Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein GTR2

Gene

GTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Component of the EGO complex, a complex involved in the regulation of microautophagy.2 Publications

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPSequence analysis8
Nucleotide bindingi124 – 127GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to amino acid stimulus Source: GO_Central
  • cellular response to starvation Source: GO_Central
  • lysosomal microautophagy Source: SGD
  • negative regulation of autophagy Source: SGD
  • positive regulation of GTPase activity Source: SGD
  • positive regulation of TORC1 signaling Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • protein localization to vacuolar membrane Source: SGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processAutophagy, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30862-MONOMER
ReactomeiR-SCE-165159 mTOR signalling

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein GTR2
Gene namesi
Name:GTR2
Ordered Locus Names:YGR163W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR163W
SGDiS000003395 GTR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224871 – 341GTP-binding protein GTR2Add BLAST341

Proteomic databases

MaxQBiP53290
PaxDbiP53290
PRIDEiP53290

PTM databases

iPTMnetiP53290

Interactioni

Subunit structurei

Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Component of the EGO complex, at least composed of GTR2, SLM4 and MEH1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GTR1Q005822EBI-7962,EBI-7954

Protein-protein interaction databases

BioGridi33415, 221 interactors
DIPiDIP-4521N
IntActiP53290, 32 interactors
MINTiP53290
STRINGi4932.YGR163W

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 15Combined sources4
Helixi24 – 30Combined sources7
Helixi36 – 38Combined sources3
Turni42 – 44Combined sources3
Beta strandi50 – 52Combined sources3
Beta strandi54 – 56Combined sources3
Beta strandi58 – 62Combined sources5
Beta strandi67 – 69Combined sources3
Helixi74 – 80Combined sources7
Beta strandi84 – 89Combined sources6
Helixi98 – 113Combined sources16
Beta strandi118 – 122Combined sources5
Helixi132 – 147Combined sources16
Beta strandi150 – 153Combined sources4
Beta strandi159 – 162Combined sources4
Beta strandi166 – 169Combined sources4
Helixi170 – 179Combined sources10
Helixi186 – 193Combined sources8
Helixi195 – 197Combined sources3
Beta strandi199 – 212Combined sources14
Beta strandi216 – 218Combined sources3
Helixi225 – 242Combined sources18
Beta strandi270 – 275Combined sources6
Beta strandi280 – 285Combined sources6
Beta strandi287 – 296Combined sources10
Helixi303 – 322Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R7WX-ray2.77B/D11-341[»]
4ARZX-ray3.10B1-341[»]
ProteinModelPortaliP53290
SMRiP53290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTR/RAG GTP-binding protein family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074708
HOGENOMiHOG000203695
InParanoidiP53290
KOiK16186
OMAiEMNFEVF
OrthoDBiEOG092C3985

Family and domain databases

InterProiView protein in InterPro
IPR006762 Gtr1_RagA
IPR027417 P-loop_NTPase
PANTHERiPTHR11259 PTHR11259, 1 hit
PfamiView protein in Pfam
PF04670 Gtr1_RagA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P53290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEATDSKA MVLLMGVRRC GKSSICKVVF HNMQPLDTLY LESTSNPSLE
60 70 80 90 100
HFSTLIDLAV MELPGQLNYF EPSYDSERLF KSVGALVYVI DSQDEYINAI
110 120 130 140 150
TNLAMIIEYA YKVNPSINIE VLIHKVDGLS EDFKVDAQRD IMQRTGEELL
160 170 180 190 200
ELGLDGVQVS FYLTSIFDHS IYEAFSRIVQ KLIPELSFLE NMLDNLIQHS
210 220 230 240 250
KIEKAFLFDV NSKIYVSTDS NPVDIQMYEV CSEFIDVTID LFDLYKAPVL
260 270 280 290 300
RNSQKSSDKD NVINPRNELQ NVSQLANGVI IYLRQMIRGL ALVAIIRPNG
310 320 330 340
TDMESCLTVA DYNIDIFKKG LEDIWANARA SQAKNSIEDD V
Length:341
Mass (Da):38,600
Last modified:October 1, 1996 - v1
Checksum:i0A0D16C81F73184D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015239 Genomic DNA Translation: BAA28781.1
Z72948 Genomic DNA Translation: CAA97187.1
BK006941 Genomic DNA Translation: DAA08258.1
PIRiS64474
RefSeqiNP_011679.3, NM_001181292.3

Genome annotation databases

EnsemblFungiiYGR163W; YGR163W; YGR163W
GeneIDi853072
KEGGisce:YGR163W

Similar proteinsi

Entry informationi

Entry nameiGTR2_YEAST
AccessioniPrimary (citable) accession number: P53290
Secondary accession number(s): D6VUU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health