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P53280

- CF130_YEAST

UniProt

P53280 - CF130_YEAST

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Protein

Protein CAF130

Gene

CAF130

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.

GO - Biological processi

  1. positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  2. regulation of transcription from RNA polymerase II promoter Source: SGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30840-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CAF130
Alternative name(s):
130 kDa CCR4-associated factor
Gene namesi
Name:CAF130
Ordered Locus Names:YGR134W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR134w.
SGDiS000003366. CAF130.

Subcellular locationi

Cytoplasm Curated. Nucleus Curated

GO - Cellular componenti

  1. CCR4-NOT core complex Source: SGD
  2. cytoplasm Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11221122Protein CAF130PRO_0000202824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1042 – 10421Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53280.
PaxDbiP53280.
PeptideAtlasiP53280.

Expressioni

Gene expression databases

GenevestigatoriP53280.

Interactioni

Subunit structurei

Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BEM1P293663EBI-23322,EBI-3508
CDC39P256556EBI-23322,EBI-12139

Protein-protein interaction databases

BioGridi33382. 61 interactions.
DIPiDIP-2683N.
IntActiP53280. 9 interactions.
MINTiMINT-543779.
STRINGi4932.YGR134W.

Structurei

3D structure databases

ProteinModelPortaliP53280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG39522.
HOGENOMiHOG000111568.
InParanoidiP53280.
OMAiLWKCHTN.
OrthoDBiEOG7NSB9P.

Sequencei

Sequence statusi: Complete.

P53280-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKKKAATNY AERQNLASED SSGDSVHFKD FIPLQELLKD KNYVPSVENL
60 70 80 90 100
EKILYNETMF NDQKICSNLL LEALIITLFT TISGKSALRL IQTSSLKERK
110 120 130 140 150
SWAQSFENNS SSYASIVLSW KDNDILLLKF LRFLLANKTA PLQINRYNLP
160 170 180 190 200
EYKLPLSFLI VSKITIPSIL LNETYNLLKD YLYSITGRIE SLISCSSTFD
210 220 230 240 250
KPALVVRKIL KDYNRMIECR NFYFWYSFNA ENRVNLTFSD NISLLMENDE
260 270 280 290 300
GNAGSGLDDS RFDHQKQPRE AIMGRTINDQ EQIYSFELNQ DGTLEIPNVM
310 320 330 340 350
EHSLLRHELL FKILNLTTVL TPLLELQFST LCGLVDPLMQ PTPNDKHIIS
360 370 380 390 400
IDFLFQLFLG LMSQSIKTSQ EHNDHYDWKF YMCFNMQKII DATMLRLNCF
410 420 430 440 450
DFDILNSVNN TDNAVHWKTQ LHRWLPHGLN TQDLELLYMI DILAVYTIYK
460 470 480 490 500
LYEKIPIQLN PFLFSLISLW KNLSCVILLA LEIDRIEEEN GTYETPLMVR
510 520 530 540 550
ATIRGAAALR SVIATVLNGL VKNNDHDFKH ESLNTFMSPY GRKLCHGALY
560 570 580 590 600
ADLRSHTASL LALGASIEDV TDLFADLQSG DRFDEDIRYM FDYECEDYDE
610 620 630 640 650
SFSESDHGGL DESVVNPTEK IASGSNNVFF RRRCNCIFND DKLVAEDGAN
660 670 680 690 700
EAFGSTNSEN VEGAMHNNRN AVHNATTATS DHVVTSPNPL SVRSRSTFEF
710 720 730 740 750
DYSGEDWRDV PRDFNMYYSP SYSFIHEPKL DVIFSLTLRG ATEKLNKEES
760 770 780 790 800
ILLVRSVASC VRNEQDQMIL ADLESNFSAS INGDVEGEGN TKMSKIDNED
810 820 830 840 850
LRRTTPDDIY EIWSEESAFE RMLNVNHDVA WRLMDEMLMC TGYRRILIWF
860 870 880 890 900
LTHLELKHSL IYYVFELIMG LRGKPFSGEA SDQDKKDDMI YEILKKKQKN
910 920 930 940 950
EDASGLPFSR QGPIVLSDIE TKMLLQEFFM NAAIFLSSKN NEEENEDGEK
960 970 980 990 1000
ISLYSLGLVR LICYMVQTLI ANDKFFFTKS ECTFELQTLL MTWIGILPEA
1010 1020 1030 1040 1050
KDLFFKIKTR LAMEEEDSAD TMQHEGRKNS DIEKKLNAKP ASELNLKLLN
1060 1070 1080 1090 1100
LFPSKPANKD DSSPINTLRS FIADYSFDTQ VNPPGRRVVF YDGKILPLPK
1110 1120
ADKPIPLHEY ITLAELDVGD SE
Length:1,122
Mass (Da):128,780
Last modified:October 1, 1996 - v1
Checksum:iBF3542816CC78490
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72919 Genomic DNA. Translation: CAA97147.1.
AY558112 Genomic DNA. Translation: AAS56438.1.
BK006941 Genomic DNA. Translation: DAA08227.1.
PIRiS64443.
RefSeqiNP_011650.3. NM_001181263.3.

Genome annotation databases

EnsemblFungiiYGR134W; YGR134W; YGR134W.
GeneIDi853035.
KEGGisce:YGR134W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72919 Genomic DNA. Translation: CAA97147.1 .
AY558112 Genomic DNA. Translation: AAS56438.1 .
BK006941 Genomic DNA. Translation: DAA08227.1 .
PIRi S64443.
RefSeqi NP_011650.3. NM_001181263.3.

3D structure databases

ProteinModelPortali P53280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33382. 61 interactions.
DIPi DIP-2683N.
IntActi P53280. 9 interactions.
MINTi MINT-543779.
STRINGi 4932.YGR134W.

Proteomic databases

MaxQBi P53280.
PaxDbi P53280.
PeptideAtlasi P53280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR134W ; YGR134W ; YGR134W .
GeneIDi 853035.
KEGGi sce:YGR134W.

Organism-specific databases

CYGDi YGR134w.
SGDi S000003366. CAF130.

Phylogenomic databases

eggNOGi NOG39522.
HOGENOMi HOG000111568.
InParanoidi P53280.
OMAi LWKCHTN.
OrthoDBi EOG7NSB9P.

Enzyme and pathway databases

BioCyci YEAST:G3O-30840-MONOMER.

Miscellaneous databases

NextBioi 972932.

Gene expression databases

Genevestigatori P53280.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex."
    Chen J., Rappsilber J., Chiang Y.C., Russell P., Mann M., Denis C.L.
    J. Mol. Biol. 314:683-694(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CCR4-NOT CORE COMPLEX, INTERACTION WITH NOT1.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1042, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCF130_YEAST
AccessioniPrimary (citable) accession number: P53280
Secondary accession number(s): D6VUR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1320 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3