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Protein

54S ribosomal protein L12, mitochondrial

Gene

MNP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30572-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L12, mitochondrial
Alternative name(s):
Mitochondrial-nucleoid protein 1
Gene namesi
Name:MNP1
Synonyms:MRPL12
Ordered Locus Names:YGL068W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL068W.
SGDiS000003036. MNP1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial large ribosomal subunit Source: SGD
  • mitochondrial nucleoid Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333Mitochondrion1 PublicationAdd
BLAST
Chaini34 – 19416154S ribosomal protein L12, mitochondrialPRO_0000030460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP53163.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).2 Publications

Protein-protein interaction databases

BioGridi33179. 31 interactions.
DIPiDIP-6428N.
IntActiP53163. 4 interactions.
MINTiMINT-705819.

Structurei

3D structure databases

ProteinModelPortaliP53163.
SMRiP53163. Positions 139-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L7/L12P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000000190.
HOGENOMiHOG000248814.
InParanoidiP53163.
KOiK02935.
OMAiEFISNMT.
OrthoDBiEOG092C5NJO.

Family and domain databases

CDDicd00387. Ribosomal_L7_L12. 1 hit.
Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00368. Ribosomal_L7_L12. 1 hit.
InterProiIPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
[Graphical view]
PfamiPF00542. Ribosomal_L12. 1 hit.
PF16320. Ribosomal_L12_N. 1 hit.
[Graphical view]
ProDomiPD001326. Ribosomal_L7/L12_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRILAKRS SSIWMKTRVT PALISPITIT TRFNSTTTTA PSHKDDVRPV
60 70 80 90 100
DPKISKIVQD ISQLTLLETS SLINELKTVL NIPEISMPMG GFMAGAAGAG
110 120 130 140 150
AGNVPSSTGE AGSGAEEEAK PEAKTVFTVK LDSFDTKTKA KVIKEVKGLL
160 170 180 190
GLSLVEAKKF VEAAPKVLKE NVAKDDAEKI KKTLEDLGAK VSLE
Length:194
Mass (Da):20,650
Last modified:October 1, 1996 - v1
Checksum:iD7892681B778B8A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341N → D AA sequence (PubMed:15221522).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72591 Genomic DNA. Translation: CAA96773.1.
BK006941 Genomic DNA. Translation: DAA08034.1.
PIRiS64075.
RefSeqiNP_011447.1. NM_001180933.1.

Genome annotation databases

EnsemblFungiiYGL068W; YGL068W; YGL068W.
GeneIDi852811.
KEGGisce:YGL068W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72591 Genomic DNA. Translation: CAA96773.1.
BK006941 Genomic DNA. Translation: DAA08034.1.
PIRiS64075.
RefSeqiNP_011447.1. NM_001180933.1.

3D structure databases

ProteinModelPortaliP53163.
SMRiP53163. Positions 139-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33179. 31 interactions.
DIPiDIP-6428N.
IntActiP53163. 4 interactions.
MINTiMINT-705819.

Proteomic databases

MaxQBiP53163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL068W; YGL068W; YGL068W.
GeneIDi852811.
KEGGisce:YGL068W.

Organism-specific databases

EuPathDBiFungiDB:YGL068W.
SGDiS000003036. MNP1.

Phylogenomic databases

GeneTreeiENSGT00390000000190.
HOGENOMiHOG000248814.
InParanoidiP53163.
KOiK02935.
OMAiEFISNMT.
OrthoDBiEOG092C5NJO.

Enzyme and pathway databases

BioCyciYEAST:G3O-30572-MONOMER.

Miscellaneous databases

PROiP53163.

Family and domain databases

CDDicd00387. Ribosomal_L7_L12. 1 hit.
Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00368. Ribosomal_L7_L12. 1 hit.
InterProiIPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
[Graphical view]
PfamiPF00542. Ribosomal_L12. 1 hit.
PF16320. Ribosomal_L12_N. 1 hit.
[Graphical view]
ProDomiPD001326. Ribosomal_L7/L12_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMNP1_YEAST
AccessioniPrimary (citable) accession number: P53163
Secondary accession number(s): D6VU73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6900 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.