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P53173

- ERV14_YEAST

UniProt

P53173 - ERV14_YEAST

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Protein

ER-derived vesicles protein ERV14

Gene
ERV14, YGL054C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Could regulate export of the bud site and axial growth sites selection protein AXL2 and possibly other secretory proteins from the endoplasmic reticulum in COPII-coated vesicles. Seems to be required for axial budding pattern in haploid cells.1 Publication

GO - Molecular functioni

  1. receptor activity Source: SGD

GO - Biological processi

  1. ascospore formation Source: SGD
  2. axial cellular bud site selection Source: SGD
  3. ER to Golgi vesicle-mediated transport Source: SGD
  4. intracellular signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER-derived vesicles protein ERV14
Gene namesi
Name:ERV14
Ordered Locus Names:YGL054C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

SGDiS000003022. ERV14.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Note: Resides in the endoplasmic and Golgi compartments, and then packaged into endoplasmic reticulum derived vesicles.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 65Cytoplasmic Reviewed prediction
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Topological domaini28 – 5225Extracellular Reviewed predictionAdd
BLAST
Transmembranei53 – 7321Helical; Reviewed predictionAdd
BLAST
Topological domaini74 – 11138Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei112 – 13221Helical; Reviewed predictionAdd
BLAST
Topological domaini133 – 1386Extracellular Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: SGD
  2. ER to Golgi transport vesicle Source: SGD
  3. Golgi membrane Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Defects in cell polarity. Strains homozygous for ERV14 deletion do not sporulate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 138137ER-derived vesicles protein ERV14PRO_0000122236Add
BLAST

Proteomic databases

MaxQBiP53173.
PaxDbiP53173.
PeptideAtlasiP53173.

Expressioni

Gene expression databases

GenevestigatoriP53173.

Interactioni

Protein-protein interaction databases

BioGridi33193. 241 interactions.
DIPiDIP-5457N.
IntActiP53173. 1 interaction.
MINTiMINT-487265.
STRINGi4932.YGL054C.

Structurei

3D structure databases

ProteinModelPortaliP53173.

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250091.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
OMAiTAVFCIT.
OrthoDBiEOG7XSTSN.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53173-1 [UniParc]FASTAAdd to Basket

« Hide

MGAWLFILAV VVNCINLFGQ VHFTILYADL EADYINPIEL CSKVNKLITP    50
EAALHGALSL LFLLNGYWFV FLLNLPVLAY NLNKIYNKVQ LLDATEIFRT 100
LGKHKRESFL KLGFHLLMFF FYLYRMIMAL IAESGDDF 138
Length:138
Mass (Da):15,930
Last modified:January 23, 2007 - v3
Checksum:iE81CC3B31C50CD9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72576 Genomic DNA. Translation: CAA96756.1.
AY558483 Genomic DNA. Translation: AAS56809.1.
BK006941 Genomic DNA. Translation: DAA08048.1.
PIRiS64058.
RefSeqiNP_011461.1. NM_001180919.1.

Genome annotation databases

EnsemblFungiiYGL054C; YGL054C; YGL054C.
GeneIDi852826.
KEGGisce:YGL054C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72576 Genomic DNA. Translation: CAA96756.1 .
AY558483 Genomic DNA. Translation: AAS56809.1 .
BK006941 Genomic DNA. Translation: DAA08048.1 .
PIRi S64058.
RefSeqi NP_011461.1. NM_001180919.1.

3D structure databases

ProteinModelPortali P53173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33193. 241 interactions.
DIPi DIP-5457N.
IntActi P53173. 1 interaction.
MINTi MINT-487265.
STRINGi 4932.YGL054C.

Proteomic databases

MaxQBi P53173.
PaxDbi P53173.
PeptideAtlasi P53173.

Protocols and materials databases

DNASUi 852826.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL054C ; YGL054C ; YGL054C .
GeneIDi 852826.
KEGGi sce:YGL054C.

Organism-specific databases

SGDi S000003022. ERV14.

Phylogenomic databases

eggNOGi NOG250091.
GeneTreei ENSGT00390000015751.
HOGENOMi HOG000214661.
OMAi TAVFCIT.
OrthoDBi EOG7XSTSN.

Enzyme and pathway databases

BioCyci YEAST:G3O-30563-MONOMER.

Miscellaneous databases

NextBioi 972384.

Gene expression databases

Genevestigatori P53173.

Family and domain databases

InterProi IPR003377. Cornichon.
[Graphical view ]
Pfami PF03311. Cornichon. 1 hit.
[Graphical view ]
PROSITEi PS01340. CORNICHON. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes."
    Feuermann M., de Montigny J., Potier S., Souciet J.-L.
    Yeast 13:861-869(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product."
    Powers J., Barlowe C.
    J. Cell Biol. 142:1209-1222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-19, FUNCTION, DISRUPTION PHENOTYPE.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiERV14_YEAST
AccessioniPrimary (citable) accession number: P53173
Secondary accession number(s): D6VU87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7110 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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