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P53173

- ERV14_YEAST

UniProt

P53173 - ERV14_YEAST

Protein

ER-derived vesicles protein ERV14

Gene

ERV14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells.1 Publication

    GO - Molecular functioni

    1. receptor activity Source: SGD

    GO - Biological processi

    1. ascospore formation Source: SGD
    2. axial cellular bud site selection Source: SGD
    3. ER to Golgi vesicle-mediated transport Source: SGD
    4. intracellular signal transduction Source: InterPro

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30563-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER-derived vesicles protein ERV14
    Gene namesi
    Name:ERV14
    Ordered Locus Names:YGL054C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    SGDiS000003022. ERV14.

    Subcellular locationi

    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
    Note: Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: SGD
    2. ER to Golgi transport vesicle Source: SGD
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Defects in cell polarity. Strains homozygous for ERV14 deletion do not sporulate.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 138137ER-derived vesicles protein ERV14PRO_0000122236Add
    BLAST

    Proteomic databases

    MaxQBiP53173.
    PaxDbiP53173.
    PeptideAtlasiP53173.

    Expressioni

    Gene expression databases

    GenevestigatoriP53173.

    Interactioni

    Protein-protein interaction databases

    BioGridi33193. 241 interactions.
    DIPiDIP-5457N.
    IntActiP53173. 1 interaction.
    MINTiMINT-487265.
    STRINGi4932.YGL054C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53173.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 65CytoplasmicSequence Analysis
    Topological domaini28 – 5225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini74 – 11138CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 1386ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cornichon family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG250091.
    GeneTreeiENSGT00390000015751.
    HOGENOMiHOG000214661.
    OMAiTAVFCIT.
    OrthoDBiEOG7XSTSN.

    Family and domain databases

    InterProiIPR003377. Cornichon.
    [Graphical view]
    PfamiPF03311. Cornichon. 1 hit.
    [Graphical view]
    PROSITEiPS01340. CORNICHON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P53173-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAWLFILAV VVNCINLFGQ VHFTILYADL EADYINPIEL CSKVNKLITP    50
    EAALHGALSL LFLLNGYWFV FLLNLPVLAY NLNKIYNKVQ LLDATEIFRT 100
    LGKHKRESFL KLGFHLLMFF FYLYRMIMAL IAESGDDF 138
    Length:138
    Mass (Da):15,930
    Last modified:January 23, 2007 - v3
    Checksum:iE81CC3B31C50CD9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72576 Genomic DNA. Translation: CAA96756.1.
    AY558483 Genomic DNA. Translation: AAS56809.1.
    BK006941 Genomic DNA. Translation: DAA08048.1.
    PIRiS64058.
    RefSeqiNP_011461.1. NM_001180919.1.

    Genome annotation databases

    EnsemblFungiiYGL054C; YGL054C; YGL054C.
    GeneIDi852826.
    KEGGisce:YGL054C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72576 Genomic DNA. Translation: CAA96756.1 .
    AY558483 Genomic DNA. Translation: AAS56809.1 .
    BK006941 Genomic DNA. Translation: DAA08048.1 .
    PIRi S64058.
    RefSeqi NP_011461.1. NM_001180919.1.

    3D structure databases

    ProteinModelPortali P53173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33193. 241 interactions.
    DIPi DIP-5457N.
    IntActi P53173. 1 interaction.
    MINTi MINT-487265.
    STRINGi 4932.YGL054C.

    Proteomic databases

    MaxQBi P53173.
    PaxDbi P53173.
    PeptideAtlasi P53173.

    Protocols and materials databases

    DNASUi 852826.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL054C ; YGL054C ; YGL054C .
    GeneIDi 852826.
    KEGGi sce:YGL054C.

    Organism-specific databases

    SGDi S000003022. ERV14.

    Phylogenomic databases

    eggNOGi NOG250091.
    GeneTreei ENSGT00390000015751.
    HOGENOMi HOG000214661.
    OMAi TAVFCIT.
    OrthoDBi EOG7XSTSN.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30563-MONOMER.

    Miscellaneous databases

    NextBioi 972384.

    Gene expression databases

    Genevestigatori P53173.

    Family and domain databases

    InterProi IPR003377. Cornichon.
    [Graphical view ]
    Pfami PF03311. Cornichon. 1 hit.
    [Graphical view ]
    PROSITEi PS01340. CORNICHON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes."
      Feuermann M., de Montigny J., Potier S., Souciet J.-L.
      Yeast 13:861-869(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product."
      Powers J., Barlowe C.
      J. Cell Biol. 142:1209-1222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-19, FUNCTION, DISRUPTION PHENOTYPE.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiERV14_YEAST
    AccessioniPrimary (citable) accession number: P53173
    Secondary accession number(s): D6VU87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 7110 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3