ID   KXD1_YEAST              Reviewed;         218 AA.
AC   P53158; D6VU65;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 133.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit KXD1;
DE            Short=BLOC-1 subunit KXD1;
DE   AltName: Full=KxDL homolog;
GN   Name=KXD1; OrderedLocusNames=YGL079W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9290212;
RX   DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA   Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT   "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT   chromosome VII.";
RL   Yeast 13:1077-1090(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   IDENTIFICATION IN THE BLOC-1 COMPLEX, AND FUNCTION.
RX   PubMed=21159114; DOI=10.1111/j.1600-0854.2010.01151.x;
RA   Hayes M.J., Bryon K., Satkurunathan J., Levine T.P.;
RT   "Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as
RT   conserved interactors of BLOC-1.";
RL   Traffic 12:260-268(2011).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) involved in endosomal cargo sorting.
CC       {ECO:0000269|PubMed:21159114}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1
CC       and VAB2. {ECO:0000269|PubMed:21159114}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR   EMBL; Z72601; CAA96784.1; -; Genomic_DNA.
DR   EMBL; AY558485; AAS56811.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA08026.1; -; Genomic_DNA.
DR   PIR; S64086; S64086.
DR   RefSeq; NP_011436.1; NM_001180944.1.
DR   AlphaFoldDB; P53158; -.
DR   SMR; P53158; -.
DR   BioGRID; 33171; 97.
DR   ComplexPortal; CPX-1153; BLOC-1 complex.
DR   DIP; DIP-5247N; -.
DR   IntAct; P53158; 7.
DR   MINT; P53158; -.
DR   STRING; 4932.YGL079W; -.
DR   MaxQB; P53158; -.
DR   PaxDb; 4932-YGL079W; -.
DR   PeptideAtlas; P53158; -.
DR   EnsemblFungi; YGL079W_mRNA; YGL079W; YGL079W.
DR   GeneID; 852801; -.
DR   KEGG; sce:YGL079W; -.
DR   AGR; SGD:S000003047; -.
DR   SGD; S000003047; KXD1.
DR   VEuPathDB; FungiDB:YGL079W; -.
DR   eggNOG; ENOG502S1H5; Eukaryota.
DR   HOGENOM; CLU_099155_0_0_1; -.
DR   InParanoid; P53158; -.
DR   OMA; TPMFDTS; -.
DR   OrthoDB; 2030018at2759; -.
DR   BioCyc; YEAST:G3O-30580-MONOMER; -.
DR   BioGRID-ORCS; 852801; 7 hits in 10 CRISPR screens.
DR   PRO; PR:P53158; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P53158; Protein.
DR   GO; GO:0031083; C:BLOC-1 complex; IDA:SGD.
DR   GO; GO:0005768; C:endosome; IDA:ComplexPortal.
DR   GO; GO:0007032; P:endosome organization; IMP:SGD.
DR   GO; GO:0032880; P:regulation of protein localization; IMP:SGD.
DR   InterPro; IPR019371; KxDL_dom.
DR   PANTHER; PTHR37787; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1; 1.
DR   PANTHER; PTHR37787:SF1; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1; 1.
DR   Pfam; PF10241; KxDL; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Endosome; Reference proteome; Transport.
FT   CHAIN           1..218
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit KXD1"
FT                   /id="PRO_0000202759"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          142..192
FT                   /evidence="ECO:0000255"
FT   MOTIF           175..179
FT                   /note="KxDL"
FT   COMPBIAS        16..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   218 AA;  24442 MW;  61541771FBEC8F8C CRC64;
     MVTGISEEND DEETFSAVHS STPSINSQSY AIPITEEMSS SFHDSISTTS NSSGSFDSDG
     SNVSDVVEQN EMDNESNVDE DLFLDNDIPQ SSNLLPTDAQ DPGPIFDVSR YIFDSLKQSI
     DSADFSEALS LQTKTSAVIN SKSLELKQYI DEMKSRLTQL QEKFENGEAT SKKIKRDLET
     SRKNIDYLNA ALRVDFPIEF NQAREKILER RLNEDHDC
//