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Protein

U1 small nuclear ribonucleoprotein component SNU71

Gene

SNU71

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.1 Publication

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • RNA binding Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein component SNU71
Gene namesi
Name:SNU71
Ordered Locus Names:YGR013W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR013W.
SGDiS000003245. SNU71.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • U1 snRNP Source: SGD
  • U2-type prespliceosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002027811 – 620U1 small nuclear ribonucleoprotein component SNU71Add BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei512PhosphoserineCombined sources1
Modified residuei514PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53207.
PRIDEiP53207.

PTM databases

iPTMnetiP53207.

Interactioni

Subunit structurei

Component of the 18S U1 snRNP particle, a subcomplex of the spliceosome.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRP40P332035EBI-736,EBI-701

Protein-protein interaction databases

BioGridi33256. 45 interactors.
DIPiDIP-5507N.
IntActiP53207. 24 interactors.
MINTiMINT-480691.

Structurei

3D structure databases

ProteinModelPortaliP53207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili296 – 385Sequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the SNU71 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000154360.
InParanoidiP53207.
OMAiEQQLHTV.
OrthoDBiEOG092C4L8W.

Family and domain databases

Gene3Di1.20.1390.10. 1 hit.
InterProiIPR002483. PWI_dom.
[Graphical view]
SMARTiSM00311. PWI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDIVFVSPQ LYLSSQEGWK SDSAKSGFIP ILKNDLQRFQ DSLKHIVDAR
60 70 80 90 100
NSLSETLLNS NDDGSIHNSD QNTGLNKDKE ASIADNNSAN KCATSSSRYQ
110 120 130 140 150
ELKQFLPISL DQQIHTVSLQ GVSSSFSRGQ IESLLDHCLN LALTETQSNS
160 170 180 190 200
ALKVEAWSSF SSFLDTQDIF IRFSKVDEDE AFVNTLNYCK ALFAFIRKLH
210 220 230 240 250
EDFKIELHLD LNTKEYVEDR TGTIPSVKPE KASEFYSVFK NIEDQTDERN
260 270 280 290 300
SKKEQLDDSS TQYKVDTNTL SDLPSDALDQ LCKDIIEFRT KVVSIEKEKK
310 320 330 340 350
MKSTYEESRR QRHQMQKVFD QIRKNHSGAK GSANTEEEDT NMEDEDEEDD
360 370 380 390 400
TEDDLALEKR KEERDLEESN RRYEDMLHQL HSNTEPKIKS IRADIMSAEN
410 420 430 440 450
YEEHLEKNRS LYLKELLHLA NDVHYDHHRS FKEQEERRDE EDRAKNGNAK
460 470 480 490 500
ELAPIQLSDG KAISAGKAAA ITLPEGTVKS ENYNADKNVS ESSEHVKIKF
510 520 530 540 550
DFKKAIDHSV ESSSEDEGYR ESELPPTKPS ERSAAEDRLP FTADELNIRL
560 570 580 590 600
TNLKESRYVD ELVREFLGVY EDELVEYILE NIRVNQSKQA LLNELRETFD
610 620
EDGETIADRL WSRKEFRLGT
Length:620
Mass (Da):71,383
Last modified:October 1, 1996 - v1
Checksum:i2659AAA62C4993D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72798 Genomic DNA. Translation: CAA96996.1.
BK006941 Genomic DNA. Translation: DAA08110.1.
PIRiS64304.
RefSeqiNP_011527.1. NM_001181142.1.

Genome annotation databases

EnsemblFungiiYGR013W; YGR013W; YGR013W.
GeneIDi852896.
KEGGisce:YGR013W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72798 Genomic DNA. Translation: CAA96996.1.
BK006941 Genomic DNA. Translation: DAA08110.1.
PIRiS64304.
RefSeqiNP_011527.1. NM_001181142.1.

3D structure databases

ProteinModelPortaliP53207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33256. 45 interactors.
DIPiDIP-5507N.
IntActiP53207. 24 interactors.
MINTiMINT-480691.

PTM databases

iPTMnetiP53207.

Proteomic databases

MaxQBiP53207.
PRIDEiP53207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR013W; YGR013W; YGR013W.
GeneIDi852896.
KEGGisce:YGR013W.

Organism-specific databases

EuPathDBiFungiDB:YGR013W.
SGDiS000003245. SNU71.

Phylogenomic databases

HOGENOMiHOG000154360.
InParanoidiP53207.
OMAiEQQLHTV.
OrthoDBiEOG092C4L8W.

Enzyme and pathway databases

BioCyciYEAST:G3O-30740-MONOMER.

Miscellaneous databases

PROiP53207.

Family and domain databases

Gene3Di1.20.1390.10. 1 hit.
InterProiIPR002483. PWI_dom.
[Graphical view]
SMARTiSM00311. PWI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNU71_YEAST
AccessioniPrimary (citable) accession number: P53207
Secondary accession number(s): D6VUE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 782 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.