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P53118

- ROG1_YEAST

UniProt

P53118 - ROG1_YEAST

Protein

Putative lipase ROG1

Gene

ROG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei269 – 2691Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. lipase activity Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cellular lipid metabolic process Source: SGD
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30638-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative lipase ROG1 (EC:3.1.-.-)
    Alternative name(s):
    Revertant of glycogen synthase kinase mutation protein 1
    Gene namesi
    Name:ROG1
    Ordered Locus Names:YGL144C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL144c.
    SGDiS000003112. ROG1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 685685Putative lipase ROG1PRO_0000202735Add
    BLAST

    Proteomic databases

    MaxQBiP53118.
    PaxDbiP53118.

    Expressioni

    Gene expression databases

    GenevestigatoriP53118.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSB3P436032EBI-24005,EBI-22980

    Protein-protein interaction databases

    BioGridi33108. 24 interactions.
    IntActiP53118. 3 interactions.
    MINTiMINT-597995.
    STRINGi4932.YGL144C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53118.
    SMRiP53118. Positions 189-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the putative lipase ROG1 family.Curated

    Phylogenomic databases

    eggNOGiNOG316299.
    GeneTreeiENSGT00390000013022.
    HOGENOMiHOG000094252.
    OMAiHGLHSNV.
    OrthoDBiEOG7VHT5J.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR007751. DUF676_lipase-like.
    IPR016445. Lipase_YDL109c.
    [Graphical view]
    PfamiPF05057. DUF676. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005412. UCP005412_abhydr. 1 hit.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53118-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLTPTNEIL FHYKSSVKVG ELERYVITYH LYDGEEIPPD LNLNSLWLKV    50
    RNMNPLSYRA AYLMGPFMLY CDVKTAQYHH SQKIVASVDY PKFEPNVQTQ 100
    QDFVAELSVH NIRQKYVWIA DVMSQILFTT NTNVTYEVTI GTSKESVENP 150
    HDLPSHLGSY SPKLTVNRLT TLDLWNLPVQ ITTPQKKKHL VVLTHGLHSN 200
    VSTDLVYIME QIYKAQKNYP HEQIVVKGYR GNVCQTEKGV KYLGTRLAEY 250
    IIQDLYDESI RKISFVGHSL GGLIQAFAIA YIYEVYPWFF KKVNPINFIT 300
    LASPLLGIVT DNPAYIKVLL SFGVIGKTGQ DLGLENDVEV GKPLLYLLSG 350
    LPLIEILRRF KRRTVYANAI NDGIVPLYTA SLLFLDYNDI LEQLQKLKEN 400
    SKKSPLINDA STPVNQDFFN KTFISPLTKM LSILAPQKFP TENGSEIPKV 450
    SFFESASSIL LPPLPERAYI MDPDSRDPVI IHDKIYNEDD IPQSEFDIED 500
    GFFGKKNILL QAFFAGKKER AKYRNLEETI ARRWHEGMAW RKVVVALKPD 550
    AHNNIIVRRK FANAYGWPVI DHLIDVHFNG DDDDDNDEND DINSTQVVEP 600
    IQSVTEGKKK YRKAENIPQE YGWLNKVETN GVFDEGPTGM ISTVGEIVEA 650
    LAKRGFSAVI DRRNASEDPN DEVLRFEEMN SDLVQ 685
    Length:685
    Mass (Da):78,142
    Last modified:October 1, 1996 - v1
    Checksum:iBE800C5E15148E4A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti514 – 5141F → S in AAU09729. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99960 Genomic DNA. Translation: CAA68218.1.
    Z72666 Genomic DNA. Translation: CAA96856.1.
    AY723812 Genomic DNA. Translation: AAU09729.1.
    BK006941 Genomic DNA. Translation: DAA07966.1.
    PIRiS64158.
    RefSeqiNP_011371.1. NM_001181009.1.

    Genome annotation databases

    EnsemblFungiiYGL144C; YGL144C; YGL144C.
    GeneIDi852733.
    KEGGisce:YGL144C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99960 Genomic DNA. Translation: CAA68218.1 .
    Z72666 Genomic DNA. Translation: CAA96856.1 .
    AY723812 Genomic DNA. Translation: AAU09729.1 .
    BK006941 Genomic DNA. Translation: DAA07966.1 .
    PIRi S64158.
    RefSeqi NP_011371.1. NM_001181009.1.

    3D structure databases

    ProteinModelPortali P53118.
    SMRi P53118. Positions 189-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33108. 24 interactions.
    IntActi P53118. 3 interactions.
    MINTi MINT-597995.
    STRINGi 4932.YGL144C.

    Proteomic databases

    MaxQBi P53118.
    PaxDbi P53118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL144C ; YGL144C ; YGL144C .
    GeneIDi 852733.
    KEGGi sce:YGL144C.

    Organism-specific databases

    CYGDi YGL144c.
    SGDi S000003112. ROG1.

    Phylogenomic databases

    eggNOGi NOG316299.
    GeneTreei ENSGT00390000013022.
    HOGENOMi HOG000094252.
    OMAi HGLHSNV.
    OrthoDBi EOG7VHT5J.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30638-MONOMER.

    Miscellaneous databases

    NextBioi 972132.

    Gene expression databases

    Genevestigatori P53118.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR007751. DUF676_lipase-like.
    IPR016445. Lipase_YDL109c.
    [Graphical view ]
    Pfami PF05057. DUF676. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005412. UCP005412_abhydr. 1 hit.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a nearly unclonable 22.8 kb segment on the left arm chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1, MRF1 genes and six new open reading frames."
      Voet M., Defoor E., Verhasselt P., Riles L., Robben J., Volckaert G.
      Yeast 13:177-182(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiROG1_YEAST
    AccessioniPrimary (citable) accession number: P53118
    Secondary accession number(s): D6VU05, Q66RA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3