P53118 (ROG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative lipase ROG1
EC=3.1.-.-

Alternative name(s):
Revertant of glycogen synthase kinase mutation protein 1

Gene names

Name:	ROG1
Ordered Locus Names:	YGL144C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	685 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the putative lipase ROG1 family.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular lipid metabolic process Inferred from mutant phenotype PubMed 10341423. Source: SGD lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipase activity Non-traceable author statement PubMed 10341423. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSB3	P43603	1	EBI-24005,EBI-22980
YSC84	P32793	1	EBI-24005,EBI-24460

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 685	685	Putative lipase ROG1		PRO_0000202735
Sites
	Active site	269	1	Charge relay system By similarity
Experimental info
	Sequence conflict	514	1	F → S in AAU09729. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P53118 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: BE800C5E15148E4A	FASTA	685	78,142
	10 20 30 40 50 60 MSLTPTNEIL FHYKSSVKVG ELERYVITYH LYDGEEIPPD LNLNSLWLKV RNMNPLSYRA 70 80 90 100 110 120 AYLMGPFMLY CDVKTAQYHH SQKIVASVDY PKFEPNVQTQ QDFVAELSVH NIRQKYVWIA 130 140 150 160 170 180 DVMSQILFTT NTNVTYEVTI GTSKESVENP HDLPSHLGSY SPKLTVNRLT TLDLWNLPVQ 190 200 210 220 230 240 ITTPQKKKHL VVLTHGLHSN VSTDLVYIME QIYKAQKNYP HEQIVVKGYR GNVCQTEKGV 250 260 270 280 290 300 KYLGTRLAEY IIQDLYDESI RKISFVGHSL GGLIQAFAIA YIYEVYPWFF KKVNPINFIT 310 320 330 340 350 360 LASPLLGIVT DNPAYIKVLL SFGVIGKTGQ DLGLENDVEV GKPLLYLLSG LPLIEILRRF 370 380 390 400 410 420 KRRTVYANAI NDGIVPLYTA SLLFLDYNDI LEQLQKLKEN SKKSPLINDA STPVNQDFFN 430 440 450 460 470 480 KTFISPLTKM LSILAPQKFP TENGSEIPKV SFFESASSIL LPPLPERAYI MDPDSRDPVI 490 500 510 520 530 540 IHDKIYNEDD IPQSEFDIED GFFGKKNILL QAFFAGKKER AKYRNLEETI ARRWHEGMAW 550 560 570 580 590 600 RKVVVALKPD AHNNIIVRRK FANAYGWPVI DHLIDVHFNG DDDDDNDEND DINSTQVVEP 610 620 630 640 650 660 IQSVTEGKKK YRKAENIPQE YGWLNKVETN GVFDEGPTGM ISTVGEIVEA LAKRGFSAVI 670 680 DRRNASEDPN DEVLRFEEMN SDLVQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of a nearly unclonable 22.8 kb segment on the left arm chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1, MRF1 genes and six new open reading frames." Voet M., Defoor E., Verhasselt P., Riles L., Robben J., Volckaert G. Yeast 13:177-182(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99960 Genomic DNA. Translation: CAA68218.1. Z72666 Genomic DNA. Translation: CAA96856.1. AY723812 Genomic DNA. Translation: AAU09729.1. BK006941 Genomic DNA. Translation: DAA07966.1.
PIR	S64158.
RefSeq	NP_011371.1. NM_001181009.1.
3D structure databases
ProteinModelPortal	P53118.
ModBase	Search...
Protein-protein interaction databases
IntAct	P53118. 3 interactions.
MINT	MINT-597995.
STRING	4932.YGL144C.
Proteomic databases
PaxDb	P53118.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL144C; YGL144C; YGL144C.
GeneID	852733.
KEGG	sce:YGL144C.
Organism-specific databases
CYGD	YGL144c.
SGD	S000003112. ROG1.
Phylogenomic databases
eggNOG	NOG316299.
GeneTree	ENSGT00390000013022.
HOGENOM	HOG000094252.
OMA	HGLHSNV.
OrthoDB	EOG4K6KCQ.
Gene expression databases
Genevestigator	P53118.
GermOnline	YGL144C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007751. DUF676_lipase-like. IPR016445. Lipase_YDL109c. [Graphical view]
Pfam	PF05057. DUF676. 1 hit. [Graphical view]
PIRSF	PIRSF005412. UCP005412_abhydr. 1 hit.
PROSITE	PS00120. LIPASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	972132.

Entry information

Entry name

ROG1_YEAST

Accession

Primary (citable) accession number: P53118
Secondary accession number(s): D6VU05, Q66RA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program