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P53195

- COG7_YEAST

UniProt

P53195 - COG7_YEAST

Protein

Conserved oligomeric Golgi complex subunit 7

Gene

COG7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. CVT pathway Source: SGD
    2. intra-Golgi vesicle-mediated transport Source: SGD

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30529-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Conserved oligomeric Golgi complex subunit 7
    Short name:
    COG complex subunit 7
    Alternative name(s):
    Complexed with DOR1 protein 5
    Component of oligomeric Golgi complex 7
    Gene namesi
    Name:COG7
    Synonyms:COD5
    Ordered Locus Names:YGL005C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL005c.
    SGDiS000002973. COG7.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. Golgi transport complex Source: SGD

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Conserved oligomeric Golgi complex subunit 7PRO_0000213520Add
    BLAST

    Proteomic databases

    MaxQBiP53195.
    PaxDbiP53195.

    Expressioni

    Gene expression databases

    GenevestigatoriP53195.

    Interactioni

    Subunit structurei

    Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COG2P532712EBI-4847,EBI-16614
    COG3P400942EBI-4847,EBI-16605
    COG4Q060962EBI-4847,EBI-4823
    COG5P539516EBI-4847,EBI-4841
    COG6P539593EBI-4847,EBI-4829
    COG8Q046322EBI-4847,EBI-6035

    Protein-protein interaction databases

    BioGridi33240. 184 interactions.
    DIPiDIP-4580N.
    IntActiP53195. 8 interactions.
    MINTiMINT-573650.
    STRINGi4932.YGL005C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45611.
    HOGENOMiHOG000111883.
    OMAiLVTHLDY.
    OrthoDBiEOG72RNB8.

    Sequencei

    Sequence statusi: Complete.

    P53195-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVELTITGDD DDILSMFFDE EFVPHAFVDI LLSNALNEDQ IQTQSVSSLL    50
    LTRLDFYTKN LTKELESTIW NLDKLSQTLP RTWASSRYHK EAEQNDSSLY 100
    STESLKSSKL EYYLDTLASA VRALETGMHN VTEKLSDLDN ENNRNTNVRQ 150
    QLQSLMLIKE RIEKVVYYLE QVRTVTNIST VRENNTTSTG TDLSITDFRT 200
    SLKALEDTID ESLSSAIDNE AKDETNKDLI GRIDSLSELK CLFKGLDKFF 250
    AEYSNFSESI KSKAQSYLST KNIDDGMIS 279
    Length:279
    Mass (Da):31,775
    Last modified:October 1, 1996 - v1
    Checksum:iA72B39889DC74625
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121D → G in AAT93150. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72527 Genomic DNA. Translation: CAA96705.1.
    AY693131 Genomic DNA. Translation: AAT93150.1.
    BK006941 Genomic DNA. Translation: DAA08094.1.
    PIRiS64007.
    RefSeqiNP_011510.1. NM_001180870.1.

    Genome annotation databases

    EnsemblFungiiYGL005C; YGL005C; YGL005C.
    GeneIDi852879.
    KEGGisce:YGL005C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72527 Genomic DNA. Translation: CAA96705.1 .
    AY693131 Genomic DNA. Translation: AAT93150.1 .
    BK006941 Genomic DNA. Translation: DAA08094.1 .
    PIRi S64007.
    RefSeqi NP_011510.1. NM_001180870.1.

    3D structure databases

    ProteinModelPortali P53195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33240. 184 interactions.
    DIPi DIP-4580N.
    IntActi P53195. 8 interactions.
    MINTi MINT-573650.
    STRINGi 4932.YGL005C.

    Proteomic databases

    MaxQBi P53195.
    PaxDbi P53195.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL005C ; YGL005C ; YGL005C .
    GeneIDi 852879.
    KEGGi sce:YGL005C.

    Organism-specific databases

    CYGDi YGL005c.
    SGDi S000002973. COG7.

    Phylogenomic databases

    eggNOGi NOG45611.
    HOGENOMi HOG000111883.
    OMAi LVTHLDY.
    OrthoDBi EOG72RNB8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30529-MONOMER.

    Miscellaneous databases

    NextBioi 972520.

    Gene expression databases

    Genevestigatori P53195.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic."
      Whyte J.R., Munro S.
      Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "The binary interacting network of the conserved oligomeric Golgi tethering complex."
      Loh E., Hong W.
      J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG4.

    Entry informationi

    Entry nameiCOG7_YEAST
    AccessioniPrimary (citable) accession number: P53195
    Secondary accession number(s): D6VUD3, E9P921
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1360 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3