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Protein

Homeobox protein TOS8

Gene

TOS8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi194 – 256Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • chromatin binding Source: SGD
  • DNA binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30596-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TOS8
Alternative name(s):
Target of SBF 8
Gene namesi
Name:TOS8
Ordered Locus Names:YGL096W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL096W.
SGDiS000003064. TOS8.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000494001 – 276Homeobox protein TOS8Add BLAST276

Proteomic databases

PRIDEiP53147.

PTM databases

iPTMnetiP53147.

Interactioni

Protein-protein interaction databases

BioGridi33154. 22 interactors.
DIPiDIP-980N.
IntActiP53147. 3 interactors.
MINTiMINT-397623.

Structurei

3D structure databases

ProteinModelPortaliP53147.
SMRiP53147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/CUP9 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00550000074260.
InParanoidiP53147.
OrthoDBiEOG092C3ZE7.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSIVNLNQ KIELPPIQVL FESLNRENET KPHFEERRLY QPNPSFVPRT
60 70 80 90 100
NIAVGSPVNP VPVSSPVFFI GPSPQRSIQN HNAIMTQNIR QYPVIYNNNR
110 120 130 140 150
EVISTGERNY IITVGGPPVT SSQPEYEHIS TPNFYQEQRL AQPHPVNESM
160 170 180 190 200
MIGGYTNPQP ISISRGKMLS GNISTNSVRG SNNGYSAKEK KHKAHGKRSN
210 220 230 240 250
LPKATVSILN KWLHEHVNNP YPTVQEKREL LAKTGLTKLQ ISNWFINARR
260 270
RKIFSGQNDA NNFRRKFSSS TNLAKF
Length:276
Mass (Da):31,257
Last modified:October 1, 1996 - v1
Checksum:i113BE5C51A8D7FFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72618 Genomic DNA. Translation: CAA96802.1.
AY558496 Genomic DNA. Translation: AAS56822.1.
BK006941 Genomic DNA. Translation: DAA08010.1.
PIRiS64103.
RefSeqiNP_011419.1. NM_001180961.1.

Genome annotation databases

EnsemblFungiiYGL096W; YGL096W; YGL096W.
GeneIDi852783.
KEGGisce:YGL096W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72618 Genomic DNA. Translation: CAA96802.1.
AY558496 Genomic DNA. Translation: AAS56822.1.
BK006941 Genomic DNA. Translation: DAA08010.1.
PIRiS64103.
RefSeqiNP_011419.1. NM_001180961.1.

3D structure databases

ProteinModelPortaliP53147.
SMRiP53147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33154. 22 interactors.
DIPiDIP-980N.
IntActiP53147. 3 interactors.
MINTiMINT-397623.

PTM databases

iPTMnetiP53147.

Proteomic databases

PRIDEiP53147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL096W; YGL096W; YGL096W.
GeneIDi852783.
KEGGisce:YGL096W.

Organism-specific databases

EuPathDBiFungiDB:YGL096W.
SGDiS000003064. TOS8.

Phylogenomic databases

GeneTreeiENSGT00550000074260.
InParanoidiP53147.
OrthoDBiEOG092C3ZE7.

Enzyme and pathway databases

BioCyciYEAST:G3O-30596-MONOMER.

Miscellaneous databases

PROiP53147.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOS8_YEAST
AccessioniPrimary (citable) accession number: P53147
Secondary accession number(s): D6VU49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.