P53233 (FMP48_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine/threonine-protein kinase FMP48
EC=2.7.11.1

Alternative name(s):
Found in mitochondrial proteome protein 48

Gene names

Name:	FMP48
Ordered Locus Names:	YGR052W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Mitochondrion Ref.4 Ref.5.
Induction	By treatment with 8-methoxypsoralen and UVA irradiation. Ref.6
Miscellaneous	Present with 339 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from direct assay Ref.4Ref.5. Source: SGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase activity Inferred from direct assay PubMed 16319894. Source: SGD protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC14	Q00684	2	EBI-9664,EBI-4192
HIS4	P00815	4	EBI-9664,EBI-8334
TOR1	P35169	3	EBI-9664,EBI-19374

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Probable serine/threonine-protein kinase FMP48		PRO_0000086113
Regions
	Domain	2 – 369	368	Protein kinase
	Nucleotide binding	8 – 16	9	ATP By similarity
Sites
	Active site	133	1	Proton acceptor By similarity
	Binding site	31	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P53233 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 9F34E38FDD3C5892	FASTA	369	42,823
	10 20 30 40 50 60 MYTKLRSIQS GTFSTVYKAW STTHNRYVAL KITPKYKTSE ANMKNEYDVM KILSSCNPHP 70 80 90 100 110 120 NICSMLDFYT DDSYYIMVLE YCECGDLYDF LDIAKSQGSP SSPSLIQIDM QKIIKQLCSA 130 140 150 160 170 180 ISFAHSLGIA HRDIKPENIL LTINGDIKLA DWGHAIQSPK SNDFQIGTDN YRAPETFSGR 190 200 210 220 230 240 VSNSCFKKNF DRSSAPLYNT YQADYWSLGA TIFYLMFGDC LFRVSKSKKV QHLKNFDEFE 250 260 270 280 290 300 KDPFAFIYRK YVVPRLSCGY NDEEDLHVSL QHTRQYIWQD LPDIYDVFHL CKIMVDTLLK 310 320 330 340 350 360 VSNAKERSME NFINEVDSAW NKDSSMDSCF SYQNKIDLFW EQWSVNTETV PAKFQLKNFE KPCLIQDGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
[5]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast." Dardalhon M., Lin W., Nicolas A., Averbeck D. FEMS Yeast Res. 7:866-878(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z72837 Genomic DNA. Translation: CAA97052.1. BK006941 Genomic DNA. Translation: DAA08148.1.
PIR	S64346.
RefSeq	NP_011566.1. NM_001181181.1.
3D structure databases
ProteinModelPortal	P53233.
SMR	P53233. Positions 1-313.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5516N.
IntAct	P53233. 33 interactions.
MINT	MINT-545426.
STRING	4932.YGR052W.
Proteomic databases
PaxDb	P53233.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR052W; YGR052W; YGR052W.
GeneID	852943.
KEGG	sce:YGR052W.
Organism-specific databases
CYGD	YGR052w.
SGD	S000003284. FMP48.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00390000011998.
KO	K08286.
OMA	ADWGHAI.
OrthoDB	EOG4WWVV0.
Gene expression databases
ArrayExpress	P53233.
Genevestigator	P53233.
GermOnline	YGR052W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	972684.

Entry information

Entry name

FMP48_YEAST

Accession

Primary (citable) accession number: P53233
Secondary accession number(s): D6VUI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program