ID   GPG1_YEAST              Reviewed;         126 AA.
AC   P53130; D6VU27;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   08-NOV-2023, entry version 130.
DE   RecName: Full=Heterotrimeric G protein gamma subunit GPG1;
GN   Name=GPG1; OrderedLocusNames=YGL121C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH GPA2; GPB1 AND GPB2.
RX   PubMed=12150916; DOI=10.1016/s1097-2765(02)00569-5;
RA   Harashima T., Heitman J.;
RT   "The Galpha protein Gpa2 controls yeast differentiation by interacting with
RT   kelch repeat proteins that mimic Gbeta subunits.";
RL   Mol. Cell 10:163-173(2002).
RN   [4]
RP   INDUCTION.
RX   PubMed=14561723; DOI=10.1093/jb/mvg155;
RA   Sakaki K., Tashiro K., Kuhara S., Mihara K.;
RT   "Response of genes associated with mitochondrial function to mild heat
RT   stress in yeast Saccharomyces cerevisiae.";
RL   J. Biochem. 134:373-384(2003).
CC   -!- FUNCTION: Gamma subunit of a guanine nucleotide-binding protein (G
CC       protein). G proteins are involved as modulators or transducers in
CC       various transmembrane signaling systems. The beta and gamma chains are
CC       required for the GTPase activity, for replacement of GDP by GTP, and
CC       for G protein-effector interaction. Involved in the determination of
CC       the cAMP level according to nutritional conditions, most probably as a
CC       regulator of cAMP phosphodiesterase. Required for the control of
CC       pseudohyphal and haploid invasive growth.
CC       {ECO:0000269|PubMed:12150916}.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC       GPG1 interacts with the beta subunits GBP1 and GPB2.
CC       {ECO:0000269|PubMed:12150916}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: By heat. {ECO:0000269|PubMed:14561723}.
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DR   EMBL; Z72643; CAA96829.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA07988.1; -; Genomic_DNA.
DR   PIR; S64131; S64131.
DR   RefSeq; NP_011394.1; NM_001180986.1.
DR   AlphaFoldDB; P53130; -.
DR   BioGRID; 33130; 71.
DR   DIP; DIP-6469N; -.
DR   IntAct; P53130; 5.
DR   MINT; P53130; -.
DR   STRING; 4932.YGL121C; -.
DR   MaxQB; P53130; -.
DR   PaxDb; 4932-YGL121C; -.
DR   PeptideAtlas; P53130; -.
DR   EnsemblFungi; YGL121C_mRNA; YGL121C; YGL121C.
DR   GeneID; 852756; -.
DR   KEGG; sce:YGL121C; -.
DR   AGR; SGD:S000003089; -.
DR   SGD; S000003089; GPG1.
DR   VEuPathDB; FungiDB:YGL121C; -.
DR   eggNOG; ENOG502SAR2; Eukaryota.
DR   HOGENOM; CLU_150807_0_0_1; -.
DR   InParanoid; P53130; -.
DR   OMA; ILMEATR; -.
DR   OrthoDB; 2025367at2759; -.
DR   BioCyc; YEAST:G3O-30618-MONOMER; -.
DR   BioGRID-ORCS; 852756; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P53130; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P53130; Protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; Transducer.
FT   CHAIN           1..126
FT                   /note="Heterotrimeric G protein gamma subunit GPG1"
FT                   /id="PRO_0000202745"
SQ   SEQUENCE   126 AA;  14922 MW;  8F1CADCFCF3F657E CRC64;
     MFYLSDIEEE ASAGAEPTYN FWEVLLFSNT QENLVTVVGE LHTLTDRVVH YKIEPESREV
     TATTLPSLLA LLLEKRNQAR RLYRDVLSMK MSELDWDIDD LFTQLQEELT RTDDTLSMYP
     RRRFYH
//