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Protein

Protein LST7

Gene

LST7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the nitrogen-regulated transport of amino acid permeases GAP1 and PUT4 from the Golgi to the cell surface.1 Publication

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • positive regulation of GTPase activity Source: SGD
  • positive regulation of TORC1 signaling Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30774-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LST7
Alternative name(s):
Lethal with SEC thirteen protein 7
Gene namesi
Name:LST7
Ordered Locus Names:YGR057C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR057C.
SGDiS000003289. LST7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002028011 – 242Protein LST7Add BLAST242

Proteomic databases

MaxQBiP53237.
PRIDEiP53237.

Interactioni

Protein-protein interaction databases

BioGridi33302. 109 interactors.
DIPiDIP-1424N.
IntActiP53237. 2 interactors.
MINTiMINT-395024.
STRINGi4932.YGR057C.

Structurei

3D structure databases

ProteinModelPortaliP53237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 212uDENN FLCN/SMCR8-typePROSITE-ProRule annotationAdd BLAST165

Phylogenomic databases

HOGENOMiHOG000000953.
InParanoidiP53237.
OMAiRGSERKY.
OrthoDBiEOG092C4RNN.

Family and domain databases

InterProiView protein in InterPro
IPR021713. Folliculin.
PANTHERiPTHR31441. PTHR31441. 2 hits.
PROSITEiView protein in PROSITE
PS51834. DENN_FLCN_SMCR8. 1 hit.

Sequencei

Sequence statusi: Complete.

P53237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTVISLAH FCDKHGPRII SVTQSAEKGT LGEELLVPDY PTESYCESCL
60 70 80 90 100
LQFPEESTRS MRCFIEDVPF ITTQYSSIRY QLLNSIIKRA FSEETMIYDN
110 120 130 140 150
MPFIFFDDLR GLNLVIGFKL YDENARGNER RYCFILTVDS RSHDDSMKML
160 170 180 190 200
SEHWNFIIGG FDKMIAYIKN IHKSEFLGKN KTVENNLETL NNNAFIGSYL
210 220 230 240
RANKSKFGRN LVSLTDDKFL FVRIHKWNSF LLHTVMNENK LP
Length:242
Mass (Da):28,136
Last modified:May 16, 2006 - v2
Checksum:i410B0A6E670FACA2
GO

Sequence cautioni

The sequence CAA97058 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA97060 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti4T → I in strain: SK1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115391 Genomic DNA. Translation: AAZ22470.1.
Z72842 Genomic DNA. Translation: CAA97058.1. Different initiation.
Z72843 Genomic DNA. Translation: CAA97060.1. Different initiation.
BK006941 Genomic DNA. Translation: DAA08153.1.
PIRiS64351.
RefSeqiNP_011571.4. NM_001181186.3.

Genome annotation databases

EnsemblFungiiYGR057C; YGR057C; YGR057C.
GeneIDi852948.
KEGGisce:YGR057C.

Similar proteinsi

Entry informationi

Entry nameiLST7_YEAST
AccessioniPrimary (citable) accession number: P53237
Secondary accession number(s): D6VUJ2, Q45U29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2006
Last modified: November 22, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names