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Protein

GTP-binding protein GTR2

Gene

GTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Component of the EGO complex, a complex involved in the regulation of microautophagy.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTPSequence analysis
Nucleotide bindingi124 – 1274GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to amino acid stimulus Source: GO_Central
  • cellular response to starvation Source: GO_Central
  • lysosomal microautophagy Source: SGD
  • negative regulation of autophagy Source: SGD
  • positive regulation of GTPase activity Source: SGD
  • positive regulation of TORC1 signaling Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • protein localization to vacuolar membrane Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30862-MONOMER.
ReactomeiR-SCE-165159. mTOR signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein GTR2
Gene namesi
Name:GTR2
Ordered Locus Names:YGR163W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR163W.
SGDiS000003395. GTR2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • EGO complex Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • Gtr1-Gtr2 GTPase complex Source: SGD
  • late endosome membrane Source: SGD
  • lysosome Source: GO_Central
  • nuclear chromatin Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341GTP-binding protein GTR2PRO_0000122487Add
BLAST

Proteomic databases

MaxQBiP53290.

PTM databases

iPTMnetiP53290.

Interactioni

Subunit structurei

Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Component of the EGO complex, at least composed of GTR2, SLM4 and MEH1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MEH1Q022053EBI-7962,EBI-27062

Protein-protein interaction databases

BioGridi33415. 43 interactions.
DIPiDIP-4521N.
IntActiP53290. 22 interactions.
MINTiMINT-492141.

Structurei

Secondary structure

1
341
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 154Combined sources
Helixi24 – 307Combined sources
Helixi36 – 383Combined sources
Turni42 – 443Combined sources
Beta strandi50 – 523Combined sources
Beta strandi54 – 563Combined sources
Beta strandi58 – 625Combined sources
Beta strandi67 – 693Combined sources
Helixi74 – 807Combined sources
Beta strandi84 – 896Combined sources
Helixi98 – 11316Combined sources
Beta strandi118 – 1225Combined sources
Helixi132 – 14716Combined sources
Beta strandi150 – 1534Combined sources
Beta strandi159 – 1624Combined sources
Beta strandi166 – 1694Combined sources
Helixi170 – 17910Combined sources
Helixi186 – 1938Combined sources
Helixi195 – 1973Combined sources
Beta strandi199 – 21214Combined sources
Beta strandi216 – 2183Combined sources
Helixi225 – 24218Combined sources
Beta strandi270 – 2756Combined sources
Beta strandi280 – 2856Combined sources
Beta strandi287 – 29610Combined sources
Helixi303 – 32220Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R7WX-ray2.77B/D11-341[»]
4ARZX-ray3.10B1-341[»]
ProteinModelPortaliP53290.
SMRiP53290. Positions 5-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTR/RAG GTP-binding protein family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074708.
HOGENOMiHOG000203695.
InParanoidiP53290.
KOiK16186.
OMAiVLIHKID.
OrthoDBiEOG092C3985.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006762. Gtr1_RagA.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11259. PTHR11259. 1 hit.
PfamiPF04670. Gtr1_RagA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P53290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEATDSKA MVLLMGVRRC GKSSICKVVF HNMQPLDTLY LESTSNPSLE
60 70 80 90 100
HFSTLIDLAV MELPGQLNYF EPSYDSERLF KSVGALVYVI DSQDEYINAI
110 120 130 140 150
TNLAMIIEYA YKVNPSINIE VLIHKVDGLS EDFKVDAQRD IMQRTGEELL
160 170 180 190 200
ELGLDGVQVS FYLTSIFDHS IYEAFSRIVQ KLIPELSFLE NMLDNLIQHS
210 220 230 240 250
KIEKAFLFDV NSKIYVSTDS NPVDIQMYEV CSEFIDVTID LFDLYKAPVL
260 270 280 290 300
RNSQKSSDKD NVINPRNELQ NVSQLANGVI IYLRQMIRGL ALVAIIRPNG
310 320 330 340
TDMESCLTVA DYNIDIFKKG LEDIWANARA SQAKNSIEDD V
Length:341
Mass (Da):38,600
Last modified:October 1, 1996 - v1
Checksum:i0A0D16C81F73184D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015239 Genomic DNA. Translation: BAA28781.1.
Z72948 Genomic DNA. Translation: CAA97187.1.
BK006941 Genomic DNA. Translation: DAA08258.1.
PIRiS64474.
RefSeqiNP_011679.3. NM_001181292.3.

Genome annotation databases

EnsemblFungiiYGR163W; YGR163W; YGR163W.
GeneIDi853072.
KEGGisce:YGR163W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015239 Genomic DNA. Translation: BAA28781.1.
Z72948 Genomic DNA. Translation: CAA97187.1.
BK006941 Genomic DNA. Translation: DAA08258.1.
PIRiS64474.
RefSeqiNP_011679.3. NM_001181292.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R7WX-ray2.77B/D11-341[»]
4ARZX-ray3.10B1-341[»]
ProteinModelPortaliP53290.
SMRiP53290. Positions 5-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33415. 43 interactions.
DIPiDIP-4521N.
IntActiP53290. 22 interactions.
MINTiMINT-492141.

PTM databases

iPTMnetiP53290.

Proteomic databases

MaxQBiP53290.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR163W; YGR163W; YGR163W.
GeneIDi853072.
KEGGisce:YGR163W.

Organism-specific databases

EuPathDBiFungiDB:YGR163W.
SGDiS000003395. GTR2.

Phylogenomic databases

GeneTreeiENSGT00550000074708.
HOGENOMiHOG000203695.
InParanoidiP53290.
KOiK16186.
OMAiVLIHKID.
OrthoDBiEOG092C3985.

Enzyme and pathway databases

BioCyciYEAST:G3O-30862-MONOMER.
ReactomeiR-SCE-165159. mTOR signalling.

Miscellaneous databases

PROiP53290.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006762. Gtr1_RagA.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11259. PTHR11259. 1 hit.
PfamiPF04670. Gtr1_RagA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGTR2_YEAST
AccessioniPrimary (citable) accession number: P53290
Secondary accession number(s): D6VUU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.