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Protein

Uncharacterized vacuolar membrane protein YGR125W

Gene

YGR125W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30831-MONOMER.

Protein family/group databases

TCDBi2.A.53.3.10. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized vacuolar membrane protein YGR125W
Gene namesi
Ordered Locus Names:YGR125W
ORF Names:G6362
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR125W.
SGDiS000003357. YGR125W.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 213VacuolarSequence analysisAdd BLAST213
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 236CytoplasmicSequence analysis2
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 269VacuolarSequence analysisAdd BLAST12
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 300CytoplasmicSequence analysis10
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 338VacuolarSequence analysisAdd BLAST17
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 375CytoplasmicSequence analysisAdd BLAST16
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 405VacuolarSequence analysis9
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 473CytoplasmicSequence analysisAdd BLAST47
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 515VacuolarSequence analysisAdd BLAST21
Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Topological domaini537 – 546CytoplasmicSequence analysis10
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568VacuolarSequence analysis1
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21
Topological domaini590 – 604CytoplasmicSequence analysisAdd BLAST15
Transmembranei605 – 625HelicalSequence analysisAdd BLAST21
Topological domaini626 – 664VacuolarSequence analysisAdd BLAST39
Transmembranei665 – 685HelicalSequence analysisAdd BLAST21
Topological domaini686 – 1036CytoplasmicSequence analysisAdd BLAST351

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028191 – 1036Uncharacterized vacuolar membrane protein YGR125WAdd BLAST1036

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei153PhosphoserineCombined sources1
Modified residuei842PhosphoserineCombined sources1
Modified residuei847PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53273.
PRIDEiP53273.

PTM databases

iPTMnetiP53273.

Interactioni

Protein-protein interaction databases

BioGridi33373. 101 interactors.
DIPiDIP-7435N.
IntActiP53273. 3 interactors.
MINTiMINT-1360603.

Structurei

3D structure databases

ProteinModelPortaliP53273.
SMRiP53273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini660 – 781STASPROSITE-ProRule annotationAdd BLAST122

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000192103.
InParanoidiP53273.
KOiK03321.
OMAiDYSAAEG.
OrthoDBiEOG092C0A65.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
3.30.750.24. 1 hit.
InterProiIPR003103. BAG_domain.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF52091. SSF52091. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRTIRRRRS NSSLSEAISV SLGINQDSSV NKMHRASVSA MSPPLCRSYM
60 70 80 90 100
SGFFTGGNSP MINNLSDSKL PISNKQHPKV IHGSENLHRQ TAQLSNEFCS
110 120 130 140 150
SSVEENSPTI KDYMDIIGNG DRKDDQSMRT IEENIDEEYS DEYSRLLLSP
160 170 180 190 200
ASSNVDDDRN RGLQNSSLPE LEDGYAGGYQ SLRPSHNLRF RPRNLWHMCT
210 220 230 240 250
SFPSKFAHYL PAAVLGLLLN ILDALSYGMI IFPITEPVFS HLGPTGISMF
260 270 280 290 300
YISTIISQAV YSGGWSSFPS GIGSEMIEIT PFYHTMALAI KEALAGNDDE
310 320 330 340 350
IITTTIFCYV ISSMLTGVVF YALGKLRLGK IVGFFPRHIL IGCIGGVGYF
360 370 380 390 400
LIITGIEVTT RVAKFEYSWP FFSGLFTDYD TLAKWLLPVL LTVVLIGTQR
410 420 430 440 450
YFKNSLVLPS FYILTLVLFH FIVAIIPTLS LDALRQAGWI FPIANSDSKW
460 470 480 490 500
YDHYRLFNVH KVHWSLVLQQ IPTMMALTFF GILHVPINVP ALAMSLQMDK
510 520 530 540 550
YDVDRELIAH GYSNFFSGLL GSVQNYLVYT NSVLFIRAGA DSPFAGFLLI
560 570 580 590 600
ALTICIMIIG PVIISFIPIC IVGSLIFLLG YELLVEALVD TWNKLNRFEY
610 620 630 640 650
LTVVIIVFTM GIFDFVLGII VGILIACFSF LVDSTKLQTI NGEYNGNVAR
660 670 680 690 700
STVYRDYVQT KFLDGIGEQI YVLKLQNLLF FGTIISIEEK IERLLQISNK
710 720 730 740 750
DATKRRIKYL ILDFKNINAD NIDYSAAEGF NRIKRFTETK RIKLIISSIK
760 770 780 790 800
ERDRIYNAFN NVGLLNDVEL FADLNSALEW CENEFLFQYK QLRKKAKERL
810 820 830 840 850
EEGKQNNVVS AVIAATKNKK IDTIGNGLNR GSNGDTARNL MSLPTNTPRN
860 870 880 890 900
YQILSVAQNV FVNDEQAVKN FKKEYKDDEP VLPILLFALK QYRPDIISEV
910 920 930 940 950
QKVREKEIKF WAQLCPYFTR RRLASQSHLL HADNIFFLVE TGMLKATYEL
960 970 980 990 1000
PQGTLYEIFS NGTCFGKIIA PGNAMPREQK LTIETETDSV LWVIDSSSLN
1010 1020 1030
KLKEDNLALY VEVALMVMCI KDTRFKELLG YTLVSA
Length:1,036
Mass (Da):116,971
Last modified:October 1, 1996 - v1
Checksum:i91A50225CA7FFCB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83099 Genomic DNA. Translation: CAA58161.1.
Z72910 Genomic DNA. Translation: CAA97136.1.
BK006941 Genomic DNA. Translation: DAA08218.1.
PIRiS55984.
RefSeqiNP_011641.1. NM_001181254.1.

Genome annotation databases

EnsemblFungiiYGR125W; YGR125W; YGR125W.
GeneIDi853026.
KEGGisce:YGR125W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83099 Genomic DNA. Translation: CAA58161.1.
Z72910 Genomic DNA. Translation: CAA97136.1.
BK006941 Genomic DNA. Translation: DAA08218.1.
PIRiS55984.
RefSeqiNP_011641.1. NM_001181254.1.

3D structure databases

ProteinModelPortaliP53273.
SMRiP53273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33373. 101 interactors.
DIPiDIP-7435N.
IntActiP53273. 3 interactors.
MINTiMINT-1360603.

Protein family/group databases

TCDBi2.A.53.3.10. the sulfate permease (sulp) family.

PTM databases

iPTMnetiP53273.

Proteomic databases

MaxQBiP53273.
PRIDEiP53273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR125W; YGR125W; YGR125W.
GeneIDi853026.
KEGGisce:YGR125W.

Organism-specific databases

EuPathDBiFungiDB:YGR125W.
SGDiS000003357. YGR125W.

Phylogenomic databases

HOGENOMiHOG000192103.
InParanoidiP53273.
KOiK03321.
OMAiDYSAAEG.
OrthoDBiEOG092C0A65.

Enzyme and pathway databases

BioCyciYEAST:G3O-30831-MONOMER.

Miscellaneous databases

PROiP53273.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
3.30.750.24. 1 hit.
InterProiIPR003103. BAG_domain.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF52091. SSF52091. 1 hit.
SSF63491. SSF63491. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYG35_YEAST
AccessioniPrimary (citable) accession number: P53273
Secondary accession number(s): D6VUQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1420 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.