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P53311

- MPC3_YEAST

UniProt

P53311 - MPC3_YEAST

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Protein

Mitochondrial pyruvate carrier 3

Gene

FMP43

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.2 Publications

GO - Molecular functioni

  1. pyruvate transmembrane transporter activity Source: SGD

GO - Biological processi

  1. mitochondrial pyruvate transport Source: SGD
  2. pyruvate transmembrane transport Source: GOC
  3. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30919-MONOMER.
ReactomeiREACT_259911. Pyruvate metabolism.

Protein family/group databases

TCDBi2.A.105.1.1. the mitochondrial pyruvate carrier (mpc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 3
Short name:
MPC3
Alternative name(s):
Protein FMP43
Gene namesi
Name:FMP43
Ordered Locus Names:YGR243W
ORF Names:G8620
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR243w.
SGDiS000003475. FMP43.

Subcellular locationi

Mitochondrion inner membrane 4 Publications; Multi-pass membrane protein 4 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 3917HelicalSequence AnalysisAdd
BLAST
Transmembranei55 – 7117HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. mitochondrial membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Grows more slowly in amino acid-free medium (SD), when combined with disruption of mpc2.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2020MitochondrionSequence AnalysisAdd
BLAST
Chaini21 – 146126Mitochondrial pyruvate carrier 3PRO_0000212800Add
BLAST

Proteomic databases

PaxDbiP53311.

Expressioni

Inductioni

Expression regulated by osmotic and alkaline stresses. Under the control of the SKO1 transcription factor.3 Publications

Gene expression databases

GenevestigatoriP53311.

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of mpc1 and either mpc2 or mpc3.2 Publications

Protein-protein interaction databases

BioGridi33494. 16 interactions.
DIPiDIP-2027N.
MINTiMINT-535950.
STRINGi4932.YGR243W.

Structurei

3D structure databases

ProteinModelPortaliP53311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250420.
GeneTreeiENSGT00510000047120.
HOGENOMiHOG000188910.
InParanoidiP53311.
OMAiKPANTIA.
OrthoDBiEOG72RNB3.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53311-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSASAFNFAF RRFWNSETGP KTVHFWAPTL KWGLVFAGLN DIKRPVEKVS
60 70 80 90 100
GAQNLSLLAT ALIWTRWSFV IKPKNYLLAS VNFFLGCTAG YHLTRIANFR
110 120 130 140
IRNGDSFKQV IHYIIKGETP AAVAAKQTAS TSMNKGVIGT NPPITH
Length:146
Mass (Da):16,230
Last modified:October 1, 1996 - v1
Checksum:iE0B13933AB142B4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73028 Genomic DNA. Translation: CAA97272.1.
AY558546 Genomic DNA. Translation: AAS56872.1.
BK006941 Genomic DNA. Translation: DAA08334.1.
PIRiS64569.
RefSeqiNP_011759.1. NM_001181372.1.

Genome annotation databases

EnsemblFungiiYGR243W; YGR243W; YGR243W.
GeneIDi853158.
KEGGisce:YGR243W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73028 Genomic DNA. Translation: CAA97272.1 .
AY558546 Genomic DNA. Translation: AAS56872.1 .
BK006941 Genomic DNA. Translation: DAA08334.1 .
PIRi S64569.
RefSeqi NP_011759.1. NM_001181372.1.

3D structure databases

ProteinModelPortali P53311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33494. 16 interactions.
DIPi DIP-2027N.
MINTi MINT-535950.
STRINGi 4932.YGR243W.

Protein family/group databases

TCDBi 2.A.105.1.1. the mitochondrial pyruvate carrier (mpc) family.

Proteomic databases

PaxDbi P53311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR243W ; YGR243W ; YGR243W .
GeneIDi 853158.
KEGGi sce:YGR243W.

Organism-specific databases

CYGDi YGR243w.
SGDi S000003475. FMP43.

Phylogenomic databases

eggNOGi NOG250420.
GeneTreei ENSGT00510000047120.
HOGENOMi HOG000188910.
InParanoidi P53311.
OMAi KPANTIA.
OrthoDBi EOG72RNB3.

Enzyme and pathway databases

BioCyci YEAST:G3O-30919-MONOMER.
Reactomei REACT_259911. Pyruvate metabolism.

Miscellaneous databases

NextBioi 973255.

Gene expression databases

Genevestigatori P53311.

Family and domain databases

InterProi IPR005336. MPC.
[Graphical view ]
Pfami PF03650. MPC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing of a 9.9 kb segment on the right arm of yeast chromosome VII reveals four open reading frames, including PFK1, the gene coding for succinyl-CoA synthetase (beta-chain) and two ORFs sharing homology with ORFs of the yeast chromosome VIII."
    Guerreiro P., Azevedo D., Barreiros T., Rodrigues-Pousada C.
    Yeast 13:275-280(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  8. "Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae."
    Viladevall L., Serrano R., Ruiz A., Domenech G., Giraldo J., Barcelo A., Arino J.
    J. Biol. Chem. 279:43614-43624(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae."
    Proft M., Gibbons F.D., Copeland M., Roth F.P., Struhl K.
    Eukaryot. Cell 4:1343-1352(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  10. "Genetic and comparative transcriptome analysis of bromodomain factor 1 in the salt stress response of Saccharomyces cerevisiae."
    Liu X., Zhang X., Wang C., Liu L., Lei M., Bao X.
    Curr. Microbiol. 54:325-330(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  11. "Identification and functional expression of the mitochondrial pyruvate carrier."
    Herzig S., Raemy E., Montessuit S., Veuthey J.L., Zamboni N., Westermann B., Kunji E.R., Martinou J.C.
    Science 337:93-96(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, DISRUPTION PHENOTYPE.
  12. Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT.

Entry informationi

Entry nameiMPC3_YEAST
AccessioniPrimary (citable) accession number: P53311
Secondary accession number(s): D6VV23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6750 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3