UniProtKB - P53221 (RL26B_YEAST)
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Protein
60S ribosomal protein L26-B
Gene
RPL26B
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication
Miscellaneous
Present with 33200 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uL24 in yeast.Curated
GO - Molecular functioni
- RNA binding Source: SGD
- structural constituent of ribosome Source: SGD
GO - Biological processi
- cytoplasmic translation Source: SGD
- ribosomal large subunit biogenesis Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
BioCyci | YEAST:G3O-30756-MONOMER. |
Reactomei | R-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression. R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane. R-SCE-72689. Formation of a pool of free 40S subunits. R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit. R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC). R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC). |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L26-B1 PublicationAlternative name(s): L33 Large ribosomal subunit protein uL24-B1 Publication YL33 |
Gene namesi | Ordered Locus Names:YGR034W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YGR034W. |
SGDi | S000003266. RPL26B. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000130802 | 2 – 127 | 60S ribosomal protein L26-BAdd BLAST | 126 |
Proteomic databases
MaxQBi | P53221. |
PaxDbi | P53221. |
PRIDEi | P53221. |
TopDownProteomicsi | P53221. |
PTM databases
iPTMneti | P53221. |
Interactioni
Subunit structurei
Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication
Protein-protein interaction databases
BioGridi | 33279. 134 interactors. |
DIPi | DIP-5757N. |
IntActi | P53221. 9 interactors. |
MINTi | P53221. |
STRINGi | 4932.YGR034W. |
Structurei
3D structure databases
ProteinModelPortali | P53221. |
SMRi | P53221. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL24 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000014165. |
HOGENOMi | HOG000216571. |
InParanoidi | P53221. |
KOi | K02898. |
OMAi | VRIMRGD. |
OrthoDBi | EOG092C5U93. |
Family and domain databases
Gene3Di | 2.30.30.30. 1 hit. |
InterProi | View protein in InterPro IPR005824. KOW. IPR014722. Rib_L2_dom2. IPR005825. Ribosomal_L24/26_CS. IPR005756. Ribosomal_L26/L24P_euk/arc. IPR008991. Translation_prot_SH3-like_sf. |
PANTHERi | PTHR11143. PTHR11143. 1 hit. |
Pfami | View protein in Pfam PF00467. KOW. 1 hit. PF16906. Ribosomal_L26. 1 hit. |
SUPFAMi | SSF50104. SSF50104. 1 hit. |
TIGRFAMsi | TIGR01080. rplX_A_E. 1 hit. |
PROSITEi | View protein in PROSITE PS01108. RIBOSOMAL_L24. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P53221-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKQSLDVSS DRRKARKAYF TAPSSERRVL LSAPLSKELR AQYGIKALPI
60 70 80 90 100
RRDDEVLVVR GSKKGQEGKI SSVYRLKFAV QVDKVTKEKV NGASVPINLH
110 120
PSKLVITKLH LDKDRKALIQ RKGGKLE
Sequence cautioni
The sequence AAZ22449 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA97022 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ115390 Genomic DNA. Translation: AAZ22449.1. Sequence problems. Z72819 Genomic DNA. Translation: CAA97022.1. Sequence problems. DQ881451 mRNA. Translation: ABI95878.1. BK006941 Genomic DNA. Translation: DAA08131.1. |
PIRi | S64325. |
RefSeqi | NP_011548.2. NM_001181163.1. |
Genome annotation databases
EnsemblFungii | YGR034W; YGR034W; YGR034W. |
GeneIDi | 852922. |
KEGGi | sce:YGR034W. |
Similar proteinsi
Entry informationi
Entry namei | RL26B_YEAST | |
Accessioni | P53221Primary (citable) accession number: P53221 Secondary accession number(s): D6VUH0, Q06HN2, Q45U50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 23, 2007 | |
Last modified: | March 28, 2018 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |