P53195 (COG7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Conserved oligomeric Golgi complex subunit 7
Short name=COG complex subunit 7

Alternative name(s):
Complexed with DOR1 protein 5
Component of oligomeric Golgi complex 7

Gene names

Name:	COG7
Synonyms:	COD5
Ordered Locus Names:	YGL005C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
Subunit structure	Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8. Ref.4
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein By similarity.
Miscellaneous	Present with 1360 molecules/cell in log phase SD medium.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CVT pathway Inferred from mutant phenotype PubMed 20065092. Source: SGD intra-Golgi vesicle-mediated transport Inferred from genetic interaction Ref.4. Source: SGD
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell Golgi transport complex Inferred from physical interaction Ref.4. Source: SGD mitochondrion Inferred from direct assay PubMed 14576278PubMed 16823961. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COG2	P53271	2	EBI-4847,EBI-16614
COG3	P40094	2	EBI-4847,EBI-16605
COG4	Q06096	2	EBI-4847,EBI-4823
COG5	P53951	6	EBI-4847,EBI-4841
COG6	P53959	3	EBI-4847,EBI-4829
COG8	Q04632	2	EBI-4847,EBI-6035

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Conserved oligomeric Golgi complex subunit 7		PRO_0000213520
Amino acid modifications
	Modified residue	235	1	Phosphoserine Ref.7
Experimental info
	Sequence conflict	12	1	D → G in AAT93150. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P53195 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: A72B39889DC74625	FASTA	279	31,775
	10 20 30 40 50 60 MVELTITGDD DDILSMFFDE EFVPHAFVDI LLSNALNEDQ IQTQSVSSLL LTRLDFYTKN 70 80 90 100 110 120 LTKELESTIW NLDKLSQTLP RTWASSRYHK EAEQNDSSLY STESLKSSKL EYYLDTLASA 130 140 150 160 170 180 VRALETGMHN VTEKLSDLDN ENNRNTNVRQ QLQSLMLIKE RIEKVVYYLE QVRTVTNIST 190 200 210 220 230 240 VRENNTTSTG TDLSITDFRT SLKALEDTID ESLSSAIDNE AKDETNKDLI GRIDSLSELK 250 260 270 CLFKGLDKFF AEYSNFSESI KSKAQSYLST KNIDDGMIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic." Whyte J.R., Munro S. Dev. Cell 1:527-537(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"The binary interacting network of the conserved oligomeric Golgi tethering complex." Loh E., Hong W. J. Biol. Chem. 279:24640-24648(2004) [PubMed] [Europe PMC] [Abstract] Cited for: COMPOSITION OF THE COG COMPLEX, INTERACTION WITH COG4.
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z72527 Genomic DNA. Translation: CAA96705.1. AY693131 Genomic DNA. Translation: AAT93150.1. BK006941 Genomic DNA. Translation: DAA08094.1.
PIR	S64007.
RefSeq	NP_011510.1. NM_001180870.1.
3D structure databases
ProteinModelPortal	P53195.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4580N.
IntAct	P53195. 8 interactions.
MINT	MINT-573650.
STRING	4932.YGL005C.
Proteomic databases
PaxDb	P53195.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL005C; YGL005C; YGL005C.
GeneID	852879.
KEGG	sce:YGL005C.
Organism-specific databases
CYGD	YGL005c.
SGD	S000002973. COG7.
Phylogenomic databases
eggNOG	NOG45611.
HOGENOM	HOG000111883.
OMA	SSKLEYY.
OrthoDB	EOG40CMSG.
Enzyme and pathway databases
BioCyc	YEAST:G3O-30529-MONOMER.
Gene expression databases
Genevestigator	P53195.
GermOnline	YGL005C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	972520.

Entry information

Entry name

COG7_YEAST

Accession

Primary (citable) accession number: P53195
Secondary accession number(s): D6VUD3, E9P921

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program