P53230 (TAM41_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial translocator assembly and maintenance protein 41

Alternative name(s):
Mitochondrial import protein MMP37
Mitochondrial matrix protein of 37 kDa

Gene names

Name:	TAM41
Synonyms:	MMP37
Ordered Locus Names:	YGR046W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mitochondrial matrix protein involved in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required for the assembly and stability of the TIM23 complex. May enhance the early stages of the TIM23 matrix import pathway to ensure engagement of incoming preproteins with the PAM complex. Ref.6
Subunit structure	Does not act as a component of the TIM23 complex.
Subcellular location	Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein Ref.4 Ref.6.
Miscellaneous	Present with 195 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the MMP37/TAM41 family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cardiolipin biosynthetic process Inferred from mutant phenotype. Source: SGD protein import into mitochondrial matrix Inferred from mutant phenotype Ref.6. Source: SGD
Cellular component	extrinsic to mitochondrial inner membrane Inferred from direct assay Ref.6. Source: SGD mitochondrial matrix Inferred from direct assay Ref.6. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSP60	P19882	1	EBI-23156,EBI-8586

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 34	34	Mitochondrion Potential
	Chain	35 – 385	351	Mitochondrial translocator assembly and maintenance protein 41		PRO_0000202796
Natural variations
	Natural variant	8	1	G → S in strain: SK1. Ref.1
	Natural variant	127	1	V → A in strain: SK1. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P53230 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: A0E9DDCB1F8E8043	FASTA	385	44,200
	10 20 30 40 50 60 MLRVSENGLR FLLKCHSTNV SMFNRLLSTQ IKEGRSSIDD AGIIPDGTIN ERPNHYIEGI 70 80 90 100 110 120 TKGSDLDLLE KGIRKTDEMT SNFTNYMYKF HRLPPNYGSN QLITIDKELQ KELDGVMSSF 130 140 150 160 170 180 KAPCRFVFGY GSGVFEQAGY SKSHSKPQID IILGVTYPSH FHSINMRQNP QHYSSLKYFG 190 200 210 220 230 240 SEFVSKFQQI GAGVYFNPFA NINGHDVKYG VVSMETLLKD IATWNTFYLA GRLQKPVKIL 250 260 270 280 290 300 KNDLRVQYWN QLNLKAAATL AKHYTLEKNN NKFDEFQFYK EITALSYAGD IRYKLGGENP 310 320 330 340 350 360 DKVNNIVTKN FERFQEYYKP IYKEVVLNDS FYLPKGFTLK NTQRLLLSRI SKSSALQTIK 370 380 GVFTAGITKS IKYAWAKKLK SMRRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Quantitative trait loci mapped to single-nucleotide resolution in yeast." Deutschbauer A.M., Davis R.W. Nat. Genet. 37:1333-1340(2005) [PubMed: 16273108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-8 AND ALA-127. Strain: SK1.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import." Gallas M.R., Dienhart M.K., Stuart R.A., Long R.M. Mol. Biol. Cell 17:4051-4062(2006) [PubMed: 16790493] [Abstract] Cited for: FUNCTION, LACK OF INTERACTION WITH THE TIM23 COMPLEX, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ115391 Genomic DNA. Translation: AAZ22461.1. Z72831 Genomic DNA. Translation: CAA97045.1. BK006941 Genomic DNA. Translation: DAA08144.1.
PIR	S64340.
RefSeq	NP_011560.1. NM_001181175.1.
3D structure databases
ProteinModelPortal	P53230.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1622N.
IntAct	P53230. 26 interactions.
MINT	MINT-402930.
STRING	P53230.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGR046W; YGR046W; YGR046W.
GeneID	852937.
KEGG	sce:YGR046W.
NMPDR	fig|4932.3.peg.2676.
Organism-specific databases
CYGD	YGR046w.
SGD	S000003278. TAM41.
Phylogenomic databases
eggNOG	fuNOG06617.
GeneTree	EFGT00050000000815.
HOGENOM	HBG204349.
OMA	FTEFELY.
OrthoDB	EOG4PCF2M.
Gene expression databases
ArrayExpress	P53230.
Genevestigator	P53230.
GermOnline	YGR046W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR015222. Mmp37. [Graphical view]
PANTHER	PTHR13619. Mmp37. 1 hit.
Pfam	PF09139. Mmp37. 2 hits. [Graphical view]
PIRSF	PIRSF028840. Mmp37. 1 hit.
ProtoNet	Search...
Other
NextBio	972672.

Entry information

Entry name

TAM41_YEAST

Accession

Primary (citable) accession number: P53230
Secondary accession number(s): D6VUI3, Q45U38

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program