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P53244

- ART5_YEAST

UniProt

P53244 - ART5_YEAST

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Protein

Arrestin-related trafficking adapter 5

Gene

ART5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.1 Publication

GO - Molecular functioni

  1. ubiquitin protein ligase binding Source: SGD

GO - Biological processi

  1. ubiquitin-dependent endocytosis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30782-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arrestin-related trafficking adapter 5
Gene namesi
Name:ART5
Ordered Locus Names:YGR068C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR068c.
SGDiS000003300. ART5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Arrestin-related trafficking adapter 5PRO_0000202804Add
BLAST

Post-translational modificationi

Ubiquitinated by RSP5.2 Publications

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP53244.
PaxDbiP53244.
PeptideAtlasiP53244.

Expressioni

Gene expression databases

GenevestigatoriP53244.

Interactioni

Subunit structurei

Interacts with RSP5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399404EBI-23201,EBI-16219

Protein-protein interaction databases

BioGridi33312. 22 interactions.
DIPiDIP-1864N.
IntActiP53244. 13 interactions.
MINTiMINT-396449.
STRINGi4932.YGR068C.

Structurei

3D structure databases

ProteinModelPortaliP53244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi199 – 2046Poly-Ser

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiNOG316809.
GeneTreeiENSGT00730000112717.
InParanoidiP53244.
OMAiGKIHFRP.
OrthoDBiEOG78WM17.

Family and domain databases

InterProiIPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53244-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSLSSLSSS GGHSEQKERE RISYFDIRIN SPYKDIILIQ GSPLELSSIP
60 70 80 90 100
LSGNLVISVK NEIVVKKISL RLVGRFKLEF LQVGRYKKNS SSLASLVKEK
110 120 130 140 150
RKIFECYWDN LLVSSKGDVL VGGENAENQH NSSSGRSTSN QDMDTSGNAI
160 170 180 190 200
FLSKRSLSSP VFNKIIRRKT HSSHRKILEL PENGVTGTPF EGLRENARSR
210 220 230 240 250
SSSSNTLNNN SHSYSNRDGS GSSYLFLMKR GNYELPFNTM LPPEVCETIE
260 270 280 290 300
GLQSGSILYS FEAIIDGRQL WDTDLSVHTS PHGPIGSTST SGNGMRTKNK
310 320 330 340 350
IIIKKFKYLR ILRTLSMDNL AMQEEISVGN TWRDKLQYET SIPSRAVPIG
360 370 380 390 400
STTPVKIKIF PFEKNIRLDR IEMALIQYYA MKDSSAQIYD DEIAVMKITH
410 420 430 440 450
LADFGPLTDK LDVDCPFTIP DNLKQITQDC CLQDNLIRVM HKLQVRILLQ
460 470 480 490 500
RQVDGEYKNL EIKAQLPMLL FISPHLPMKG RLVLFDKHDG KIHFRPGELV
510 520 530 540 550
PLFLTTYPAQ GLTPGVELNS TTTAHLALPQ PPPNYHESTN DHLMPALQPL
560 570 580
GADSVVLTVP SYEQAQAQAS ASSYVTGSVP AYCDDD
Length:586
Mass (Da):65,477
Last modified:October 1, 1996 - v1
Checksum:iC85B0D42116C041A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72853 Genomic DNA. Translation: CAA97070.1.
BK006941 Genomic DNA. Translation: DAA08163.1.
PIRiS64363.
RefSeqiNP_011582.1. NM_001181197.1.

Genome annotation databases

EnsemblFungiiYGR068C; YGR068C; YGR068C.
GeneIDi852960.
KEGGisce:YGR068C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72853 Genomic DNA. Translation: CAA97070.1 .
BK006941 Genomic DNA. Translation: DAA08163.1 .
PIRi S64363.
RefSeqi NP_011582.1. NM_001181197.1.

3D structure databases

ProteinModelPortali P53244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33312. 22 interactions.
DIPi DIP-1864N.
IntActi P53244. 13 interactions.
MINTi MINT-396449.
STRINGi 4932.YGR068C.

Proteomic databases

MaxQBi P53244.
PaxDbi P53244.
PeptideAtlasi P53244.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR068C ; YGR068C ; YGR068C .
GeneIDi 852960.
KEGGi sce:YGR068C.

Organism-specific databases

CYGDi YGR068c.
SGDi S000003300. ART5.

Phylogenomic databases

eggNOGi NOG316809.
GeneTreei ENSGT00730000112717.
InParanoidi P53244.
OMAi GKIHFRP.
OrthoDBi EOG78WM17.

Enzyme and pathway databases

BioCyci YEAST:G3O-30782-MONOMER.

Miscellaneous databases

NextBioi 972729.

Gene expression databases

Genevestigatori P53244.

Family and domain databases

InterProi IPR011022. Arrestin_C-like.
[Graphical view ]
Pfami PF02752. Arrestin_C. 1 hit.
[Graphical view ]
SMARTi SM01017. Arrestin_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. "Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast."
    Gupta R., Kus B., Fladd C., Wasmuth J., Tonikian R., Sidhu S., Krogan N.J., Parkinson J., Rotin D.
    Mol. Syst. Biol. 3:116-116(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RSP5, UBIQUITINATION BY RSP5.
  5. "Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface."
    Lin C.H., MacGurn J.A., Chu T., Stefan C.J., Emr S.D.
    Cell 135:714-725(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RPS5, FUNCTION.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Functional dissection of a HECT ubiquitin E3 ligase."
    Lu J., Lin Y., Qian J., Tao S., Zhu J., Pickart C., Zhu H.
    Mol. Cell. Proteomics 7:35-45(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY RSP5.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiART5_YEAST
AccessioniPrimary (citable) accession number: P53244
Secondary accession number(s): D6VUK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1970 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3