Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P53130 (GPG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heterotrimeric G protein gamma subunit GPG1
Gene names
Name:GPG1
Ordered Locus Names:YGL121C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gamma subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth. Ref.3

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma. GPG1 interacts with the beta subunits GBP1 and GPB2. Ref.3

Subcellular location

Cytoplasm Probable.

Induction

By heat. Ref.4

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransducer
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinvasive growth in response to glucose limitation

Inferred from mutant phenotype Ref.3. Source: SGD

signal transduction

Inferred from physical interaction Ref.3. Source: SGD

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsignal transducer activity

Inferred from physical interaction Ref.3. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 126126Heterotrimeric G protein gamma subunit GPG1
PRO_0000202745

Sequences

Sequence LengthMass (Da)Tools
P53130 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8F1CADCFCF3F657E

FASTA12614,922
        10         20         30         40         50         60 
MFYLSDIEEE ASAGAEPTYN FWEVLLFSNT QENLVTVVGE LHTLTDRVVH YKIEPESREV 

        70         80         90        100        110        120 
TATTLPSLLA LLLEKRNQAR RLYRDVLSMK MSELDWDIDD LFTQLQEELT RTDDTLSMYP 


RRRFYH 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits."
Harashima T., Heitman J.
Mol. Cell 10:163-173(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH GPA2; GPB1 AND GPB2.
[4]"Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae."
Sakaki K., Tashiro K., Kuhara S., Mihara K.
J. Biochem. 134:373-384(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z72643 Genomic DNA. Translation: CAA96829.1.
BK006941 Genomic DNA. Translation: DAA07988.1.
PIRS64131.
RefSeqNP_011394.1. NM_001180986.1.

3D structure databases

ProteinModelPortalP53130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33130. 26 interactions.
DIPDIP-6469N.
IntActP53130. 1 interaction.
MINTMINT-709546.
STRING4932.YGL121C.

Proteomic databases

PaxDbP53130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL121C; YGL121C; YGL121C.
GeneID852756.
KEGGsce:YGL121C.

Organism-specific databases

CYGDYGL121c.
SGDS000003089. GPG1.

Phylogenomic databases

eggNOGNOG72591.
HOGENOMHOG000000924.
OMAWDLENIV.
OrthoDBEOG71K6G2.

Enzyme and pathway databases

BioCycYEAST:G3O-30618-MONOMER.

Gene expression databases

GenevestigatorP53130.

Family and domain databases

ProtoNetSearch...

Other

NextBio972198.

Entry information

Entry nameGPG1_YEAST
AccessionPrimary (citable) accession number: P53130
Secondary accession number(s): D6VU27
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD