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Protein

Arrestin-related trafficking adapter 5

Gene

ART5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.1 Publication

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30782-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-related trafficking adapter 5
Gene namesi
Name:ART5
Ordered Locus Names:YGR068C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR068C.
SGDiS000003300. ART5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028041 – 586Arrestin-related trafficking adapter 5Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Post-translational modificationi

Ubiquitinated by RSP5.2 Publications

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP53244.
PRIDEiP53244.

PTM databases

iPTMnetiP53244.

Interactioni

Subunit structurei

Interacts with RSP5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399404EBI-23201,EBI-16219

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

Protein-protein interaction databases

BioGridi33312. 22 interactors.
DIPiDIP-1864N.
IntActiP53244. 13 interactors.
MINTiMINT-396449.

Structurei

3D structure databases

ProteinModelPortaliP53244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi199 – 204Poly-Ser6

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000112717.
InParanoidiP53244.
KOiK20062.
OMAiRIEMALI.
OrthoDBiEOG092C0NX0.

Family and domain databases

InterProiIPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLSSLSSS GGHSEQKERE RISYFDIRIN SPYKDIILIQ GSPLELSSIP
60 70 80 90 100
LSGNLVISVK NEIVVKKISL RLVGRFKLEF LQVGRYKKNS SSLASLVKEK
110 120 130 140 150
RKIFECYWDN LLVSSKGDVL VGGENAENQH NSSSGRSTSN QDMDTSGNAI
160 170 180 190 200
FLSKRSLSSP VFNKIIRRKT HSSHRKILEL PENGVTGTPF EGLRENARSR
210 220 230 240 250
SSSSNTLNNN SHSYSNRDGS GSSYLFLMKR GNYELPFNTM LPPEVCETIE
260 270 280 290 300
GLQSGSILYS FEAIIDGRQL WDTDLSVHTS PHGPIGSTST SGNGMRTKNK
310 320 330 340 350
IIIKKFKYLR ILRTLSMDNL AMQEEISVGN TWRDKLQYET SIPSRAVPIG
360 370 380 390 400
STTPVKIKIF PFEKNIRLDR IEMALIQYYA MKDSSAQIYD DEIAVMKITH
410 420 430 440 450
LADFGPLTDK LDVDCPFTIP DNLKQITQDC CLQDNLIRVM HKLQVRILLQ
460 470 480 490 500
RQVDGEYKNL EIKAQLPMLL FISPHLPMKG RLVLFDKHDG KIHFRPGELV
510 520 530 540 550
PLFLTTYPAQ GLTPGVELNS TTTAHLALPQ PPPNYHESTN DHLMPALQPL
560 570 580
GADSVVLTVP SYEQAQAQAS ASSYVTGSVP AYCDDD
Length:586
Mass (Da):65,477
Last modified:October 1, 1996 - v1
Checksum:iC85B0D42116C041A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72853 Genomic DNA. Translation: CAA97070.1.
BK006941 Genomic DNA. Translation: DAA08163.1.
PIRiS64363.
RefSeqiNP_011582.1. NM_001181197.1.

Genome annotation databases

EnsemblFungiiYGR068C; YGR068C; YGR068C.
GeneIDi852960.
KEGGisce:YGR068C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72853 Genomic DNA. Translation: CAA97070.1.
BK006941 Genomic DNA. Translation: DAA08163.1.
PIRiS64363.
RefSeqiNP_011582.1. NM_001181197.1.

3D structure databases

ProteinModelPortaliP53244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33312. 22 interactors.
DIPiDIP-1864N.
IntActiP53244. 13 interactors.
MINTiMINT-396449.

PTM databases

iPTMnetiP53244.

Proteomic databases

MaxQBiP53244.
PRIDEiP53244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR068C; YGR068C; YGR068C.
GeneIDi852960.
KEGGisce:YGR068C.

Organism-specific databases

EuPathDBiFungiDB:YGR068C.
SGDiS000003300. ART5.

Phylogenomic databases

GeneTreeiENSGT00730000112717.
InParanoidiP53244.
KOiK20062.
OMAiRIEMALI.
OrthoDBiEOG092C0NX0.

Enzyme and pathway databases

BioCyciYEAST:G3O-30782-MONOMER.

Miscellaneous databases

PROiP53244.

Family and domain databases

InterProiIPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiART5_YEAST
AccessioniPrimary (citable) accession number: P53244
Secondary accession number(s): D6VUK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1970 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.