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P53280

- CF130_YEAST

UniProt

P53280 - CF130_YEAST

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Protein
Protein CAF130
Gene
CAF130, YGR134W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
  2. regulation of transcription from RNA polymerase II promoter Source: SGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30840-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CAF130
Alternative name(s):
130 kDa CCR4-associated factor
Gene namesi
Name:CAF130
Ordered Locus Names:YGR134W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR134w.
SGDiS000003366. CAF130.

Subcellular locationi

Cytoplasm Inferred. Nucleus Inferred

GO - Cellular componenti

  1. CCR4-NOT core complex Source: SGD
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11221122Protein CAF130
PRO_0000202824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1042 – 10421Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53280.
PaxDbiP53280.
PeptideAtlasiP53280.

Expressioni

Gene expression databases

GenevestigatoriP53280.

Interactioni

Subunit structurei

Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BEM1P293663EBI-23322,EBI-3508
CDC39P256556EBI-23322,EBI-12139

Protein-protein interaction databases

BioGridi33382. 61 interactions.
DIPiDIP-2683N.
IntActiP53280. 9 interactions.
MINTiMINT-543779.
STRINGi4932.YGR134W.

Structurei

3D structure databases

ProteinModelPortaliP53280.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG39522.
HOGENOMiHOG000111568.
OMAiLWKCHTN.
OrthoDBiEOG7NSB9P.

Sequencei

Sequence statusi: Complete.

P53280-1 [UniParc]FASTAAdd to Basket

« Hide

MTKKKAATNY AERQNLASED SSGDSVHFKD FIPLQELLKD KNYVPSVENL     50
EKILYNETMF NDQKICSNLL LEALIITLFT TISGKSALRL IQTSSLKERK 100
SWAQSFENNS SSYASIVLSW KDNDILLLKF LRFLLANKTA PLQINRYNLP 150
EYKLPLSFLI VSKITIPSIL LNETYNLLKD YLYSITGRIE SLISCSSTFD 200
KPALVVRKIL KDYNRMIECR NFYFWYSFNA ENRVNLTFSD NISLLMENDE 250
GNAGSGLDDS RFDHQKQPRE AIMGRTINDQ EQIYSFELNQ DGTLEIPNVM 300
EHSLLRHELL FKILNLTTVL TPLLELQFST LCGLVDPLMQ PTPNDKHIIS 350
IDFLFQLFLG LMSQSIKTSQ EHNDHYDWKF YMCFNMQKII DATMLRLNCF 400
DFDILNSVNN TDNAVHWKTQ LHRWLPHGLN TQDLELLYMI DILAVYTIYK 450
LYEKIPIQLN PFLFSLISLW KNLSCVILLA LEIDRIEEEN GTYETPLMVR 500
ATIRGAAALR SVIATVLNGL VKNNDHDFKH ESLNTFMSPY GRKLCHGALY 550
ADLRSHTASL LALGASIEDV TDLFADLQSG DRFDEDIRYM FDYECEDYDE 600
SFSESDHGGL DESVVNPTEK IASGSNNVFF RRRCNCIFND DKLVAEDGAN 650
EAFGSTNSEN VEGAMHNNRN AVHNATTATS DHVVTSPNPL SVRSRSTFEF 700
DYSGEDWRDV PRDFNMYYSP SYSFIHEPKL DVIFSLTLRG ATEKLNKEES 750
ILLVRSVASC VRNEQDQMIL ADLESNFSAS INGDVEGEGN TKMSKIDNED 800
LRRTTPDDIY EIWSEESAFE RMLNVNHDVA WRLMDEMLMC TGYRRILIWF 850
LTHLELKHSL IYYVFELIMG LRGKPFSGEA SDQDKKDDMI YEILKKKQKN 900
EDASGLPFSR QGPIVLSDIE TKMLLQEFFM NAAIFLSSKN NEEENEDGEK 950
ISLYSLGLVR LICYMVQTLI ANDKFFFTKS ECTFELQTLL MTWIGILPEA 1000
KDLFFKIKTR LAMEEEDSAD TMQHEGRKNS DIEKKLNAKP ASELNLKLLN 1050
LFPSKPANKD DSSPINTLRS FIADYSFDTQ VNPPGRRVVF YDGKILPLPK 1100
ADKPIPLHEY ITLAELDVGD SE 1122
Length:1,122
Mass (Da):128,780
Last modified:October 1, 1996 - v1
Checksum:iBF3542816CC78490
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72919 Genomic DNA. Translation: CAA97147.1.
AY558112 Genomic DNA. Translation: AAS56438.1.
BK006941 Genomic DNA. Translation: DAA08227.1.
PIRiS64443.
RefSeqiNP_011650.3. NM_001181263.3.

Genome annotation databases

EnsemblFungiiYGR134W; YGR134W; YGR134W.
GeneIDi853035.
KEGGisce:YGR134W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72919 Genomic DNA. Translation: CAA97147.1 .
AY558112 Genomic DNA. Translation: AAS56438.1 .
BK006941 Genomic DNA. Translation: DAA08227.1 .
PIRi S64443.
RefSeqi NP_011650.3. NM_001181263.3.

3D structure databases

ProteinModelPortali P53280.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33382. 61 interactions.
DIPi DIP-2683N.
IntActi P53280. 9 interactions.
MINTi MINT-543779.
STRINGi 4932.YGR134W.

Proteomic databases

MaxQBi P53280.
PaxDbi P53280.
PeptideAtlasi P53280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR134W ; YGR134W ; YGR134W .
GeneIDi 853035.
KEGGi sce:YGR134W.

Organism-specific databases

CYGDi YGR134w.
SGDi S000003366. CAF130.

Phylogenomic databases

eggNOGi NOG39522.
HOGENOMi HOG000111568.
OMAi LWKCHTN.
OrthoDBi EOG7NSB9P.

Enzyme and pathway databases

BioCyci YEAST:G3O-30840-MONOMER.

Miscellaneous databases

NextBioi 972932.

Gene expression databases

Genevestigatori P53280.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex."
    Chen J., Rappsilber J., Chiang Y.C., Russell P., Mann M., Denis C.L.
    J. Mol. Biol. 314:683-694(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CCR4-NOT CORE COMPLEX, INTERACTION WITH NOT1.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1042, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCF130_YEAST
AccessioniPrimary (citable) accession number: P53280
Secondary accession number(s): D6VUR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1320 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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