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Protein

ER-derived vesicles protein ERV14

Gene

ERV14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells.1 Publication

GO - Molecular functioni

  1. receptor activity Source: SGD

GO - Biological processi

  1. ascospore formation Source: SGD
  2. axial cellular bud site selection Source: SGD
  3. ER to Golgi vesicle-mediated transport Source: SGD
  4. intracellular signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER-derived vesicles protein ERV14
Gene namesi
Name:ERV14
Ordered Locus Names:YGL054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL054C.
SGDiS000003022. ERV14.

Subcellular locationi

  1. Endoplasmic reticulum membrane; Multi-pass membrane protein
  2. Golgi apparatus membrane; Multi-pass membrane protein

  3. Note: Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 65CytoplasmicSequence Analysis
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Topological domaini28 – 5225ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 11138CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST
Topological domaini133 – 1386ExtracellularSequence Analysis

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: SGD
  2. ER to Golgi transport vesicle Source: SGD
  3. Golgi membrane Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Defects in cell polarity. Strains homozygous for ERV14 deletion do not sporulate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 138137ER-derived vesicles protein ERV14PRO_0000122236Add
BLAST

Proteomic databases

MaxQBiP53173.
PaxDbiP53173.
PeptideAtlasiP53173.

Expressioni

Gene expression databases

GenevestigatoriP53173.

Interactioni

Protein-protein interaction databases

BioGridi33193. 241 interactions.
DIPiDIP-5457N.
IntActiP53173. 1 interaction.
MINTiMINT-487265.
STRINGi4932.YGL054C.

Structurei

3D structure databases

ProteinModelPortaliP53173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250091.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
InParanoidiP53173.
OMAiFWLIYST.
OrthoDBiEOG7XSTSN.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAWLFILAV VVNCINLFGQ VHFTILYADL EADYINPIEL CSKVNKLITP
60 70 80 90 100
EAALHGALSL LFLLNGYWFV FLLNLPVLAY NLNKIYNKVQ LLDATEIFRT
110 120 130
LGKHKRESFL KLGFHLLMFF FYLYRMIMAL IAESGDDF
Length:138
Mass (Da):15,930
Last modified:January 23, 2007 - v3
Checksum:iE81CC3B31C50CD9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72576 Genomic DNA. Translation: CAA96756.1.
AY558483 Genomic DNA. Translation: AAS56809.1.
BK006941 Genomic DNA. Translation: DAA08048.1.
PIRiS64058.
RefSeqiNP_011461.1. NM_001180919.1.

Genome annotation databases

EnsemblFungiiYGL054C; YGL054C; YGL054C.
GeneIDi852826.
KEGGisce:YGL054C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72576 Genomic DNA. Translation: CAA96756.1.
AY558483 Genomic DNA. Translation: AAS56809.1.
BK006941 Genomic DNA. Translation: DAA08048.1.
PIRiS64058.
RefSeqiNP_011461.1. NM_001180919.1.

3D structure databases

ProteinModelPortaliP53173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33193. 241 interactions.
DIPiDIP-5457N.
IntActiP53173. 1 interaction.
MINTiMINT-487265.
STRINGi4932.YGL054C.

Proteomic databases

MaxQBiP53173.
PaxDbiP53173.
PeptideAtlasiP53173.

Protocols and materials databases

DNASUi852826.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL054C; YGL054C; YGL054C.
GeneIDi852826.
KEGGisce:YGL054C.

Organism-specific databases

EuPathDBiFungiDB:YGL054C.
SGDiS000003022. ERV14.

Phylogenomic databases

eggNOGiNOG250091.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
InParanoidiP53173.
OMAiFWLIYST.
OrthoDBiEOG7XSTSN.

Enzyme and pathway databases

BioCyciYEAST:G3O-30563-MONOMER.

Miscellaneous databases

NextBioi972384.
PROiP53173.

Gene expression databases

GenevestigatoriP53173.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes."
    Feuermann M., de Montigny J., Potier S., Souciet J.-L.
    Yeast 13:861-869(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product."
    Powers J., Barlowe C.
    J. Cell Biol. 142:1209-1222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-19, FUNCTION, DISRUPTION PHENOTYPE.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiERV14_YEAST
AccessioniPrimary (citable) accession number: P53173
Secondary accession number(s): D6VU87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7110 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.