P53188 (CGR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
rRNA-processing protein CGR1

Alternative name(s):
Coiled-coil growth-regulated protein 1

Gene names

Name:	CGR1
Ordered Locus Names:	YGL029W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Ref.4 Ref.5 Ref.9
Subcellular location	Nucleus › nucleolus Ref.4 Ref.6.
Induction	In response to cytotoxic stress but not genotoxic stress. Ref.8
Miscellaneous	Present with 2340 molecules/cell in log phase SD medium. Ref.7
Sequence similarities	Belongs to the CGR1 family.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Nucleus
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from direct assay Ref.5. Source: SGD
Cellular component	nucleolus Inferred from direct assay Ref.4. Source: SGD preribosome, large subunit precursor Inferred from direct assay. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EBP2	P36049	1	EBI-23731,EBI-6289
LOC1	P43586	1	EBI-23731,EBI-22906
RRS1	Q08746	1	EBI-23731,EBI-16026

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	rRNA-processing protein CGR1		PRO_0000202773
Regions
	Coiled coil	47 – 106	60	Potential

Sequences

	Sequence		Length	Mass (Da)
	P53188 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: E2750E786489E9CA	FASTA	120	14,417
	10 20 30 40 50 60 MVNETGESQK AAKGTPVSGK VWKAEKTPLR AKSRVVKNKK LTSWELKKQK RLEDKQFKER 70 80 90 100 110 120 LKALKDEKEE ARQAKITMLK ERREKKEENE RYERLAAKMH AKKVERMRRR EKRNKALKER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed: 9169869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Cgr1p, a novel nucleolar protein encoded by Saccharomyces cerevisiae orf YGL0292w." Sun J., McFarland M., Boettner D., Panepinto J., Rhodes J.C., Askew D.S. Curr. Microbiol. 42:65-69(2001) [PubMed: 11116400] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]	"Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis." Moy T.I., Boettner D., Rhodes J.C., Silver P.A., Askew D.S. Microbiology 148:1081-1090(2002) [PubMed: 11932453] [Abstract] Cited for: FUNCTION.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Differentiating mechanisms of toxicity using global gene expression analysis in Saccharomyces cerevisiae." Caba E., Dickinson D.A., Warnes G.R., Aubrecht J. Mutat. Res. 575:34-46(2005) [PubMed: 15878181] [Abstract] Cited for: INDUCTION.
[9]	"The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes." Wade C.H., Umbarger M.A., McAlear M.A. Yeast 23:293-306(2006) [PubMed: 16544271] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z72551 Genomic DNA. Translation: CAA96730.1. AY558480 Genomic DNA. Translation: AAS56806.1. BK006941 Genomic DNA. Translation: DAA08070.1.
PIR	S64031.
RefSeq	NP_011486.1. NM_001180894.1.
3D structure databases
ProteinModelPortal	P53188.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5450N.
IntAct	P53188. 40 interactions.
MINT	MINT-565178.
STRING	P53188.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL029W; YGL029W; YGL029W.
GeneID	852854.
KEGG	sce:YGL029W.
NMPDR	fig|4932.3.peg.2593.
Organism-specific databases
CYGD	YGL029w.
SGD	S000002997. CGR1.
Phylogenomic databases
eggNOG	fuNOG12737.
GeneTree	EFGT00050000003107.
HOGENOM	HBG395657.
OMA	KMHAKKV.
OrthoDB	EOG4NPBD8.
Gene expression databases
ArrayExpress	P53188.
Genevestigator	P53188.
GermOnline	YGL029W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005579. Cgr1. [Graphical view]
KO	K14822.
Pfam	PF03879. Cgr1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	972452.

Entry information

Entry name

CGR1_YEAST

Accession

Primary (citable) accession number: P53188
Secondary accession number(s): D6VUA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program