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Protein

UDP-N-acetylglucosamine transferase subunit ALG13

Gene

ALG13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.2 Publications

Catalytic activityi

UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N'-diacetylchitobiosyl-diphosphodolichol.

GO - Molecular functioni

GO - Biological processi

  • dolichol-linked oligosaccharide biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-20.
YEAST:MONOMER3O-20.
BRENDAi2.4.1.141. 984.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine transferase subunit ALG13 (EC:2.4.1.141)
Alternative name(s):
Asparagine-linked glycosylation protein 13
Gene namesi
Name:ALG13
Ordered Locus Names:YGL047W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL047W.
SGDiS000003015. ALG13.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytosol Source: SGD
  • extrinsic component of endoplasmic reticulum membrane Source: SGD
  • UDP-N-acetylglucosamine transferase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156051 – 202UDP-N-acetylglucosamine transferase subunit ALG13Add BLAST202

Proteomic databases

MaxQBiP53178.
PRIDEiP53178.

Interactioni

Subunit structurei

Heterodimer with ALG14 to form a functional enzyme.

Binary interactionsi

WithEntry#Exp.IntActNotes
ALG14P382423EBI-23770,EBI-21477

Protein-protein interaction databases

BioGridi33201. 22 interactors.
DIPiDIP-4726N.
IntActiP53178. 1 interactor.
MINTiMINT-543662.

Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Beta strandi15 – 17Combined sources3
Helixi20 – 26Combined sources7
Helixi29 – 36Combined sources8
Turni37 – 39Combined sources3
Beta strandi43 – 45Combined sources3
Beta strandi49 – 51Combined sources3
Helixi58 – 62Combined sources5
Beta strandi65 – 68Combined sources4
Turni73 – 76Combined sources4
Beta strandi83 – 87Combined sources5
Turni88 – 90Combined sources3
Beta strandi91 – 96Combined sources6
Beta strandi99 – 102Combined sources4
Helixi103 – 110Combined sources8
Beta strandi114 – 118Combined sources5
Helixi120 – 128Combined sources9
Beta strandi133 – 136Combined sources4
Helixi145 – 156Combined sources12
Beta strandi157 – 162Combined sources6
Turni166 – 168Combined sources3
Helixi169 – 176Combined sources8
Beta strandi187 – 189Combined sources3
Helixi192 – 199Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JZCNMR-A2-202[»]
2KS6NMR-A2-202[»]
ProteinModelPortaliP53178.
SMRiP53178.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53178.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family.Curated

Phylogenomic databases

GeneTreeiENSGT00510000047493.
HOGENOMiHOG000192807.
InParanoidiP53178.
KOiK07432.
OMAiRNYSSEF.
OrthoDBiEOG092C5DNC.

Family and domain databases

InterProiIPR007235. Glyco_trans_28_C.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIIEEKALF VTCGATVPFP KLVSCVLSDE FCQELIQYGF VRLIIQFGRN
60 70 80 90 100
YSSEFEHLVQ ERGGQRESQK IPIDQFGCGD TARQYVLMNG KLKVIGFDFS
110 120 130 140 150
TKMQSIIRDY SDLVISHAGT GSILDSLRLN KPLIVCVNDS LMDNHQQQIA
160 170 180 190 200
DKFVELGYVW SCAPTETGLI AGLRASQTEK LKPFPVSHNP SFERLLVETI

YS
Length:202
Mass (Da):22,661
Last modified:October 1, 1996 - v1
Checksum:i9D5CDB366BBC1ED0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72569 Genomic DNA. Translation: CAA96749.1.
BK006941 Genomic DNA. Translation: DAA08054.1.
PIRiS64051.
RefSeqiNP_011468.1. NM_001180912.1.

Genome annotation databases

EnsemblFungiiYGL047W; YGL047W; YGL047W.
GeneIDi852835.
KEGGisce:YGL047W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72569 Genomic DNA. Translation: CAA96749.1.
BK006941 Genomic DNA. Translation: DAA08054.1.
PIRiS64051.
RefSeqiNP_011468.1. NM_001180912.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JZCNMR-A2-202[»]
2KS6NMR-A2-202[»]
ProteinModelPortaliP53178.
SMRiP53178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33201. 22 interactors.
DIPiDIP-4726N.
IntActiP53178. 1 interactor.
MINTiMINT-543662.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

MaxQBiP53178.
PRIDEiP53178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL047W; YGL047W; YGL047W.
GeneIDi852835.
KEGGisce:YGL047W.

Organism-specific databases

EuPathDBiFungiDB:YGL047W.
SGDiS000003015. ALG13.

Phylogenomic databases

GeneTreeiENSGT00510000047493.
HOGENOMiHOG000192807.
InParanoidiP53178.
KOiK07432.
OMAiRNYSSEF.
OrthoDBiEOG092C5DNC.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-20.
YEAST:MONOMER3O-20.
BRENDAi2.4.1.141. 984.

Miscellaneous databases

EvolutionaryTraceiP53178.
PROiP53178.

Family and domain databases

InterProiIPR007235. Glyco_trans_28_C.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALG13_YEAST
AccessioniPrimary (citable) accession number: P53178
Secondary accession number(s): D6VU93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1950 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.