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Protein

Mitochondrial pyruvate carrier 3

Gene

MPC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.2 Publications

GO - Molecular functioni

  • pyruvate transmembrane transporter activity Source: SGD

GO - Biological processi

  • mitochondrial pyruvate transmembrane transport Source: SGD
  • mitochondrial pyruvate transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Stress response, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30919-MONOMER.

Protein family/group databases

TCDBi2.A.105.1.1. the mitochondrial pyruvate carrier (mpc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 32 Publications
Short name:
MPC32 Publications
Alternative name(s):
Protein FMP431 Publication
Gene namesi
Name:MPC32 Publications
Synonyms:FMP431 Publication
Ordered Locus Names:YGR243WImported
ORF Names:G8620
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR243W.
SGDiS000003475. MPC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 39HelicalSequence analysisAdd BLAST17
Transmembranei55 – 71HelicalSequence analysisAdd BLAST17
Transmembranei78 – 94HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Grows more slowly in amino acid-free medium (SD), when combined with disruption of MPC2.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000021280021 – 146Mitochondrial pyruvate carrier 3Add BLAST126

Proteomic databases

MaxQBiP53311.
PRIDEiP53311.

Expressioni

Inductioni

Mainly expressed when grown on lactate containing growth medium (PubMed:22628554). Expression regulated by osmotic and alkaline stresses (PubMed:15299026, PubMed:16087739, PubMed:17334841). Under the control of the SKO1 transcription factor (PubMed:16087739).4 Publications

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and either MPC2 or MPC3.2 Publications

Protein-protein interaction databases

BioGridi33494. 18 interactors.
DIPiDIP-2027N.
MINTiMINT-535950.

Structurei

3D structure databases

ProteinModelPortaliP53311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000047120.
HOGENOMiHOG000188910.
InParanoidiP53311.
OMAiKPANTIA.
OrthoDBiEOG092C5HBA.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASAFNFAF RRFWNSETGP KTVHFWAPTL KWGLVFAGLN DIKRPVEKVS
60 70 80 90 100
GAQNLSLLAT ALIWTRWSFV IKPKNYLLAS VNFFLGCTAG YHLTRIANFR
110 120 130 140
IRNGDSFKQV IHYIIKGETP AAVAAKQTAS TSMNKGVIGT NPPITH
Length:146
Mass (Da):16,230
Last modified:October 1, 1996 - v1
Checksum:iE0B13933AB142B4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73028 Genomic DNA. Translation: CAA97272.1.
AY558546 Genomic DNA. Translation: AAS56872.1.
BK006941 Genomic DNA. Translation: DAA08334.1.
PIRiS64569.
RefSeqiNP_011759.1. NM_001181372.1.

Genome annotation databases

EnsemblFungiiYGR243W; YGR243W; YGR243W.
GeneIDi853158.
KEGGisce:YGR243W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73028 Genomic DNA. Translation: CAA97272.1.
AY558546 Genomic DNA. Translation: AAS56872.1.
BK006941 Genomic DNA. Translation: DAA08334.1.
PIRiS64569.
RefSeqiNP_011759.1. NM_001181372.1.

3D structure databases

ProteinModelPortaliP53311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33494. 18 interactors.
DIPiDIP-2027N.
MINTiMINT-535950.

Protein family/group databases

TCDBi2.A.105.1.1. the mitochondrial pyruvate carrier (mpc) family.

Proteomic databases

MaxQBiP53311.
PRIDEiP53311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR243W; YGR243W; YGR243W.
GeneIDi853158.
KEGGisce:YGR243W.

Organism-specific databases

EuPathDBiFungiDB:YGR243W.
SGDiS000003475. MPC3.

Phylogenomic databases

GeneTreeiENSGT00510000047120.
HOGENOMiHOG000188910.
InParanoidiP53311.
OMAiKPANTIA.
OrthoDBiEOG092C5HBA.

Enzyme and pathway databases

BioCyciYEAST:G3O-30919-MONOMER.

Miscellaneous databases

PROiP53311.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPC3_YEAST
AccessioniPrimary (citable) accession number: P53311
Secondary accession number(s): D6VV23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6750 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.