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P53289

- RTS3_YEAST

UniProt

P53289 - RTS3_YEAST

Protein

Protein phosphatase type 2A regulatory subunit RTS3

Gene

RTS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May be a component of a protein phosphatase type 2A (PP2A) complex. Negatively regulates SIT4 phosphatase, a modulators of caffeine sensitivity.3 Publications

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30860-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase type 2A regulatory subunit RTS3
    Gene namesi
    Name:RTS3
    Ordered Locus Names:YGR161C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR161c.
    SGDiS000003393. RTS3.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Protein phosphatase type 2A regulatory subunit RTS3PRO_0000202835Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei172 – 1721Phosphoserine1 Publication
    Modified residuei192 – 1921Phosphoserine1 Publication
    Modified residuei214 – 2141Phosphoserine1 Publication
    Modified residuei238 – 2381Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53289.
    PaxDbiP53289.

    Expressioni

    Gene expression databases

    GenevestigatoriP53289.

    Interactioni

    Protein-protein interaction databases

    BioGridi33408. 62 interactions.
    DIPiDIP-6319N.
    IntActiP53289. 14 interactions.
    MINTiMINT-657378.
    STRINGi4932.YGR161C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG85313.
    OMAiHISHSAR.
    OrthoDBiEOG7SJDGV.

    Sequencei

    Sequence statusi: Complete.

    P53289-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIATSRAVNM NKESKHKKAV AKPCRERQTS VTRAMRPAVA RDPRRLSTSS    50
    SPSSSPMSAQ RRLSREEIIN EMEKEQDAIV VRLLREIETL KEENSRLKNQ 100
    LHHPVPARRS SPFFEGESAI LDDDDCNYGY TLDTPKLKLT DGASRHTVLP 150
    LTPKDSMTHI SHSARRSSRN ASISNGTSIS DTIFPIETKI HSAPTTNRNL 200
    PSADLPHHTL LPRSLSGISS SDLTESGALL HDRRRRSSNY SLDGSNSLKA 250
    DLMAKRFQTG SLK 263
    Length:263
    Mass (Da):29,263
    Last modified:October 1, 1996 - v1
    Checksum:iBA31D32B9ADF02AB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201V → I.1 Publication
    Natural varianti201 – 2011P → S.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY301067 Genomic DNA. Translation: AAP48998.1.
    Z72946 Genomic DNA. Translation: CAA97175.1.
    BK006941 Genomic DNA. Translation: DAA08251.1.
    PIRiS64472.
    RefSeqiNP_011677.3. NM_001181290.3.

    Genome annotation databases

    EnsemblFungiiYGR161C; YGR161C; YGR161C.
    GeneIDi853065.
    KEGGisce:YGR161C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY301067 Genomic DNA. Translation: AAP48998.1 .
    Z72946 Genomic DNA. Translation: CAA97175.1 .
    BK006941 Genomic DNA. Translation: DAA08251.1 .
    PIRi S64472.
    RefSeqi NP_011677.3. NM_001181290.3.

    3D structure databases

    ProteinModelPortali P53289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33408. 62 interactions.
    DIPi DIP-6319N.
    IntActi P53289. 14 interactions.
    MINTi MINT-657378.
    STRINGi 4932.YGR161C.

    Proteomic databases

    MaxQBi P53289.
    PaxDbi P53289.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR161C ; YGR161C ; YGR161C .
    GeneIDi 853065.
    KEGGi sce:YGR161C.

    Organism-specific databases

    CYGDi YGR161c.
    SGDi S000003393. RTS3.

    Phylogenomic databases

    eggNOGi NOG85313.
    OMAi HISHSAR.
    OrthoDBi EOG7SJDGV.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30860-MONOMER.

    Miscellaneous databases

    NextBioi 973007.

    Gene expression databases

    Genevestigatori P53289.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Polymorphism detected in the yeast ORF YGR161C."
      Reis V.C.B., Torres F.A.G.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-20 AND SER-201.
    2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
      Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
      Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Predicting protein functions from redundancies in large-scale protein interaction networks."
      Samanta M.P., Liang S.
      Proc. Natl. Acad. Sci. U.S.A. 100:12579-12583(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast."
      Queralt E., Lehane C., Novak B., Uhlmann F.
      Cell 125:719-732(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172; SER-214 AND SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Identification of phosphatase 2A-like Sit4-mediated signalling and ubiquitin-dependent protein sorting as modulators of caffeine sensitivity in S. cerevisiae."
      Hood-DeGrenier J.K.
      Yeast 28:189-204(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRTS3_YEAST
    AccessioniPrimary (citable) accession number: P53289
    Secondary accession number(s): D6VUU0, Q7ZA12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2100 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3