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Protein

Probable serine/threonine-protein kinase FMP48

Gene

FMP48

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311ATPPROSITE-ProRule annotation
Active sitei133 – 1331Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: SGD
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein phosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30769-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase FMP48 (EC:2.7.11.1)
Alternative name(s):
Found in mitochondrial proteome protein 48
Gene namesi
Name:FMP48
Ordered Locus Names:YGR052W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR052w.
SGDiS000003284. FMP48.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Probable serine/threonine-protein kinase FMP48PRO_0000086113Add
BLAST

Proteomic databases

PaxDbiP53233.

Expressioni

Inductioni

By treatment with 8-methoxypsoralen and UVA irradiation.1 Publication

Gene expression databases

ExpressionAtlasiP53233. differential.
GenevestigatoriP53233.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC14Q006842EBI-9664,EBI-4192
HIS4P008152EBI-9664,EBI-8334
TOR1P351693EBI-9664,EBI-19374

Protein-protein interaction databases

BioGridi33297. 68 interactions.
DIPiDIP-5516N.
IntActiP53233. 31 interactions.
MINTiMINT-545426.
STRINGi4932.YGR052W.

Structurei

3D structure databases

ProteinModelPortaliP53233.
SMRiP53233. Positions 1-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 369368Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiP53233.
KOiK08286.
OMAiADWGHAI.
OrthoDBiEOG72G1K9.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTKLRSIQS GTFSTVYKAW STTHNRYVAL KITPKYKTSE ANMKNEYDVM
60 70 80 90 100
KILSSCNPHP NICSMLDFYT DDSYYIMVLE YCECGDLYDF LDIAKSQGSP
110 120 130 140 150
SSPSLIQIDM QKIIKQLCSA ISFAHSLGIA HRDIKPENIL LTINGDIKLA
160 170 180 190 200
DWGHAIQSPK SNDFQIGTDN YRAPETFSGR VSNSCFKKNF DRSSAPLYNT
210 220 230 240 250
YQADYWSLGA TIFYLMFGDC LFRVSKSKKV QHLKNFDEFE KDPFAFIYRK
260 270 280 290 300
YVVPRLSCGY NDEEDLHVSL QHTRQYIWQD LPDIYDVFHL CKIMVDTLLK
310 320 330 340 350
VSNAKERSME NFINEVDSAW NKDSSMDSCF SYQNKIDLFW EQWSVNTETV
360
PAKFQLKNFE KPCLIQDGK
Length:369
Mass (Da):42,823
Last modified:October 1, 1996 - v1
Checksum:i9F34E38FDD3C5892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72837 Genomic DNA. Translation: CAA97052.1.
BK006941 Genomic DNA. Translation: DAA08148.1.
PIRiS64346.
RefSeqiNP_011566.1. NM_001181181.1.

Genome annotation databases

EnsemblFungiiYGR052W; YGR052W; YGR052W.
GeneIDi852943.
KEGGisce:YGR052W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72837 Genomic DNA. Translation: CAA97052.1.
BK006941 Genomic DNA. Translation: DAA08148.1.
PIRiS64346.
RefSeqiNP_011566.1. NM_001181181.1.

3D structure databases

ProteinModelPortaliP53233.
SMRiP53233. Positions 1-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33297. 68 interactions.
DIPiDIP-5516N.
IntActiP53233. 31 interactions.
MINTiMINT-545426.
STRINGi4932.YGR052W.

Proteomic databases

PaxDbiP53233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR052W; YGR052W; YGR052W.
GeneIDi852943.
KEGGisce:YGR052W.

Organism-specific databases

CYGDiYGR052w.
SGDiS000003284. FMP48.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiP53233.
KOiK08286.
OMAiADWGHAI.
OrthoDBiEOG72G1K9.

Enzyme and pathway databases

BioCyciYEAST:G3O-30769-MONOMER.

Miscellaneous databases

NextBioi972684.

Gene expression databases

ExpressionAtlasiP53233. differential.
GenevestigatoriP53233.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  5. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. "Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast."
    Dardalhon M., Lin W., Nicolas A., Averbeck D.
    FEMS Yeast Res. 7:866-878(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiFMP48_YEAST
AccessioniPrimary (citable) accession number: P53233
Secondary accession number(s): D6VUI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.