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P53139 (YGK8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein YGL108C
Gene names
Ordered Locus Names:YGL108C
ORF Names:G3070
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Lipid-anchor Ref.4.

Post-translational modification

Myristoylated.

The N-myristoylated protein is further palmitoylated by ERF2, PFA4 and slightly by PFA5, but not by PFA3. Ref.6 Ref.7

Miscellaneous

Present with 2430 molecules/cell in log phase SD medium.

Sequence similarities

To S.pombe new13.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   PTMLipoprotein
Myristate
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Potential
Chain2 – 140139Uncharacterized protein YGL108C
PRO_0000202751

Regions

Compositional bias41 – 499Poly-Lys

Amino acid modifications

Lipidation21N-myristoyl glycine Potential
Lipidation41S-palmitoyl cysteine Probable

Sequences

Sequence LengthMass (Da)Tools
P53139 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 89C6AEC296CA9E57

FASTA14016,037
        10         20         30         40         50         60 
MGLCGSKTQP MPSQTTTVAT KARTKPINRD TVKSKQELRH KEKKDKKKKT QLKSTTVPVV 

        70         80         90        100        110        120 
QRKEGSKLTD TSDPSKNKVS PKEAARLAAE KRFQETNEKY NKGELGKKLA QERAKSHKTR 

       130        140 
LMEEAEKKHA ERERENMIYD 

« Hide

References

« Hide 'large scale' references
[1]"The genes encoding the transcription factor yTAFII60, the G4p1 protein and a putative glucose transporter are contained in a 12.3 kb DNA fragment on the left arm of Saccharomyces cerevisiae chromosome VII."
Paoluzi S., Minenkova O., Castagnoli L.
Yeast 13:85-91(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein palmitoylation in yeast."
Roth A.F., Wan J., Bailey A.O., Sun B., Kuchar J.A., Green W.N., Phinney B.S., Yates J.R. III, Davis N.G.
Cell 125:1003-1013(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION.
[7]"Molecular recognition of the palmitoylation substrate Vac8 by its palmitoyltransferase Pfa3."
Nadolski M.J., Linder M.E.
J. Biol. Chem. 284:17720-17730(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: MYRISTOYLATION, PALMITOYLATION BY ERF2; PFA4 AND PFA5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X97644 Genomic DNA. Translation: CAA66244.1.
Z72631 Genomic DNA. Translation: CAA96816.1.
BK006941 Genomic DNA. Translation: DAA07999.1.
PIRS64116.
RefSeqNP_011407.3. NM_001180973.3.

3D structure databases

ProteinModelPortalP53139.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33142. 18 interactions.
IntActP53139. 11 interactions.
MINTMINT-2493356.
STRING4932.YGL108C.

Proteomic databases

PaxDbP53139.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL108C; YGL108C; YGL108C.
GeneID852770.
KEGGsce:YGL108C.

Organism-specific databases

CYGDYGL108c.
SGDS000003076. YGL108C.

Phylogenomic databases

eggNOGNOG272727.
HOGENOMHOG000142362.
OMAERENMIY.
OrthoDBEOG718KS0.

Enzyme and pathway databases

BioCycYEAST:G3O-30607-MONOMER.

Gene expression databases

GenevestigatorP53139.

Family and domain databases

ProtoNetSearch...

Other

NextBio972233.

Entry information

Entry nameYGK8_YEAST
AccessionPrimary (citable) accession number: P53139
Secondary accession number(s): D6VU38
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD