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P53142

- VPS73_YEAST

UniProt

P53142 - VPS73_YEAST

Protein

Vacuolar protein sorting-associated protein 73

Gene

VPS73

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May be involved in vacuolar protein sorting.1 Publication

    GO - Molecular functioni

    1. substrate-specific transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. transmembrane transport Source: SGD
    3. transport Source: SGD

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30603-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.1.93. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 73
    Gene namesi
    Name:VPS73
    Ordered Locus Names:YGL104C
    ORF Names:G3090
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL104c.
    SGDiS000003072. VPS73.

    Subcellular locationi

    Mitochondrion membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Vacuolar protein sorting-associated protein 73PRO_0000050462Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP53142.

    Interactioni

    Protein-protein interaction databases

    BioGridi33146. 42 interactions.
    DIPiDIP-1727N.
    IntActiP53142. 9 interactions.
    MINTiMINT-401590.
    STRINGi4932.YGL104C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53142.
    SMRiP53142. Positions 84-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini48 – 9043Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini112 – 1198CytoplasmicSequence Analysis
    Topological domaini141 – 1466Mitochondrial intermembraneSequence Analysis
    Topological domaini168 – 17811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini200 – 2089Mitochondrial intermembraneSequence Analysis
    Topological domaini230 – 30576CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 34216Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini364 – 3663CytoplasmicSequence Analysis
    Topological domaini388 – 3969Mitochondrial intermembraneSequence Analysis
    Topological domaini418 – 43215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini454 – 4541Mitochondrial intermembraneSequence Analysis
    Topological domaini476 – 48611CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei397 – 41721Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei433 – 45321Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00720000108560.
    HOGENOMiHOG000199277.
    OMAiENEMVIN.
    OrthoDBiEOG71P2M5.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53142-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRILSSASL LSNVSMPRQN KHKITKALCY AIIVASIGSI QFGYHLSELN    50
    APQQVLSCSE FDIPMEGYPY DRTWLGKRGY KQCIPLNDEQ IGIVTSVFCI 100
    GGILGSYFAT SLANIYGRKF SSLINCTLNI VGSLIIFNSN SYRGLIIGRI 150
    LVGISCGSLI VIIPLFIKEV APSGWEGLLG SMTQICIRLG VLLTQGIALP 200
    LTDSYRWRWI LFGSFLIAVL NFFMWFIVDE SPKWLLAHGR VTDAKLSLCK 250
    LRGVTFDEAA QEIQDWQLQI ESGDPLIEPT TTNSISGSNS LWKYLRDRTN 300
    VKSRHVITVL LFGQQFCGIN SIVLYGTKII SQLYPQHAIR INFFISMVNV 350
    LVTILVSLLI HSLPRKPLLM TSTVLVSVTA FIMGIAMNHN KMNLLIVFSF 400
    IYMGVFTMGL NPLPFIIMRE VSKPQDMVLA QRYGTICNWV GTFIIAYTFP 450
    IIHDVLSGYV FIIFAIIACS ISAFIWKKVP ETKRSG 486
    Length:486
    Mass (Da):54,331
    Last modified:October 1, 1996 - v1
    Checksum:iD924D9112516450D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72626 Genomic DNA. Translation: CAA96811.1.
    Z72625 Genomic DNA. Translation: CAA96810.1.
    X97644 Genomic DNA. Translation: CAA66249.1.
    BK006941 Genomic DNA. Translation: DAA08003.1.
    PIRiS64111.
    RefSeqiNP_011411.3. NM_001180969.3.

    Genome annotation databases

    EnsemblFungiiYGL104C; YGL104C; YGL104C.
    GeneIDi852774.
    KEGGisce:YGL104C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72626 Genomic DNA. Translation: CAA96811.1 .
    Z72625 Genomic DNA. Translation: CAA96810.1 .
    X97644 Genomic DNA. Translation: CAA66249.1 .
    BK006941 Genomic DNA. Translation: DAA08003.1 .
    PIRi S64111.
    RefSeqi NP_011411.3. NM_001180969.3.

    3D structure databases

    ProteinModelPortali P53142.
    SMRi P53142. Positions 84-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33146. 42 interactions.
    DIPi DIP-1727N.
    IntActi P53142. 9 interactions.
    MINTi MINT-401590.
    STRINGi 4932.YGL104C.

    Protein family/group databases

    TCDBi 2.A.1.1.93. the major facilitator superfamily (mfs).

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL104C ; YGL104C ; YGL104C .
    GeneIDi 852774.
    KEGGi sce:YGL104C.

    Organism-specific databases

    CYGDi YGL104c.
    SGDi S000003072. VPS73.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00720000108560.
    HOGENOMi HOG000199277.
    OMAi ENEMVIN.
    OrthoDBi EOG71P2M5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30603-MONOMER.

    Miscellaneous databases

    NextBioi 972245.

    Gene expression databases

    Genevestigatori P53142.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
      Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
      Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-151.
      Strain: ATCC 204508 / S288c.
    4. "The genes encoding the transcription factor yTAFII60, the G4p1 protein and a putative glucose transporter are contained in a 12.3 kb DNA fragment on the left arm of Saccharomyces cerevisiae chromosome VII."
      Paoluzi S., Minenkova O., Castagnoli L.
      Yeast 13:85-91(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-486.
    5. "Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae."
      Bonangelino C.J., Chavez E.M., Bonifacino J.S.
      Mol. Biol. Cell 13:2486-2501(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVPS73_YEAST
    AccessioniPrimary (citable) accession number: P53142
    Secondary accession number(s): D6VU42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3