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P53158

- KXD1_YEAST

UniProt

P53158 - KXD1_YEAST

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Protein

Biogenesis of lysosome-related organelles complex 1 subunit KXD1

Gene
KXD1, YGL079W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.1 Publication

GO - Biological processi

  1. endosome organization Source: SGD
  2. regulation of protein localization Source: SGD
  3. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30580-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Biogenesis of lysosome-related organelles complex 1 subunit KXD1
Short name:
BLOC-1 subunit KXD1
Alternative name(s):
KxDL homolog
Gene namesi
Name:KXD1
Ordered Locus Names:YGL079W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL079w.
SGDiS000003047. KXD1.

Subcellular locationi

Endosome 1 Publication

GO - Cellular componenti

  1. BLOC-1 complex Source: SGD
  2. endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Biogenesis of lysosome-related organelles complex 1 subunit KXD1PRO_0000202759Add
BLAST

Proteomic databases

MaxQBiP53158.
PaxDbiP53158.

Expressioni

Gene expression databases

GenevestigatoriP53158.

Interactioni

Subunit structurei

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.1 Publication

Protein-protein interaction databases

BioGridi33171. 31 interactions.
DIPiDIP-5247N.
IntActiP53158. 5 interactions.
MINTiMINT-510293.
STRINGi4932.YGL079W.

Structurei

3D structure databases

ProteinModelPortaliP53158.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili142 – 19251 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1795KxDL

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 6449Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the KXD1 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG42733.
OMAiITEEMSS.
OrthoDBiEOG7ZPNZC.

Family and domain databases

InterProiIPR019371. Uncharacterised_KxDL.
[Graphical view]
PfamiPF10241. KxDL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53158-1 [UniParc]FASTAAdd to Basket

« Hide

MVTGISEEND DEETFSAVHS STPSINSQSY AIPITEEMSS SFHDSISTTS    50
NSSGSFDSDG SNVSDVVEQN EMDNESNVDE DLFLDNDIPQ SSNLLPTDAQ 100
DPGPIFDVSR YIFDSLKQSI DSADFSEALS LQTKTSAVIN SKSLELKQYI 150
DEMKSRLTQL QEKFENGEAT SKKIKRDLET SRKNIDYLNA ALRVDFPIEF 200
NQAREKILER RLNEDHDC 218
Length:218
Mass (Da):24,442
Last modified:October 1, 1996 - v1
Checksum:i61541771FBEC8F8C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72601 Genomic DNA. Translation: CAA96784.1.
AY558485 Genomic DNA. Translation: AAS56811.1.
BK006941 Genomic DNA. Translation: DAA08026.1.
PIRiS64086.
RefSeqiNP_011436.1. NM_001180944.1.

Genome annotation databases

EnsemblFungiiYGL079W; YGL079W; YGL079W.
GeneIDi852801.
KEGGisce:YGL079W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72601 Genomic DNA. Translation: CAA96784.1 .
AY558485 Genomic DNA. Translation: AAS56811.1 .
BK006941 Genomic DNA. Translation: DAA08026.1 .
PIRi S64086.
RefSeqi NP_011436.1. NM_001180944.1.

3D structure databases

ProteinModelPortali P53158.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33171. 31 interactions.
DIPi DIP-5247N.
IntActi P53158. 5 interactions.
MINTi MINT-510293.
STRINGi 4932.YGL079W.

Proteomic databases

MaxQBi P53158.
PaxDbi P53158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL079W ; YGL079W ; YGL079W .
GeneIDi 852801.
KEGGi sce:YGL079W.

Organism-specific databases

CYGDi YGL079w.
SGDi S000003047. KXD1.

Phylogenomic databases

eggNOGi NOG42733.
OMAi ITEEMSS.
OrthoDBi EOG7ZPNZC.

Enzyme and pathway databases

BioCyci YEAST:G3O-30580-MONOMER.

Miscellaneous databases

NextBioi 972318.

Gene expression databases

Genevestigatori P53158.

Family and domain databases

InterProi IPR019371. Uncharacterised_KxDL.
[Graphical view ]
Pfami PF10241. KxDL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
    Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
    Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1."
    Hayes M.J., Bryon K., Satkurunathan J., Levine T.P.
    Traffic 12:260-268(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION.

Entry informationi

Entry nameiKXD1_YEAST
AccessioniPrimary (citable) accession number: P53158
Secondary accession number(s): D6VU65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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