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Reviewed, UniProtKB/Swiss-Prot P53172 (SDS23_YEAST)

Last modified November 24, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein SDS23
Gene names
Name: SDS23
Ordered Locus Names: YGL056C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in DNA replication and cell separation during budding. Ref.6

Subcellular location

Cytoplasm. Nucleus.

Miscellaneous

Present with 21200 molecules/cell in log phase SD medium. Ref.5

Sequence similarities

Belongs to the SDS23 family.

Contains 4 CBS domains.

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Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainCBS domain
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell separation during cytokinesis Ref.6

Inferred from genetic interaction. Source: SGD

   Cellular componentcytoplasm Ref.4

Inferred from direct assay. Source: SGD

nucleus Ref.4

Inferred from direct assay. Source: SGD

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Protein SDS23
PRO_0000202767

Regions

Domain101 – 16262CBS 1
Domain185 – 24359CBS 2
Domain272 – 33059CBS 3
Domain335 – 39157CBS 4

Amino acid modifications

Modified residue421Phosphoserine Ref.9 Ref.11
Modified residue461Phosphoserine Ref.9
Modified residue3991Phosphoserine Ref.10
Modified residue4001Phosphoserine Ref.11 Ref.10
Modified residue4301Phosphoserine Ref.11 Ref.7 Ref.8

Experimental info

Sequence conflict1801A → G in AAT93032. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
P53172-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 1153416F1DF456E2

FASTA52758,112
        10         20         30         40         50         60 
MPQNTRHTSI VEMLSTPPQL PNSTDLNSLS EQTDKNTEAN KSDTESLHKS ISKSSSSSSL 

        70         80         90        100        110        120 
STLDNTEYSN NNGNSLSTLN SQNLLSVHRQ EWQHTPLSNL VEQNKLIFIR GSISVEEAFN 

       130        140        150        160        170        180 
TLVKHQLTSL PVENFPGDMN CLTFDYNDLN AYLLLVLNRI KVSNDKITSD CQNGKSVPVA 

       190        200        210        220        230        240 
EIVKLTPKNP FYKLPETENL STVIGILGSG VHRVAITNVE MTQIKGILSQ RRLIKYLWEN 

       250        260        270        280        290        300 
ARSFPNLKPL LDSSLEELNI GVLNAARDKP TFKQSRVISI QGDEHLIMAL HKMYVERISS 

       310        320        330        340        350        360 
IAVVDPQGNL IGNISVTDVK HVTRTSQYPL LHNTCRHFVS VILNLRGLET GKDSFPIFHV 

       370        380        390        400        410        420 
YPTSSLARTF AKLVATKSHR LWIVQPNDNQ PTASSEKSSS PSPSTPPVTT LPSLASSYHS 

       430        440        450        460        470        480 
NTQSSRMANS PVLKSSDTSN NKINVNINLS GPSPSQPQSP SATMPPPQSP SNCPASPTPA 

       490        500        510        520 
HFEKEYRTGK LIGVVSLTDI LSVLARKQTH HKEIDPQMAR KQRGHIG

« Hide

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References

« Hide 'large scale' references
[1]"The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes."
Feuermann M., de Montigny J., Potier S., Souciet J.-L.
Yeast 13:861-869(1997) [PubMed: 9234674] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed: 9169869] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Functional conservation between fission yeast moc1/sds23 and its two orthologs, budding yeast SDS23 and SDS24, and phenotypic differences in their disruptants."
Goldar M.M., Nishie T., Ishikura Y., Fukuda T., Takegawa K., Kawamukai M.
Biosci. Biotechnol. Biochem. 69:1422-1426(2005) [PubMed: 16041152] [Abstract]
Cited for: FUNCTION.
[7]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, MASS SPECTROMETRY.
[8]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, MASS SPECTROMETRY.
[9]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-46, MASS SPECTROMETRY.
[10]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399 AND SER-400, MASS SPECTROMETRY.
[11]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-400 AND SER-430, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z72578 Genomic DNA. Translation: CAA96759.1.
Z72577 Genomic DNA. Translation: CAA96758.1.
AY693013 Genomic DNA. Translation: AAT93032.1.
PIRS64060.
RefSeqNP_011459.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP53172. 34 interactions.
STRINGP53172.

Proteomic databases

PeptideAtlasP53172.

Genome annotation databases

EnsemblYGL056C; YGL056C; YGL056C; Saccharomyces cerevisiae. [Genome view]
GeneID852824.
KEGGsce:YGL056C.
NMPDRfig|4932.3.peg.2565.

Organism-specific databases

CYGDYGL056c.
SGDS000003024. SDS23.

Phylogenomic databases

HOGENOMP53172.
OMAMWENARR
OrthoDBEOG9SN34X

Gene expression databases

ArrayExpressP53172.
GenevestigatorP53172.
GermOnlineYGL056C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR000644. Cysta_beta_synth_core.
IPR016711. Ssd23.
[Graphical view]
PfamPF00571. CBS. 2 hits.
[Graphical view]
PIRSFPIRSF018148. UCP018148_CBS_YBR214w. 1 hit.
SMARTSM00116. CBS. 2 hits.
[Graphical view]
PROSITEPS51371. CBS. 3 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio972378.

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Entry information

Entry nameSDS23_YEAST
AccessionPrimary (citable) accession number: P53172
Secondary accession number(s): Q6B1R7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 24, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents