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Protein

Putative lipase ROG1

Gene

ROG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei269 – 2691Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. acylglycerol lipase activity Source: SGD

GO - Biological processi

  1. cellular lipid metabolic process Source: SGD
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:G3O-30638-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipase ROG1 (EC:3.1.-.-)
Alternative name(s):
Revertant of glycogen synthase kinase mutation protein 1
Gene namesi
Name:ROG1
Ordered Locus Names:YGL144C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VII

Organism-specific databases

CYGDiYGL144c.
SGDiS000003112. ROG1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Putative lipase ROG1PRO_0000202735Add
BLAST

Proteomic databases

MaxQBiP53118.
PaxDbiP53118.

Expressioni

Gene expression databases

GenevestigatoriP53118.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSB3P436032EBI-24005,EBI-22980

Protein-protein interaction databases

BioGridi33108. 25 interactions.
IntActiP53118. 3 interactions.
MINTiMINT-597995.
STRINGi4932.YGL144C.

Structurei

3D structure databases

ProteinModelPortaliP53118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the putative lipase ROG1 family.Curated

Phylogenomic databases

eggNOGiNOG316299.
GeneTreeiENSGT00390000013022.
HOGENOMiHOG000094252.
InParanoidiP53118.
OMAiHGLHSNV.
OrthoDBiEOG7VHT5J.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007751. DUF676_lipase-like.
IPR016445. Lipase.
[Graphical view]
PANTHERiPTHR12482:SF9. PTHR12482:SF9. 1 hit.
PfamiPF05057. DUF676. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTPTNEIL FHYKSSVKVG ELERYVITYH LYDGEEIPPD LNLNSLWLKV
60 70 80 90 100
RNMNPLSYRA AYLMGPFMLY CDVKTAQYHH SQKIVASVDY PKFEPNVQTQ
110 120 130 140 150
QDFVAELSVH NIRQKYVWIA DVMSQILFTT NTNVTYEVTI GTSKESVENP
160 170 180 190 200
HDLPSHLGSY SPKLTVNRLT TLDLWNLPVQ ITTPQKKKHL VVLTHGLHSN
210 220 230 240 250
VSTDLVYIME QIYKAQKNYP HEQIVVKGYR GNVCQTEKGV KYLGTRLAEY
260 270 280 290 300
IIQDLYDESI RKISFVGHSL GGLIQAFAIA YIYEVYPWFF KKVNPINFIT
310 320 330 340 350
LASPLLGIVT DNPAYIKVLL SFGVIGKTGQ DLGLENDVEV GKPLLYLLSG
360 370 380 390 400
LPLIEILRRF KRRTVYANAI NDGIVPLYTA SLLFLDYNDI LEQLQKLKEN
410 420 430 440 450
SKKSPLINDA STPVNQDFFN KTFISPLTKM LSILAPQKFP TENGSEIPKV
460 470 480 490 500
SFFESASSIL LPPLPERAYI MDPDSRDPVI IHDKIYNEDD IPQSEFDIED
510 520 530 540 550
GFFGKKNILL QAFFAGKKER AKYRNLEETI ARRWHEGMAW RKVVVALKPD
560 570 580 590 600
AHNNIIVRRK FANAYGWPVI DHLIDVHFNG DDDDDNDEND DINSTQVVEP
610 620 630 640 650
IQSVTEGKKK YRKAENIPQE YGWLNKVETN GVFDEGPTGM ISTVGEIVEA
660 670 680
LAKRGFSAVI DRRNASEDPN DEVLRFEEMN SDLVQ
Length:685
Mass (Da):78,142
Last modified:September 30, 1996 - v1
Checksum:iBE800C5E15148E4A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti514 – 5141F → S in AAU09729 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99960 Genomic DNA. Translation: CAA68218.1.
Z72666 Genomic DNA. Translation: CAA96856.1.
AY723812 Genomic DNA. Translation: AAU09729.1.
BK006941 Genomic DNA. Translation: DAA07966.1.
PIRiS64158.
RefSeqiNP_011371.1. NM_001181009.1.

Genome annotation databases

EnsemblFungiiYGL144C; YGL144C; YGL144C.
GeneIDi852733.
KEGGisce:YGL144C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99960 Genomic DNA. Translation: CAA68218.1.
Z72666 Genomic DNA. Translation: CAA96856.1.
AY723812 Genomic DNA. Translation: AAU09729.1.
BK006941 Genomic DNA. Translation: DAA07966.1.
PIRiS64158.
RefSeqiNP_011371.1. NM_001181009.1.

3D structure databases

ProteinModelPortaliP53118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33108. 25 interactions.
IntActiP53118. 3 interactions.
MINTiMINT-597995.
STRINGi4932.YGL144C.

Proteomic databases

MaxQBiP53118.
PaxDbiP53118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL144C; YGL144C; YGL144C.
GeneIDi852733.
KEGGisce:YGL144C.

Organism-specific databases

CYGDiYGL144c.
SGDiS000003112. ROG1.

Phylogenomic databases

eggNOGiNOG316299.
GeneTreeiENSGT00390000013022.
HOGENOMiHOG000094252.
InParanoidiP53118.
OMAiHGLHSNV.
OrthoDBiEOG7VHT5J.

Enzyme and pathway databases

BioCyciYEAST:G3O-30638-MONOMER.

Miscellaneous databases

NextBioi972132.

Gene expression databases

GenevestigatoriP53118.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007751. DUF676_lipase-like.
IPR016445. Lipase.
[Graphical view]
PANTHERiPTHR12482:SF9. PTHR12482:SF9. 1 hit.
PfamiPF05057. DUF676. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a nearly unclonable 22.8 kb segment on the left arm chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1, MRF1 genes and six new open reading frames."
    Voet M., Defoor E., Verhasselt P., Riles L., Robben J., Volckaert G.
    Yeast 13:177-182(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiROG1_YEAST
AccessioniPrimary (citable) accession number: P53118
Secondary accession number(s): D6VU05, Q66RA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1996
Last sequence update: September 30, 1996
Last modified: March 31, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.