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Protein

Arrestin-related trafficking adapter 5

Gene

ART5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.1 Publication

Miscellaneous

Present with 1970 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

GO - Biological processi

Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30782-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-related trafficking adapter 5
Gene namesi
Name:ART5
Ordered Locus Names:YGR068C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR068C
SGDiS000003300 ART5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028041 – 586Arrestin-related trafficking adapter 5Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki364Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Post-translational modificationi

Ubiquitinated by RSP5.2 Publications

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP53244
PaxDbiP53244
PRIDEiP53244

PTM databases

iPTMnetiP53244

Interactioni

Subunit structurei

Interacts with RSP5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399404EBI-23201,EBI-16219

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

Protein-protein interaction databases

BioGridi33312, 91 interactors
DIPiDIP-1864N
IntActiP53244, 13 interactors
MINTiP53244
STRINGi4932.YGR068C

Structurei

3D structure databases

ProteinModelPortaliP53244
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi199 – 204Poly-Ser6

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000112717
InParanoidiP53244
KOiK20062
OMAiKHIRIVR
OrthoDBiEOG092C0NX0

Family and domain databases

InterProiView protein in InterPro
IPR011022 Arrestin_C-like
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit

Sequencei

Sequence statusi: Complete.

P53244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLSSLSSS GGHSEQKERE RISYFDIRIN SPYKDIILIQ GSPLELSSIP
60 70 80 90 100
LSGNLVISVK NEIVVKKISL RLVGRFKLEF LQVGRYKKNS SSLASLVKEK
110 120 130 140 150
RKIFECYWDN LLVSSKGDVL VGGENAENQH NSSSGRSTSN QDMDTSGNAI
160 170 180 190 200
FLSKRSLSSP VFNKIIRRKT HSSHRKILEL PENGVTGTPF EGLRENARSR
210 220 230 240 250
SSSSNTLNNN SHSYSNRDGS GSSYLFLMKR GNYELPFNTM LPPEVCETIE
260 270 280 290 300
GLQSGSILYS FEAIIDGRQL WDTDLSVHTS PHGPIGSTST SGNGMRTKNK
310 320 330 340 350
IIIKKFKYLR ILRTLSMDNL AMQEEISVGN TWRDKLQYET SIPSRAVPIG
360 370 380 390 400
STTPVKIKIF PFEKNIRLDR IEMALIQYYA MKDSSAQIYD DEIAVMKITH
410 420 430 440 450
LADFGPLTDK LDVDCPFTIP DNLKQITQDC CLQDNLIRVM HKLQVRILLQ
460 470 480 490 500
RQVDGEYKNL EIKAQLPMLL FISPHLPMKG RLVLFDKHDG KIHFRPGELV
510 520 530 540 550
PLFLTTYPAQ GLTPGVELNS TTTAHLALPQ PPPNYHESTN DHLMPALQPL
560 570 580
GADSVVLTVP SYEQAQAQAS ASSYVTGSVP AYCDDD
Length:586
Mass (Da):65,477
Last modified:October 1, 1996 - v1
Checksum:iC85B0D42116C041A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72853 Genomic DNA Translation: CAA97070.1
BK006941 Genomic DNA Translation: DAA08163.1
PIRiS64363
RefSeqiNP_011582.1, NM_001181197.1

Genome annotation databases

EnsemblFungiiYGR068C; YGR068C; YGR068C
GeneIDi852960
KEGGisce:YGR068C

Similar proteinsi

Entry informationi

Entry nameiART5_YEAST
AccessioniPrimary (citable) accession number: P53244
Secondary accession number(s): D6VUK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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