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P53203

- PEX31_YEAST

UniProt

P53203 - PEX31_YEAST

Protein

Peroxisomal membrane protein PEX31

Gene

PEX31

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. peroxisome organization Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30735-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PEX31
    Alternative name(s):
    Peroxin-31
    Gene namesi
    Name:PEX31
    Ordered Locus Names:YGR004W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR004w.
    SGDiS000003236. PEX31.

    Subcellular locationi

    Peroxisome membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Peroxisomal membrane protein PEX31PRO_0000202779Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei432 – 4321Phosphoserine3 Publications
    Modified residuei435 – 4351Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53203.
    PaxDbiP53203.
    PRIDEiP53203.

    Expressioni

    Gene expression databases

    GenevestigatoriP53203.

    Interactioni

    Protein-protein interaction databases

    BioGridi33248. 43 interactions.
    DIPiDIP-5455N.
    IntActiP53203. 3 interactions.
    MINTiMINT-480826.
    STRINGi4932.YGR004W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53203.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini112 – 17564PeroxisomalSequence AnalysisAdd
    BLAST
    Topological domaini197 – 462266CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEX28-32 family. PEX30/31 subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72309.
    GeneTreeiENSGT00390000017777.
    HOGENOMiHOG000180096.
    OMAiTANEVHI.
    OrthoDBiEOG72VHGD.

    Family and domain databases

    InterProiIPR010482. Peroxin/Dysferlin.
    IPR006614. Peroxin/Ferlin.
    [Graphical view]
    PfamiPF06398. Pex24p. 1 hit.
    [Graphical view]
    SMARTiSM00694. DysFC. 1 hit.
    SM00693. DysFN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53203-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEINNENLE PTSSTVAEST ESKNKHIRSA LRKRRGKLSA QTYEEDQEAI    50
    LSSPLLTSTP KTVSRSLVRL YPYLIVVDNF LSIITWSNDN VSANLLGIFL 100
    FTVCVLYFGF ITRYFGHLMI VGIIWVYLLI DKHVQETMAS CPSLDDIIHV 150
    MDRVSMKSSA VLSPITILSA QDVRRLLFTI AFLSPVYIFL TVFVLSPNYL 200
    MLIGGLYVLT YHSKLIRRMR RYLWKFRVVR LLVFFITGLD LGGPDNNRRL 250
    FASVNKKIRS FVWNEVGNTS NTKKTVLFKV ALFENQRRWL GIGWTSTMLS 300
    YERASWTDEF LNTSPSPEVF TLPEEQSGMA WEWHDKDWML DLTNDGIIQL 350
    PASAAKTKVK PGADEGFIYY DNTWNNPSAT DTYKKYTRRR RWIRTATVTT 400
    TYDDEPTVEK ATPNSHALKS EENNRVRKRK VSFSTANEVH IIPSSDSSKL 450
    IQISDVSMSP SL 462
    Length:462
    Mass (Da):52,943
    Last modified:October 1, 1996 - v1
    Checksum:i3F875D40748AB6C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72789 Genomic DNA. Translation: CAA96987.1.
    BK006941 Genomic DNA. Translation: DAA08102.1.
    PIRiS64293.
    RefSeqiNP_011518.1. NM_001181133.1.

    Genome annotation databases

    EnsemblFungiiYGR004W; YGR004W; YGR004W.
    GeneIDi852887.
    KEGGisce:YGR004W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72789 Genomic DNA. Translation: CAA96987.1 .
    BK006941 Genomic DNA. Translation: DAA08102.1 .
    PIRi S64293.
    RefSeqi NP_011518.1. NM_001181133.1.

    3D structure databases

    ProteinModelPortali P53203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33248. 43 interactions.
    DIPi DIP-5455N.
    IntActi P53203. 3 interactions.
    MINTi MINT-480826.
    STRINGi 4932.YGR004W.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi P53203.
    PaxDbi P53203.
    PRIDEi P53203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR004W ; YGR004W ; YGR004W .
    GeneIDi 852887.
    KEGGi sce:YGR004W.

    Organism-specific databases

    CYGDi YGR004w.
    SGDi S000003236. PEX31.

    Phylogenomic databases

    eggNOGi NOG72309.
    GeneTreei ENSGT00390000017777.
    HOGENOMi HOG000180096.
    OMAi TANEVHI.
    OrthoDBi EOG72VHGD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30735-MONOMER.

    Miscellaneous databases

    NextBioi 972544.

    Gene expression databases

    Genevestigatori P53203.

    Family and domain databases

    InterProi IPR010482. Peroxin/Dysferlin.
    IPR006614. Peroxin/Ferlin.
    [Graphical view ]
    Pfami PF06398. Pex24p. 1 hit.
    [Graphical view ]
    SMARTi SM00694. DysFC. 1 hit.
    SM00693. DysFN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432 AND THR-435, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPEX31_YEAST
    AccessioniPrimary (citable) accession number: P53203
    Secondary accession number(s): D6VUE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 238 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3