 140 150
HQGNQLNLGP TVYTINESLI GGGETANRKI AEEYASMLPA SFDLILLGCG
160 170 180 190 200
EDGHTCSLFP GVEFNYLVEE MDRKVLWCNN SPKAPKDRIT FTLAVVAEAK
210 220 230 240 250
SVCFLVRGAA KKAIMHDVLI VKNSELPSVL VNEMVGTKVT WFLDDEAGAL

IPENC
Length:255
Mass (Da):28,448
Last modified:October 1, 1996 - v1
Checksum:i691C9DDA04E5BEF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73033 Genomic DNA. Translation: CAA97277.1.
BK006941 Genomic DNA. Translation: DAA08339.1.
PIRiS64574.
RefSeqiNP_011764.3. NM_001181377.3.

Genome annotation databases

EnsemblFungiiYGR248W; YGR248W; YGR248W.
GeneIDi853163.
KEGGisce:YGR248W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73033 Genomic DNA. Translation: CAA97277.1.
BK006941 Genomic DNA. Translation: DAA08339.1.
PIRiS64574.
RefSeqiNP_011764.3. NM_001181377.3.

3D structure databases

ProteinModelPortaliP53315.
SMRiP53315. Positions 39-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33499. 41 interactions.
IntActiP53315. 4 interactions.
MINTiMINT-2780364.
STRINGi4932.YGR248W.

Proteomic databases

MaxQBiP53315.
PaxDbiP53315.
PeptideAtlasiP53315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR248W; YGR248W; YGR248W.
GeneIDi853163.
KEGGisce:YGR248W.

Organism-specific databases

CYGDiYGR248w.
SGDiS000003480. SOL4.

Phylogenomic databases

eggNOGiCOG0363.
GeneTreeiENSGT00550000075110.
HOGENOMiHOG000256285.
InParanoidiP53315.
KOiK01057.
OMAiYRNSESA.
OrthoDBiEOG7MD51D.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
BioCyciYEAST:MONOMER3O-4047.
ReactomeiREACT_233695. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

NextBioi973270.

Gene expression databases

GenevestigatoriP53315.

Family and domain databases

InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 17.9 kb region from Saccharomyces cerevisiae chromosome VII reveals the presence of eight open reading frames, including BRF1 (TFIIIB70) and GCN5 genes."
    Feroli F., Carignani G., Pavanello A., Guerreiro P., Azevedo D., Rodrigues-Pousada C., Melchioretto P., Panzeri L., Agostoni Carbone M.L.
    Yeast 13:373-377(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism."
    Stanford D.R., Whitney M.L., Hurto R.L., Eisaman D.M., Shen W.-C., Hopper A.K.
    Genetics 168:117-127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSOL4_YEAST
AccessioniPrimary (citable) accession number: P53315
Secondary accession number(s): D6VV28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4320 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.