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Protein

Conserved oligomeric Golgi complex subunit 2

Gene

COG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG2 is required for ER to Golgi vesicle docking. Not essential for viability.2 Publications

GO - Biological processi

  • CVT pathway Source: SGD
  • ER to Golgi vesicle-mediated transport Source: SGD
  • intra-Golgi vesicle-mediated transport Source: SGD
  • macroautophagy Source: SGD
  • pexophagy Source: SGD
  • retrograde transport, vesicle recycling within Golgi Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30827-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 2
Short name:
COG complex subunit 2
Alternative name(s):
Component of oligomeric Golgi complex 2
Protein SEC35
Gene namesi
Name:COG2
Synonyms:SEC35
Ordered Locus Names:YGR120C
ORF Names:G6324
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR120C.
SGDiS000003352. COG2.

Subcellular locationi

GO - Cellular componenti

  • extrinsic component of membrane Source: SGD
  • Golgi membrane Source: UniProtKB-SubCell
  • Golgi transport complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002134991 – 262Conserved oligomeric Golgi complex subunit 2Add BLAST262

Proteomic databases

MaxQBiP53271.
PRIDEiP53271.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. The COG complex interacts with the Rab GTPase YPT1, the Glogi SNAREs GOS1, SEC22, SED5, VTI1 and YKT6 and the COPI coatomer subunit gamma SEC21.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
COG1P530798EBI-16614,EBI-4835
COG3P4009412EBI-16614,EBI-16605
COG4Q0609611EBI-16614,EBI-4823
COG5P539513EBI-16614,EBI-4841
COG6P539593EBI-16614,EBI-4829
COG7P531952EBI-16614,EBI-4847
COG8Q046324EBI-16614,EBI-6035
SED5Q015902EBI-16614,EBI-16930

Protein-protein interaction databases

BioGridi33365. 89 interactors.
DIPiDIP-1194N.
IntActiP53271. 29 interactors.
MINTiMINT-376961.

Structurei

Secondary structure

1262
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi110 – 127Combined sources18
Helixi133 – 151Combined sources19
Beta strandi154 – 157Combined sources4
Helixi158 – 177Combined sources20
Helixi184 – 208Combined sources25
Helixi214 – 243Combined sources30
Turni245 – 248Combined sources4
Helixi249 – 258Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JQQNMR-A61-262[»]
ProteinModelPortaliP53271.
SMRiP53271.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53271.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000111879.
InParanoidiP53271.
OMAiVESKIEY.
OrthoDBiEOG092C443C.

Family and domain databases

InterProiIPR024602. COG_su2_N.
[Graphical view]
PfamiPF06148. COG2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53271-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNDDELD LDLPVTAEIS KELFATEIEK YRESETNGTD VDNFDVDRFL
60 70 80 90 100
VQKNFHYLPL DSLIRDLSGL SQKMVQTLLE QIRSNYDDYL TFSNTYTDEE
110 120 130 140 150
NETLINLEKT QSDLQKFMTQ LDHLIKDDIS NTQEIIKDVL EYLKKLDEIY
160 170 180 190 200
GSLRNHSQLT EALSLGKRLS KSLHEMCGIE PLEEEICSGL IEQLYKLITA
210 220 230 240 250
SRRILESCAD SNSPYIHHLR NDYQDLLQEF QISLKILTEK CLENPSSLQN
260
LSLTLVSIIK TA
Length:262
Mass (Da):30,325
Last modified:July 11, 2006 - v2
Checksum:i0ED457A7466F0F53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83099 Genomic DNA. Translation: CAA58155.1.
Z72905 Genomic DNA. Translation: CAA97130.1.
BK006941 Genomic DNA. Translation: DAA08212.1.
PIRiS55978.
RefSeqiNP_011635.2. NM_001181249.1.

Genome annotation databases

EnsemblFungiiYGR120C; YGR120C; YGR120C.
GeneIDi853017.
KEGGisce:YGR120C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83099 Genomic DNA. Translation: CAA58155.1.
Z72905 Genomic DNA. Translation: CAA97130.1.
BK006941 Genomic DNA. Translation: DAA08212.1.
PIRiS55978.
RefSeqiNP_011635.2. NM_001181249.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JQQNMR-A61-262[»]
ProteinModelPortaliP53271.
SMRiP53271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33365. 89 interactors.
DIPiDIP-1194N.
IntActiP53271. 29 interactors.
MINTiMINT-376961.

Proteomic databases

MaxQBiP53271.
PRIDEiP53271.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR120C; YGR120C; YGR120C.
GeneIDi853017.
KEGGisce:YGR120C.

Organism-specific databases

EuPathDBiFungiDB:YGR120C.
SGDiS000003352. COG2.

Phylogenomic databases

HOGENOMiHOG000111879.
InParanoidiP53271.
OMAiVESKIEY.
OrthoDBiEOG092C443C.

Enzyme and pathway databases

BioCyciYEAST:G3O-30827-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP53271.
PROiP53271.

Family and domain databases

InterProiIPR024602. COG_su2_N.
[Graphical view]
PfamiPF06148. COG2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOG2_YEAST
AccessioniPrimary (citable) accession number: P53271
Secondary accession number(s): D6VUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2006
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3270 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.