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P53142

- VPS73_YEAST

UniProt

P53142 - VPS73_YEAST

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Protein

Vacuolar protein sorting-associated protein 73

Gene

VPS73

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in vacuolar protein sorting.1 Publication

GO - Molecular functioni

  1. substrate-specific transmembrane transporter activity Source: SGD

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. transmembrane transport Source: SGD
  3. transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30603-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.93. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 73
Gene namesi
Name:VPS73
Ordered Locus Names:YGL104C
ORF Names:G3090
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL104c.
SGDiS000003072. VPS73.

Subcellular locationi

Mitochondrion membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Vacuolar protein sorting-associated protein 73PRO_0000050462Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP53142.

Interactioni

Protein-protein interaction databases

BioGridi33146. 42 interactions.
DIPiDIP-1727N.
IntActiP53142. 9 interactions.
MINTiMINT-401590.
STRINGi4932.YGL104C.

Structurei

3D structure databases

ProteinModelPortaliP53142.
SMRiP53142. Positions 25-483.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini48 – 9043Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini112 – 1198CytoplasmicSequence Analysis
Topological domaini141 – 1466Mitochondrial intermembraneSequence Analysis
Topological domaini168 – 17811CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini200 – 2089Mitochondrial intermembraneSequence Analysis
Topological domaini230 – 30576CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini327 – 34216Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini364 – 3663CytoplasmicSequence Analysis
Topological domaini388 – 3969Mitochondrial intermembraneSequence Analysis
Topological domaini418 – 43215CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini454 – 4541Mitochondrial intermembraneSequence Analysis
Topological domaini476 – 48611CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei209 – 22921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei306 – 32621Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei343 – 36321Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei367 – 38721Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei397 – 41721Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei433 – 45321Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei455 – 47521Helical; Name=12Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000199277.
InParanoidiP53142.
OMAiENEMVIN.
OrthoDBiEOG71P2M5.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53142-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRILSSASL LSNVSMPRQN KHKITKALCY AIIVASIGSI QFGYHLSELN
60 70 80 90 100
APQQVLSCSE FDIPMEGYPY DRTWLGKRGY KQCIPLNDEQ IGIVTSVFCI
110 120 130 140 150
GGILGSYFAT SLANIYGRKF SSLINCTLNI VGSLIIFNSN SYRGLIIGRI
160 170 180 190 200
LVGISCGSLI VIIPLFIKEV APSGWEGLLG SMTQICIRLG VLLTQGIALP
210 220 230 240 250
LTDSYRWRWI LFGSFLIAVL NFFMWFIVDE SPKWLLAHGR VTDAKLSLCK
260 270 280 290 300
LRGVTFDEAA QEIQDWQLQI ESGDPLIEPT TTNSISGSNS LWKYLRDRTN
310 320 330 340 350
VKSRHVITVL LFGQQFCGIN SIVLYGTKII SQLYPQHAIR INFFISMVNV
360 370 380 390 400
LVTILVSLLI HSLPRKPLLM TSTVLVSVTA FIMGIAMNHN KMNLLIVFSF
410 420 430 440 450
IYMGVFTMGL NPLPFIIMRE VSKPQDMVLA QRYGTICNWV GTFIIAYTFP
460 470 480
IIHDVLSGYV FIIFAIIACS ISAFIWKKVP ETKRSG
Length:486
Mass (Da):54,331
Last modified:October 1, 1996 - v1
Checksum:iD924D9112516450D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72626 Genomic DNA. Translation: CAA96811.1.
Z72625 Genomic DNA. Translation: CAA96810.1.
X97644 Genomic DNA. Translation: CAA66249.1.
BK006941 Genomic DNA. Translation: DAA08003.1.
PIRiS64111.
RefSeqiNP_011411.3. NM_001180969.3.

Genome annotation databases

EnsemblFungiiYGL104C; YGL104C; YGL104C.
GeneIDi852774.
KEGGisce:YGL104C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72626 Genomic DNA. Translation: CAA96811.1 .
Z72625 Genomic DNA. Translation: CAA96810.1 .
X97644 Genomic DNA. Translation: CAA66249.1 .
BK006941 Genomic DNA. Translation: DAA08003.1 .
PIRi S64111.
RefSeqi NP_011411.3. NM_001180969.3.

3D structure databases

ProteinModelPortali P53142.
SMRi P53142. Positions 25-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33146. 42 interactions.
DIPi DIP-1727N.
IntActi P53142. 9 interactions.
MINTi MINT-401590.
STRINGi 4932.YGL104C.

Protein family/group databases

TCDBi 2.A.1.1.93. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL104C ; YGL104C ; YGL104C .
GeneIDi 852774.
KEGGi sce:YGL104C.

Organism-specific databases

CYGDi YGL104c.
SGDi S000003072. VPS73.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000119022.
HOGENOMi HOG000199277.
InParanoidi P53142.
OMAi ENEMVIN.
OrthoDBi EOG71P2M5.

Enzyme and pathway databases

BioCyci YEAST:G3O-30603-MONOMER.

Miscellaneous databases

NextBioi 972245.

Gene expression databases

Genevestigatori P53142.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
    Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
    Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-151.
    Strain: ATCC 204508 / S288c.
  4. "The genes encoding the transcription factor yTAFII60, the G4p1 protein and a putative glucose transporter are contained in a 12.3 kb DNA fragment on the left arm of Saccharomyces cerevisiae chromosome VII."
    Paoluzi S., Minenkova O., Castagnoli L.
    Yeast 13:85-91(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-486.
  5. "Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae."
    Bonangelino C.J., Chavez E.M., Bonifacino J.S.
    Mol. Biol. Cell 13:2486-2501(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVPS73_YEAST
AccessioniPrimary (citable) accession number: P53142
Secondary accession number(s): D6VU42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3