Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P53233

- FMP48_YEAST

UniProt

P53233 - FMP48_YEAST

Protein

Probable serine/threonine-protein kinase FMP48

Gene

FMP48

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311ATPPROSITE-ProRule annotation
    Active sitei133 – 1331Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein kinase activity Source: SGD
    4. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein phosphorylation Source: SGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30769-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable serine/threonine-protein kinase FMP48 (EC:2.7.11.1)
    Alternative name(s):
    Found in mitochondrial proteome protein 48
    Gene namesi
    Name:FMP48
    Ordered Locus Names:YGR052W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR052w.
    SGDiS000003284. FMP48.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Probable serine/threonine-protein kinase FMP48PRO_0000086113Add
    BLAST

    Proteomic databases

    PaxDbiP53233.

    Expressioni

    Inductioni

    By treatment with 8-methoxypsoralen and UVA irradiation.1 Publication

    Gene expression databases

    GenevestigatoriP53233.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC14Q006842EBI-9664,EBI-4192
    HIS4P008152EBI-9664,EBI-8334
    TOR1P351693EBI-9664,EBI-19374

    Protein-protein interaction databases

    BioGridi33297. 68 interactions.
    DIPiDIP-5516N.
    IntActiP53233. 31 interactions.
    MINTiMINT-545426.
    STRINGi4932.YGR052W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53233.
    SMRiP53233. Positions 1-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 369368Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00390000011998.
    KOiK08286.
    OMAiADWGHAI.
    OrthoDBiEOG72G1K9.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53233-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYTKLRSIQS GTFSTVYKAW STTHNRYVAL KITPKYKTSE ANMKNEYDVM    50
    KILSSCNPHP NICSMLDFYT DDSYYIMVLE YCECGDLYDF LDIAKSQGSP 100
    SSPSLIQIDM QKIIKQLCSA ISFAHSLGIA HRDIKPENIL LTINGDIKLA 150
    DWGHAIQSPK SNDFQIGTDN YRAPETFSGR VSNSCFKKNF DRSSAPLYNT 200
    YQADYWSLGA TIFYLMFGDC LFRVSKSKKV QHLKNFDEFE KDPFAFIYRK 250
    YVVPRLSCGY NDEEDLHVSL QHTRQYIWQD LPDIYDVFHL CKIMVDTLLK 300
    VSNAKERSME NFINEVDSAW NKDSSMDSCF SYQNKIDLFW EQWSVNTETV 350
    PAKFQLKNFE KPCLIQDGK 369
    Length:369
    Mass (Da):42,823
    Last modified:October 1, 1996 - v1
    Checksum:i9F34E38FDD3C5892
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72837 Genomic DNA. Translation: CAA97052.1.
    BK006941 Genomic DNA. Translation: DAA08148.1.
    PIRiS64346.
    RefSeqiNP_011566.1. NM_001181181.1.

    Genome annotation databases

    EnsemblFungiiYGR052W; YGR052W; YGR052W.
    GeneIDi852943.
    KEGGisce:YGR052W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72837 Genomic DNA. Translation: CAA97052.1 .
    BK006941 Genomic DNA. Translation: DAA08148.1 .
    PIRi S64346.
    RefSeqi NP_011566.1. NM_001181181.1.

    3D structure databases

    ProteinModelPortali P53233.
    SMRi P53233. Positions 1-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33297. 68 interactions.
    DIPi DIP-5516N.
    IntActi P53233. 31 interactions.
    MINTi MINT-545426.
    STRINGi 4932.YGR052W.

    Proteomic databases

    PaxDbi P53233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR052W ; YGR052W ; YGR052W .
    GeneIDi 852943.
    KEGGi sce:YGR052W.

    Organism-specific databases

    CYGDi YGR052w.
    SGDi S000003284. FMP48.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00390000011998.
    KOi K08286.
    OMAi ADWGHAI.
    OrthoDBi EOG72G1K9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30769-MONOMER.

    Miscellaneous databases

    NextBioi 972684.

    Gene expression databases

    Genevestigatori P53233.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    5. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
      Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
      J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. "Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast."
      Dardalhon M., Lin W., Nicolas A., Averbeck D.
      FEMS Yeast Res. 7:866-878(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiFMP48_YEAST
    AccessioniPrimary (citable) accession number: P53233
    Secondary accession number(s): D6VUI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 339 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3