Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P53154

- GUP1_YEAST

UniProt

P53154 - GUP1_YEAST

Protein

Glycerol uptake protein 1

Gene

GUP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in active uptake of glycerol driven by electrogenic proton symport.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei447 – 4471Sequence Analysis

    GO - Molecular functioni

    1. O-acyltransferase activity Source: SGD
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. glycerol catabolic process Source: SGD
    2. glycerol transport Source: SGD
    3. GPI anchor biosynthetic process Source: SGD

    Keywords - Biological processi

    Symport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30585-MONOMER.

    Protein family/group databases

    TCDBi2.A.50.1.1. the glycerol uptake (gup) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol uptake protein 1
    Gene namesi
    Name:GUP1
    Ordered Locus Names:YGL084C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL084c.
    SGDiS000003052. GUP1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: SGD
    4. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Glycerol uptake protein 1PRO_0000213132Add
    BLAST

    Proteomic databases

    MaxQBiP53154.
    PaxDbiP53154.
    PeptideAtlasiP53154.

    Expressioni

    Gene expression databases

    GenevestigatoriP53154.

    Interactioni

    Protein-protein interaction databases

    BioGridi33166. 282 interactions.
    DIPiDIP-4367N.
    IntActiP53154. 1 interaction.
    MINTiMINT-561950.
    STRINGi4932.YGL084C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53154.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 10137ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 1319CytoplasmicSequence Analysis
    Topological domaini153 – 276124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 32225CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini344 – 3529ExtracellularSequence Analysis
    Topological domaini374 – 43259CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini450 – 4545ExtracellularSequence Analysis
    Topological domaini475 – 48511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini507 – 52620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini548 – 56013CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei433 – 44917HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1696.
    GeneTreeiENSGT00530000063629.
    HOGENOMiHOG000182736.
    OMAiFEYREEE.
    OrthoDBiEOG7B5X4V.

    Family and domain databases

    InterProiIPR004299. MBOAT_fam.
    [Graphical view]
    PfamiPF03062. MBOAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53154-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLISILSPL ITSEGLDSRI KPSPKKDAST TTKPSLWKTT EFKFYYIAFL    50
    VVVPLMFYAG LQASSPENPN YARYERLLSQ GWLFGRKVDN SDSQYRFFRD 100
    NFALLSVLML VHTSIKRIVL YSTNITKLRF DLIFGLIFLV AAHGVNSIRI 150
    LAHMLILYAI AHVLKNFRRI ATISIWIYGI STLFINDNFR AYPFGNICSF 200
    LSPLDHWYRG IIPRWDVFFN FTLLRVLSYN LDFLERWENL QKKKSPSYES 250
    KEAKSAILLN ERARLTAAHP IQDYSLMNYI AYVTYTPLFI AGPIITFNDY 300
    VYQSKHTLPS INFKFIFYYA VRFVIALLSM EFILHFLHVV AISKTKAWEN 350
    DTPFQISMIG LFNLNIIWLK LLIPWRLFRL WALLDGIDTP ENMIRCVDNN 400
    YSSLAFWRAW HRSYNKWVVR YIYIPLGGSK NRVLTSLAVF SFVAIWHDIE 450
    LKLLLWGWLI VLFLLPEIFA TQIFSHYTDA VWYRHVCAVG AVFNIWVMMI 500
    ANLFGFCLGS DGTKKLLSDM FCTVSGFKFV ILASVSLFIA VQIMFEIREE 550
    EKRHGIYLKC 560
    Length:560
    Mass (Da):65,340
    Last modified:October 1, 1996 - v1
    Checksum:iF8E9017D3E856A35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72606 Genomic DNA. Translation: CAA96789.1.
    BK006941 Genomic DNA. Translation: DAA08021.1.
    PIRiS64091.
    RefSeqiNP_011431.1. NM_001180949.1.

    Genome annotation databases

    EnsemblFungiiYGL084C; YGL084C; YGL084C.
    GeneIDi852796.
    KEGGisce:YGL084C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72606 Genomic DNA. Translation: CAA96789.1 .
    BK006941 Genomic DNA. Translation: DAA08021.1 .
    PIRi S64091.
    RefSeqi NP_011431.1. NM_001180949.1.

    3D structure databases

    ProteinModelPortali P53154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33166. 282 interactions.
    DIPi DIP-4367N.
    IntActi P53154. 1 interaction.
    MINTi MINT-561950.
    STRINGi 4932.YGL084C.

    Protein family/group databases

    TCDBi 2.A.50.1.1. the glycerol uptake (gup) family.

    Proteomic databases

    MaxQBi P53154.
    PaxDbi P53154.
    PeptideAtlasi P53154.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL084C ; YGL084C ; YGL084C .
    GeneIDi 852796.
    KEGGi sce:YGL084C.

    Organism-specific databases

    CYGDi YGL084c.
    SGDi S000003052. GUP1.

    Phylogenomic databases

    eggNOGi COG1696.
    GeneTreei ENSGT00530000063629.
    HOGENOMi HOG000182736.
    OMAi FEYREEE.
    OrthoDBi EOG7B5X4V.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30585-MONOMER.

    Miscellaneous databases

    NextBioi 972303.
    PROi P53154.

    Gene expression databases

    Genevestigatori P53154.

    Family and domain databases

    InterProi IPR004299. MBOAT_fam.
    [Graphical view ]
    Pfami PF03062. MBOAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
      Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
      Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae."
      Holst B., Lunde C., Lages F., Oliveira R., Lucas C., Kielland-Brandt M.C.
      Mol. Microbiol. 37:108-124(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGUP1_YEAST
    AccessioniPrimary (citable) accession number: P53154
    Secondary accession number(s): D6VU60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 672 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3