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P53311

- MPC3_YEAST

UniProt

P53311 - MPC3_YEAST

Protein

Mitochondrial pyruvate carrier 3

Gene

FMP43

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Mediates the uptake of pyruvate into mitochondria.2 Publications

    GO - Molecular functioni

    1. pyruvate transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. mitochondrial pyruvate transport Source: SGD
    2. pyruvate transmembrane transport Source: GOC
    3. response to stress Source: UniProtKB-KW

    Keywords - Biological processi

    Stress response, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30919-MONOMER.

    Protein family/group databases

    TCDBi2.A.105.1.1. the mitochondrial pyruvate carrier (mpc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial pyruvate carrier 3
    Short name:
    MPC3
    Alternative name(s):
    Protein FMP43
    Gene namesi
    Name:FMP43
    Ordered Locus Names:YGR243W
    ORF Names:G8620
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR243w.
    SGDiS000003475. FMP43.

    Subcellular locationi

    Mitochondrion inner membrane 4 Publications; Multi-pass membrane protein 4 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrial membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Grows more slowly in amino acid-free medium (SD), when combined with disruption of mpc2.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2020MitochondrionSequence AnalysisAdd
    BLAST
    Chaini21 – 146126Mitochondrial pyruvate carrier 3PRO_0000212800Add
    BLAST

    Proteomic databases

    PaxDbiP53311.

    Expressioni

    Inductioni

    Expression regulated by osmotic and alkaline stresses. Under the control of the SKO1 transcription factor.3 Publications

    Gene expression databases

    GenevestigatoriP53311.

    Interactioni

    Subunit structurei

    The functional 150 kDa pyruvate import complex is a heteromer of mpc1 and either mpc2 or mpc3.2 Publications

    Protein-protein interaction databases

    BioGridi33494. 15 interactions.
    DIPiDIP-2027N.
    MINTiMINT-535950.
    STRINGi4932.YGR243W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53311.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 3917HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7117HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG250420.
    GeneTreeiENSGT00510000047120.
    HOGENOMiHOG000188910.
    OMAiKPANTIA.
    OrthoDBiEOG72RNB3.

    Family and domain databases

    InterProiIPR005336. MPC.
    [Graphical view]
    PfamiPF03650. MPC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P53311-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASAFNFAF RRFWNSETGP KTVHFWAPTL KWGLVFAGLN DIKRPVEKVS    50
    GAQNLSLLAT ALIWTRWSFV IKPKNYLLAS VNFFLGCTAG YHLTRIANFR 100
    IRNGDSFKQV IHYIIKGETP AAVAAKQTAS TSMNKGVIGT NPPITH 146
    Length:146
    Mass (Da):16,230
    Last modified:October 1, 1996 - v1
    Checksum:iE0B13933AB142B4E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73028 Genomic DNA. Translation: CAA97272.1.
    AY558546 Genomic DNA. Translation: AAS56872.1.
    BK006941 Genomic DNA. Translation: DAA08334.1.
    PIRiS64569.
    RefSeqiNP_011759.1. NM_001181372.1.

    Genome annotation databases

    EnsemblFungiiYGR243W; YGR243W; YGR243W.
    GeneIDi853158.
    KEGGisce:YGR243W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73028 Genomic DNA. Translation: CAA97272.1 .
    AY558546 Genomic DNA. Translation: AAS56872.1 .
    BK006941 Genomic DNA. Translation: DAA08334.1 .
    PIRi S64569.
    RefSeqi NP_011759.1. NM_001181372.1.

    3D structure databases

    ProteinModelPortali P53311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33494. 15 interactions.
    DIPi DIP-2027N.
    MINTi MINT-535950.
    STRINGi 4932.YGR243W.

    Protein family/group databases

    TCDBi 2.A.105.1.1. the mitochondrial pyruvate carrier (mpc) family.

    Proteomic databases

    PaxDbi P53311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR243W ; YGR243W ; YGR243W .
    GeneIDi 853158.
    KEGGi sce:YGR243W.

    Organism-specific databases

    CYGDi YGR243w.
    SGDi S000003475. FMP43.

    Phylogenomic databases

    eggNOGi NOG250420.
    GeneTreei ENSGT00510000047120.
    HOGENOMi HOG000188910.
    OMAi KPANTIA.
    OrthoDBi EOG72RNB3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30919-MONOMER.

    Miscellaneous databases

    NextBioi 973255.

    Gene expression databases

    Genevestigatori P53311.

    Family and domain databases

    InterProi IPR005336. MPC.
    [Graphical view ]
    Pfami PF03650. MPC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of a 9.9 kb segment on the right arm of yeast chromosome VII reveals four open reading frames, including PFK1, the gene coding for succinyl-CoA synthetase (beta-chain) and two ORFs sharing homology with ORFs of the yeast chromosome VIII."
      Guerreiro P., Azevedo D., Barreiros T., Rodrigues-Pousada C.
      Yeast 13:275-280(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    8. "Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae."
      Viladevall L., Serrano R., Ruiz A., Domenech G., Giraldo J., Barcelo A., Arino J.
      J. Biol. Chem. 279:43614-43624(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    9. "Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae."
      Proft M., Gibbons F.D., Copeland M., Roth F.P., Struhl K.
      Eukaryot. Cell 4:1343-1352(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    10. "Genetic and comparative transcriptome analysis of bromodomain factor 1 in the salt stress response of Saccharomyces cerevisiae."
      Liu X., Zhang X., Wang C., Liu L., Lei M., Bao X.
      Curr. Microbiol. 54:325-330(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    11. "Identification and functional expression of the mitochondrial pyruvate carrier."
      Herzig S., Raemy E., Montessuit S., Veuthey J.L., Zamboni N., Westermann B., Kunji E.R., Martinou J.C.
      Science 337:93-96(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, DISRUPTION PHENOTYPE.
    12. Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.

    Entry informationi

    Entry nameiMPC3_YEAST
    AccessioniPrimary (citable) accession number: P53311
    Secondary accession number(s): D6VV23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6750 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3