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P53303

- ZPR1_YEAST

UniProt

P53303 - ZPR1_YEAST

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Protein

Zinc finger protein ZPR1

Gene

ZPR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri54 – 8633C4-type 1Add
BLAST
Zinc fingeri295 – 32733C4-type 2Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. cellular response to starvation Source: SGD
  2. regulation of mitotic cell cycle Source: SGD
  3. response to glucose Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30893-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZPR1
Gene namesi
Name:ZPR1
Ordered Locus Names:YGR211W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR211w.
SGDiS000003443. ZPR1.

Subcellular locationi

Cytoplasm. Nucleus
Note: Translocates to the nucleus after nutrient stimulation.

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Zinc finger protein ZPR1PRO_0000119040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei407 – 4071Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53303.
PaxDbiP53303.
PeptideAtlasiP53303.

Expressioni

Gene expression databases

GenevestigatoriP53303.

Interactioni

Subunit structurei

Binds to the elongation factor 1-alpha.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-29657,EBI-29657
RNR2P099381EBI-29657,EBI-15240
TEF1P029941EBI-29657,EBI-6314

Protein-protein interaction databases

BioGridi33464. 21 interactions.
DIPiDIP-4419N.
IntActiP53303. 7 interactions.
MINTiMINT-490492.

Structurei

3D structure databases

ProteinModelPortaliP53303.
SMRiP53303. Positions 50-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZPR1 family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri54 – 8633C4-type 1Add
BLAST
Zinc fingeri295 – 32733C4-type 2Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1779.
GeneTreeiENSGT00390000005306.
HOGENOMiHOG000216492.
InParanoidiP53303.
KOiK06874.
OMAiFIMNDPA.
OrthoDBiEOG7WMCW5.

Family and domain databases

InterProiIPR004457. Znf_ZPR1.
[Graphical view]
PfamiPF03367. zf-ZPR1. 2 hits.
[Graphical view]
SMARTiSM00709. Zpr1. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00310. ZPR1_znf. 2 hits.

Sequencei

Sequence statusi: Complete.

P53303-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQKEDLFK PVGEAAAEVE DESIAEQNKA NDGVKLTGAQ DAMGHPVQEI
60 70 80 90 100
ESLCMNCGKN GTTRLLLTSI PYFREIIIMS FDCPHCGFKN CEIQPASQIQ
110 120 130 140 150
EKGSRYVLKV ECREDFNRQV IKSETATCKF VELDIEIPAK RGQLTTVEGL
160 170 180 190 200
LSEMIDDLSQ DQEMRKSIDE ALYKKIDDFI QKVKSYINCE PNTIPITFIL
210 220 230 240 250
DDPAGNSWIE YKPGEPQHKW SHTQYVRTDE QNVQVGIITR DQLEQRRQEQ
260 270 280 290 300
LKQLANRERN PSESVKVGSA NPQFLSDATD IENFNNEVQT FRASCPSCTQ
310 320 330 340 350
ECETHMKPVN IPHFKEVIIM STVCDHCGYK SNEVKTGGAI PDKGRRITLY
360 370 380 390 400
CDDAADLSRD ILKSETCSMV IPELHLDIQE GTLGGRFTTL EGLLRQVYEE
410 420 430 440 450
LESRIFTQTS DSMDEATKAR WVEFFAKLKE AIAGKVKFTV IMEDPLAGSY
460 470 480
IQNVYAPDPD PNMTIEDYER TKEQNEDLGL SDIKVE
Length:486
Mass (Da):55,072
Last modified:October 1, 1996 - v1
Checksum:iF523AF8AB5B8ACA0
GO

Sequence cautioni

The sequence AAA85586.1 differs from that shown. Reason: Frameshift at positions 171 and 419.
The sequence AAA85587.1 differs from that shown. Reason: Frameshift at positions 171 and 419.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019769 Genomic DNA. Translation: AAC33516.1.
Z72996 Genomic DNA. Translation: CAA97238.1.
U40843 Genomic DNA. Translation: AAA85586.1. Frameshift.
U40843 Genomic DNA. Translation: AAA85587.1. Frameshift.
BK006941 Genomic DNA. Translation: DAA08305.1.
PIRiS64534.
RefSeqiNP_011727.3. NM_001181340.3.

Genome annotation databases

EnsemblFungiiYGR211W; YGR211W; YGR211W.
GeneIDi853125.
KEGGisce:YGR211W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019769 Genomic DNA. Translation: AAC33516.1 .
Z72996 Genomic DNA. Translation: CAA97238.1 .
U40843 Genomic DNA. Translation: AAA85586.1 . Frameshift.
U40843 Genomic DNA. Translation: AAA85587.1 . Frameshift.
BK006941 Genomic DNA. Translation: DAA08305.1 .
PIRi S64534.
RefSeqi NP_011727.3. NM_001181340.3.

3D structure databases

ProteinModelPortali P53303.
SMRi P53303. Positions 50-477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33464. 21 interactions.
DIPi DIP-4419N.
IntActi P53303. 7 interactions.
MINTi MINT-490492.

Proteomic databases

MaxQBi P53303.
PaxDbi P53303.
PeptideAtlasi P53303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR211W ; YGR211W ; YGR211W .
GeneIDi 853125.
KEGGi sce:YGR211W.

Organism-specific databases

CYGDi YGR211w.
SGDi S000003443. ZPR1.

Phylogenomic databases

eggNOGi COG1779.
GeneTreei ENSGT00390000005306.
HOGENOMi HOG000216492.
InParanoidi P53303.
KOi K06874.
OMAi FIMNDPA.
OrthoDBi EOG7WMCW5.

Enzyme and pathway databases

BioCyci YEAST:G3O-30893-MONOMER.

Miscellaneous databases

NextBioi 973169.
PROi P53303.

Gene expression databases

Genevestigatori P53303.

Family and domain databases

InterProi IPR004457. Znf_ZPR1.
[Graphical view ]
Pfami PF03367. zf-ZPR1. 2 hits.
[Graphical view ]
SMARTi SM00709. Zpr1. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00310. ZPR1_znf. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells."
    Gangwani L., Mikrut M., Galcheva-Gargova Z., Davis R.J.
    J. Cell Biol. 143:1471-1484(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
    Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
    Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Analysis of the 15.6-kb fragment encompassing the ADE3 gene."
    Song J.M., Cheung E., Rabinowitz J.C.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-459.
    Strain: S288c / GRF88.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-407, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZPR1_YEAST
AccessioniPrimary (citable) accession number: P53303
Secondary accession number(s): D6VUZ4, Q02807, Q02808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 39900 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3