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P53130

- GPG1_YEAST

UniProt

P53130 - GPG1_YEAST

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Protein
Heterotrimeric G protein gamma subunit GPG1
Gene
GPG1, YGL121C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Gamma subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. invasive growth in response to glucose limitation Source: SGD
  2. signal transduction Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

BioCyciYEAST:G3O-30618-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterotrimeric G protein gamma subunit GPG1
Gene namesi
Name:GPG1
Ordered Locus Names:YGL121C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL121c.
SGDiS000003089. GPG1.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126Heterotrimeric G protein gamma subunit GPG1
PRO_0000202745Add
BLAST

Proteomic databases

MaxQBiP53130.
PaxDbiP53130.

Expressioni

Inductioni

By heat.1 Publication

Gene expression databases

GenevestigatoriP53130.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. GPG1 interacts with the beta subunits GBP1 and GPB2.1 Publication

Protein-protein interaction databases

BioGridi33130. 26 interactions.
DIPiDIP-6469N.
IntActiP53130. 1 interaction.
MINTiMINT-709546.
STRINGi4932.YGL121C.

Structurei

3D structure databases

ProteinModelPortaliP53130.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG72591.
HOGENOMiHOG000000924.
OMAiLINTHRC.
OrthoDBiEOG71K6G2.

Sequencei

Sequence statusi: Complete.

P53130-1 [UniParc]FASTAAdd to Basket

« Hide

MFYLSDIEEE ASAGAEPTYN FWEVLLFSNT QENLVTVVGE LHTLTDRVVH    50
YKIEPESREV TATTLPSLLA LLLEKRNQAR RLYRDVLSMK MSELDWDIDD 100
LFTQLQEELT RTDDTLSMYP RRRFYH 126
Length:126
Mass (Da):14,922
Last modified:October 1, 1996 - v1
Checksum:i8F1CADCFCF3F657E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72643 Genomic DNA. Translation: CAA96829.1.
BK006941 Genomic DNA. Translation: DAA07988.1.
PIRiS64131.
RefSeqiNP_011394.1. NM_001180986.1.

Genome annotation databases

EnsemblFungiiYGL121C; YGL121C; YGL121C.
GeneIDi852756.
KEGGisce:YGL121C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z72643 Genomic DNA. Translation: CAA96829.1 .
BK006941 Genomic DNA. Translation: DAA07988.1 .
PIRi S64131.
RefSeqi NP_011394.1. NM_001180986.1.

3D structure databases

ProteinModelPortali P53130.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33130. 26 interactions.
DIPi DIP-6469N.
IntActi P53130. 1 interaction.
MINTi MINT-709546.
STRINGi 4932.YGL121C.

Proteomic databases

MaxQBi P53130.
PaxDbi P53130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL121C ; YGL121C ; YGL121C .
GeneIDi 852756.
KEGGi sce:YGL121C.

Organism-specific databases

CYGDi YGL121c.
SGDi S000003089. GPG1.

Phylogenomic databases

eggNOGi NOG72591.
HOGENOMi HOG000000924.
OMAi LINTHRC.
OrthoDBi EOG71K6G2.

Enzyme and pathway databases

BioCyci YEAST:G3O-30618-MONOMER.

Miscellaneous databases

NextBioi 972198.

Gene expression databases

Genevestigatori P53130.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits."
    Harashima T., Heitman J.
    Mol. Cell 10:163-173(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GPA2; GPB1 AND GPB2.
  4. "Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae."
    Sakaki K., Tashiro K., Kuhara S., Mihara K.
    J. Biochem. 134:373-384(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiGPG1_YEAST
AccessioniPrimary (citable) accession number: P53130
Secondary accession number(s): D6VU27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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