P53147 (TOS8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein TOS8

Alternative name(s):
Target of SBF 8

Gene names

Name:	TOS8
Ordered Locus Names:	YGL096W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the TALE/CUP9 homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nuclear chromatin Inferred from direct assay PubMed 12464632. Source: SGD
Molecular_function	chromatin binding Inferred from direct assay PubMed 12464632. Source: SGD sequence-specific DNA binding Inferred from direct assay PubMed 19111667. Source: SGD sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Homeobox protein TOS8		PRO_0000049400
Regions
	DNA binding	194 – 256	63	Homeobox; TALE-type

Sequences

	Sequence		Length	Mass (Da)
	P53147 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 113BE5C51A8D7FFA	FASTA	276	31,257
	10 20 30 40 50 60 MGTSIVNLNQ KIELPPIQVL FESLNRENET KPHFEERRLY QPNPSFVPRT NIAVGSPVNP 70 80 90 100 110 120 VPVSSPVFFI GPSPQRSIQN HNAIMTQNIR QYPVIYNNNR EVISTGERNY IITVGGPPVT 130 140 150 160 170 180 SSQPEYEHIS TPNFYQEQRL AQPHPVNESM MIGGYTNPQP ISISRGKMLS GNISTNSVRG 190 200 210 220 230 240 SNNGYSAKEK KHKAHGKRSN LPKATVSILN KWLHEHVNNP YPTVQEKREL LAKTGLTKLQ 250 260 270 ISNWFINARR RKIFSGQNDA NNFRRKFSSS TNLAKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII." Rieger M., Brueckner M., Schaefer M., Mueller-Auer S. Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z72618 Genomic DNA. Translation: CAA96802.1. AY558496 Genomic DNA. Translation: AAS56822.1. BK006941 Genomic DNA. Translation: DAA08010.1.
PIR	S64103.
RefSeq	NP_011419.1. NM_001180961.1.
3D structure databases
ProteinModelPortal	P53147.
SMR	P53147. Positions 201-251.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-980N.
IntAct	P53147. 2 interactions.
MINT	MINT-397623.
STRING	4932.YGL096W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL096W; YGL096W; YGL096W.
GeneID	852783.
KEGG	sce:YGL096W.
Organism-specific databases
CYGD	YGL096w.
SGD	S000003064. TOS8.
Phylogenomic databases
eggNOG	NOG259970.
GeneTree	ENSGT00680000099964.
OrthoDB	EOG4K0TZ4.
Enzyme and pathway databases
BioCyc	YEAST:G3O-30596-MONOMER.
Gene expression databases
Genevestigator	P53147.
GermOnline	YGL096W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR008422. Homeobox_KN_domain. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF05920. Homeobox_KN. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	972268.

Entry information

Entry name

TOS8_YEAST

Accession

Primary (citable) accession number: P53147
Secondary accession number(s): D6VU49

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program