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P53289

- RTS3_YEAST

UniProt

P53289 - RTS3_YEAST

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Protein

Protein phosphatase type 2A regulatory subunit RTS3

Gene

RTS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be a component of a protein phosphatase type 2A (PP2A) complex. Negatively regulates SIT4 phosphatase, a modulators of caffeine sensitivity.3 Publications

Enzyme and pathway databases

BioCyciYEAST:G3O-30860-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase type 2A regulatory subunit RTS3
Gene namesi
Name:RTS3
Ordered Locus Names:YGR161C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR161c.
SGDiS000003393. RTS3.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Protein phosphatase type 2A regulatory subunit RTS3PRO_0000202835Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721Phosphoserine1 Publication
Modified residuei192 – 1921Phosphoserine1 Publication
Modified residuei214 – 2141Phosphoserine1 Publication
Modified residuei238 – 2381Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53289.
PaxDbiP53289.

Expressioni

Gene expression databases

GenevestigatoriP53289.

Interactioni

Protein-protein interaction databases

BioGridi33408. 63 interactions.
DIPiDIP-6319N.
IntActiP53289. 14 interactions.
MINTiMINT-657378.
STRINGi4932.YGR161C.

Structurei

3D structure databases

ProteinModelPortaliP53289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG85313.
InParanoidiP53289.
OMAiHISHSAR.
OrthoDBiEOG7SJDGV.

Sequencei

Sequence statusi: Complete.

P53289-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIATSRAVNM NKESKHKKAV AKPCRERQTS VTRAMRPAVA RDPRRLSTSS
60 70 80 90 100
SPSSSPMSAQ RRLSREEIIN EMEKEQDAIV VRLLREIETL KEENSRLKNQ
110 120 130 140 150
LHHPVPARRS SPFFEGESAI LDDDDCNYGY TLDTPKLKLT DGASRHTVLP
160 170 180 190 200
LTPKDSMTHI SHSARRSSRN ASISNGTSIS DTIFPIETKI HSAPTTNRNL
210 220 230 240 250
PSADLPHHTL LPRSLSGISS SDLTESGALL HDRRRRSSNY SLDGSNSLKA
260
DLMAKRFQTG SLK
Length:263
Mass (Da):29,263
Last modified:October 1, 1996 - v1
Checksum:iBA31D32B9ADF02AB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201V → I.1 Publication
Natural varianti201 – 2011P → S.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY301067 Genomic DNA. Translation: AAP48998.1.
Z72946 Genomic DNA. Translation: CAA97175.1.
BK006941 Genomic DNA. Translation: DAA08251.1.
PIRiS64472.
RefSeqiNP_011677.3. NM_001181290.3.

Genome annotation databases

EnsemblFungiiYGR161C; YGR161C; YGR161C.
GeneIDi853065.
KEGGisce:YGR161C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY301067 Genomic DNA. Translation: AAP48998.1 .
Z72946 Genomic DNA. Translation: CAA97175.1 .
BK006941 Genomic DNA. Translation: DAA08251.1 .
PIRi S64472.
RefSeqi NP_011677.3. NM_001181290.3.

3D structure databases

ProteinModelPortali P53289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33408. 63 interactions.
DIPi DIP-6319N.
IntActi P53289. 14 interactions.
MINTi MINT-657378.
STRINGi 4932.YGR161C.

Proteomic databases

MaxQBi P53289.
PaxDbi P53289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR161C ; YGR161C ; YGR161C .
GeneIDi 853065.
KEGGi sce:YGR161C.

Organism-specific databases

CYGDi YGR161c.
SGDi S000003393. RTS3.

Phylogenomic databases

eggNOGi NOG85313.
InParanoidi P53289.
OMAi HISHSAR.
OrthoDBi EOG7SJDGV.

Enzyme and pathway databases

BioCyci YEAST:G3O-30860-MONOMER.

Miscellaneous databases

NextBioi 973007.

Gene expression databases

Genevestigatori P53289.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polymorphism detected in the yeast ORF YGR161C."
    Reis V.C.B., Torres F.A.G.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-20 AND SER-201.
  2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
    Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
    Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Predicting protein functions from redundancies in large-scale protein interaction networks."
    Samanta M.P., Liang S.
    Proc. Natl. Acad. Sci. U.S.A. 100:12579-12583(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast."
    Queralt E., Lehane C., Novak B., Uhlmann F.
    Cell 125:719-732(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172; SER-214 AND SER-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Identification of phosphatase 2A-like Sit4-mediated signalling and ubiquitin-dependent protein sorting as modulators of caffeine sensitivity in S. cerevisiae."
    Hood-DeGrenier J.K.
    Yeast 28:189-204(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRTS3_YEAST
AccessioniPrimary (citable) accession number: P53289
Secondary accession number(s): D6VUU0, Q7ZA12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3