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P53244

- ART5_YEAST

UniProt

P53244 - ART5_YEAST

Protein

Arrestin-related trafficking adapter 5

Gene

ART5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ubiquitin protein ligase binding Source: SGD

    GO - Biological processi

    1. ubiquitin-dependent endocytosis Source: SGD

    Keywords - Biological processi

    Endocytosis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30782-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arrestin-related trafficking adapter 5
    Gene namesi
    Name:ART5
    Ordered Locus Names:YGR068C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR068c.
    SGDiS000003300. ART5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 586586Arrestin-related trafficking adapter 5PRO_0000202804Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by RSP5.2 Publications

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiP53244.
    PaxDbiP53244.
    PeptideAtlasiP53244.

    Expressioni

    Gene expression databases

    GenevestigatoriP53244.

    Interactioni

    Subunit structurei

    Interacts with RSP5.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RSP5P399404EBI-23201,EBI-16219

    Protein-protein interaction databases

    BioGridi33312. 21 interactions.
    DIPiDIP-1864N.
    IntActiP53244. 13 interactions.
    MINTiMINT-396449.
    STRINGi4932.YGR068C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi199 – 2046Poly-Ser

    Sequence similaritiesi

    Belongs to the arrestin family.Curated

    Phylogenomic databases

    eggNOGiNOG316809.
    GeneTreeiENSGT00730000112717.
    OMAiGKIHFRP.
    OrthoDBiEOG78WM17.

    Family and domain databases

    InterProiIPR011022. Arrestin_C-like.
    [Graphical view]
    PfamiPF02752. Arrestin_C. 1 hit.
    [Graphical view]
    SMARTiSM01017. Arrestin_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53244-1 [UniParc]FASTAAdd to Basket

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    MFSLSSLSSS GGHSEQKERE RISYFDIRIN SPYKDIILIQ GSPLELSSIP    50
    LSGNLVISVK NEIVVKKISL RLVGRFKLEF LQVGRYKKNS SSLASLVKEK 100
    RKIFECYWDN LLVSSKGDVL VGGENAENQH NSSSGRSTSN QDMDTSGNAI 150
    FLSKRSLSSP VFNKIIRRKT HSSHRKILEL PENGVTGTPF EGLRENARSR 200
    SSSSNTLNNN SHSYSNRDGS GSSYLFLMKR GNYELPFNTM LPPEVCETIE 250
    GLQSGSILYS FEAIIDGRQL WDTDLSVHTS PHGPIGSTST SGNGMRTKNK 300
    IIIKKFKYLR ILRTLSMDNL AMQEEISVGN TWRDKLQYET SIPSRAVPIG 350
    STTPVKIKIF PFEKNIRLDR IEMALIQYYA MKDSSAQIYD DEIAVMKITH 400
    LADFGPLTDK LDVDCPFTIP DNLKQITQDC CLQDNLIRVM HKLQVRILLQ 450
    RQVDGEYKNL EIKAQLPMLL FISPHLPMKG RLVLFDKHDG KIHFRPGELV 500
    PLFLTTYPAQ GLTPGVELNS TTTAHLALPQ PPPNYHESTN DHLMPALQPL 550
    GADSVVLTVP SYEQAQAQAS ASSYVTGSVP AYCDDD 586
    Length:586
    Mass (Da):65,477
    Last modified:October 1, 1996 - v1
    Checksum:iC85B0D42116C041A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72853 Genomic DNA. Translation: CAA97070.1.
    BK006941 Genomic DNA. Translation: DAA08163.1.
    PIRiS64363.
    RefSeqiNP_011582.1. NM_001181197.1.

    Genome annotation databases

    EnsemblFungiiYGR068C; YGR068C; YGR068C.
    GeneIDi852960.
    KEGGisce:YGR068C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72853 Genomic DNA. Translation: CAA97070.1 .
    BK006941 Genomic DNA. Translation: DAA08163.1 .
    PIRi S64363.
    RefSeqi NP_011582.1. NM_001181197.1.

    3D structure databases

    ProteinModelPortali P53244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33312. 21 interactions.
    DIPi DIP-1864N.
    IntActi P53244. 13 interactions.
    MINTi MINT-396449.
    STRINGi 4932.YGR068C.

    Proteomic databases

    MaxQBi P53244.
    PaxDbi P53244.
    PeptideAtlasi P53244.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR068C ; YGR068C ; YGR068C .
    GeneIDi 852960.
    KEGGi sce:YGR068C.

    Organism-specific databases

    CYGDi YGR068c.
    SGDi S000003300. ART5.

    Phylogenomic databases

    eggNOGi NOG316809.
    GeneTreei ENSGT00730000112717.
    OMAi GKIHFRP.
    OrthoDBi EOG78WM17.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30782-MONOMER.

    Miscellaneous databases

    NextBioi 972729.

    Gene expression databases

    Genevestigatori P53244.

    Family and domain databases

    InterProi IPR011022. Arrestin_C-like.
    [Graphical view ]
    Pfami PF02752. Arrestin_C. 1 hit.
    [Graphical view ]
    SMARTi SM01017. Arrestin_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    4. "Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast."
      Gupta R., Kus B., Fladd C., Wasmuth J., Tonikian R., Sidhu S., Krogan N.J., Parkinson J., Rotin D.
      Mol. Syst. Biol. 3:116-116(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RSP5, UBIQUITINATION BY RSP5.
    5. "Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface."
      Lin C.H., MacGurn J.A., Chu T., Stefan C.J., Emr S.D.
      Cell 135:714-725(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RPS5, FUNCTION.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Functional dissection of a HECT ubiquitin E3 ligase."
      Lu J., Lin Y., Qian J., Tao S., Zhu J., Pickart C., Zhu H.
      Mol. Cell. Proteomics 7:35-45(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY RSP5.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiART5_YEAST
    AccessioniPrimary (citable) accession number: P53244
    Secondary accession number(s): D6VUK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1970 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3