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Protein

Conserved oligomeric Golgi complex subunit 2

Gene

COG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG2 is required for ER to Golgi vesicle docking. Not essential for viability.2 Publications

Miscellaneous

Present with 3270 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • autophagy of peroxisome Source: SGD
  • ER to Golgi vesicle-mediated transport Source: SGD
  • intra-Golgi vesicle-mediated transport Source: SGD
  • macroautophagy Source: SGD
  • protein localization by the Cvt pathway Source: SGD
  • protein transport Source: UniProtKB-KW
  • retrograde transport, vesicle recycling within Golgi Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30827-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 2
Short name:
COG complex subunit 2
Alternative name(s):
Component of oligomeric Golgi complex 2
Protein SEC35
Gene namesi
Name:COG2
Synonyms:SEC35
Ordered Locus Names:YGR120C
ORF Names:G6324
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR120C
SGDiS000003352 COG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002134991 – 262Conserved oligomeric Golgi complex subunit 2Add BLAST262

Proteomic databases

MaxQBiP53271
PaxDbiP53271
PRIDEiP53271

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. The COG complex interacts with the Rab GTPase YPT1, the Glogi SNAREs GOS1, SEC22, SED5, VTI1 and YKT6 and the COPI coatomer subunit gamma SEC21.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33365, 232 interactors
DIPiDIP-1194N
IntActiP53271, 28 interactors
MINTiP53271
STRINGi4932.YGR120C

Structurei

Secondary structure

1262
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi110 – 127Combined sources18
Helixi133 – 151Combined sources19
Beta strandi154 – 157Combined sources4
Helixi158 – 177Combined sources20
Helixi184 – 208Combined sources25
Helixi214 – 243Combined sources30
Turni245 – 248Combined sources4
Helixi249 – 258Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JQQNMR-A61-262[»]
ProteinModelPortaliP53271
SMRiP53271
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53271

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000111879
InParanoidiP53271
OMAiVESKIEY
OrthoDBiEOG092C443C

Family and domain databases

InterProiView protein in InterPro
IPR024602 COG_su2_N
PfamiView protein in Pfam
PF06148 COG2, 1 hit

Sequencei

Sequence statusi: Complete.

P53271-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNDDELD LDLPVTAEIS KELFATEIEK YRESETNGTD VDNFDVDRFL
60 70 80 90 100
VQKNFHYLPL DSLIRDLSGL SQKMVQTLLE QIRSNYDDYL TFSNTYTDEE
110 120 130 140 150
NETLINLEKT QSDLQKFMTQ LDHLIKDDIS NTQEIIKDVL EYLKKLDEIY
160 170 180 190 200
GSLRNHSQLT EALSLGKRLS KSLHEMCGIE PLEEEICSGL IEQLYKLITA
210 220 230 240 250
SRRILESCAD SNSPYIHHLR NDYQDLLQEF QISLKILTEK CLENPSSLQN
260
LSLTLVSIIK TA
Length:262
Mass (Da):30,325
Last modified:July 11, 2006 - v2
Checksum:i0ED457A7466F0F53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83099 Genomic DNA Translation: CAA58155.1
Z72905 Genomic DNA Translation: CAA97130.1
BK006941 Genomic DNA Translation: DAA08212.1
PIRiS55978
RefSeqiNP_011635.2, NM_001181249.1

Genome annotation databases

EnsemblFungiiYGR120C; YGR120C; YGR120C
GeneIDi853017
KEGGisce:YGR120C

Similar proteinsi

Entry informationi

Entry nameiCOG2_YEAST
AccessioniPrimary (citable) accession number: P53271
Secondary accession number(s): D6VUQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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