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Protein

Vacuolar protein sorting-associated protein 73

Gene

VPS73

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in vacuolar protein sorting.1 Publication

GO - Molecular functioni

  • substrate-specific transmembrane transporter activity Source: SGD

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • transmembrane transport Source: SGD
  • transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30603-MONOMER.
ReactomeiR-SCE-189200. Hexose transport.
R-SCE-196836. Vitamin C (ascorbate) metabolism.
R-SCE-422356. Regulation of insulin secretion.
R-SCE-428776. Class II GLUTs.
R-SCE-428790. Facilitative Na+-independent glucose transporters.
R-SCE-5653890. Lactose synthesis.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-70153. Glucose transport.

Protein family/group databases

TCDBi2.A.1.1.93. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 73
Gene namesi
Name:VPS73
Ordered Locus Names:YGL104C
ORF Names:G3090
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL104C.
SGDiS000003072. VPS73.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 90Mitochondrial intermembraneSequence analysisAdd BLAST43
Transmembranei91 – 111Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini112 – 119CytoplasmicSequence analysis8
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 146Mitochondrial intermembraneSequence analysis6
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 178CytoplasmicSequence analysisAdd BLAST11
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 208Mitochondrial intermembraneSequence analysis9
Transmembranei209 – 229Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini230 – 305CytoplasmicSequence analysisAdd BLAST76
Transmembranei306 – 326Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini327 – 342Mitochondrial intermembraneSequence analysisAdd BLAST16
Transmembranei343 – 363Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini364 – 366CytoplasmicSequence analysis3
Transmembranei367 – 387Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini388 – 396Mitochondrial intermembraneSequence analysis9
Transmembranei397 – 417Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini418 – 432CytoplasmicSequence analysisAdd BLAST15
Transmembranei433 – 453Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini454Mitochondrial intermembraneSequence analysis1
Transmembranei455 – 475Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini476 – 486CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504621 – 486Vacuolar protein sorting-associated protein 73Add BLAST486

Proteomic databases

PRIDEiP53142.

PTM databases

iPTMnetiP53142.

Interactioni

Protein-protein interaction databases

BioGridi33146. 41 interactors.
DIPiDIP-1727N.
IntActiP53142. 9 interactors.
MINTiMINT-401590.

Structurei

3D structure databases

ProteinModelPortaliP53142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119022.
HOGENOMiHOG000199277.
InParanoidiP53142.
OMAiHAIRINF.
OrthoDBiEOG092C3L9H.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRILSSASL LSNVSMPRQN KHKITKALCY AIIVASIGSI QFGYHLSELN
60 70 80 90 100
APQQVLSCSE FDIPMEGYPY DRTWLGKRGY KQCIPLNDEQ IGIVTSVFCI
110 120 130 140 150
GGILGSYFAT SLANIYGRKF SSLINCTLNI VGSLIIFNSN SYRGLIIGRI
160 170 180 190 200
LVGISCGSLI VIIPLFIKEV APSGWEGLLG SMTQICIRLG VLLTQGIALP
210 220 230 240 250
LTDSYRWRWI LFGSFLIAVL NFFMWFIVDE SPKWLLAHGR VTDAKLSLCK
260 270 280 290 300
LRGVTFDEAA QEIQDWQLQI ESGDPLIEPT TTNSISGSNS LWKYLRDRTN
310 320 330 340 350
VKSRHVITVL LFGQQFCGIN SIVLYGTKII SQLYPQHAIR INFFISMVNV
360 370 380 390 400
LVTILVSLLI HSLPRKPLLM TSTVLVSVTA FIMGIAMNHN KMNLLIVFSF
410 420 430 440 450
IYMGVFTMGL NPLPFIIMRE VSKPQDMVLA QRYGTICNWV GTFIIAYTFP
460 470 480
IIHDVLSGYV FIIFAIIACS ISAFIWKKVP ETKRSG
Length:486
Mass (Da):54,331
Last modified:October 1, 1996 - v1
Checksum:iD924D9112516450D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72626 Genomic DNA. Translation: CAA96811.1.
Z72625 Genomic DNA. Translation: CAA96810.1.
X97644 Genomic DNA. Translation: CAA66249.1.
BK006941 Genomic DNA. Translation: DAA08003.1.
PIRiS64111.
RefSeqiNP_011411.3. NM_001180969.3.

Genome annotation databases

EnsemblFungiiYGL104C; YGL104C; YGL104C.
GeneIDi852774.
KEGGisce:YGL104C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72626 Genomic DNA. Translation: CAA96811.1.
Z72625 Genomic DNA. Translation: CAA96810.1.
X97644 Genomic DNA. Translation: CAA66249.1.
BK006941 Genomic DNA. Translation: DAA08003.1.
PIRiS64111.
RefSeqiNP_011411.3. NM_001180969.3.

3D structure databases

ProteinModelPortaliP53142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33146. 41 interactors.
DIPiDIP-1727N.
IntActiP53142. 9 interactors.
MINTiMINT-401590.

Protein family/group databases

TCDBi2.A.1.1.93. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP53142.

Proteomic databases

PRIDEiP53142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL104C; YGL104C; YGL104C.
GeneIDi852774.
KEGGisce:YGL104C.

Organism-specific databases

EuPathDBiFungiDB:YGL104C.
SGDiS000003072. VPS73.

Phylogenomic databases

GeneTreeiENSGT00760000119022.
HOGENOMiHOG000199277.
InParanoidiP53142.
OMAiHAIRINF.
OrthoDBiEOG092C3L9H.

Enzyme and pathway databases

BioCyciYEAST:G3O-30603-MONOMER.
ReactomeiR-SCE-189200. Hexose transport.
R-SCE-196836. Vitamin C (ascorbate) metabolism.
R-SCE-422356. Regulation of insulin secretion.
R-SCE-428776. Class II GLUTs.
R-SCE-428790. Facilitative Na+-independent glucose transporters.
R-SCE-5653890. Lactose synthesis.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-70153. Glucose transport.

Miscellaneous databases

PROiP53142.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVPS73_YEAST
AccessioniPrimary (citable) accession number: P53142
Secondary accession number(s): D6VU42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.