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P53158

- KXD1_YEAST

UniProt

P53158 - KXD1_YEAST

Protein

Biogenesis of lysosome-related organelles complex 1 subunit KXD1

Gene

KXD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.1 Publication

    GO - Biological processi

    1. endosome organization Source: SGD
    2. regulation of protein localization Source: SGD
    3. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30580-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biogenesis of lysosome-related organelles complex 1 subunit KXD1
    Short name:
    BLOC-1 subunit KXD1
    Alternative name(s):
    KxDL homolog
    Gene namesi
    Name:KXD1
    Ordered Locus Names:YGL079W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL079w.
    SGDiS000003047. KXD1.

    Subcellular locationi

    Endosome 1 Publication

    GO - Cellular componenti

    1. BLOC-1 complex Source: SGD
    2. endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Biogenesis of lysosome-related organelles complex 1 subunit KXD1PRO_0000202759Add
    BLAST

    Proteomic databases

    MaxQBiP53158.
    PaxDbiP53158.

    Expressioni

    Gene expression databases

    GenevestigatoriP53158.

    Interactioni

    Subunit structurei

    Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.1 Publication

    Protein-protein interaction databases

    BioGridi33171. 31 interactions.
    DIPiDIP-5247N.
    IntActiP53158. 5 interactions.
    MINTiMINT-510293.
    STRINGi4932.YGL079W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili142 – 19251Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi175 – 1795KxDL

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi16 – 6449Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the KXD1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG42733.
    OMAiITEEMSS.
    OrthoDBiEOG7ZPNZC.

    Family and domain databases

    InterProiIPR019371. Uncharacterised_KxDL.
    [Graphical view]
    PfamiPF10241. KxDL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53158-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTGISEEND DEETFSAVHS STPSINSQSY AIPITEEMSS SFHDSISTTS    50
    NSSGSFDSDG SNVSDVVEQN EMDNESNVDE DLFLDNDIPQ SSNLLPTDAQ 100
    DPGPIFDVSR YIFDSLKQSI DSADFSEALS LQTKTSAVIN SKSLELKQYI 150
    DEMKSRLTQL QEKFENGEAT SKKIKRDLET SRKNIDYLNA ALRVDFPIEF 200
    NQAREKILER RLNEDHDC 218
    Length:218
    Mass (Da):24,442
    Last modified:October 1, 1996 - v1
    Checksum:i61541771FBEC8F8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72601 Genomic DNA. Translation: CAA96784.1.
    AY558485 Genomic DNA. Translation: AAS56811.1.
    BK006941 Genomic DNA. Translation: DAA08026.1.
    PIRiS64086.
    RefSeqiNP_011436.1. NM_001180944.1.

    Genome annotation databases

    EnsemblFungiiYGL079W; YGL079W; YGL079W.
    GeneIDi852801.
    KEGGisce:YGL079W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72601 Genomic DNA. Translation: CAA96784.1 .
    AY558485 Genomic DNA. Translation: AAS56811.1 .
    BK006941 Genomic DNA. Translation: DAA08026.1 .
    PIRi S64086.
    RefSeqi NP_011436.1. NM_001180944.1.

    3D structure databases

    ProteinModelPortali P53158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33171. 31 interactions.
    DIPi DIP-5247N.
    IntActi P53158. 5 interactions.
    MINTi MINT-510293.
    STRINGi 4932.YGL079W.

    Proteomic databases

    MaxQBi P53158.
    PaxDbi P53158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL079W ; YGL079W ; YGL079W .
    GeneIDi 852801.
    KEGGi sce:YGL079W.

    Organism-specific databases

    CYGDi YGL079w.
    SGDi S000003047. KXD1.

    Phylogenomic databases

    eggNOGi NOG42733.
    OMAi ITEEMSS.
    OrthoDBi EOG7ZPNZC.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30580-MONOMER.

    Miscellaneous databases

    NextBioi 972318.

    Gene expression databases

    Genevestigatori P53158.

    Family and domain databases

    InterProi IPR019371. Uncharacterised_KxDL.
    [Graphical view ]
    Pfami PF10241. KxDL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
      Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
      Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1."
      Hayes M.J., Bryon K., Satkurunathan J., Levine T.P.
      Traffic 12:260-268(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION.

    Entry informationi

    Entry nameiKXD1_YEAST
    AccessioniPrimary (citable) accession number: P53158
    Secondary accession number(s): D6VU65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1630 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3