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Protein

SWR1-complex protein 4

Gene

SWC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.3 Publications

Miscellaneous

Present with 2230 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chromatin organization Source: SGD
  • chromatin remodeling Source: SGD
  • chromosome organization Source: SGD
  • DNA repair Source: SGD
  • histone exchange Source: SGD
  • histone H2A acetylation Source: GO_Central
  • histone H4 acetylation Source: GO_Central
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SWR1-complex protein 4
Alternative name(s):
ESA1-associated factor 2
Gene namesi
Name:SWC4
Synonyms:EAF2, GOD1
Ordered Locus Names:YGR002C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR002C.
SGDiS000003234. SWC4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000723452 – 476SWR1-complex protein 4Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53201.
PRIDEiP53201.

PTM databases

iPTMnetiP53201.

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1. Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Interacts with YAF9.6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33246. 635 interactors.
DIPiDIP-6510N.
IntActiP53201. 35 interactors.
MINTiMINT-675383.
STRINGi4932.YGR002C.

Structurei

3D structure databases

ProteinModelPortaliP53201.
SMRiP53201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 209SANTAdd BLAST54

Sequence similaritiesi

Belongs to the SWC4 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000016466.
HOGENOMiHOG000246708.
InParanoidiP53201.
KOiK11324.
OMAiYNRLDYP.
OrthoDBiEOG092C2QC9.

Family and domain databases

InterProiView protein in InterPro
IPR032563. DAMP1_SANT-like.
IPR009057. Homeobox-like_sf.
IPR001005. SANT/Myb.
IPR027109. Swc4/Dmap1.
PANTHERiPTHR12855. PTHR12855. 1 hit.
PfamiView protein in Pfam
PF16282. SANT_DAMP1_like. 1 hit.
SMARTiView protein in SMART
SM00717. SANT. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSDIFDVL NIKQKSRSPT NGQVSVPSSS AANRPKPQVT GMQRELFNLL
60 70 80 90 100
GENQPPVVIK SGNNFKEKML STSKPSPWSF VEFKANNSVT LRHWVKGSKE
110 120 130 140 150
LIGDTPKESP YSKFNQHLSI PSFTKEEYEA FMNENEGTQK SVESEKNHNE
160 170 180 190 200
NFTNEKKDES KNSWSFEEIE YLFNLCKKYD LRWFLIFDRY SYNNSRTLED
210 220 230 240 250
LKEKFYYTCR NYFKASDPSN PLLSSLNFSA EKEIERKKYL QRLLSRSAAE
260 270 280 290 300
IAEEEALVVE SKKFEMAAKR TLAERESLLR LLDSPHSDQT ITQYLTSQGM
310 320 330 340 350
SQLYNALLAD KTRKRKHDLN IPENPWMKQQ QQFAQHRQLQ QLNVKKSEVK
360 370 380 390 400
ENLSPKKTKR QRQEMQTALK RKSESAYAEQ LLKDFNSDER KALGVITHGE
410 420 430 440 450
KLSPGVYLRS TKLSTFKPAL QNKILAILQE LSLPSRPVMP SFDVMERQEE
460 470
LLKKINTLID LKKHVDKYEA GMSITK
Length:476
Mass (Da):55,213
Last modified:October 1, 1996 - v1
Checksum:i512CB8DF3171E7A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72787 Genomic DNA. Translation: CAA96985.1.
AY692656 Genomic DNA. Translation: AAT92675.1.
BK006941 Genomic DNA. Translation: DAA08100.1.
PIRiS64291.
RefSeqiNP_011516.1. NM_001181131.1.

Genome annotation databases

EnsemblFungiiYGR002C; YGR002C; YGR002C.
GeneIDi852885.
KEGGisce:YGR002C.

Similar proteinsi

Entry informationi

Entry nameiSWC4_YEAST
AccessioniPrimary (citable) accession number: P53201
Secondary accession number(s): D6VUD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names