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Protein

Clathrin coat assembly protein AP180B

Gene

YAP1802

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in endocytosis and clathrin cage assembly.2 Publications

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: InterPro
  • clathrin binding Source: SGD

GO - Biological processi

  • clathrin coat assembly Source: InterPro
  • endocytosis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30918-MONOMER.
ReactomeiR-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin coat assembly protein AP180B
Gene namesi
Name:YAP1802
Ordered Locus Names:YGR241C
ORF Names:G8610
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR241C.
SGDiS000003473. YAP1802.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: SGD
  • cellular bud neck Source: UniProtKB-SubCell
  • clathrin-coated vesicle Source: InterPro
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028561 – 568Clathrin coat assembly protein AP180BAdd BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki282Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei449PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP53309.
PRIDEiP53309.

PTM databases

iPTMnetiP53309.

Interactioni

Subunit structurei

Interacts with PAN1 and the clathrin heavy and light chains CHC1 and CLC1.1 Publication

GO - Molecular functioni

  • clathrin binding Source: SGD

Protein-protein interaction databases

BioGridi33493. 49 interactors.
DIPiDIP-2751N.
IntActiP53309. 18 interactors.
MINTiMINT-556894.

Structurei

3D structure databases

ProteinModelPortaliP53309.
SMRiP53309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 127ENTHPROSITE-ProRule annotationAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi379 – 383Poly-Gln5
Compositional biasi464 – 467Poly-Gln4
Compositional biasi551 – 560Poly-Gln10

Sequence similaritiesi

Belongs to the AP180 family.Curated
Contains 1 ENTH (epsin N-terminal homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000008805.
HOGENOMiHOG000033975.
InParanoidiP53309.
KOiK20044.
OMAiFTDAQTQ.
OrthoDBiEOG092C1803.

Family and domain databases

Gene3Di1.20.58.150. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR011417. ANTH_dom.
IPR014712. Clathrin_AP_2.
IPR013809. ENTH.
IPR008942. ENTH_VHS.
[Graphical view]
PfamiPF07651. ANTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLYTKLVK GATKIKMAPP KQKYVDPILS GTSSARGLQE ITHALDIRLS
60 70 80 90 100
DTAWTIVYKA LIVLHLMIQQ GEKDVTLRHY SHNLDVFQLR KISHTTKWSS
110 120 130 140 150
NDMRALQRYD EYLKTRCEEY GRLGMDHLRD NYSSLKLGSK NQLSMDEELD
160 170 180 190 200
HVESLEIQIN ALIRNKYSVS DLENHLLLYA FQLLVQDLLG LYNALNEGVI
210 220 230 240 250
TLLESFFELS IEHAKRTLDL YKDFVDMTEY VVRYLKIGKA VGLKIPVIKH
260 270 280 290 300
ITTKLINSLE EHLREETKRQ RGEPSEPQQD RKPSTAISST SSHNNNSNDK
310 320 330 340 350
NKSIAQKKLE QIREQKRLLE QQLQNQQLLI SPTVPQDAYN PFGSQQQDLN
360 370 380 390 400
NDTFSFEPTQ PQMTAQVPQP TANPFLIPQQ QQQALQLTSA STMPQPSEIQ
410 420 430 440 450
ITPNLNNQQT GMYASNLQYT PNFTGSGFGG YTTTENNAIM TGTLDPTKTG
460 470 480 490 500
SNNPFSLENI AREQQQQNFQ NSPNPFTLQQ AQTTPILAHS QTGNPFQAQN
510 520 530 540 550
VVTSPMGTYM TNPVAGQLQY ASTGAQQQPQ MMQGQQTGYV MVPTAFVPIN
560
QQQQQQQHQQ ENPNLIDI
Length:568
Mass (Da):64,328
Last modified:October 1, 1996 - v1
Checksum:iC5B5FD733739C3CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73026 Genomic DNA. Translation: CAA97270.1.
BK006941 Genomic DNA. Translation: DAA08333.1.
PIRiS64567.
RefSeqiNP_011757.3. NM_001181370.3.

Genome annotation databases

EnsemblFungiiYGR241C; YGR241C; YGR241C.
GeneIDi853157.
KEGGisce:YGR241C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73026 Genomic DNA. Translation: CAA97270.1.
BK006941 Genomic DNA. Translation: DAA08333.1.
PIRiS64567.
RefSeqiNP_011757.3. NM_001181370.3.

3D structure databases

ProteinModelPortaliP53309.
SMRiP53309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33493. 49 interactors.
DIPiDIP-2751N.
IntActiP53309. 18 interactors.
MINTiMINT-556894.

PTM databases

iPTMnetiP53309.

Proteomic databases

MaxQBiP53309.
PRIDEiP53309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR241C; YGR241C; YGR241C.
GeneIDi853157.
KEGGisce:YGR241C.

Organism-specific databases

EuPathDBiFungiDB:YGR241C.
SGDiS000003473. YAP1802.

Phylogenomic databases

GeneTreeiENSGT00390000008805.
HOGENOMiHOG000033975.
InParanoidiP53309.
KOiK20044.
OMAiFTDAQTQ.
OrthoDBiEOG092C1803.

Enzyme and pathway databases

BioCyciYEAST:G3O-30918-MONOMER.
ReactomeiR-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Miscellaneous databases

PROiP53309.

Family and domain databases

Gene3Di1.20.58.150. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR011417. ANTH_dom.
IPR014712. Clathrin_AP_2.
IPR013809. ENTH.
IPR008942. ENTH_VHS.
[Graphical view]
PfamiPF07651. ANTH. 1 hit.
[Graphical view]
SMARTiSM00273. ENTH. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50942. ENTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP18B_YEAST
AccessioniPrimary (citable) accession number: P53309
Secondary accession number(s): D6VV22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.