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P53135

- SLD3_YEAST

UniProt

P53135 - SLD3_YEAST

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Protein

DNA replication regulator SLD3

Gene
SLD3, YGL113W, G2980
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for loading and maintenance of stable association of CDC45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Required for the association of PSF1 with origins.3 Publications

GO - Molecular functioni

  1. chromatin binding Source: SGD
  2. protein binding Source: IntAct

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. DNA replication initiation Source: SGD
  3. DNA unwinding involved in DNA replication Source: SGD
  4. double-strand break repair via break-induced replication Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA replication

Enzyme and pathway databases

BioCyciYEAST:G3O-30611-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication regulator SLD3
Gene namesi
Name:SLD3
Ordered Locus Names:YGL113W
ORF Names:G2980
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL113w.
SGDiS000003081. SLD3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. DNA replication preinitiation complex Source: SGD
  2. nuclear chromatin Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668DNA replication regulator SLD3PRO_0000071954Add
BLAST

Proteomic databases

MaxQBiP53135.
PaxDbiP53135.

Expressioni

Gene expression databases

GenevestigatoriP53135.

Interactioni

Subunit structurei

Interacts with CDC45 and SLD7.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC45Q080325EBI-23925,EBI-4292
SLD7Q084579EBI-23925,EBI-36267

Protein-protein interaction databases

BioGridi33138. 26 interactions.
DIPiDIP-5481N.
IntActiP53135. 7 interactions.
MINTiMINT-564141.
STRINGi4932.YGL113W.

Structurei

3D structure databases

ProteinModelPortaliP53135.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi276 – 2794Poly-Leu

Phylogenomic databases

eggNOGiNOG123149.
HOGENOMiHOG000065971.
KOiK10731.
OMAiNRLQKRQ.
OrthoDBiEOG7G4QQB.

Family and domain databases

InterProiIPR013948. DNA_replication_reg_Sld3.
[Graphical view]
PfamiPF08639. SLD3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53135-1 [UniParc]FASTAAdd to Basket

« Hide

METWEVIASV KEATKGLDLS LDHPLIIKSE DVPSNILQLL QQKNRRQLKH    50
ICMKSRKEYF LLEEYGPGFW VKWPYNYFNG YSLPERRTEV VTTVERERAK 100
RETLKTWDEL KFKELLHLWS EEPKGSCKLE KDKDLKLDMN PPDMKGESKI 150
NDYYSDPKEY IESKYYDALF SIHTPLAYFV KSNLVRLKNT CRTKYGSDSY 200
KIAYQAMLQK FLLSIVQFKD RHDNRLLLEP FSSPIADEKR KNCLTKFVIQ 250
DENKNSSTIA DLCVVLKSRE IKLQILLLLE IIGLNDLDWN FRDFEKKYKL 300
KLKKRSLNLT KKGLVRRRSK KKTSEKDKGI ERITTSLDYC EQLDLYLDRA 350
CILDILLSSE TPNPDAIEAS NGTIQEHKKN ILDKSKEASL VGFINYVLIP 400
YFNKKVPHAV EFIIQKLKGP SMRPKRALKK VNDSTNVSSP NTVETYNRLS 450
TSQRASRSSI INSVPSSPAL RRVDANLFSR KSIASPTPEL LNSRTNSNLN 500
EFLESETRSL KRPSQLGRTK SDLTMNHLQK RQFSVSDLST TRVPNSSTIT 550
LKTPFSHSTI NAYKTMNNSF RRVGKRKDIN ETIRLHERVD SEENVQVQAT 600
PAVKKRTVTP NKKAQLQSII ESPLNFKDDD THEGRKNTSN ITSTPTNKPP 650
ENSSKRRVRR RLFAPEST 668
Length:668
Mass (Da):77,298
Last modified:October 1, 1996 - v1
Checksum:i6E59D0DB3C082C28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72635 Genomic DNA. Translation: CAA96821.1.
Z72634 Genomic DNA. Translation: CAA96820.1.
X97644 Genomic DNA. Translation: CAA66239.1.
BK006941 Genomic DNA. Translation: DAA07995.1.
PIRiS64123.
RefSeqiNP_011402.3. NM_001180978.3.

Genome annotation databases

EnsemblFungiiYGL113W; YGL113W; YGL113W.
GeneIDi852765.
KEGGisce:YGL113W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72635 Genomic DNA. Translation: CAA96821.1 .
Z72634 Genomic DNA. Translation: CAA96820.1 .
X97644 Genomic DNA. Translation: CAA66239.1 .
BK006941 Genomic DNA. Translation: DAA07995.1 .
PIRi S64123.
RefSeqi NP_011402.3. NM_001180978.3.

3D structure databases

ProteinModelPortali P53135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33138. 26 interactions.
DIPi DIP-5481N.
IntActi P53135. 7 interactions.
MINTi MINT-564141.
STRINGi 4932.YGL113W.

Proteomic databases

MaxQBi P53135.
PaxDbi P53135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL113W ; YGL113W ; YGL113W .
GeneIDi 852765.
KEGGi sce:YGL113W.

Organism-specific databases

CYGDi YGL113w.
SGDi S000003081. SLD3.

Phylogenomic databases

eggNOGi NOG123149.
HOGENOMi HOG000065971.
KOi K10731.
OMAi NRLQKRQ.
OrthoDBi EOG7G4QQB.

Enzyme and pathway databases

BioCyci YEAST:G3O-30611-MONOMER.

Miscellaneous databases

NextBioi 972221.

Gene expression databases

Genevestigatori P53135.

Family and domain databases

InterProi IPR013948. DNA_replication_reg_Sld3.
[Graphical view ]
Pfami PF08639. SLD3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The genes encoding the transcription factor yTAFII60, the G4p1 protein and a putative glucose transporter are contained in a 12.3 kb DNA fragment on the left arm of Saccharomyces cerevisiae chromosome VII."
    Paoluzi S., Minenkova O., Castagnoli L.
    Yeast 13:85-91(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 492-668.
  4. "Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae."
    Kamimura Y., Tak Y.-S., Sugino A., Araki H.
    EMBO J. 20:2097-2107(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CDC45.
  5. "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast."
    Takayama Y., Kamimura Y., Okawa M., Muramatsu S., Sugino A., Araki H.
    Genes Dev. 17:1153-1165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast."
    Tanaka T., Umemori T., Endo S., Muramatsu S., Kanemaki M., Kamimura Y., Obuse C., Araki H.
    EMBO J. 30:2019-2030(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLD7.

Entry informationi

Entry nameiSLD3_YEAST
AccessioniPrimary (citable) accession number: P53135
Secondary accession number(s): D6VU34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 125 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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