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P53280

- CF130_YEAST

UniProt

P53280 - CF130_YEAST

Protein

Protein CAF130

Gene

CAF130

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
    2. regulation of transcription from RNA polymerase II promoter Source: SGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30840-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CAF130
    Alternative name(s):
    130 kDa CCR4-associated factor
    Gene namesi
    Name:CAF130
    Ordered Locus Names:YGR134W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR134w.
    SGDiS000003366. CAF130.

    Subcellular locationi

    Cytoplasm Curated. Nucleus Curated

    GO - Cellular componenti

    1. CCR4-NOT core complex Source: SGD
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11221122Protein CAF130PRO_0000202824Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1042 – 10421Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53280.
    PaxDbiP53280.
    PeptideAtlasiP53280.

    Expressioni

    Gene expression databases

    GenevestigatoriP53280.

    Interactioni

    Subunit structurei

    Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BEM1P293663EBI-23322,EBI-3508
    CDC39P256556EBI-23322,EBI-12139

    Protein-protein interaction databases

    BioGridi33382. 61 interactions.
    DIPiDIP-2683N.
    IntActiP53280. 9 interactions.
    MINTiMINT-543779.
    STRINGi4932.YGR134W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG39522.
    HOGENOMiHOG000111568.
    OMAiLWKCHTN.
    OrthoDBiEOG7NSB9P.

    Sequencei

    Sequence statusi: Complete.

    P53280-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKKKAATNY AERQNLASED SSGDSVHFKD FIPLQELLKD KNYVPSVENL     50
    EKILYNETMF NDQKICSNLL LEALIITLFT TISGKSALRL IQTSSLKERK 100
    SWAQSFENNS SSYASIVLSW KDNDILLLKF LRFLLANKTA PLQINRYNLP 150
    EYKLPLSFLI VSKITIPSIL LNETYNLLKD YLYSITGRIE SLISCSSTFD 200
    KPALVVRKIL KDYNRMIECR NFYFWYSFNA ENRVNLTFSD NISLLMENDE 250
    GNAGSGLDDS RFDHQKQPRE AIMGRTINDQ EQIYSFELNQ DGTLEIPNVM 300
    EHSLLRHELL FKILNLTTVL TPLLELQFST LCGLVDPLMQ PTPNDKHIIS 350
    IDFLFQLFLG LMSQSIKTSQ EHNDHYDWKF YMCFNMQKII DATMLRLNCF 400
    DFDILNSVNN TDNAVHWKTQ LHRWLPHGLN TQDLELLYMI DILAVYTIYK 450
    LYEKIPIQLN PFLFSLISLW KNLSCVILLA LEIDRIEEEN GTYETPLMVR 500
    ATIRGAAALR SVIATVLNGL VKNNDHDFKH ESLNTFMSPY GRKLCHGALY 550
    ADLRSHTASL LALGASIEDV TDLFADLQSG DRFDEDIRYM FDYECEDYDE 600
    SFSESDHGGL DESVVNPTEK IASGSNNVFF RRRCNCIFND DKLVAEDGAN 650
    EAFGSTNSEN VEGAMHNNRN AVHNATTATS DHVVTSPNPL SVRSRSTFEF 700
    DYSGEDWRDV PRDFNMYYSP SYSFIHEPKL DVIFSLTLRG ATEKLNKEES 750
    ILLVRSVASC VRNEQDQMIL ADLESNFSAS INGDVEGEGN TKMSKIDNED 800
    LRRTTPDDIY EIWSEESAFE RMLNVNHDVA WRLMDEMLMC TGYRRILIWF 850
    LTHLELKHSL IYYVFELIMG LRGKPFSGEA SDQDKKDDMI YEILKKKQKN 900
    EDASGLPFSR QGPIVLSDIE TKMLLQEFFM NAAIFLSSKN NEEENEDGEK 950
    ISLYSLGLVR LICYMVQTLI ANDKFFFTKS ECTFELQTLL MTWIGILPEA 1000
    KDLFFKIKTR LAMEEEDSAD TMQHEGRKNS DIEKKLNAKP ASELNLKLLN 1050
    LFPSKPANKD DSSPINTLRS FIADYSFDTQ VNPPGRRVVF YDGKILPLPK 1100
    ADKPIPLHEY ITLAELDVGD SE 1122
    Length:1,122
    Mass (Da):128,780
    Last modified:October 1, 1996 - v1
    Checksum:iBF3542816CC78490
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72919 Genomic DNA. Translation: CAA97147.1.
    AY558112 Genomic DNA. Translation: AAS56438.1.
    BK006941 Genomic DNA. Translation: DAA08227.1.
    PIRiS64443.
    RefSeqiNP_011650.3. NM_001181263.3.

    Genome annotation databases

    EnsemblFungiiYGR134W; YGR134W; YGR134W.
    GeneIDi853035.
    KEGGisce:YGR134W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72919 Genomic DNA. Translation: CAA97147.1 .
    AY558112 Genomic DNA. Translation: AAS56438.1 .
    BK006941 Genomic DNA. Translation: DAA08227.1 .
    PIRi S64443.
    RefSeqi NP_011650.3. NM_001181263.3.

    3D structure databases

    ProteinModelPortali P53280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33382. 61 interactions.
    DIPi DIP-2683N.
    IntActi P53280. 9 interactions.
    MINTi MINT-543779.
    STRINGi 4932.YGR134W.

    Proteomic databases

    MaxQBi P53280.
    PaxDbi P53280.
    PeptideAtlasi P53280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR134W ; YGR134W ; YGR134W .
    GeneIDi 853035.
    KEGGi sce:YGR134W.

    Organism-specific databases

    CYGDi YGR134w.
    SGDi S000003366. CAF130.

    Phylogenomic databases

    eggNOGi NOG39522.
    HOGENOMi HOG000111568.
    OMAi LWKCHTN.
    OrthoDBi EOG7NSB9P.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30840-MONOMER.

    Miscellaneous databases

    NextBioi 972932.

    Gene expression databases

    Genevestigatori P53280.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex."
      Chen J., Rappsilber J., Chiang Y.C., Russell P., Mann M., Denis C.L.
      J. Mol. Biol. 314:683-694(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CCR4-NOT CORE COMPLEX, INTERACTION WITH NOT1.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1042, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCF130_YEAST
    AccessioniPrimary (citable) accession number: P53280
    Secondary accession number(s): D6VUR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1320 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3