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Protein

ER-derived vesicles protein ERV14

Gene

ERV14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells.1 Publication

Miscellaneous

Present with 7110 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cargo receptor activity Source: SGD

GO - Biological processi

  • ascospore formation Source: SGD
  • axial cellular bud site selection Source: SGD
  • ER to Golgi vesicle-mediated transport Source: SGD
  • negative regulation of receptor localization to synapse Source: UniProtKB
  • regulation of AMPA receptor activity Source: UniProtKB

Enzyme and pathway databases

BioCyciYEAST:G3O-30563-MONOMER

Protein family/group databases

TCDBi8.A.61.1.1 the endoplasmic reticulum-derived vesicle protein, erv14 (erv14) family

Names & Taxonomyi

Protein namesi
Recommended name:
ER-derived vesicles protein ERV14
Gene namesi
Name:ERV14
Ordered Locus Names:YGL054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL054C
SGDiS000003022 ERV14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 6CytoplasmicSequence analysis5
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 52ExtracellularSequence analysisAdd BLAST25
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 111CytoplasmicSequence analysisAdd BLAST38
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 138ExtracellularSequence analysis6

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Defects in cell polarity. Strains homozygous for ERV14 deletion do not sporulate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001222362 – 138ER-derived vesicles protein ERV14Add BLAST137

Proteomic databases

MaxQBiP53173
PaxDbiP53173
PRIDEiP53173
TopDownProteomicsiP53173

Interactioni

Protein-protein interaction databases

BioGridi33193, 435 interactors
DIPiDIP-5457N
IntActiP53173, 1 interactor
STRINGi4932.YGL054C

Structurei

3D structure databases

ProteinModelPortaliP53173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000015751
HOGENOMiHOG000214661
InParanoidiP53173
KOiK20368
OMAiKNPIEQC
OrthoDBiEOG092C5GJN

Family and domain databases

InterProiView protein in InterPro
IPR003377 Cornichon
IPR033466 Cornichon_conserved
PfamiView protein in Pfam
PF03311 Cornichon, 1 hit
SMARTiView protein in SMART
SM01398 Cornichon, 1 hit
PROSITEiView protein in PROSITE
PS01340 CORNICHON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAWLFILAV VVNCINLFGQ VHFTILYADL EADYINPIEL CSKVNKLITP
60 70 80 90 100
EAALHGALSL LFLLNGYWFV FLLNLPVLAY NLNKIYNKVQ LLDATEIFRT
110 120 130
LGKHKRESFL KLGFHLLMFF FYLYRMIMAL IAESGDDF
Length:138
Mass (Da):15,930
Last modified:January 23, 2007 - v3
Checksum:iE81CC3B31C50CD9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72576 Genomic DNA Translation: CAA96756.1
AY558483 Genomic DNA Translation: AAS56809.1
BK006941 Genomic DNA Translation: DAA08048.1
PIRiS64058
RefSeqiNP_011461.1, NM_001180919.1

Genome annotation databases

EnsemblFungiiYGL054C; YGL054C; YGL054C
GeneIDi852826
KEGGisce:YGL054C

Similar proteinsi

Entry informationi

Entry nameiERV14_YEAST
AccessioniPrimary (citable) accession number: P53173
Secondary accession number(s): D6VU87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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