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Protein

Alcohol O-acetyltransferase 2

Gene

ATF2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + an alcohol = CoA + an acetyl ester.

GO - Molecular functioni

  • alcohol O-acetyltransferase activity Source: SGD

GO - Biological processi

  • acetate ester metabolic process involved in fermentation Source: SGD
  • response to toxic substance Source: SGD
  • steroid metabolic process Source: SGD
  • sterol acetylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:YGR177C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol O-acetyltransferase 2 (EC:2.3.1.84)
Short name:
AATase 2
Gene namesi
Name:ATF2
Ordered Locus Names:YGR177C
ORF Names:G7135
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR177C.
SGDiS000003409. ATF2.

Subcellular locationi

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535Alcohol O-acetyltransferase 2PRO_0000064721Add
BLAST

Proteomic databases

MaxQBiP53296.
PeptideAtlasiP53296.
PRIDEiP53296.

Interactioni

Protein-protein interaction databases

BioGridi33429. 41 interactions.
DIPiDIP-5544N.
IntActiP53296. 6 interactions.
MINTiMINT-495559.

Structurei

3D structure databases

ProteinModelPortaliP53296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To yeast ATF1.Curated

Phylogenomic databases

GeneTreeiENSGT00390000000257.
HOGENOMiHOG000034125.
InParanoidiP53296.
KOiK00664.
OMAiRMGHLEN.
OrthoDBiEOG7DNP43.

Family and domain databases

InterProiIPR010828. Atf2/Sli1-like.
[Graphical view]
PfamiPF07247. AATase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDIEGYEPH ITQELIDRGH ARRMGHLENY FAVLSRQKMY SNFTVYAELN
60 70 80 90 100
KGVNKRQLML VLKVLLQKYS TLAHTIIPKH YPHHEAYYSS EEYLSKPFPQ
110 120 130 140 150
HDFIKVISHL EFDDLIMNNQ PEYREVMEKI SEQFKKDDFK VTNRLIELIS
160 170 180 190 200
PVIIPLGNPK RPNWRLICLP GKDTDGFETW KNFVYVTNHC GSDGVSGSNF
210 220 230 240 250
FKDLALLFCK IEEKGFDYDE EFIEDQVIID YDRDYTEISK LPKPITDRID
260 270 280 290 300
YKPALTSLPK FFLTTFIYEH CNFKTSSEST LTARYSPSSN ANASYNYLLH
310 320 330 340 350
FSTKQVEQIR AQIKKNVHDG CTLTPFIQAC FLVALYRLDK LFTKSLLEYG
360 370 380 390 400
FDVAIPSNAR RFLPNDEELR DSYKYGSNVG GSHYAYLISS FDIPEGDNDK
410 420 430 440 450
FWSLVEYYYD RFLESYDNGD HLIGLGVLQL DFIVENKNID SLLANSYLHQ
460 470 480 490 500
QRGGAIISNT GLVSQDTTKP YYVRDLIFSQ SAGALRFAFG LNVCSTNVNG
510 520 530
MNMDMSVVQG TLRDRGEWES FCKLFYQTIG EFASL
Length:535
Mass (Da):61,898
Last modified:October 1, 1996 - v1
Checksum:iD615241A7DF1ECD5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791T → A in AAU09735 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72961 Genomic DNA. Translation: CAA97203.1.
AY723818 Genomic DNA. Translation: AAU09735.1.
BK006941 Genomic DNA. Translation: DAA08272.1.
PIRiS64491.
RefSeqiNP_011693.1. NM_001181306.1.

Genome annotation databases

EnsemblFungiiYGR177C; YGR177C; YGR177C.
GeneIDi853088.
KEGGisce:YGR177C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72961 Genomic DNA. Translation: CAA97203.1.
AY723818 Genomic DNA. Translation: AAU09735.1.
BK006941 Genomic DNA. Translation: DAA08272.1.
PIRiS64491.
RefSeqiNP_011693.1. NM_001181306.1.

3D structure databases

ProteinModelPortaliP53296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33429. 41 interactions.
DIPiDIP-5544N.
IntActiP53296. 6 interactions.
MINTiMINT-495559.

Proteomic databases

MaxQBiP53296.
PeptideAtlasiP53296.
PRIDEiP53296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR177C; YGR177C; YGR177C.
GeneIDi853088.
KEGGisce:YGR177C.

Organism-specific databases

EuPathDBiFungiDB:YGR177C.
SGDiS000003409. ATF2.

Phylogenomic databases

GeneTreeiENSGT00390000000257.
HOGENOMiHOG000034125.
InParanoidiP53296.
KOiK00664.
OMAiRMGHLEN.
OrthoDBiEOG7DNP43.

Enzyme and pathway databases

BioCyciYEAST:YGR177C-MONOMER.

Miscellaneous databases

PROiP53296.

Family and domain databases

InterProiIPR010828. Atf2/Sli1-like.
[Graphical view]
PfamiPF07247. AATase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATF2_YEAST
AccessioniPrimary (citable) accession number: P53296
Secondary accession number(s): D6VUW1, E9P955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.