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Protein

Glycerol uptake protein 1

Gene

GUP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in active uptake of glycerol driven by electrogenic proton symport.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei447Sequence analysis1

GO - Molecular functioni

  • O-acyltransferase activity Source: SGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • glycerol catabolic process Source: SGD
  • glycerol transport Source: SGD
  • GPI anchor biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30585-MONOMER.

Protein family/group databases

TCDBi2.A.50.1.1. the glycerol uptake (gup) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol uptake protein 1
Gene namesi
Name:GUP1
Ordered Locus Names:YGL084C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL084C.
SGDiS000003052. GUP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 101ExtracellularSequence analysisAdd BLAST37
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 131CytoplasmicSequence analysis9
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 276ExtracellularSequence analysisAdd BLAST124
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 322CytoplasmicSequence analysisAdd BLAST25
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 352ExtracellularSequence analysis9
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 432CytoplasmicSequence analysisAdd BLAST59
Transmembranei433 – 449HelicalSequence analysisAdd BLAST17
Topological domaini450 – 454ExtracellularSequence analysis5
Transmembranei455 – 474HelicalSequence analysisAdd BLAST20
Topological domaini475 – 485CytoplasmicSequence analysisAdd BLAST11
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 526ExtracellularSequence analysisAdd BLAST20
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 560CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • endoplasmic reticulum Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: SGD
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002131321 – 560Glycerol uptake protein 1Add BLAST560

Proteomic databases

MaxQBiP53154.
PRIDEiP53154.

PTM databases

iPTMnetiP53154.

Interactioni

Protein-protein interaction databases

BioGridi33166. 281 interactors.
DIPiDIP-4367N.
IntActiP53154. 1 interactor.
MINTiMINT-561950.

Structurei

3D structure databases

ProteinModelPortaliP53154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063629.
HOGENOMiHOG000182736.
InParanoidiP53154.
OMAiIVRYIYI.
OrthoDBiEOG092C24E9.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLISILSPL ITSEGLDSRI KPSPKKDAST TTKPSLWKTT EFKFYYIAFL
60 70 80 90 100
VVVPLMFYAG LQASSPENPN YARYERLLSQ GWLFGRKVDN SDSQYRFFRD
110 120 130 140 150
NFALLSVLML VHTSIKRIVL YSTNITKLRF DLIFGLIFLV AAHGVNSIRI
160 170 180 190 200
LAHMLILYAI AHVLKNFRRI ATISIWIYGI STLFINDNFR AYPFGNICSF
210 220 230 240 250
LSPLDHWYRG IIPRWDVFFN FTLLRVLSYN LDFLERWENL QKKKSPSYES
260 270 280 290 300
KEAKSAILLN ERARLTAAHP IQDYSLMNYI AYVTYTPLFI AGPIITFNDY
310 320 330 340 350
VYQSKHTLPS INFKFIFYYA VRFVIALLSM EFILHFLHVV AISKTKAWEN
360 370 380 390 400
DTPFQISMIG LFNLNIIWLK LLIPWRLFRL WALLDGIDTP ENMIRCVDNN
410 420 430 440 450
YSSLAFWRAW HRSYNKWVVR YIYIPLGGSK NRVLTSLAVF SFVAIWHDIE
460 470 480 490 500
LKLLLWGWLI VLFLLPEIFA TQIFSHYTDA VWYRHVCAVG AVFNIWVMMI
510 520 530 540 550
ANLFGFCLGS DGTKKLLSDM FCTVSGFKFV ILASVSLFIA VQIMFEIREE
560
EKRHGIYLKC
Length:560
Mass (Da):65,340
Last modified:October 1, 1996 - v1
Checksum:iF8E9017D3E856A35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72606 Genomic DNA. Translation: CAA96789.1.
BK006941 Genomic DNA. Translation: DAA08021.1.
PIRiS64091.
RefSeqiNP_011431.1. NM_001180949.1.

Genome annotation databases

EnsemblFungiiYGL084C; YGL084C; YGL084C.
GeneIDi852796.
KEGGisce:YGL084C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72606 Genomic DNA. Translation: CAA96789.1.
BK006941 Genomic DNA. Translation: DAA08021.1.
PIRiS64091.
RefSeqiNP_011431.1. NM_001180949.1.

3D structure databases

ProteinModelPortaliP53154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33166. 281 interactors.
DIPiDIP-4367N.
IntActiP53154. 1 interactor.
MINTiMINT-561950.

Protein family/group databases

TCDBi2.A.50.1.1. the glycerol uptake (gup) family.

PTM databases

iPTMnetiP53154.

Proteomic databases

MaxQBiP53154.
PRIDEiP53154.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL084C; YGL084C; YGL084C.
GeneIDi852796.
KEGGisce:YGL084C.

Organism-specific databases

EuPathDBiFungiDB:YGL084C.
SGDiS000003052. GUP1.

Phylogenomic databases

GeneTreeiENSGT00530000063629.
HOGENOMiHOG000182736.
InParanoidiP53154.
OMAiIVRYIYI.
OrthoDBiEOG092C24E9.

Enzyme and pathway databases

BioCyciYEAST:G3O-30585-MONOMER.

Miscellaneous databases

PROiP53154.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUP1_YEAST
AccessioniPrimary (citable) accession number: P53154
Secondary accession number(s): D6VU60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.