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Protein

Vitamin H transporter

Gene

VHT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in uptake of biotin with the concomitant entry of protons.

GO - Molecular functioni

GO - Biological processi

  • biotin transport Source: SGD
  • transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Keywords - Ligandi

Biotin

Enzyme and pathway databases

BioCyciYEAST:G3O-30779-MONOMER.

Protein family/group databases

TCDBi2.A.1.14.12. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin H transporter
Alternative name(s):
H(+)/biotin symporter
Gene namesi
Name:VHT1
Ordered Locus Names:YGR065C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR065C.
SGDiS000003297. VHT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 121ExtracellularSequence analysisAdd BLAST121
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 166CytoplasmicSequence analysisAdd BLAST24
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 190ExtracellularSequence analysis3
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 224CytoplasmicSequence analysisAdd BLAST13
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 291ExtracellularSequence analysisAdd BLAST46
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 361CytoplasmicSequence analysisAdd BLAST49
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 408ExtracellularSequence analysisAdd BLAST26
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Topological domaini430 – 432CytoplasmicSequence analysis3
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Topological domaini454 – 460ExtracellularSequence analysis7
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 492CytoplasmicSequence analysisAdd BLAST11
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 526ExtracellularSequence analysisAdd BLAST13
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 593CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213721 – 593Vitamin H transporterAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei43PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53241.
PRIDEiP53241.

PTM databases

iPTMnetiP53241.

Interactioni

Protein-protein interaction databases

BioGridi33309. 19 interactors.
DIPiDIP-5519N.
IntActiP53241. 10 interactors.
MINTiMINT-533395.

Structurei

3D structure databases

ProteinModelPortaliP53241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088258.
HOGENOMiHOG000179304.
InParanoidiP53241.
OMAiCSWNNMT.
OrthoDBiEOG092C2VR3.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

P53241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISNKSWRS YFPHLRKLPE DDQYLYSDDT NSSIIAEEEL HHSVDKSSKT
60 70 80 90 100
DVTAETTAVE PHPHNLRHDL PYEVRDEAGR KWWKYFDEFE YRVNKEYKKS
110 120 130 140 150
RKWYEFLYPN HTTQTKAERR LLYKLDIIIA LYFFMLCWSK SVDLNNYTNA
160 170 180 190 200
YVSNMKEDLN MKGNDYVYTS TIANVGAIVF QLPFMYLLPR FPSHIILPVM
210 220 230 240 250
DLGWTWFTFA CYRANSLAEL RAYRFILSAF GAAYYPVSQY ILGCWYAPDE
260 270 280 290 300
INSRVCLFFC GQQLGSVTSG LLQSRIFKSL NGVHGLAGWR WMFLIDAIAI
310 320 330 340 350
SLPTAIIGFF VIPGVPSKCY SLFLTDEEIR IARARNKRNQ IKDGVDKSKL
360 370 380 390 400
APLWSRKLWK KVFCTPAFWV LVVFDTCSWN NMTAYSGSYT LWLKSNTKYS
410 420 430 440 450
IAQVNNLSVI PACLGFAYVI FCAFGADLFR CKWIFMVFAA IMNTVSCALL
460 470 480 490 500
IKWDIPSKAK WYAFFTTYFS VAASPCLWSF INDFLRFDPQ VKAITWIAIY
510 520 530 540 550
SFSQSTYAWI PTLAWPTVES PRFKTGYTVS LIFGAIYGLW TFVVLFFYKR
560 570 580 590
NEKKHALGNG IILYDSNKGE ELPEFVKKNM EERDGYYYLK RSS
Length:593
Mass (Da):69,083
Last modified:October 1, 1996 - v1
Checksum:i8B91D6247867386D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72850 Genomic DNA. Translation: CAA97067.1.
BK006941 Genomic DNA. Translation: DAA08160.1.
PIRiS64360.
RefSeqiNP_011579.1. NM_001181194.1.

Genome annotation databases

EnsemblFungiiYGR065C; YGR065C; YGR065C.
GeneIDi852956.
KEGGisce:YGR065C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72850 Genomic DNA. Translation: CAA97067.1.
BK006941 Genomic DNA. Translation: DAA08160.1.
PIRiS64360.
RefSeqiNP_011579.1. NM_001181194.1.

3D structure databases

ProteinModelPortaliP53241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33309. 19 interactors.
DIPiDIP-5519N.
IntActiP53241. 10 interactors.
MINTiMINT-533395.

Protein family/group databases

TCDBi2.A.1.14.12. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP53241.

Proteomic databases

MaxQBiP53241.
PRIDEiP53241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR065C; YGR065C; YGR065C.
GeneIDi852956.
KEGGisce:YGR065C.

Organism-specific databases

EuPathDBiFungiDB:YGR065C.
SGDiS000003297. VHT1.

Phylogenomic databases

GeneTreeiENSGT00620000088258.
HOGENOMiHOG000179304.
InParanoidiP53241.
OMAiCSWNNMT.
OrthoDBiEOG092C2VR3.

Enzyme and pathway databases

BioCyciYEAST:G3O-30779-MONOMER.

Miscellaneous databases

PROiP53241.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVHT1_YEAST
AccessioniPrimary (citable) accession number: P53241
Secondary accession number(s): D6VUJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.