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P53303

- ZPR1_YEAST

UniProt

P53303 - ZPR1_YEAST

Protein

Zinc finger protein ZPR1

Gene

ZPR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri54 – 8633C4-type 1Add
    BLAST
    Zinc fingeri295 – 32733C4-type 2Add
    BLAST

    GO - Molecular functioni

    1. protein binding Source: SGD
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cellular response to starvation Source: SGD
    2. regulation of mitotic cell cycle Source: SGD
    3. response to glucose Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30893-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein ZPR1
    Gene namesi
    Name:ZPR1
    Ordered Locus Names:YGR211W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR211w.
    SGDiS000003443. ZPR1.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Translocates to the nucleus after nutrient stimulation.

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Zinc finger protein ZPR1PRO_0000119040Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei407 – 4071Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53303.
    PaxDbiP53303.
    PeptideAtlasiP53303.

    Expressioni

    Gene expression databases

    GenevestigatoriP53303.

    Interactioni

    Subunit structurei

    Binds to the elongation factor 1-alpha.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself1EBI-29657,EBI-29657
    RNR2P099381EBI-29657,EBI-15240
    TEF1P029941EBI-29657,EBI-6314

    Protein-protein interaction databases

    BioGridi33464. 20 interactions.
    DIPiDIP-4419N.
    IntActiP53303. 7 interactions.
    MINTiMINT-490492.

    Structurei

    3D structure databases

    ProteinModelPortaliP53303.
    SMRiP53303. Positions 50-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ZPR1 family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri54 – 8633C4-type 1Add
    BLAST
    Zinc fingeri295 – 32733C4-type 2Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1779.
    GeneTreeiENSGT00390000005306.
    HOGENOMiHOG000216492.
    KOiK06874.
    OMAiFIMNDPA.
    OrthoDBiEOG7WMCW5.

    Family and domain databases

    InterProiIPR004457. Znf_ZPR1.
    [Graphical view]
    PfamiPF03367. zf-ZPR1. 2 hits.
    [Graphical view]
    SMARTiSM00709. Zpr1. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00310. ZPR1_znf. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P53303-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQKEDLFK PVGEAAAEVE DESIAEQNKA NDGVKLTGAQ DAMGHPVQEI    50
    ESLCMNCGKN GTTRLLLTSI PYFREIIIMS FDCPHCGFKN CEIQPASQIQ 100
    EKGSRYVLKV ECREDFNRQV IKSETATCKF VELDIEIPAK RGQLTTVEGL 150
    LSEMIDDLSQ DQEMRKSIDE ALYKKIDDFI QKVKSYINCE PNTIPITFIL 200
    DDPAGNSWIE YKPGEPQHKW SHTQYVRTDE QNVQVGIITR DQLEQRRQEQ 250
    LKQLANRERN PSESVKVGSA NPQFLSDATD IENFNNEVQT FRASCPSCTQ 300
    ECETHMKPVN IPHFKEVIIM STVCDHCGYK SNEVKTGGAI PDKGRRITLY 350
    CDDAADLSRD ILKSETCSMV IPELHLDIQE GTLGGRFTTL EGLLRQVYEE 400
    LESRIFTQTS DSMDEATKAR WVEFFAKLKE AIAGKVKFTV IMEDPLAGSY 450
    IQNVYAPDPD PNMTIEDYER TKEQNEDLGL SDIKVE 486
    Length:486
    Mass (Da):55,072
    Last modified:October 1, 1996 - v1
    Checksum:iF523AF8AB5B8ACA0
    GO

    Sequence cautioni

    The sequence AAA85586.1 differs from that shown. Reason: Frameshift at positions 171 and 419.
    The sequence AAA85587.1 differs from that shown. Reason: Frameshift at positions 171 and 419.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF019769 Genomic DNA. Translation: AAC33516.1.
    Z72996 Genomic DNA. Translation: CAA97238.1.
    U40843 Genomic DNA. Translation: AAA85586.1. Frameshift.
    U40843 Genomic DNA. Translation: AAA85587.1. Frameshift.
    BK006941 Genomic DNA. Translation: DAA08305.1.
    PIRiS64534.
    RefSeqiNP_011727.3. NM_001181340.3.

    Genome annotation databases

    EnsemblFungiiYGR211W; YGR211W; YGR211W.
    GeneIDi853125.
    KEGGisce:YGR211W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF019769 Genomic DNA. Translation: AAC33516.1 .
    Z72996 Genomic DNA. Translation: CAA97238.1 .
    U40843 Genomic DNA. Translation: AAA85586.1 . Frameshift.
    U40843 Genomic DNA. Translation: AAA85587.1 . Frameshift.
    BK006941 Genomic DNA. Translation: DAA08305.1 .
    PIRi S64534.
    RefSeqi NP_011727.3. NM_001181340.3.

    3D structure databases

    ProteinModelPortali P53303.
    SMRi P53303. Positions 50-477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33464. 20 interactions.
    DIPi DIP-4419N.
    IntActi P53303. 7 interactions.
    MINTi MINT-490492.

    Proteomic databases

    MaxQBi P53303.
    PaxDbi P53303.
    PeptideAtlasi P53303.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR211W ; YGR211W ; YGR211W .
    GeneIDi 853125.
    KEGGi sce:YGR211W.

    Organism-specific databases

    CYGDi YGR211w.
    SGDi S000003443. ZPR1.

    Phylogenomic databases

    eggNOGi COG1779.
    GeneTreei ENSGT00390000005306.
    HOGENOMi HOG000216492.
    KOi K06874.
    OMAi FIMNDPA.
    OrthoDBi EOG7WMCW5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30893-MONOMER.

    Miscellaneous databases

    NextBioi 973169.
    PROi P53303.

    Gene expression databases

    Genevestigatori P53303.

    Family and domain databases

    InterProi IPR004457. Znf_ZPR1.
    [Graphical view ]
    Pfami PF03367. zf-ZPR1. 2 hits.
    [Graphical view ]
    SMARTi SM00709. Zpr1. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00310. ZPR1_znf. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells."
      Gangwani L., Mikrut M., Galcheva-Gargova Z., Davis R.J.
      J. Cell Biol. 143:1471-1484(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
      Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
      Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Analysis of the 15.6-kb fragment encompassing the ADE3 gene."
      Song J.M., Cheung E., Rabinowitz J.C.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-459.
      Strain: S288c / GRF88.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-407, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZPR1_YEAST
    AccessioniPrimary (citable) accession number: P53303
    Secondary accession number(s): D6VUZ4, Q02807, Q02808
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 39900 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3