Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Imitation switch two complex protein 1

Gene

ITC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. THe ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. ITC1 is required for nucleosome-stimulated ATPase activity and chromatin-remodeling activity of the complex. Required for the repression of MATa a-specific genes.6 Publications

GO - Biological processi

  • chromatin remodeling Source: SGD
  • chromatin silencing at telomere Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30628-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Imitation switch two complex protein 1
Gene namesi
Name:ITC1
Ordered Locus Names:YGL133W
ORF Names:G2842
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL133W.
SGDiS000003101. ITC1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • CHRAC Source: SGD
  • chromosome, telomeric region Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12641264Imitation switch two complex protein 1PRO_0000084270Add
BLAST

Proteomic databases

MaxQBiP53125.

PTM databases

iPTMnetiP53125.

Interactioni

Subunit structurei

Component of the ISW2 complex, which at least consists of ISW2, ITC1, DLS1 and DPB4. May form a stable subcomplex with ISW2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ISW2Q087733EBI-23967,EBI-31118

Protein-protein interaction databases

BioGridi33119. 140 interactions.
DIPiDIP-6737N.
IntActiP53125. 36 interactions.
MINTiMINT-469555.

Structurei

3D structure databases

ProteinModelPortaliP53125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 130108WACPROSITE-ProRule annotationAdd
BLAST
Domaini423 – 48361DDTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DDT domain.PROSITE-ProRule annotation
Contains 1 WAC domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000066815.
HOGENOMiHOG000065973.
InParanoidiP53125.
OMAiKHLIKCF.
OrthoDBiEOG092C0J3Q.

Family and domain databases

InterProiIPR018501. DDT_dom.
IPR028941. WHIM2_dom.
IPR013136. WSTF_Acf1_Cbp146.
[Graphical view]
PfamiPF02791. DDT. 1 hit.
PF10537. WAC_Acf1_DNA_bd. 1 hit.
PF15613. WSD. 1 hit.
[Graphical view]
SMARTiSM00571. DDT. 1 hit.
[Graphical view]
PROSITEiPS50827. DDT. 1 hit.
PS51136. WAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLYKRKPIL LPDPKPLPLD LNVQVWHIEE TGEWFSSYEE FLERFDFYTR
60 70 80 90 100
HHFTCEITGT SCLTFFQALD SEETQFKYVE DRFPLKLREP VARFLHFNGI
110 120 130 140 150
RRLDALVEKV YARFKNDFFP GEVVYLRKQK DSSTTSSNSQ QSTPQPDDMV
160 170 180 190 200
EINSVGNPGL PQYQYQRRYV IKEKVQFNAT INPESREIVM PAHTKYMLIE
210 220 230 240 250
EAASSNKSFI VDQGQIYRDR STFTKHLIKC FFKITLQRAS SKMGAPWCVK
260 270 280 290 300
PEYLAMYGLT MEWPKDMLKY KEDEPVVARR SNSANVSSPE SEKNKRQSKS
310 320 330 340 350
SGKSNTSNDA SNKKETKKKR KPTEVNDSEN NSSEEDKKKG QNVTSETHSK
360 370 380 390 400
KRKKEANEEP NTENVESVPT PANAEPQAVT ITSIMDDLAL PYQHPPNIFP
410 420 430 440 450
NLTYYNEKLE CISLGSTKLS RPFDSFGKLL QAYQFLNTFG SKICLSHFSL
460 470 480 490 500
DQFITSLKCT DPYELKGEVV LVNIRTQTSK EQEIENNGLP MKNKAETTTE
510 520 530 540 550
EDSENPSDWQ RNSFIRDMIM KRNSDKVEYK IVHDDPASDD ILDNINHNGS
560 570 580 590 600
ALLIEVFTAL LRLFINEEGD WSCIVVENWI IDDKGVLMER KDERGEGEAK
610 620 630 640 650
QKRNAHGYFL QDKEKIDNLK DTLKENATEV QKESDAKNET NSESDSKSDS
660 670 680 690 700
DSEERDPKLE KCLNYRNVNW IERLTKRQFN NSYWLIILLG VLEDCRHLPM
710 720 730 740 750
YTEFIDSFIE KIIPKDISAT QLPKQLWRNF CRKLSFSDKV NALWILVDLV
760 770 780 790 800
SHFSPDIKAA VDDSMELCGQ IRSERFKVAR ELKTEAAVLS NLQGDLQAIQ
810 820 830 840 850
EKLNKTDENT PSADGADKKD DSESNSEPID LIIIEKKQKL IEEQDKKVQA
860 870 880 890 900
LQSDKNFLDN CLFENDLQRL KPLGLDRYGN RYFWLDHNGV PFPQYPAGMN
910 920 930 940 950
ETPKSNNSLS YHSGRLLIQG PKASSAKFFL NVSDEQLSNW QKIRNSEGIS
960 970 980 990 1000
EATREVFGIS KTSSGSYNYV ENGIEVELLD SNDRVNPLIE LTPIQKKIMD
1010 1020 1030 1040 1050
ETPSRLLLSP DQWYCIDKLE DLSRIMDWLD NWGRKEHDLL RQIRPIMERI
1060 1070 1080 1090 1100
KSSLSLRDHA LSLTAFTKNE EKLLKELENN EFTENELNVD SMDVDDKNSG
1110 1120 1130 1140 1150
VKSEVDVQVD AEEKREAVID EKLEVIADEL MKLDDSSKTR NVLNRIQELE
1160 1170 1180 1190 1200
DQRDELLEQK KSIINSQRPG ARILARSERK RTKISRGNKV NKQIEILTDL
1210 1220 1230 1240 1250
VNYRHFKAME DVIAWKNVLA NSIWGSSLRK NASGNKRSGV IETVDDKLKD
1260
IVGQTSRTVT PAPN
Length:1,264
Mass (Da):145,643
Last modified:October 1, 1996 - v1
Checksum:i45E4CF8835C7C746
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72655 Genomic DNA. Translation: CAA96844.1.
BK006941 Genomic DNA. Translation: DAA07977.1.
PIRiS64146.
RefSeqiNP_011382.1. NM_001180998.1.

