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Protein

SWR1-complex protein 4

Gene

SWC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.3 Publications

Miscellaneous

Present with 2230 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chromatin organization Source: SGD
  • chromatin remodeling Source: SGD
  • chromosome organization Source: SGD
  • DNA repair Source: SGD
  • histone exchange Source: SGD
  • histone H2A acetylation Source: GO_Central
  • histone H4 acetylation Source: GO_Central
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30733-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
SWR1-complex protein 4
Alternative name(s):
ESA1-associated factor 2
Gene namesi
Name:SWC4
Synonyms:EAF2, GOD1
Ordered Locus Names:YGR002C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YGR002C
SGDiS000003234 SWC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000723452 – 476SWR1-complex protein 4Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53201
PaxDbiP53201
PRIDEiP53201

PTM databases

iPTMnetiP53201

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1. Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Interacts with YAF9. Interacts with EAF1.7 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33246, 638 interactors
DIPiDIP-6510N
IntActiP53201, 35 interactors
MINTiP53201
STRINGi4932.YGR002C

Structurei

3D structure databases

ProteinModelPortaliP53201
SMRiP53201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 209SANTAdd BLAST54

Sequence similaritiesi

Belongs to the SWC4 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000016466
HOGENOMiHOG000246708
InParanoidiP53201
KOiK11324
OMAiYNRLDYP
OrthoDBiEOG092C2QC9

Family and domain databases

InterProiView protein in InterPro
IPR032563 DAMP1_SANT-like
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR027109 Swc4/Dmap1
PANTHERiPTHR12855 PTHR12855, 1 hit
PfamiView protein in Pfam
PF16282 SANT_DAMP1_like, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSDIFDVL NIKQKSRSPT NGQVSVPSSS AANRPKPQVT GMQRELFNLL
60 70 80 90 100
GENQPPVVIK SGNNFKEKML STSKPSPWSF VEFKANNSVT LRHWVKGSKE
110 120 130 140 150
LIGDTPKESP YSKFNQHLSI PSFTKEEYEA FMNENEGTQK SVESEKNHNE
160 170 180 190 200
NFTNEKKDES KNSWSFEEIE YLFNLCKKYD LRWFLIFDRY SYNNSRTLED
210 220 230 240 250
LKEKFYYTCR NYFKASDPSN PLLSSLNFSA EKEIERKKYL QRLLSRSAAE
260 270 280 290 300
IAEEEALVVE SKKFEMAAKR TLAERESLLR LLDSPHSDQT ITQYLTSQGM
310 320 330 340 350
SQLYNALLAD KTRKRKHDLN IPENPWMKQQ QQFAQHRQLQ QLNVKKSEVK
360 370 380 390 400
ENLSPKKTKR QRQEMQTALK RKSESAYAEQ LLKDFNSDER KALGVITHGE
410 420 430 440 450
KLSPGVYLRS TKLSTFKPAL QNKILAILQE LSLPSRPVMP SFDVMERQEE
460 470
LLKKINTLID LKKHVDKYEA GMSITK
Length:476
Mass (Da):55,213
Last modified:October 1, 1996 - v1
Checksum:i512CB8DF3171E7A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72787 Genomic DNA Translation: CAA96985.1
AY692656 Genomic DNA Translation: AAT92675.1
BK006941 Genomic DNA Translation: DAA08100.1
PIRiS64291
RefSeqiNP_011516.1, NM_001181131.1

Genome annotation databases

EnsemblFungiiYGR002C; YGR002C; YGR002C
GeneIDi852885
KEGGisce:YGR002C

Entry informationi

Entry nameiSWC4_YEAST
AccessioniPrimary (citable) accession number: P53201
Secondary accession number(s): D6VUD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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