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P53158 (KXD1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biogenesis of lysosome-related organelles complex 1 subunit KXD1

Short name=BLOC-1 subunit KXD1
Alternative name(s):
KxDL homolog
Gene names
Name:KXD1
Ordered Locus Names:YGL079W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting. Ref.7

Subunit structure

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2. Ref.7

Subcellular location

Endosome Ref.5.

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the KXD1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Biogenesis of lysosome-related organelles complex 1 subunit KXD1
PRO_0000202759

Regions

Coiled coil142 – 19251 Potential
Motif175 – 1795KxDL
Compositional bias16 – 6449Ser-rich

Sequences

Sequence LengthMass (Da)Tools
P53158 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 61541771FBEC8F8C

FASTA21824,442
        10         20         30         40         50         60 
MVTGISEEND DEETFSAVHS STPSINSQSY AIPITEEMSS SFHDSISTTS NSSGSFDSDG 

        70         80         90        100        110        120 
SNVSDVVEQN EMDNESNVDE DLFLDNDIPQ SSNLLPTDAQ DPGPIFDVSR YIFDSLKQSI 

       130        140        150        160        170        180 
DSADFSEALS LQTKTSAVIN SKSLELKQYI DEMKSRLTQL QEKFENGEAT SKKIKRDLET 

       190        200        210 
SRKNIDYLNA ALRVDFPIEF NQAREKILER RLNEDHDC 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1."
Hayes M.J., Bryon K., Satkurunathan J., Levine T.P.
Traffic 12:260-268(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE BLOC-1 COMPLEX, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z72601 Genomic DNA. Translation: CAA96784.1.
AY558485 Genomic DNA. Translation: AAS56811.1.
BK006941 Genomic DNA. Translation: DAA08026.1.
PIRS64086.
RefSeqNP_011436.1. NM_001180944.1.

3D structure databases

ProteinModelPortalP53158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33171. 31 interactions.
DIPDIP-5247N.
IntActP53158. 5 interactions.
MINTMINT-510293.
STRING4932.YGL079W.

Proteomic databases

PaxDbP53158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL079W; YGL079W; YGL079W.
GeneID852801.
KEGGsce:YGL079W.

Organism-specific databases

CYGDYGL079w.
SGDS000003047. KXD1.

Phylogenomic databases

eggNOGNOG42733.
OMAITEEMSS.
OrthoDBEOG7ZPNZC.

Enzyme and pathway databases

BioCycYEAST:G3O-30580-MONOMER.

Gene expression databases

GenevestigatorP53158.

Family and domain databases

InterProIPR019371. Uncharacterised_KxDL.
[Graphical view]
PfamPF10241. KxDL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio972318.

Entry information

Entry nameKXD1_YEAST
AccessionPrimary (citable) accession number: P53158
Secondary accession number(s): D6VU65
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families