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Protein

Protein ERP6

Gene

ERP6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in vesicular protein trafficking.By similarity

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30526-MONOMER.
ReactomeiR-SCE-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ERP6
Gene namesi
Name:ERP6
Ordered Locus Names:YGL002W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL002W.
SGDiS000002970. ERP6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 183LumenalSequence analysisAdd BLAST164
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 216CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001041320 – 216Protein ERP6Add BLAST197

Proteomic databases

MaxQBiP53198.
PRIDEiP53198.

PTM databases

iPTMnetiP53198.

Interactioni

Protein-protein interaction databases

BioGridi33243. 46 interactors.
ELMiP53198.
IntActiP53198. 2 interactors.
STRINGi4932.YGL002W.

Structurei

3D structure databases

ProteinModelPortaliP53198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 130GOLDPROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00430000030848.
HOGENOMiHOG000160228.
InParanoidiP53198.
KOiK20346.
OMAiEHANNYP.
OrthoDBiEOG092C4DMK.

Family and domain databases

InterProiView protein in InterPro
IPR009038. GOLD_dom.
IPR015720. TMP21-related.
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiView protein in Pfam
PF01105. EMP24_GP25L. 1 hit.
SMARTiView protein in SMART
SM01190. EMP24_GP25L. 1 hit.
PROSITEiView protein in PROSITE
PS50866. GOLD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSHYIFLAF VLLPFRVSAF YFYGYGGDRK CFLKELSKDT LLKGSYNLEV
60 70 80 90 100
YDDKLADYAL PSYNDYGIVI DVEEVFDNNH RVVHQQGSPS GDFSFLALES
110 120 130 140 150
GEYKICLQSR VNNWVGKTKT KLEIEFEVGF EAMLDMQRKE TLESLHGKVS
160 170 180 190 200
ILNSKIVDIR REQQLMRERE ESFRDISESV NSRAMWWTVT QVTLLIIICV
210
WQMKSLRSFF VKQKVL
Length:216
Mass (Da):25,275
Last modified:October 1, 1996 - v1
Checksum:iB0204BCAA7E12782
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106C → W in AAT93094 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72524 Genomic DNA. Translation: CAA96702.1.
AY693075 Genomic DNA. Translation: AAT93094.1.
BK006941 Genomic DNA. Translation: DAA08097.1.
PIRiS64004.
RefSeqiNP_011513.1. NM_001180867.1.

Genome annotation databases

EnsemblFungiiYGL002W; YGL002W; YGL002W.
GeneIDi852882.
KEGGisce:YGL002W.

Similar proteinsi

Entry informationi

Entry nameiERP6_YEAST
AccessioniPrimary (citable) accession number: P53198
Secondary accession number(s): D6VUD6, E9P916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names