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Protein

PAB1-binding protein 1

Gene

PBP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to promote proper polyadenylation. In the absence of PBP1, the 3'termini of pre-mRNAs are properly cleaved but lack full-length poly(A) tails. May act to repress the ability of PAB1 to negatively regulate polyadenylation. Negative regulator of poly(A) nuclease (PAN) activity.2 Publications

GO - Biological processi

  • maintenance of rDNA Source: SGD
  • mRNA polyadenylation Source: SGD
  • positive regulation of translation Source: SGD
  • regulation of cytoplasmic mRNA processing body assembly Source: GO_Central
  • stress granule assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30871-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PAB1-binding protein 1
Gene namesi
Name:PBP1
Synonyms:MRS16
Ordered Locus Names:YGR178C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR178C.
SGDiS000003410. PBP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic stress granule Source: SGD
  • mitochondrion Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • polysome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582441 – 722PAB1-binding protein 1Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphoserineCombined sources1
Modified residuei193PhosphothreonineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Cross-linki344Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei436PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP53297.
PRIDEiP53297.

PTM databases

iPTMnetiP53297.

Interactioni

Subunit structurei

Interacts with FIR1, IGO1, LSM12, PBP4 and PAB1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM12P388286EBI-12961,EBI-24700

Protein-protein interaction databases

BioGridi33430. 134 interactors.
DIPiDIP-2464N.
IntActiP53297. 23 interactors.
MINTiMINT-488669.

Structurei

3D structure databases

ProteinModelPortaliP53297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ataxin-2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063565.
HOGENOMiHOG000093792.
InParanoidiP53297.
OMAiIEKPYFT.
OrthoDBiEOG092C56A1.

Family and domain databases

InterProiIPR009604. LsmAD_domain.
IPR025852. SM_dom_ATX.
[Graphical view]
PfamiPF06741. LsmAD. 1 hit.
PF14438. SM-ATX. 1 hit.
[Graphical view]
SMARTiSM01272. LsmAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGNFRKRDS STNSRKGGNS DSNYTNGGVP NQNNSSMFYE NPEITRNFDD
60 70 80 90 100
RQDYLLANSI GSDVTVTVTS GVKYTGLLVS CNLESTNGID VVLRFPRVAD
110 120 130 140 150
SGVSDSVDDL AKTLGETLLI HGEDVAELEL KNIDLSLDEK WENSKAQETT
160 170 180 190 200
PARTNIEKER VNGESNEVTK FRTDVDISGS GREIKERKLE KWTPEEGAEH
210 220 230 240 250
FDINKGKALE DDSASWDQFA VNEKKFGVKS TFDEHLYTTK INKDDPNYSK
260 270 280 290 300
RLQEAERIAK EIESQGTSGN IHIAEDRGII IDDSGLDEED LYSGVDRRGD
310 320 330 340 350
ELLAALKSNS KPNSNKGNRY VPPTLRQQPH HMDPAIISSS NSNKNENAVS
360 370 380 390 400
TDTSTPAAAG APEGKPPQKT SKNKKSLSSK EAQIEELKKF SEKFKVPYDI
410 420 430 440 450
PKDMLEVLKR SSSTLKSNSS LPPKPISKTP SAKTVSPTTQ ISAGKSESRR
460 470 480 490 500
SGSNISQGQS STGHTTRSST SLRRRNHGSF FGAKNPHTND AKRVLFGKSF
510 520 530 540 550
NMFIKSKEAH DEKKKGDDAS ENMEPFFIEK PYFTAPTWLN TIEESYKTFF
560 570 580 590 600
PDEDTAIQEA QTRFQQRQLN SMGNAVPGMN PAMGMNMGGM MGFPMGGPSA
610 620 630 640 650
SPNPMMNGFA AGSMGMYMPF QPQPMFYHPS MPQMMPVMGS NGAEEGGGNI
660 670 680 690 700
SPHVPAGFMA AGPGAPMGAF GYPGGIPFQG MMGSGPSGMP ANGSAMHSHG
710 720
HSRNYHQTSH HGHHNSSTSG HK
Length:722
Mass (Da):78,781
Last modified:October 1, 1996 - v1
Checksum:i92005F3A2346193E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46931 Genomic DNA. Translation: AAB94294.1.
Z72963 Genomic DNA. Translation: CAA97204.1.
BK006941 Genomic DNA. Translation: DAA08273.1.
PIRiS64492.
RefSeqiNP_011694.3. NM_001181307.3.

Genome annotation databases

EnsemblFungiiYGR178C; YGR178C; YGR178C.
GeneIDi853089.
KEGGisce:YGR178C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46931 Genomic DNA. Translation: AAB94294.1.
Z72963 Genomic DNA. Translation: CAA97204.1.
BK006941 Genomic DNA. Translation: DAA08273.1.
PIRiS64492.
RefSeqiNP_011694.3. NM_001181307.3.

3D structure databases

ProteinModelPortaliP53297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33430. 134 interactors.
DIPiDIP-2464N.
IntActiP53297. 23 interactors.
MINTiMINT-488669.

PTM databases

iPTMnetiP53297.

Proteomic databases

MaxQBiP53297.
PRIDEiP53297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR178C; YGR178C; YGR178C.
GeneIDi853089.
KEGGisce:YGR178C.

Organism-specific databases

EuPathDBiFungiDB:YGR178C.
SGDiS000003410. PBP1.

Phylogenomic databases

GeneTreeiENSGT00530000063565.
HOGENOMiHOG000093792.
InParanoidiP53297.
OMAiIEKPYFT.
OrthoDBiEOG092C56A1.

Enzyme and pathway databases

BioCyciYEAST:G3O-30871-MONOMER.

Miscellaneous databases

PROiP53297.

Family and domain databases

InterProiIPR009604. LsmAD_domain.
IPR025852. SM_dom_ATX.
[Graphical view]
PfamiPF06741. LsmAD. 1 hit.
PF14438. SM-ATX. 1 hit.
[Graphical view]
SMARTiSM01272. LsmAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPBP1_YEAST
AccessioniPrimary (citable) accession number: P53297
Secondary accession number(s): D6VUW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2870 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.