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P53130

- GPG1_YEAST

UniProt

P53130 - GPG1_YEAST

Protein

Heterotrimeric G protein gamma subunit GPG1

Gene

GPG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Gamma subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth.1 Publication

    GO - Molecular functioni

    1. signal transducer activity Source: SGD

    GO - Biological processi

    1. invasive growth in response to glucose limitation Source: SGD
    2. signal transduction Source: SGD

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30618-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heterotrimeric G protein gamma subunit GPG1
    Gene namesi
    Name:GPG1
    Ordered Locus Names:YGL121C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL121c.
    SGDiS000003089. GPG1.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 126126Heterotrimeric G protein gamma subunit GPG1PRO_0000202745Add
    BLAST

    Proteomic databases

    MaxQBiP53130.
    PaxDbiP53130.

    Expressioni

    Inductioni

    By heat.1 Publication

    Gene expression databases

    GenevestigatoriP53130.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma. GPG1 interacts with the beta subunits GBP1 and GPB2.1 Publication

    Protein-protein interaction databases

    BioGridi33130. 26 interactions.
    DIPiDIP-6469N.
    IntActiP53130. 1 interaction.
    MINTiMINT-709546.
    STRINGi4932.YGL121C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG72591.
    HOGENOMiHOG000000924.
    OMAiLINTHRC.
    OrthoDBiEOG71K6G2.

    Sequencei

    Sequence statusi: Complete.

    P53130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFYLSDIEEE ASAGAEPTYN FWEVLLFSNT QENLVTVVGE LHTLTDRVVH    50
    YKIEPESREV TATTLPSLLA LLLEKRNQAR RLYRDVLSMK MSELDWDIDD 100
    LFTQLQEELT RTDDTLSMYP RRRFYH 126
    Length:126
    Mass (Da):14,922
    Last modified:October 1, 1996 - v1
    Checksum:i8F1CADCFCF3F657E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72643 Genomic DNA. Translation: CAA96829.1.
    BK006941 Genomic DNA. Translation: DAA07988.1.
    PIRiS64131.
    RefSeqiNP_011394.1. NM_001180986.1.

    Genome annotation databases

    EnsemblFungiiYGL121C; YGL121C; YGL121C.
    GeneIDi852756.
    KEGGisce:YGL121C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72643 Genomic DNA. Translation: CAA96829.1 .
    BK006941 Genomic DNA. Translation: DAA07988.1 .
    PIRi S64131.
    RefSeqi NP_011394.1. NM_001180986.1.

    3D structure databases

    ProteinModelPortali P53130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33130. 26 interactions.
    DIPi DIP-6469N.
    IntActi P53130. 1 interaction.
    MINTi MINT-709546.
    STRINGi 4932.YGL121C.

    Proteomic databases

    MaxQBi P53130.
    PaxDbi P53130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL121C ; YGL121C ; YGL121C .
    GeneIDi 852756.
    KEGGi sce:YGL121C.

    Organism-specific databases

    CYGDi YGL121c.
    SGDi S000003089. GPG1.

    Phylogenomic databases

    eggNOGi NOG72591.
    HOGENOMi HOG000000924.
    OMAi LINTHRC.
    OrthoDBi EOG71K6G2.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30618-MONOMER.

    Miscellaneous databases

    NextBioi 972198.

    Gene expression databases

    Genevestigatori P53130.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits."
      Harashima T., Heitman J.
      Mol. Cell 10:163-173(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GPA2; GPB1 AND GPB2.
    4. "Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae."
      Sakaki K., Tashiro K., Kuhara S., Mihara K.
      J. Biochem. 134:373-384(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiGPG1_YEAST
    AccessioniPrimary (citable) accession number: P53130
    Secondary accession number(s): D6VU27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3