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Protein

pH-response regulator protein palF/RIM8

Gene

RIM8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH, which is necessary for sporulation and invasive growth.2 Publications

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • invasive growth in response to glucose limitation Source: SGD
  • meiotic cell cycle Source: SGD
  • protein processing Source: SGD
  • signal transduction Source: InterPro
  • ubiquitin-dependent endocytosis Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30556-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
pH-response regulator protein palF/RIM8
Alternative name(s):
Regulator of IME2 protein 8
Gene namesi
Name:RIM8
Synonyms:PAL3
Ordered Locus Names:YGL045W
ORF Names:YGL046W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL045W
SGDiS000003013 RIM8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581941 – 542pH-response regulator protein palF/RIM8Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki521Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP53179
PaxDbiP53179
PRIDEiP53179

PTM databases

iPTMnetiP53179

Expressioni

Inductioni

Expressed under acidic conditions and repressed by the processed, active form of RIM101 under alkaline conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33203, 468 interactors
DIPiDIP-5115N
MINTiP53179
STRINGi4932.YGL045W

Structurei

3D structure databases

ProteinModelPortaliP53179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi244 – 250Poly-Ser7

Sequence similaritiesi

Belongs to the arrestin family. PalF/RIM8 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000115430
InParanoidiP53179
KOiK20063
OMAiFRKDICQ
OrthoDBiEOG092C1DIY

Family and domain databases

Gene3Di2.60.40.640, 1 hit
InterProiView protein in InterPro
IPR011021 Arrestin-like_N
IPR014752 Arrestin_C
IPR011022 Arrestin_C-like
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

P53179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRLWNKE SRAPSKIKSH GIVGSYGNSM LAHNNVKQFR IDIDEPHRVW
60 70 80 90 100
KPNESITGEA VIDIKRDITN VAIKLSLVCE VRVKTGNSPT SKNKRIEKTL
110 120 130 140 150
EKSTFLYGQD YVKTAFSAKE KKPHVDKTTI LNGLSKGEHR FPFRIRIPRG
160 170 180 190 200
RGMLSSIKFE RGSITYFLSC TLESLNNING LKKPEARCER EFAVIVPLDV
210 220 230 240 250
SRLPKPKTKT VVLQSASMVQ NKKNKSTEDE SSSYTQLTQK STTSNSSSSS
260 270 280 290 300
VNSKTSPLPN KTVTISVDIP QAGFMIGEII PIDVKIDHYK PFYAPAGLTT
310 320 330 340 350
TLVRICRVGG AGKDDPMETF RKDICQSISP IYINPETLQF QSRVYLKVPL
360 370 380 390 400
DAFSTLTTVG KFFSFQYYIE VMVNLSKKNV VYTESNRIIG TPIGEQNGLG
410 420 430 440 450
VENNINRIQR KMLRMVNPET LENDSEGYES SIFFKDMVNV EKLKRLRNVT
460 470 480 490 500
GMSIETVIGT TRSEQQQSDA SIPSQSSITA PQNSPSNLRD WLAPLNAYDS
510 520 530 540
DDVPVPKYSP NDKVSVPSED KQELEQKRLQ QLESDPPPCD DY
Length:542
Mass (Da):60,864
Last modified:June 21, 2005 - v2
Checksum:i5639227A1225ACC2
GO

Sequence cautioni

The sequence CAA96748 differs from that shown. Reason: Frameshift at positions 262, 270, 295 and 315.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238650 Genomic DNA Translation: CAB59334.1
Z72567 Genomic DNA Translation: CAA96747.1 Frameshift.
Z72568 Genomic DNA Translation: CAA96748.1 Frameshift.
AY693085 Genomic DNA Translation: AAT93104.1
BK006941 Genomic DNA Translation: DAA08055.1
PIRiS64049
S64050
RefSeqiNP_011470.4, NM_001180910.3

Genome annotation databases

EnsemblFungiiYGL045W; YGL045W; YGL045W
GeneIDi852837
KEGGisce:YGL045W

Similar proteinsi

Entry informationi

Entry nameiPALF_YEAST
AccessioniPrimary (citable) accession number: P53179
Secondary accession number(s): D6VU94, P53180, Q9URQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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