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Protein

Mitochondrial pyruvate carrier 3

Gene

MPC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.2 Publications

Miscellaneous

Present with 6750 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • pyruvate transmembrane transporter activity Source: SGD

GO - Biological processi

  • mitochondrial pyruvate transmembrane transport Source: SGD

Keywordsi

Biological processStress response, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30919-MONOMER

Protein family/group databases

TCDBi2.A.105.1.1 the mitochondrial pyruvate carrier (mpc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 32 Publications
Short name:
MPC32 Publications
Alternative name(s):
Protein FMP431 Publication
Gene namesi
Name:MPC32 Publications
Synonyms:FMP431 Publication
Ordered Locus Names:YGR243WImported
ORF Names:G8620
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR243W
SGDiS000003475 MPC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 39HelicalSequence analysisAdd BLAST17
Transmembranei55 – 71HelicalSequence analysisAdd BLAST17
Transmembranei78 – 94HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Grows more slowly in amino acid-free medium (SD), when combined with disruption of MPC2.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000021280021 – 146Mitochondrial pyruvate carrier 3Add BLAST126

Proteomic databases

MaxQBiP53311
PaxDbiP53311
PRIDEiP53311

Expressioni

Inductioni

Mainly expressed when grown on lactate containing growth medium (PubMed:22628554). Expression regulated by osmotic and alkaline stresses (PubMed:15299026, PubMed:16087739, PubMed:17334841). Under the control of the SKO1 transcription factor (PubMed:16087739).4 Publications

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and either MPC2 or MPC3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MPC1P531574EBI-23568,EBI-23845

Protein-protein interaction databases

BioGridi33494, 85 interactors
DIPiDIP-2027N
IntActiP53311, 4 interactors
STRINGi4932.YGR243W

Structurei

3D structure databases

ProteinModelPortaliP53311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000047120
HOGENOMiHOG000188910
InParanoidiP53311
KOiK22139
OMAiQCPAIEA
OrthoDBiEOG092C5HBA

Family and domain databases

InterProiView protein in InterPro
IPR005336 MPC
PfamiView protein in Pfam
PF03650 MPC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASAFNFAF RRFWNSETGP KTVHFWAPTL KWGLVFAGLN DIKRPVEKVS
60 70 80 90 100
GAQNLSLLAT ALIWTRWSFV IKPKNYLLAS VNFFLGCTAG YHLTRIANFR
110 120 130 140
IRNGDSFKQV IHYIIKGETP AAVAAKQTAS TSMNKGVIGT NPPITH
Length:146
Mass (Da):16,230
Last modified:October 1, 1996 - v1
Checksum:iE0B13933AB142B4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73028 Genomic DNA Translation: CAA97272.1
AY558546 Genomic DNA Translation: AAS56872.1
BK006941 Genomic DNA Translation: DAA08334.1
PIRiS64569
RefSeqiNP_011759.1, NM_001181372.1

Genome annotation databases

EnsemblFungiiYGR243W; YGR243W; YGR243W
GeneIDi853158
KEGGisce:YGR243W

Similar proteinsi

Entry informationi

Entry nameiMPC3_YEAST
AccessioniPrimary (citable) accession number: P53311
Secondary accession number(s): D6VV23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health