Genome annotation databases

EnsemblFungiiYGL133W; YGL133W; YGL133W.
GeneIDi852744.
KEGGisce:YGL133W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72655 Genomic DNA. Translation: CAA96844.1.
BK006941 Genomic DNA. Translation: DAA07977.1.
PIRiS64146.
RefSeqiNP_011382.1. NM_001180998.1.

3D structure databases

ProteinModelPortaliP53125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33119. 140 interactions.
DIPiDIP-6737N.
IntActiP53125. 36 interactions.
MINTiMINT-469555.

PTM databases

iPTMnetiP53125.

Proteomic databases

MaxQBiP53125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL133W; YGL133W; YGL133W.
GeneIDi852744.
KEGGisce:YGL133W.

Organism-specific databases

EuPathDBiFungiDB:YGL133W.
SGDiS000003101. ITC1.

Phylogenomic databases

GeneTreeiENSGT00530000066815.
HOGENOMiHOG000065973.
InParanoidiP53125.
OMAiKHLIKCF.
OrthoDBiEOG092C0J3Q.

Enzyme and pathway databases

BioCyciYEAST:G3O-30628-MONOMER.

Miscellaneous databases

PROiP53125.

Family and domain databases

InterProiIPR018501. DDT_dom.
IPR028941. WHIM2_dom.
IPR013136. WSTF_Acf1_Cbp146.
[Graphical view]
PfamiPF02791. DDT. 1 hit.
PF10537. WAC_Acf1_DNA_bd. 1 hit.
PF15613. WSD. 1 hit.
[Graphical view]
SMARTiSM00571. DDT. 1 hit.
[Graphical view]
PROSITEiPS50827. DDT. 1 hit.
PS51136. WAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITC1_YEAST
AccessioniPrimary (citable) accession number: P53125
Secondary accession number(s): D6VU16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2610 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.