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Protein

Ligase-interacting factor 1

Gene

LIF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stabilizes DNL4. Involved in non-homologous repair of DNA double-strand breaks.1 Publication

Miscellaneous

Present with 876 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • double-strand break repair via nonhomologous end joining Source: SGD

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-30590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ligase-interacting factor 1
Gene namesi
Name:LIF1
Ordered Locus Names:YGL090W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL090W.
SGDiS000003058. LIF1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844191 – 421Ligase-interacting factor 1Add BLAST421

Proteomic databases

MaxQBiP53150.
PRIDEiP53150.

PTM databases

iPTMnetiP53150.

Interactioni

Subunit structurei

Interacts with the BRCT domain of DNL4 and with NEJ1. The DNL4-LIF1 complex interacts with POL4.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33161. 63 interactors.
DIPiDIP-5477N.
IntActiP53150. 14 interactors.
MINTiMINT-492607.
STRINGi4932.YGL090W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z56X-ray3.92A/B1-246[»]
ProteinModelPortaliP53150.
SMRiP53150.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53150.

Family & Domainsi

Phylogenomic databases

InParanoidiP53150.
KOiK10982.
OMAiASHCELN.
OrthoDBiEOG092C2JP3.

Family and domain databases

InterProiView protein in InterPro
IPR015381. XLF_fam.
PfamiView protein in Pfam
PF09302. XLF. 1 hit.

Sequencei

Sequence statusi: Complete.

P53150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLTEFISC IPVVNEEQNE EDERGLCKIQ IEDGAMLETL DENSLSGLRI
60 70 80 90 100
EKMLVSEGTG IFSKSSFGIN DLRIFTGENI DEESKKYVWY ELLKMLTGHK
110 120 130 140 150
VYIASLDEKV VFTKWTCRMQ DDEVWKVVME LESSAIIRKI AELTLHPVKK
160 170 180 190 200
GEIDLFEMAD KLYKDICCVN DSYRNIKESD SSNRNRVEQL ARERELLDKL
210 220 230 240 250
LETRDERTRA MMVTLLNEKK KKIRELHEIL RQNNIKLSDD DVLDSALINT
260 270 280 290 300
EVQKPISELN SPGKRMKRRK TVVEPQNLQK KLKDTSRRRA NRKISNQSVI
310 320 330 340 350
KMEDDDFDDF QFFGLSKRPI ITAKDKLSEK YDDITSFGDD TQSISFESDS
360 370 380 390 400
SSDVQKHLVS LEDNGIQISA GRSDEDYGDI SGSESETDAS AGEKKSSNHS
410 420
EQSGNDREPC LQTESETDIE T
Length:421
Mass (Da):48,259
Last modified:October 1, 1996 - v1
Checksum:i5BEDC72059E9996F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44S → G in AAU09724 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72612 Genomic DNA. Translation: CAA96796.1.
AY723807 Genomic DNA. Translation: AAU09724.1.
BK006941 Genomic DNA. Translation: DAA08016.1.
PIRiS64097.
RefSeqiNP_011425.1. NM_001180955.1.

Genome annotation databases

EnsemblFungiiYGL090W; YGL090W; YGL090W.
GeneIDi852790.
KEGGisce:YGL090W.

Similar proteinsi

Entry informationi

Entry nameiLIF1_YEAST
AccessioniPrimary (citable) accession number: P53150
Secondary accession number(s): D6VU55, E9P953
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names