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P53295

- RBG2_YEAST

UniProt

P53295 - RBG2_YEAST

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Protein

Ribosome-interacting GTPase 2

Gene

RBG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in ribosomal function.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 778GTPPROSITE-ProRule annotation
Nucleotide bindingi116 – 1205GTPPROSITE-ProRule annotation
Nucleotide bindingi250 – 2534GTPPROSITE-ProRule annotation

GO - Molecular functioni

  1. GTP binding Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30869-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-interacting GTPase 2
Alternative name(s):
GTP-binding protein RBG2
Gene namesi
Name:RBG2
Synonyms:GIR1
Ordered Locus Names:YGR173W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR173w.
SGDiS000003405. RBG2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Ribosome-interacting GTPase 2PRO_0000205450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei364 – 3641Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53295.
PaxDbiP53295.
PeptideAtlasiP53295.
PRIDEiP53295.

Expressioni

Gene expression databases

GenevestigatoriP53295.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GIR2Q037685EBI-23421,EBI-7618

Protein-protein interaction databases

BioGridi33425. 28 interactions.
DIPiDIP-2827N.
IntActiP53295. 16 interactions.
MINTiMINT-405787.
STRINGi4932.YGR173W.

Structurei

3D structure databases

ProteinModelPortaliP53295.
SMRiP53295. Positions 28-229, 291-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 292229OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1163.
GeneTreeiENSGT00550000075059.
InParanoidiP53295.
KOiK06944.
OMAiRALEKMY.
OrthoDBiEOG70S7GB.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53295-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGIIDKIKAI EEEMARTQKN KATEHHLGLL KGKLARYRQQ LLADEAGSGG
60 70 80 90 100
GGGSGFEVAK SGDARVVLIG YPSVGKSSLL GKITTTKSEI AHYAFTTLTS
110 120 130 140 150
VPGVLKYQGA EIQIVDLPGI IYGASQGKGR GRQVVATART ADLVLMVLDA
160 170 180 190 200
TKSEHQRASL EKELENVGIR LNKEKPNIYY KKKETGGVKV TFTSPPKTNL
210 220 230 240 250
TEQAIKMILR DYRIHNAEVL VRDDQCTIDD FIDVINEQHR NYVKCLYVYN
260 270 280 290 300
KIDAVSLEEV DKLAREPNTV VMSCEMDLGL QDVVEEIWYQ LNLSRVYTKK
310 320 330 340 350
RGVRPVFDDP LVVRNNSTIG DLCHGIHRDF KDKFKYALVW GSSAKHSPQK
360
CGLNHRIDDE DVVSLFAK
Length:368
Mass (Da):41,006
Last modified:October 1, 1996 - v1
Checksum:iD144569C9C5D777C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72958 Genomic DNA. Translation: CAA97199.1.
BK006941 Genomic DNA. Translation: DAA08268.1.
PIRiS64487.
RefSeqiNP_011689.1. NM_001181302.1.

Genome annotation databases

EnsemblFungiiYGR173W; YGR173W; YGR173W.
GeneIDi853083.
KEGGisce:YGR173W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72958 Genomic DNA. Translation: CAA97199.1 .
BK006941 Genomic DNA. Translation: DAA08268.1 .
PIRi S64487.
RefSeqi NP_011689.1. NM_001181302.1.

3D structure databases

ProteinModelPortali P53295.
SMRi P53295. Positions 28-229, 291-368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33425. 28 interactions.
DIPi DIP-2827N.
IntActi P53295. 16 interactions.
MINTi MINT-405787.
STRINGi 4932.YGR173W.

Proteomic databases

MaxQBi P53295.
PaxDbi P53295.
PeptideAtlasi P53295.
PRIDEi P53295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR173W ; YGR173W ; YGR173W .
GeneIDi 853083.
KEGGi sce:YGR173W.

Organism-specific databases

CYGDi YGR173w.
SGDi S000003405. RBG2.

Phylogenomic databases

eggNOGi COG1163.
GeneTreei ENSGT00550000075059.
InParanoidi P53295.
KOi K06944.
OMAi RALEKMY.
OrthoDBi EOG70S7GB.

Enzyme and pathway databases

BioCyci YEAST:G3O-30869-MONOMER.

Miscellaneous databases

NextBioi 973056.
PROi P53295.

Gene expression databases

Genevestigatori P53295.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01926. MMR_HSR1. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
PRINTSi PR00326. GTP1OBG.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on polyribosomes with Gcn1."
    Wout P.K., Sattlegger E., Sullivan S.M., Maddock J.R.
    Eukaryot. Cell 8:1061-1071(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRBG2_YEAST
AccessioniPrimary (citable) accession number: P53295
Secondary accession number(s): D6VUV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6200 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3