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Protein

Peroxisomal membrane protein PEX31

Gene

PEX31

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • peroxisome organization Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30735-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX31
Alternative name(s):
Peroxin-31
Gene namesi
Name:PEX31
Ordered Locus Names:YGR004W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VII

Organism-specific databases

CYGDiYGR004w.
EuPathDBiFungiDB:YGR004W.
SGDiS000003236. PEX31.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Topological domaini112 – 17564PeroxisomalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 462266CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Peroxisomal membrane protein PEX31PRO_0000202779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei432 – 4321Phosphoserine3 Publications
Modified residuei435 – 4351Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53203.
PaxDbiP53203.
PRIDEiP53203.

Expressioni

Gene expression databases

GenevestigatoriP53203.

Interactioni

Protein-protein interaction databases

BioGridi33248. 44 interactions.
DIPiDIP-5455N.
IntActiP53203. 3 interactions.
MINTiMINT-480826.
STRINGi4932.YGR004W.

Structurei

3D structure databases

ProteinModelPortaliP53203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEX28-32 family. PEX30/31 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72309.
GeneTreeiENSGT00390000017777.
HOGENOMiHOG000180096.
InParanoidiP53203.
OMAiRWIRTAT.
OrthoDBiEOG72VHGD.

Family and domain databases

InterProiIPR010482. Peroxin/Dysferlin.
IPR006614. Peroxin/Ferlin.
[Graphical view]
PfamiPF06398. Pex24p. 1 hit.
[Graphical view]
SMARTiSM00694. DysFC. 1 hit.
SM00693. DysFN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEINNENLE PTSSTVAEST ESKNKHIRSA LRKRRGKLSA QTYEEDQEAI
60 70 80 90 100
LSSPLLTSTP KTVSRSLVRL YPYLIVVDNF LSIITWSNDN VSANLLGIFL
110 120 130 140 150
FTVCVLYFGF ITRYFGHLMI VGIIWVYLLI DKHVQETMAS CPSLDDIIHV
160 170 180 190 200
MDRVSMKSSA VLSPITILSA QDVRRLLFTI AFLSPVYIFL TVFVLSPNYL
210 220 230 240 250
MLIGGLYVLT YHSKLIRRMR RYLWKFRVVR LLVFFITGLD LGGPDNNRRL
260 270 280 290 300
FASVNKKIRS FVWNEVGNTS NTKKTVLFKV ALFENQRRWL GIGWTSTMLS
310 320 330 340 350
YERASWTDEF LNTSPSPEVF TLPEEQSGMA WEWHDKDWML DLTNDGIIQL
360 370 380 390 400
PASAAKTKVK PGADEGFIYY DNTWNNPSAT DTYKKYTRRR RWIRTATVTT
410 420 430 440 450
TYDDEPTVEK ATPNSHALKS EENNRVRKRK VSFSTANEVH IIPSSDSSKL
460
IQISDVSMSP SL
Length:462
Mass (Da):52,943
Last modified:October 1, 1996 - v1
Checksum:i3F875D40748AB6C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72789 Genomic DNA. Translation: CAA96987.1.
BK006941 Genomic DNA. Translation: DAA08102.1.
PIRiS64293.
RefSeqiNP_011518.1. NM_001181133.1.

Genome annotation databases

EnsemblFungiiYGR004W; YGR004W; YGR004W.
GeneIDi852887.
KEGGisce:YGR004W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72789 Genomic DNA. Translation: CAA96987.1.
BK006941 Genomic DNA. Translation: DAA08102.1.
PIRiS64293.
RefSeqiNP_011518.1. NM_001181133.1.

3D structure databases

ProteinModelPortaliP53203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33248. 44 interactions.
DIPiDIP-5455N.
IntActiP53203. 3 interactions.
MINTiMINT-480826.
STRINGi4932.YGR004W.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiP53203.
PaxDbiP53203.
PRIDEiP53203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR004W; YGR004W; YGR004W.
GeneIDi852887.
KEGGisce:YGR004W.

Organism-specific databases

CYGDiYGR004w.
EuPathDBiFungiDB:YGR004W.
SGDiS000003236. PEX31.

Phylogenomic databases

eggNOGiNOG72309.
GeneTreeiENSGT00390000017777.
HOGENOMiHOG000180096.
InParanoidiP53203.
OMAiRWIRTAT.
OrthoDBiEOG72VHGD.

Enzyme and pathway databases

BioCyciYEAST:G3O-30735-MONOMER.

Miscellaneous databases

NextBioi972544.
PROiP53203.

Gene expression databases

GenevestigatoriP53203.

Family and domain databases

InterProiIPR010482. Peroxin/Dysferlin.
IPR006614. Peroxin/Ferlin.
[Graphical view]
PfamiPF06398. Pex24p. 1 hit.
[Graphical view]
SMARTiSM00694. DysFC. 1 hit.
SM00693. DysFN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432 AND THR-435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX31_YEAST
AccessioniPrimary (citable) accession number: P53203
Secondary accession number(s): D6VUE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 29, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.