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Protein

Late endosome and vacuole interface protein 11

Gene

ENV11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in vacuolar processing and morphology.2 Publications

Miscellaneous

Present with 1050 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 138BED-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

GO - Biological processi

  • vacuolar protein processing Source: SGD
  • vacuole organization Source: SGD

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30784-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Late endosome and vacuole interface protein 11
Gene namesi
Name:ENV11
Ordered Locus Names:YGR071C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR071C
SGDiS000003303 ENV11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Exhibits cold sensitivity, a significant increase in cells with fragmented vacuoles, internal accumulation of precursor CPY, increased glycogen accumulation, and displays elongated buds.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028061 – 860Late endosome and vacuole interface protein 11Add BLAST860

Proteomic databases

MaxQBiP53246
PaxDbiP53246
PRIDEiP53246

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TBF1Q024578EBI-23209,EBI-19005

Protein-protein interaction databases

BioGridi33314, 100 interactors
DIPiDIP-5521N
IntActiP53246, 21 interactors
MINTiP53246
STRINGi4932.YGR071C

Structurei

3D structure databases

ProteinModelPortaliP53246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VID22 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 138BED-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00530000068309
InParanoidiP53246
OrthoDBiEOG092C27YN

Family and domain databases

InterProiView protein in InterPro
IPR003656 Znf_BED
PfamiView protein in Pfam
PF02892 zf-BED, 1 hit
SMARTiView protein in SMART
SM00614 ZnF_BED, 1 hit
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 1 hit

Sequencei

Sequence statusi: Complete.

P53246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTALDDLHG DLVTLEDNEI INNSDHSSSH STSHEEEDEE EDDTEDIELI
60 70 80 90 100
EKDGNKILSS RIHPEDEIIN DGLNIWIPVQ MLKKNIAKFW SHFLAIEKKL
110 120 130 140 150
TKVKCKHCGE ILTRSDASLT KTFRSHLKTK HNISANKNFY SMNFTVGDSN
160 170 180 190 200
LKNNTSSTEI TRRHGYDSLT FNSDQSFKCF DIGKLQSSNY LSISQLVAIV
210 220 230 240 250
IASENLPLNF FENVSFKSLL SKFHRIPPLT TNIIEESIIG LSKSIDELIR
260 270 280 290 300
RSISRNDTQL PFTIHLSDSK ESNQPLYLKY SREIRAQLSN LDLSHLISVN
310 320 330 340 350
FTELAGKRSL FSLQLFDNTN KVSKGLPLSI FVRKTTDIDI SVWQEQLNNL
360 370 380 390 400
YSKYPGLQKS VISITLPQSH YTMVLENRNS HNFTFHSGSV REIKYHTCIV
410 420 430 440 450
SELLHCFLQP LFNVPTESML SSFSVAKENH SGGSLLDSLI DFSHIDLSST
460 470 480 490 500
ILGKICCLIE EVNLNDSLKS DFLLYCQNYT QPNCNELTSI LSCNCDRFSA
510 520 530 540 550
LKSILEKFAN LVPFFKSINS HLENESLSES DFRLINTVEE TLRTFEQSIE
560 570 580 590 600
YFASSAPLKF THTLVFIIKF ELYLTEIIRS FKFTKSKKPF EKILARLLKV
610 620 630 640 650
KDLYLLDDVN LIGAFLYPSI FQSKSLLNEI FGTTSVNKIV HNMTKIVLRY
660 670 680 690 700
LKNFINITNF RSSNSGGESG RNSGNNLLSD YEAIFMKESR DVELLCNTKL
710 720 730 740 750
TAPLTEDSLL VQIIRDDLLR YVNRIAHELP NAYHDYLNDN DISFDGSHFT
760 770 780 790 800
KHELSEENDS NSGEWCLNPM EETFDIHIPI SDSIWNNYIS SKNKIEVIDI
810 820 830 840 850
LLQLLSVNST SSIRSELSSL TANQDFSTKL SEETIKIKLL NSQFNLEKIN
860
FHSGSIFDAC
Length:860
Mass (Da):98,109
Last modified:October 1, 1996 - v1
Checksum:i308D65E456C8FF3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72856 Genomic DNA Translation: CAA97073.1
BK006941 Genomic DNA Translation: DAA08165.1
PIRiS64366
RefSeqiNP_011585.3, NM_001181200.3

Genome annotation databases

EnsemblFungiiYGR071C; YGR071C; YGR071C
GeneIDi852962
KEGGisce:YGR071C

Similar proteinsi

Entry informationi

Entry nameiENV11_YEAST
AccessioniPrimary (citable) accession number: P53246
Secondary accession number(s): D6VUK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health