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Protein

Probable endonuclease LCL3

Gene

LCL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151PROSITE-ProRule annotation1
Metal bindingi156CalciumPROSITE-ProRule annotation1
Active sitei159PROSITE-ProRule annotation1
Active sitei199PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30586-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endonuclease LCL3 (EC:3.1.-.-)
Alternative name(s):
Long chronological lifespan protein 3
Gene namesi
Name:LCL3
Ordered Locus Names:YGL085W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL085W.
SGDiS000003053. LCL3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 32HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Leads to long chronological lifespan.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002152851 – 274Probable endonuclease LCL3Add BLAST274

Proteomic databases

MaxQBiP53153.
PRIDEiP53153.

PTM databases

iPTMnetiP53153.

Expressioni

Inductioni

By DNA-damaging agent methyl methanesulphonate (MMS) (at protein level).1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SHO1P400732EBI-23857,EBI-18140

Protein-protein interaction databases

BioGridi33165. 8 interactors.
IntActiP53153. 3 interactors.
MINTiMINT-1549028.

Structurei

3D structure databases

ProteinModelPortaliP53153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 261TNase-likePROSITE-ProRule annotationAdd BLAST209

Sequence similaritiesi

Belongs to the LCL3 family.Curated
Contains 1 TNase-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP53153.
OMAiDNFHLFH.
OrthoDBiEOG092C47TW.

Family and domain databases

Gene3Di2.40.50.90. 2 hits.
InterProiIPR016071. Staphylococal_nuclease_OB-fold.
[Graphical view]
PfamiPF00565. SNase. 1 hit.
[Graphical view]
SMARTiSM00318. SNc. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 2 hits.
PROSITEiPS50830. TNASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREGDSNSKK SADVAVLSII LTGSTLTLIY TYKRYLTQFK RTNDIPRRIF
60 70 80 90 100
RKHWLYGKVT SVGDGDNFHF FHMPGGIRGG WGWLRPVPQM IKNDSTAEKL
110 120 130 140 150
VGDSRNMRFF NFNWITHGRS TKSKIQKAKS QFLKLNVPYK NRKNLPTIPI
160 170 180 190 200
RLCGIDAPER AHFGNPAQPF GNEALIWLQN RILGKKVWVK PLSIDQYNRC
210 220 230 240 250
VARVSYWDWF GGWKDLSLEM LKDGLAVVYE GKVNTEFDDR EDKYRYYEFL
260 270
ARSRKKGLWI QNKFETPGEY KKRI
Length:274
Mass (Da):32,112
Last modified:October 1, 1996 - v1
Checksum:i38C1B01FEF4838A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72607 Genomic DNA. Translation: CAA96790.1.
BK006941 Genomic DNA. Translation: DAA08020.1.
PIRiS64092.
RefSeqiNP_011430.1. NM_001180950.1.

Genome annotation databases

EnsemblFungiiYGL085W; YGL085W; YGL085W.
GeneIDi852795.
KEGGisce:YGL085W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72607 Genomic DNA. Translation: CAA96790.1.
BK006941 Genomic DNA. Translation: DAA08020.1.
PIRiS64092.
RefSeqiNP_011430.1. NM_001180950.1.

3D structure databases

ProteinModelPortaliP53153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33165. 8 interactors.
IntActiP53153. 3 interactors.
MINTiMINT-1549028.

PTM databases

iPTMnetiP53153.

Proteomic databases

MaxQBiP53153.
PRIDEiP53153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL085W; YGL085W; YGL085W.
GeneIDi852795.
KEGGisce:YGL085W.

Organism-specific databases

EuPathDBiFungiDB:YGL085W.
SGDiS000003053. LCL3.

Phylogenomic databases

InParanoidiP53153.
OMAiDNFHLFH.
OrthoDBiEOG092C47TW.

Enzyme and pathway databases

BioCyciYEAST:G3O-30586-MONOMER.

Miscellaneous databases

PROiP53153.

Family and domain databases

Gene3Di2.40.50.90. 2 hits.
InterProiIPR016071. Staphylococal_nuclease_OB-fold.
[Graphical view]
PfamiPF00565. SNase. 1 hit.
[Graphical view]
SMARTiSM00318. SNc. 1 hit.
[Graphical view]
SUPFAMiSSF50199. SSF50199. 2 hits.
PROSITEiPS50830. TNASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCL3_YEAST
AccessioniPrimary (citable) accession number: P53153
Secondary accession number(s): D6VU59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.