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Protein

Probable serine/threonine-protein kinase FMP48

Gene

FMP48

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31ATPPROSITE-ProRule annotation1
Active sitei133Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 16ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30769-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase FMP48 (EC:2.7.11.1)
Alternative name(s):
Found in mitochondrial proteome protein 48
Gene namesi
Name:FMP48
Ordered Locus Names:YGR052W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR052W
SGDiS000003284 FMP48

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861131 – 369Probable serine/threonine-protein kinase FMP48Add BLAST369

Proteomic databases

PaxDbiP53233
PRIDEiP53233

PTM databases

iPTMnetiP53233

Expressioni

Inductioni

By treatment with 8-methoxypsoralen and UVA irradiation.1 Publication

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33297122 interactors.
DIPiDIP-5516N
IntActiP53233 46 interactors.
MINTiP53233
STRINGi4932.YGR052W

Structurei

3D structure databases

ProteinModelPortaliP53233
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 369Protein kinasePROSITE-ProRule annotationAdd BLAST368

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00910000145165
InParanoidiP53233
KOiK08286
OMAiADWGHAI
OrthoDBiEOG092C4K7T

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P53233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTKLRSIQS GTFSTVYKAW STTHNRYVAL KITPKYKTSE ANMKNEYDVM
60 70 80 90 100
KILSSCNPHP NICSMLDFYT DDSYYIMVLE YCECGDLYDF LDIAKSQGSP
110 120 130 140 150
SSPSLIQIDM QKIIKQLCSA ISFAHSLGIA HRDIKPENIL LTINGDIKLA
160 170 180 190 200
DWGHAIQSPK SNDFQIGTDN YRAPETFSGR VSNSCFKKNF DRSSAPLYNT
210 220 230 240 250
YQADYWSLGA TIFYLMFGDC LFRVSKSKKV QHLKNFDEFE KDPFAFIYRK
260 270 280 290 300
YVVPRLSCGY NDEEDLHVSL QHTRQYIWQD LPDIYDVFHL CKIMVDTLLK
310 320 330 340 350
VSNAKERSME NFINEVDSAW NKDSSMDSCF SYQNKIDLFW EQWSVNTETV
360
PAKFQLKNFE KPCLIQDGK
Length:369
Mass (Da):42,823
Last modified:October 1, 1996 - v1
Checksum:i9F34E38FDD3C5892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72837 Genomic DNA Translation: CAA97052.1
BK006941 Genomic DNA Translation: DAA08148.1
PIRiS64346
RefSeqiNP_011566.1, NM_001181181.1

Genome annotation databases

EnsemblFungiiYGR052W; YGR052W; YGR052W
GeneIDi852943
KEGGisce:YGR052W

Similar proteinsi

Entry informationi

Entry nameiFMP48_YEAST
AccessioniPrimary (citable) accession number: P53233
Secondary accession number(s): D6VUI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome