P53237 (LST7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein LST7

Alternative name(s):
Lethal with SEC thirteen protein 7

Gene names

Name:	LST7
Ordered Locus Names:	YGR057C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the nitrogen-regulated transport of amino acid permeases GAP1 and PUT4 from the Golgi to the cell surface. Ref.4
Miscellaneous	Present with 656 molecules/cell in log phase SD medium.
Sequence caution	The sequence CAA97058.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA97060.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi to plasma membrane transport Inferred from direct assay Ref.4. Source: SGD intracellular protein transport Inferred from direct assay Ref.4. Source: SGD
Cellular_component	vesicle coat Inferred from direct assay Ref.4. Source: SGD
Molecular_function	protein transporter activity Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Protein LST7		PRO_0000202801
Natural variations
	Natural variant	4	1	T → I in strain: SK1.

Sequences

	Sequence		Length	Mass (Da)
	P53237 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: 410B0A6E670FACA2	FASTA	242	28,136
	10 20 30 40 50 60 MSSTVISLAH FCDKHGPRII SVTQSAEKGT LGEELLVPDY PTESYCESCL LQFPEESTRS 70 80 90 100 110 120 MRCFIEDVPF ITTQYSSIRY QLLNSIIKRA FSEETMIYDN MPFIFFDDLR GLNLVIGFKL 130 140 150 160 170 180 YDENARGNER RYCFILTVDS RSHDDSMKML SEHWNFIIGG FDKMIAYIKN IHKSEFLGKN 190 200 210 220 230 240 KTVENNLETL NNNAFIGSYL RANKSKFGRN LVSLTDDKFL FVRIHKWNSF LLHTVMNENK LP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Quantitative trait loci mapped to single-nucleotide resolution in yeast." Deutschbauer A.M., Davis R.W. Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SK1.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8." Roberg K.J., Bickel S., Rowley N., Kaiser C.A. Genetics 147:1569-1584(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ115391 Genomic DNA. Translation: AAZ22470.1. Z72842 Genomic DNA. Translation: CAA97058.1. Different initiation. Z72843 Genomic DNA. Translation: CAA97060.1. Different initiation. BK006941 Genomic DNA. Translation: DAA08153.1.
PIR	S64351.
RefSeq	NP_011571.4. NM_001181186.3.
3D structure databases
ProteinModelPortal	P53237.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1424N.
IntAct	P53237. 2 interactions.
MINT	MINT-395024.
STRING	4932.YGR057C.
Proteomic databases
PaxDb	P53237.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR057C; YGR057C; YGR057C.
GeneID	852948.
KEGG	sce:YGR057C. sce:YGR063C.
Organism-specific databases
CYGD	YGR057c.
SGD	S000003289. LST7.
Phylogenomic databases
eggNOG	NOG324021.
HOGENOM	HOG000000953.
KO	K15171.
OMA	THYPSSQ.
OrthoDB	EOG4PRX15.
Gene expression databases
Genevestigator	P53237.
GermOnline	YGR057C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR021713. Folliculin. [Graphical view]
Pfam	PF11704. Folliculin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	972699.

Entry information

Entry name

LST7_YEAST

Accession

Primary (citable) accession number: P53237
Secondary accession number(s): D6VUJ2, Q45U29

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 16, 2006
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program