Reviewed,
UniProtKB/Swiss-Prot P53281 (LSB1_YEAST)
Last modified
January 19, 2010.
Version 70.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: LAS seventeen-binding protein 1 Short name=LAS17-binding protein 1 | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 241 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in resistance to EDTA. Ref.3 |
| Subunit structure | Interacts with LAS17. Ref.2 |
| Sequence similarities | Belongs to the LSB1 family. Contains 1 SH3 domain. |
Ontologies
| Keywords | |
|---|---|
| Domain | SH3 domain |
| PTM | Isopeptide bond Phosphoprotein Ubl conjugation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from direct assay. Source: SGD nucleusInferred from direct assay. Source: SGD |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| P38266 | 1 | EBI-23329,EBI-21584 | ||
| P43582 | 1 | EBI-23329,EBI-22766 | ||
| P53238 | 1 | EBI-23329,EBI-23185 | ||
| LAS17 | Q12446 | 5 | EBI-23329,EBI-10022 | |
| RNR2 | P09938 | 1 | EBI-23329,EBI-15240 | |
| RSP5 | P39940 | 1 | EBI-23329,EBI-16219 | |
| SRP1 | Q02821 | 1 | EBI-23329,EBI-1797 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 241 | 241 | LAS seventeen-binding protein 1 | PRO_0000202825 | |||||
Regions | |||||||||
| Domain | 53 – 112 | 60 | SH3 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 48 | 1 | Phosphoserine Ref.7 | ||||||
| Modified residue | 114 | 1 | Phosphoserine Ref.6 | ||||||
| Modified residue | 116 | 1 | Phosphoserine Ref.6 | ||||||
| Cross-link | 41 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4 Ref.5 | |||||||
| Cross-link | 79 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4 Ref.5 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. Kleine K.Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [2] | "The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex." Madania A., Dumoulin P., Grava S., Kitamoto H., Scharer-Brodbeck C., Soulard A., Moreau V., Winsor B. Mol. Biol. Cell 10:3521-3538(1999) [PubMed: 10512884] [Abstract] Cited for: INTERACTION WITH LAS17. |
| [3] | "Chemotyping of yeast mutants using robotics." Rieger K.-J., El-Alama M., Stein G., Bradshaw C., Slonimski P.P., Maundrell K. Yeast 15:973-986(1999) [PubMed: 10407277] [Abstract] Cited for: FUNCTION. |
| [4] | "A proteomics approach to understanding protein ubiquitination." Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G., Roelofs J., Finley D., Gygi S.P. Nat. Biotechnol. 21:921-926(2003) [PubMed: 12872131] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-41 AND LYS-79, MASS SPECTROMETRY. |
| [5] | "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery." Hitchcock A.L., Auld K., Gygi S.P., Silver P.A. Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed: 14557538] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-41 AND LYS-79, MASS SPECTROMETRY. |
| [6] | "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114 AND SER-116, MASS SPECTROMETRY. |
| [7] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z72921 Genomic DNA. Translation: CAA97149.1. |
| PIR | S64445. |
| RefSeq | NP_011652.1. |
3D structure databases | |
| SMR | P53281. Positions 56-111. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-1863N. |
| IntAct | P53281. 14 interactions. |
| STRING | P53281. |
Proteomic databases | |
| PeptideAtlas | P53281. |
Genome annotation databases | |
| Ensembl | YGR136W; YGR136W; YGR136W; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 853037. |
| KEGG | sce:YGR136W. |
| NMPDR | fig|4932.3.peg.2771. |
Organism-specific databases | |
| CYGD | YGR136w. |
| SGD | S000003368. LSB1. |
Phylogenomic databases | |
| eggNOG | fuNOG11568. |
| HOGENOM | HBG396736. |
| OMA | DWWKGYK. |
| OrthoDB | EOG91NW35. |
| PhylomeDB | P53281. |
Gene expression databases | |
| ArrayExpress | P53281. |
| Genevestigator | P53281. |
| GermOnline | YGR136W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR000108. Neu_cyt_fact_2. IPR001452. SH3_domain. IPR020473. SH3_region. [Graphical view] |
| Pfam | PF00018. SH3_1. 1 hit. [Graphical view] |
| PRINTS | PR00499. P67PHOX. PR00452. SH3DOMAIN. |
| SMART | SM00326. SH3. 1 hit. [Graphical view] |
| PROSITE | PS50002. SH3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 972938. |
Entry information
| Entry name | LSB1_YEAST | ||||||||
| Accession | Primary (citable) accession number: P53281 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome VII Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names |

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