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P53315

- SOL4_YEAST

UniProt

P53315 - SOL4_YEAST

Protein

6-phosphogluconolactonase 4

Gene

SOL4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.1 Publication

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: SGD

    GO - Biological processi

    1. pentose-phosphate shunt, oxidative branch Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciYEAST:MONOMER3O-4047.
    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonase 4 (EC:3.1.1.31)
    Short name:
    6PGL
    Gene namesi
    Name:SOL4
    Ordered Locus Names:YGR248W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR248w.
    SGDiS000003480. SOL4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2552556-phosphogluconolactonase 4PRO_0000090085Add
    BLAST

    Proteomic databases

    MaxQBiP53315.
    PaxDbiP53315.
    PeptideAtlasiP53315.

    Expressioni

    Gene expression databases

    GenevestigatoriP53315.

    Interactioni

    Protein-protein interaction databases

    BioGridi33499. 41 interactions.
    IntActiP53315. 4 interactions.
    MINTiMINT-2780364.
    STRINGi4932.YGR248W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53315.
    SMRiP53315. Positions 39-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0363.
    GeneTreeiENSGT00550000075110.
    HOGENOMiHOG000256285.
    KOiK01057.
    OMAiNEYADIT.
    OrthoDBiEOG7MD51D.

    Family and domain databases

    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view]
    PfamiPF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01198. pgl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53315-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKLQRFSEK KSLIHEFGKF ILEKQESALT GDADAVFNIA ISGGSMNQAL    50
    YESLVNDKNI FPHIKWPQWR IFFCDERLVP FEDPQSNYGQ FKKTVLDPLV 100
    HQGNQLNLGP TVYTINESLI GGGETANRKI AEEYASMLPA SFDLILLGCG 150
    EDGHTCSLFP GVEFNYLVEE MDRKVLWCNN SPKAPKDRIT FTLAVVAEAK 200
    SVCFLVRGAA KKAIMHDVLI VKNSELPSVL VNEMVGTKVT WFLDDEAGAL 250
    IPENC 255
    Length:255
    Mass (Da):28,448
    Last modified:October 1, 1996 - v1
    Checksum:i691C9DDA04E5BEF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73033 Genomic DNA. Translation: CAA97277.1.
    BK006941 Genomic DNA. Translation: DAA08339.1.
    PIRiS64574.
    RefSeqiNP_011764.3. NM_001181377.3.

    Genome annotation databases

    EnsemblFungiiYGR248W; YGR248W; YGR248W.
    GeneIDi853163.
    KEGGisce:YGR248W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73033 Genomic DNA. Translation: CAA97277.1 .
    BK006941 Genomic DNA. Translation: DAA08339.1 .
    PIRi S64574.
    RefSeqi NP_011764.3. NM_001181377.3.

    3D structure databases

    ProteinModelPortali P53315.
    SMRi P53315. Positions 39-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33499. 41 interactions.
    IntActi P53315. 4 interactions.
    MINTi MINT-2780364.
    STRINGi 4932.YGR248W.

    Proteomic databases

    MaxQBi P53315.
    PaxDbi P53315.
    PeptideAtlasi P53315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR248W ; YGR248W ; YGR248W .
    GeneIDi 853163.
    KEGGi sce:YGR248W.

    Organism-specific databases

    CYGDi YGR248w.
    SGDi S000003480. SOL4.

    Phylogenomic databases

    eggNOGi COG0363.
    GeneTreei ENSGT00550000075110.
    HOGENOMi HOG000256285.
    KOi K01057.
    OMAi NEYADIT.
    OrthoDBi EOG7MD51D.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .
    BioCyci YEAST:MONOMER3O-4047.

    Miscellaneous databases

    NextBioi 973270.

    Gene expression databases

    Genevestigatori P53315.

    Family and domain databases

    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view ]
    Pfami PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 17.9 kb region from Saccharomyces cerevisiae chromosome VII reveals the presence of eight open reading frames, including BRF1 (TFIIIB70) and GCN5 genes."
      Feroli F., Carignani G., Pavanello A., Guerreiro P., Azevedo D., Rodrigues-Pousada C., Melchioretto P., Panzeri L., Agostoni Carbone M.L.
      Yeast 13:373-377(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism."
      Stanford D.R., Whitney M.L., Hurto R.L., Eisaman D.M., Shen W.-C., Hopper A.K.
      Genetics 168:117-127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSOL4_YEAST
    AccessioniPrimary (citable) accession number: P53315
    Secondary accession number(s): D6VV28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 4320 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3