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P53173 (ERV14_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ER-derived vesicles protein ERV14
Gene names
Name:ERV14
Ordered Locus Names:YGL054C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells. Ref.5

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note: Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.

Disruption phenotype

Defects in cell polarity. Strains homozygous for ERV14 deletion do not sporulate. Ref.5

Miscellaneous

Present with 7110 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the cornichon family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 138137ER-derived vesicles protein ERV14
PRO_0000122236

Regions

Topological domain2 – 65Cytoplasmic Potential
Transmembrane7 – 2721Helical; Potential
Topological domain28 – 5225Extracellular Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 11138Cytoplasmic Potential
Transmembrane112 – 13221Helical; Potential
Topological domain133 – 1386Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
P53173 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: E81CC3B31C50CD9F

FASTA13815,930
        10         20         30         40         50         60 
MGAWLFILAV VVNCINLFGQ VHFTILYADL EADYINPIEL CSKVNKLITP EAALHGALSL 

        70         80         90        100        110        120 
LFLLNGYWFV FLLNLPVLAY NLNKIYNKVQ LLDATEIFRT LGKHKRESFL KLGFHLLMFF 

       130 
FYLYRMIMAL IAESGDDF 

« Hide

References

« Hide 'large scale' references
[1]"The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes."
Feuermann M., de Montigny J., Potier S., Souciet J.-L.
Yeast 13:861-869(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product."
Powers J., Barlowe C.
J. Cell Biol. 142:1209-1222(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-19, FUNCTION, DISRUPTION PHENOTYPE.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z72576 Genomic DNA. Translation: CAA96756.1.
AY558483 Genomic DNA. Translation: AAS56809.1.
BK006941 Genomic DNA. Translation: DAA08048.1.
PIRS64058.
RefSeqNP_011461.1. NM_001180919.1.

3D structure databases

ProteinModelPortalP53173.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33193. 240 interactions.
DIPDIP-5457N.
IntActP53173. 1 interaction.
MINTMINT-487265.
STRING4932.YGL054C.

Proteomic databases

MaxQBP53173.
PaxDbP53173.
PeptideAtlasP53173.

Protocols and materials databases

DNASU852826.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL054C; YGL054C; YGL054C.
GeneID852826.
KEGGsce:YGL054C.

Organism-specific databases

SGDS000003022. ERV14.

Phylogenomic databases

eggNOGNOG250091.
GeneTreeENSGT00390000015751.
HOGENOMHOG000214661.
OMATAVFCIT.
OrthoDBEOG7XSTSN.

Enzyme and pathway databases

BioCycYEAST:G3O-30563-MONOMER.

Gene expression databases

GenevestigatorP53173.

Family and domain databases

InterProIPR003377. Cornichon.
[Graphical view]
PfamPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEPS01340. CORNICHON. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio972384.

Entry information

Entry nameERV14_YEAST
AccessionPrimary (citable) accession number: P53173
Secondary accession number(s): D6VU87
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families