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Protein

Uncharacterized vacuolar membrane protein YGR125W

Gene

YGR125W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1420 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-30831-MONOMER

Protein family/group databases

TCDBi2.A.53.3.10 the sulfate permease (sulp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized vacuolar membrane protein YGR125W
Gene namesi
Ordered Locus Names:YGR125W
ORF Names:G6362
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR125W
SGDiS000003357 YGR125W

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 213VacuolarSequence analysisAdd BLAST213
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 236CytoplasmicSequence analysis2
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 269VacuolarSequence analysisAdd BLAST12
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 300CytoplasmicSequence analysis10
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 338VacuolarSequence analysisAdd BLAST17
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 375CytoplasmicSequence analysisAdd BLAST16
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 405VacuolarSequence analysis9
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 473CytoplasmicSequence analysisAdd BLAST47
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 515VacuolarSequence analysisAdd BLAST21
Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Topological domaini537 – 546CytoplasmicSequence analysis10
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568VacuolarSequence analysis1
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21
Topological domaini590 – 604CytoplasmicSequence analysisAdd BLAST15
Transmembranei605 – 625HelicalSequence analysisAdd BLAST21
Topological domaini626 – 664VacuolarSequence analysisAdd BLAST39
Transmembranei665 – 685HelicalSequence analysisAdd BLAST21
Topological domaini686 – 1036CytoplasmicSequence analysisAdd BLAST351

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028191 – 1036Uncharacterized vacuolar membrane protein YGR125WAdd BLAST1036

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei842PhosphoserineCombined sources1
Modified residuei847PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53273
PaxDbiP53273
PRIDEiP53273

PTM databases

iPTMnetiP53273

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33373, 117 interactors
DIPiDIP-7435N
IntActiP53273, 3 interactors
MINTiP53273
STRINGi4932.YGR125W

Structurei

3D structure databases

ProteinModelPortaliP53273
SMRiP53273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini660 – 781STASPROSITE-ProRule annotationAdd BLAST122

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000192103
InParanoidiP53273
KOiK03321
OMAiDYSAAEG
OrthoDBiEOG092C0A65

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
3.30.750.24, 1 hit
InterProiView protein in InterPro
IPR036533 BAG_dom_sf
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF52091 SSF52091, 1 hit
SSF63491 SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS50801 STAS, 1 hit

Sequencei

Sequence statusi: Complete.

P53273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRTIRRRRS NSSLSEAISV SLGINQDSSV NKMHRASVSA MSPPLCRSYM
60 70 80 90 100
SGFFTGGNSP MINNLSDSKL PISNKQHPKV IHGSENLHRQ TAQLSNEFCS
110 120 130 140 150
SSVEENSPTI KDYMDIIGNG DRKDDQSMRT IEENIDEEYS DEYSRLLLSP
160 170 180 190 200
ASSNVDDDRN RGLQNSSLPE LEDGYAGGYQ SLRPSHNLRF RPRNLWHMCT
210 220 230 240 250
SFPSKFAHYL PAAVLGLLLN ILDALSYGMI IFPITEPVFS HLGPTGISMF
260 270 280 290 300
YISTIISQAV YSGGWSSFPS GIGSEMIEIT PFYHTMALAI KEALAGNDDE
310 320 330 340 350
IITTTIFCYV ISSMLTGVVF YALGKLRLGK IVGFFPRHIL IGCIGGVGYF
360 370 380 390 400
LIITGIEVTT RVAKFEYSWP FFSGLFTDYD TLAKWLLPVL LTVVLIGTQR
410 420 430 440 450
YFKNSLVLPS FYILTLVLFH FIVAIIPTLS LDALRQAGWI FPIANSDSKW
460 470 480 490 500
YDHYRLFNVH KVHWSLVLQQ IPTMMALTFF GILHVPINVP ALAMSLQMDK
510 520 530 540 550
YDVDRELIAH GYSNFFSGLL GSVQNYLVYT NSVLFIRAGA DSPFAGFLLI
560 570 580 590 600
ALTICIMIIG PVIISFIPIC IVGSLIFLLG YELLVEALVD TWNKLNRFEY
610 620 630 640 650
LTVVIIVFTM GIFDFVLGII VGILIACFSF LVDSTKLQTI NGEYNGNVAR
660 670 680 690 700
STVYRDYVQT KFLDGIGEQI YVLKLQNLLF FGTIISIEEK IERLLQISNK
710 720 730 740 750
DATKRRIKYL ILDFKNINAD NIDYSAAEGF NRIKRFTETK RIKLIISSIK
760 770 780 790 800
ERDRIYNAFN NVGLLNDVEL FADLNSALEW CENEFLFQYK QLRKKAKERL
810 820 830 840 850
EEGKQNNVVS AVIAATKNKK IDTIGNGLNR GSNGDTARNL MSLPTNTPRN
860 870 880 890 900
YQILSVAQNV FVNDEQAVKN FKKEYKDDEP VLPILLFALK QYRPDIISEV
910 920 930 940 950
QKVREKEIKF WAQLCPYFTR RRLASQSHLL HADNIFFLVE TGMLKATYEL
960 970 980 990 1000
PQGTLYEIFS NGTCFGKIIA PGNAMPREQK LTIETETDSV LWVIDSSSLN
1010 1020 1030
KLKEDNLALY VEVALMVMCI KDTRFKELLG YTLVSA
Length:1,036
Mass (Da):116,971
Last modified:October 1, 1996 - v1
Checksum:i91A50225CA7FFCB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83099 Genomic DNA Translation: CAA58161.1
Z72910 Genomic DNA Translation: CAA97136.1
BK006941 Genomic DNA Translation: DAA08218.1
PIRiS55984
RefSeqiNP_011641.1, NM_001181254.1

Genome annotation databases

EnsemblFungiiYGR125W; YGR125W; YGR125W
GeneIDi853026
KEGGisce:YGR125W

Similar proteinsi

Entry informationi

Entry nameiYG35_YEAST
AccessioniPrimary (citable) accession number: P53273
Secondary accession number(s): D6VUQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health